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1. 发明公开

EP4427032A1 REDOX CAPACITANCE SENSING OF PARTICLES UNDER FLOW 审中-实审
公开(公告)号：EP4427032A1
公开(公告)日：2024-09-11
申请号：EP22798367.3
申请日：2022-10-31
申请人： Oxford University Innovation Limited
发明人： PATRICK, Sophie , HEIN, Robert , BEER, Paul , DAVIS, Jason
IPC分类号： G01N27/327 , G01N33/487
CPC分类号： G01N33/487 , G01N27/3277

2. 发明授权

EP2844988B1 ELECTROCHEMICAL DETECTION METHOD 有权转让
公开(公告)号：EP2844988B1
公开(公告)日：2019-04-24
申请号：EP13720516.7
申请日：2013-05-01
申请人： Oxford University Innovation Limited , Universidade Estadual Paulista "Júlio De Mesquita Filho" - UNESP
发明人： DAVIS, Jason , BUENO, Paulo Roberto
IPC分类号： G01N27/02 , G01N27/327

3. 发明授权

EP3211410B1 AN ELECTRODE AND USE THEREOF 有权
公开(公告)号：EP3211410B1
公开(公告)日：2019-11-20
申请号：EP17166598.7
申请日：2013-07-02
申请人： Oxford University Innovation Limited
发明人： DAVIS, Jason
IPC分类号： G01N27/02 , G01N27/327 , G01N33/543 , A61B5/145 , A61B5/1468 , A61B5/1486

4. 发明授权

EP3250911B1 QUANTUM CAPACITANCE SENSING 有权
公开(公告)号：EP3250911B1
公开(公告)日：2019-05-22
申请号：EP16701879.5
申请日：2016-01-26
申请人： Oxford University Innovation Limited , Universidade Estadual Paulista "Júlio De Mesquita Filho" - UNESP
发明人： DAVIS, Jason , BUENO, Paulo Roberto
IPC分类号： G01N27/02 , G01N33/543

5. 发明公开

EP4058807A1 BIOMARKERS FOR THE PREDICTION AND IDENTIFICATION OF PARKINSON'S DISEASE 审中-公开
公开(公告)号：EP4058807A1
公开(公告)日：2022-09-21
申请号：EP20807481.5
申请日：2020-11-11
申请人： Oxford University Innovation Limited
发明人： TOFARIS, George , DAVIS, Jason , JIANG, Cheng
IPC分类号： G01N33/68

6. 发明公开

EP4058803A1 METHOD OF ISOLATING A SELECTED POPULATION OF EXOSOMES 审中-公开
公开(公告)号：EP4058803A1
公开(公告)日：2022-09-21
申请号：EP20807480.7
申请日：2020-11-11
申请人： Oxford University Innovation Limited
发明人： TOFARIS, George , DAVIS, Jason , JIANG, Cheng
IPC分类号： G01N33/543

7. 发明公开

EP3250911A1 QUANTUM CAPACITANCE SENSING 有权
标题翻译：量子电容传感
公开(公告)号：EP3250911A1
公开(公告)日：2017-12-06
申请号：EP16701879.5
申请日：2016-01-26
申请人： Oxford University Innovation Limited , Universidade Estadual Paulista "Júlio De Mesquita Filho" - UNESP
发明人： DAVIS, Jason , BUENO, Paulo Roberto
IPC分类号： G01N27/02 , G01N33/543
CPC分类号： G01N27/221 , G01N27/026 , G01N27/227 , G01N27/27 , G01N33/5438 , G01N33/68 , G01N2333/4737 , G01R27/2605 , H01L29/1606 , H01L31/115
摘要： The present application relates to a sensing method that is carried out using an electrode that comprises an electrode substrate functionalised with sensing elements. The method involves conducting electrochemical impedance spectroscopy at a plurality of applied voltages and then integrating measurement data as a function of voltage. Also provided is an apparatus for carrying out the sensing method. The method and apparatus are suitable for a broad range of sensing applications, including the detection of diagnostic biomarkers, drug screening, development of glycoarray systems and the sensing of environmental parameters such as light intensity, temperature and humidity.

8. 发明公开

EP4399514A1 ELECTROCHEMICAL SHOTGUN TAGGING ASSAY 审中-实审
公开(公告)号：EP4399514A1
公开(公告)日：2024-07-17
申请号：EP22773294.8
申请日：2022-09-08
申请人： Oxford University Innovation Limited
发明人： DAVIS, Jason , SHARAFELDIN, Mohamed , FLESCHHUT, Felix
IPC分类号： G01N27/327 , B01L3/00 , G01N33/543
CPC分类号： G01N27/3275 , G01N33/5438

9. 发明公开

EP3211410A1 AN ELECTRODE AND USE THEREOF 有权
标题翻译：电极及其用途
公开(公告)号：EP3211410A1
公开(公告)日：2017-08-30
申请号：EP17166598.7
申请日：2013-07-02
申请人： Oxford University Innovation Limited
发明人： DAVIS, Jason
IPC分类号： G01N27/327 , G01N27/02 , G01N33/543
摘要： The application relates to an electrode for use in the electrochemical detection of target species, and in particular for the detection of insulin. The application enables insulin to be detected with high selectivity and with a detection limit in the picomolar range or lower. The electrodes of the invention can easily be reused and are ideally suited for use in point-of-care diagnostics. In a preferred embodiment, the electrode comprises an antibody modified, polyethylene glycol (PEG) monolayer assembled on a gold surface. In a second embodiment, the electrode comprises a chemisorbed zwitterionic carboxybetaine polymer obtained by photopolymerisation of carboxybetaine methacrylate (CBMA). This allows the use of non Faradaic analysis to determine the insulin concentration even in undiluted blood serum.
摘要翻译：本申请涉及用于目标物质的电化学检测，特别是用于检测胰岛素的电极。该应用能够以高选择性检测胰岛素并且具有皮摩尔范围或更低的检测极限。本发明的电极可以容易地重复使用并且非常适合用于即时诊断。在优选的实施方案中，电极包含组装在金表面上的抗体修饰的聚乙二醇（PEG）单层。在第二个实施方案中，电极包含通过羧基甜菜碱甲基丙烯酸酯（CBMA）的光聚合获得的化学吸附的两性离子羧基甜菜碱聚合物。这允许使用非法拉第分析来确定即使在未稀释血清中的胰岛素浓度。

10. 发明授权

EP2870466B1 AN ELECTRODE AND USE THEREOF 有权转让
标题翻译：电极及其用途
公开(公告)号：EP2870466B1
公开(公告)日：2017-04-26
申请号：EP13733454.6
申请日：2013-07-02
申请人： Oxford University Innovation Limited
发明人： DAVIS, Jason
IPC分类号： G01N27/327 , G01N27/02 , G01N33/543
CPC分类号： G01N27/3275 , G01N27/026 , G01N27/3276 , G01N2333/62
摘要： The application relates to an electrode for use in the electrochemical detection of target species, and in particular for the detection of insulin. The application enables insulin to be detected with high selectivity and with a detection limit in the picomolar range or lower. The electrodes of the invention can easily be reused and are ideally suited for use in point-of-care diagnostics. In a preferred embodiment, the electrode comprises an antibody modified, polyethylene glycol (PEG) monolayer assembled on a gold surface. In a second embodiment, the electrode comprises a chemisorbed zwitterionic carboxybetaine polymer obtained by photopolymerisation of carboxybetaine methacrylate (CBMA). This allows the use of non Faradaic analysis to determine the insulin concentration even in undiluted blood serum.
摘要翻译：本申请涉及用于目标物质的电化学检测，特别是用于检测胰岛素的电极。该应用能够以高选择性检测胰岛素并且具有皮摩尔范围或更低的检测极限。本发明的电极可以容易地重复使用并且非常适合用于即时诊断。在优选的实施方案中，电极包含组装在金表面上的抗体修饰的聚乙二醇（PEG）单层。在第二个实施方案中，电极包含通过羧基甜菜碱甲基丙烯酸酯（CBMA）的光聚合获得的化学吸附的两性离子羧基甜菜碱聚合物。这允许使用非法拉第分析来确定即使在未稀释血清中的胰岛素浓度。

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