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1. 发明授权

EP2569430B1 METHODS FOR PRODUCING ENTEROENDOCRINE CELLS THAT MAKE AND SECRETE INSULIN 有权转让
公开(公告)号：EP2569430B1
公开(公告)日：2018-10-17
申请号：EP11781319.6
申请日：2011-05-12
申请人： The Trustees of Columbia University in the City of New York
发明人： TALCHAI, Chutima , ACCILI, Domenico
IPC分类号： C12N15/113 , C07H21/04 , A61K31/7088 , A61K31/713 , A61K39/00 , A61P3/08
CPC分类号： C12N15/113 , A61K31/7088 , A61K39/3955 , C12N5/0678 , C12N5/068 , C12N2310/11 , C12N2310/14 , G01N33/5008 , G01N33/5073 , G01N2333/62
摘要： Methods are described for producing enteroendocrine cells that make and secrete insulin in a mammal by blocking the expression or biological activity of one or more Foxo proteins or biologically active fragments or variants thereof.

2. 发明公开

EP3270407A1 QUANTITATION OF INSULIN BY MASS SPECTROMETRY 有权转让
标题翻译：胰岛素定量分析的质谱分析
公开(公告)号：EP3270407A1
公开(公告)日：2018-01-17
申请号：EP17189034.6
申请日：2011-12-27
申请人： Quest Diagnostics Investments Incorporated
发明人： CHEN, Zhaohui , CLARKE, Nigel
IPC分类号： H01J49/00 , G01N33/00 , G01N33/68
CPC分类号： G01N33/74 , G01N33/49 , G01N33/6848 , G01N2333/62 , H01J49/004
摘要： Methods are described for determining the amount of insulin in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying insulin in a biological sample utilizing purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
摘要翻译：描述了确定样品中胰岛素量的方法。更具体地说，描述了利用与串联质谱或高分辨率/高精度质谱技术结合的纯化方法检测和定量生物样品中的胰岛素的质谱方法。

3. 发明授权

EP2458378B1 INSULIN MEASUREMENT METHOD 失效转让
标题翻译：胰岛素测量方法
公开(公告)号：EP2458378B1
公开(公告)日：2017-12-06
申请号：EP10802293.0
申请日：2010-07-21
申请人： Sekisui Medical Co., Ltd.
发明人： KONDOU, Junichi , SHIMIZU, Tomo , YAMAMOTO, Mitsuaki , NAKAMURA, Yasushi
IPC分类号： G01N33/53 , G01N33/543 , G01N33/545
CPC分类号： G01N33/74 , C07K16/26 , G01N33/53 , G01N2333/62
摘要： The present invention provides an insulin-specific assay and an assay reagent capable of sensitively and specifically assaying insulin using an antibody having a property of reacting with insulin bound to an anti-insulin antibody while not reacting with insulin not bound to an anti-insulin antibody, without being affected by proinsulin and insulin analogs.

4. 发明授权

EP2518084B1 METHOD FOR MEASURING HUMAN INSULIN AND MEASUREMENT REAGENT 失效
标题翻译：测量人胰岛素方法确保两测定试剂
公开(公告)号：EP2518084B1
公开(公告)日：2016-11-30
申请号：EP10839612.8
申请日：2010-12-27
申请人： Sekisui Medical Co., Ltd.
发明人： SHIMIZU, Tomo , KONDOU, Junichi , NAKAMURA, Yasushi , YAMAMOTO, Mitsuaki
IPC分类号： G01N33/74 , C07K16/26
CPC分类号： G01N33/74 , C07K16/26 , C07K2317/33 , C07K2317/34 , G01N2333/62

5. 发明公开

EP3003214A1 CONTAINER 有权
标题翻译：容器
公开(公告)号：EP3003214A1
公开(公告)日：2016-04-13
申请号：EP14732598.9
申请日：2014-06-05
申请人： DE MONTFORT UNIVERSITY
发明人： TAYLOR, Margaret Joan
IPC分类号： A61F2/02 , G01N33/66
CPC分类号： A61K9/0004 , A61K9/0024 , A61K38/28 , A61K47/36 , A61K47/42 , G01N33/66 , G01N2333/4724 , G01N2333/62 , G01N2400/22
摘要： The present invention relates to a container for an analyte-sensitive gel. When analyte contacts such a gel it causes a gel-sol transition resulting in decreased viscosity of the gel. Such gels can be used for controlling the rate of release of an agent from a reservoir in response to the concentration of an analyte. The container is configured to allow analyte to pass into the container and contact the gel and to allow agent to diffuse out of the container. Such a container may be implantable in the body of a subject and therefore it is preferred if the container is constructed from materials that can be tolerated by the body for a period of time. Advantageously, the container limits the swelling and dilution of gel contained within the container caused by the influx of water into the gel by osmosis. The container therefore maintains the gel in a desired conformation and ensures a predictable release profile of the agent.
摘要翻译：本发明涉及用于分析物敏感凝胶的容器。当分析物接触这种凝胶时，它会引起凝胶 - 溶胶转变，导致凝胶的粘度降低。响应于分析物的浓度，这种凝胶可以用于控制试剂从储存器释放的速率。容器被构造成允许分析物进入容器并接触凝胶并允许药剂扩散出容器。这样的容器可以植入到受试者的身体中，因此如果容器由身体可耐受一段时间的材料构造，则是优选的。有利的是，容器限制容器内容纳的凝胶的膨胀和稀释，这是由于通过渗透将水注入凝胶而引起的。因此容器将凝胶保持在期望的构型并确保试剂的可预测的释放曲线。

6. 发明公开

EP2972230A1 DEVICE AND ASSOCIATED METHODS FOR PERFORMING LUMINESCENCE AND FLUORESCENCE MEASUREMENTS OF A SAMPLE 有权转让
标题翻译：设备和相关的METHOD FOR PERFORMING发光和荧光测量在样本
公开(公告)号：EP2972230A1
公开(公告)日：2016-01-20
申请号：EP14723936.2
申请日：2014-03-17
申请人： Hycor Biomedical, Inc.
发明人： DIAMOND, Ronald, Norman , GANN, Steve, Michael , HALL, Eric, Darnell , HWANG, Tae, Ho , MORTON, John, Lewis , MOSKALEV, Anatoly , RIEGER, Dennis , SARGEANT, Bruce, Alan , GOMBOSEV, Marinela , VAN CLEVE, Mark, David
IPC分类号： G01N21/64 , G01N21/76
CPC分类号： G01N21/645 , G01N21/6428 , G01N21/76 , G01N33/5306 , G01N33/54326 , G01N33/5434 , G01N33/54393 , G01N33/564 , G01N33/569 , G01N33/5695 , G01N33/56983 , G01N33/582 , G01N33/6854 , G01N33/6893 , G01N35/0098 , G01N35/1011 , G01N2021/6484 , G01N2035/0453 , G01N2035/1062 , G01N2201/062 , G01N2201/08 , G01N2333/4703 , G01N2333/62 , G01N2333/78 , G01N2800/24 , Y10T436/119163
摘要： A quantitative method for performing an automated diagnostic assay, comprising: incubating a capture reagent with a streptavidin-coated medium to form a solid phase complex; washing the solid phase complex to remove excess capture reagent; incubating the solid phase complex with a serum sample to form an immune complex; washing the immune complex to remove any unbound sample; incubating the immune complex with a conjugate to create an immune-conjugate complex; washing the immune-conjugate complex to remove any unbound conjugate; introducing a substrate capable of generating a quantifiable response; and calibrating the response generated from introducing the substrate.
摘要翻译：用于测量发光和样品的荧光的装置，包括：一个不透光的盒光学能够接收移液管尖端包含样品的; 在位于光学器件盒和能够在两个发光读取位置和荧光读取位置被设置在光学传感器; 的激发光的光纤束和样品传输光纤束; 激发光组件的没有项目激发光到的激发光的光纤束的第一末端端; 和在线过滤器位于沿着样品传输光纤束。

7. 发明公开

EP2970899A1 IN VITRO DIFFERENTIATION OF PLURIPOTENT STEM CELLS TO PANCREATIC ENDODERM CELLS (PEC) AND ENDOCRINE CELLS 有权
标题翻译：多能干细胞体外分化胰腺内胚层（PEC）和内分泌细胞
公开(公告)号：EP2970899A1
公开(公告)日：2016-01-20
申请号：EP14721621.2
申请日：2014-03-13
申请人： ViaCyte, Inc.
发明人： AGULNICK, Alan , D'AMOUR, Kevin
IPC分类号： C12N5/0735
CPC分类号： A61K35/39 , A61K35/545 , C12N5/0676 , C12N5/0678 , C12N2500/25 , C12N2501/115 , C12N2501/117 , C12N2501/119 , C12N2501/15 , C12N2501/155 , C12N2501/16 , C12N2501/195 , C12N2501/385 , C12N2501/415 , C12N2501/727 , C12N2501/998 , C12N2501/999 , C12N2506/02 , C12N2506/22 , C12N2506/45 , C12N2533/90 , G01N33/6893 , G01N2333/62 , G01N2800/042 , G01N2800/52
摘要： A human immature endocrine cell population and methods for making an immature endocrine cell population are provided. Specifically, immature beta cells and methods for production of immature beta cells are described. Immature beta cells co-express INS and NKX6.1 and are uni-potent and thereby develop into mature beta cells when implanted in vivo. The mature beta cells in vivo are capable of producing insulin in response to glucose stimulation.

8. 发明公开

EP2968472A1 USE OF INSULIN SIGNALING ANTAGONISTS, OPTIONALLY IN COMBINATION OF TRANSFECTION OF NON-BETA CELLS, FOR INDUCING INSULIN PRODUCTION 审中-公开
标题翻译：胰岛素信号拮抗剂，可选合用与非β细胞的转染使用诱导的胰岛素产生
公开(公告)号：EP2968472A1
公开(公告)日：2016-01-20
申请号：EP14715686.3
申请日：2014-03-14
申请人： Université de Genève
发明人： HERRERA, Pedro , THOREL, Fabrizio , CHERA, Simona
IPC分类号： A61K38/28 , A61K31/00 , A61K31/366 , C12Q1/00 , C12N5/00 , G01N33/00 , A61P3/10
CPC分类号： A61K31/366 , A61K38/16 , A61K38/1709 , A61K38/28 , A61K45/06 , A61K48/00 , C12N5/0676 , C12N2501/60 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , G01N33/507 , G01N33/6872 , G01N2333/4703 , G01N2333/62 , G01N2500/10 , G01N2800/042 , G01N2800/52
摘要： The invention relates to methods of inducing insulin production in non-beta-cells or converting non-beta-cells into insulin producing cells, as well as methods of preventing and/or treating diabetes and methods of predicting the susceptibility of a diabetic subject to a treatment.
摘要翻译：本发明涉及在非β细胞或转化的非β细胞成产生胰岛素的细胞，以及预防和/或治疗糖尿病和预测糖尿病受试者的易感性的方法的方法诱导的胰岛素产生的方法治疗。

9. 发明公开

EP2758565A4 CELL SURFACE DISPLAY OF LIGANDS FOR THE INSULIN AND/OR INSULIN GROWTH FACTOR 1 RECEPTOR AND APPLICATIONS THEREOF 审中-公开
标题翻译：配体的胰岛素和/或胰岛素生长因子-1受体与细胞表面展示及其用途
公开(公告)号：EP2758565A4
公开(公告)日：2015-03-04
申请号：EP12834491
申请日：2012-09-18
申请人： MERCK SHARP & DOHME
发明人： CHEN MING-TANG , CHOI BYUNG-KWON , SETHURMAN NATARAJAN , STADHEIM TERRANCE , ZHA DONGXING , SHAHEEN HUSSAM HISHAM , LIN SONG
IPC分类号： C40B40/02 , C12N15/10 , G01N33/50 , G01N33/567 , G01N33/569 , G01N33/74
CPC分类号： G01N33/74 , C12N15/1037 , C40B40/02 , G01N33/5023 , G01N2333/62 , G01N2333/71 , G01N2333/72

10. 发明公开

EP2812707A1 ASSAY AND METHOD FOR DETERMINING INSULIN-RESISTANCE 审中-公开
标题翻译：测定胰岛素抗性的测定法和方法
公开(公告)号：EP2812707A1
公开(公告)日：2014-12-17
申请号：EP13706939.9
申请日：2013-02-08
申请人： Alere Switzerland GmbH
发明人： MOERMAN, Piet
IPC分类号： G01N33/74 , C12Q1/00
CPC分类号： G01N33/74 , C12Q1/006 , G01N33/5438 , G01N2333/62 , G01N2800/042 , G01N2800/50
摘要： The present invention provides for a home test or a point of care test device that can both detect blood glucose and insulin levels and methods using said device. The device and methods can be used to aid diabetic patients and medical practitioners to fine tune insulin administration, and to monitor disease progression or treatment.
摘要翻译：本发明提供可以检测血糖和胰岛素水平的家庭测试或点测试设备以及使用所述设备的方法。该装置和方法可用于帮助糖尿病患者和医师调整胰岛素施用，并监测疾病进展或治疗。

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