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1. 发明授权

EP2080501B1 DRUG SOLUTION CONTAINING PACK WITH REDUCED DISSOLVED OXYGEN CONTENT 有权转让
标题翻译：具有减少溶解氧含量药物捆绑解决方案
公开(公告)号：EP2080501B1
公开(公告)日：2015-06-17
申请号：EP07830562.0
申请日：2007-10-25
申请人： OTSUKA PHARMACEUTICAL FACTORY, INC.
发明人： SUMIYOSHI, Nobuaki , TATEISHI, Isamu , MORI, Hitoshi , MORIMOTO, Yasushi
IPC分类号： A61J1/10 , A61K9/08 , A61J1/20
CPC分类号： A61J1/10 , A61J1/2093 , A61K9/08
摘要： It is an object of the present invention to provide a drug solution which has a reduced dissolved oxygen content and is less susceptible to oxidative degradation and highly stable over time, a production method therefor, and a drug solution containing pack which is capable of maintaining the dissolved oxygen content of a drug solution at a reduced level, less susceptible to oxidative degradation of the drug solution and highly stable over time. To achieve the aforementioned object, the reduced-dissolved-oxygen-content drug solution is produced by filling and sealing the drug solution in a drug solution container (15) formed of a plastic material having an oxygen permeability of not lower than 200 cm 3 /m 2 ·24h·atm at 25°C at 60%RH within 12 hours after a steam sterilization process or a hot water sterilization process and having a steady-state oxygen permeability of not higher than 100 cm 3 /m 2 ·24h·atm at 25°C at 60%RH, subjecting the drug solution container to the steam sterilization process or the hot water sterilization process, and storing the drug solution container in an environment having deoxidization means for reducing the dissolved oxygen concentration of the drug solution to not higher than 2 ppm when the oxygen permeability of the plastic material reaches the steady-state level.

2. 发明授权

EP2402156B1 MULTILAYER FILM AND BAG FORMED OF THE FILM 有权转让
标题翻译：由膜形成的多层膜和袋
公开(公告)号：EP2402156B1
公开(公告)日：2018-02-14
申请号：EP10746203.8
申请日：2010-02-23
申请人： Otsuka Pharmaceutical Factory, Inc.
发明人： IGARASHI, Koichi , SAITO, Tetsuya , NAGATA, Yasushi , MORI, Toshifumi , MORI, Hitoshi
IPC分类号： B32B27/32 , B65D65/40 , A61J1/10
CPC分类号： B65D65/40 , A61J1/10 , B32B7/02 , B32B27/32 , B32B27/327 , B32B2250/03 , B32B2250/05 , B32B2250/242 , B32B2270/00 , B32B2307/306 , B32B2307/308 , B32B2307/412 , B32B2307/558 , B32B2307/72 , B32B2439/46 , B32B2439/80 , B65D75/566 , B65D75/5883 , Y10T428/24975 , Y10T428/24992
摘要： A multilayer film according to the present invention is a multilayer film, in which an outermost layer and an innermost layer are laminated via an intermediate layer arranged from one to three layers, with the intermediate layer including at least one layer being made of 0 to 55 weight % of a linear polyethylene having a density of 0.910 to 0.930g/cm 3 , 5 to 15 weight % of a high-density polyethylene having a density of 0.950 to 0.970g/cm 3 , and 35 to 85 weight % of a linear polyethylene having a density of 0.900 to 0.910g/cm 3 and polymerized using a single-site catalyst, and having a density lower than the outermost layer and the innermost layer, and each of the outermost layer and the innermost layer being formed of a polyethylene or a mixture of two or more types of polyethylene.

3. 发明公开

EP2402156A1 MULTILAYER FILM AND BAG FORMED OF THE FILM 有权转让
标题翻译：由膜形成的多层膜和袋
公开(公告)号：EP2402156A1
公开(公告)日：2012-01-04
申请号：EP10746203.8
申请日：2010-02-23
申请人： Mitsui Chemicals, Inc. , Otsuka Pharmaceutical Factory, Inc.
发明人： IGARASHI, Koichi , SAITO, Tetsuya , NAGATA, Yasushi , MORI, Toshifumi , MORI, Hitoshi
IPC分类号： B32B27/32 , B65D65/40
CPC分类号： B65D65/40 , A61J1/10 , B32B7/02 , B32B27/32 , B32B27/327 , B32B2250/03 , B32B2250/05 , B32B2250/242 , B32B2270/00 , B32B2307/306 , B32B2307/308 , B32B2307/412 , B32B2307/558 , B32B2307/72 , B32B2439/46 , B32B2439/80 , B65D75/566 , B65D75/5883 , Y10T428/24975 , Y10T428/24992
摘要： A multilayer film according to the present invention is a multilayer film, in which an outermost layer and an innermost layer are laminated via an intermediate layer arranged from one to three layers, with the intermediate layer including at least one layer being made of 0 to 55 weight % of a linear polyethylene having a density of 0.910 to 0.930g/cm 3 , 5 to 15 weight % of a high-density polyethylene having a density of 0.950 to 0.970g/cm 3 , and 35 to 85 weight % of a linear polyethylene having a density of 0.900 to 0.910g/cm 3 and polymerized using a single-site catalyst, and having a density lower than the outermost layer and the innermost layer, and each of the outermost layer and the innermost layer being formed of a polyethylene or a mixture of two or more types of polyethylene.
摘要翻译：根据本发明的多层膜是多层膜，其中最外层和最内层经由布置为一层至三层的中间层层压，并且中间层包括至少一层由0至55 重量的密度为0.910-0.930克/厘米3的线性聚乙烯，5-15重量％的密度为0.950-0.970克/厘米3的高密度聚乙烯和35-85重量％的直链聚乙烯密度为0.900-0.910g / cm 3，并且使用单中心催化剂聚合，并且具有比最外层和最内层低的密度，并且最外层和最内层各自由聚乙烯或混合物形成的两种或更多种类型的聚乙烯。

4. 发明公开

EP1820521A1 MEDICAL TUBE 有权
标题翻译： MEDISINISCHER SCHLAUCH
公开(公告)号：EP1820521A1
公开(公告)日：2007-08-22
申请号：EP05809722.1
申请日：2005-11-25
申请人： Mitsui Chemicals, Inc. , OTSUKA PHARMACEUTICAL FACTORY, INC.
发明人： IGARASHI, Kouichi c/o MITSUI CHEMICALS, INC. , SHIROKUMA, Sadamu c/o MITSUI CHEMICALS, INC. , MORI, Ryoji c/o MITSUI CHEMICALS, INC. , TATEISHI, Isamu , MORI, Hitoshi , ISHII, Rie
IPC分类号： A61L29/00 , A61M1/14 , A61M5/14 , A61M25/00 , C08L23/16
CPC分类号： A61M39/08 , A61L29/041 , A61M25/0009 , C08L23/10 , C08L23/12 , C08L23/14 , C08L23/142 , Y10T428/13 , Y10T428/1397 , C08L2666/06
摘要： Medical tubes are well balanced in transparency, flexibility, heat resistance, scratch resistance and rubber elasticity.
The medical tubes including a propylene polymer composition (A) that contains a polymer with propylene units, at least part of the polymer having an isotactic structure and the total of the propylene units of the polymer being in an amount of 65 to 82 mol% (the total of the structural units of the polymer in the composition is 100 mol%), and that satisfies the following (a1), (a2) and (b1):
(a1) the modulus in tension is in the range of 5 to 25 MPa as determined in accordance with JIS K 6301;
(a2) the penetration temperature is 120°C or above as determined in accordance with JIS K 7196; and
(b1) when a tube being made of the composition (A) and having an inner diameter of 2.1 mm, an outer diameter of 3.5mm and a length of 20 cm is looped by inserting both ends thereof into a hollow jig having a hole 10 mm in diameter and 5 mm in height and, then, the both ends of the tube are pulled down until a kink occurs in the loop, the distance H from the upper surface of the jig to the upper end of the loop is not more than 60 mm.
摘要翻译：医疗管在透明度，柔韧性，耐热性，耐刮擦性和橡胶弹性方面均衡。所述医用管包括丙烯聚合物组合物（A），其含有具有丙烯单元的聚合物，所述聚合物的至少一部分具有全同立构结构，所述聚合物的丙烯单元的总量为65〜82摩尔％组合物中的聚合物的结构单元的总和为100摩尔％），满足以下（a1），（a2）和（b1）：（a1）张力的模量为5〜25的范围 MPa，根据JIS K 6301测定; （a2）根据JIS K 7196测定的穿透温度为120℃以上; 和（b1）当由组合物（A）制成并且内径为2.1mm，外径为3.5mm和长度为20cm的管时，将其两端插入具有孔的中空夹具中直径为10毫米，高度为5毫米，然后将管的两端向下拉，直到环中发生扭结，从夹具上表面到环的上端的距离H不大超过60毫米。

5. 发明授权

EP1875889B1 HOUSING BODY FOR MEDICAL LIQUID CONTAINER AND PROCESS FOR PRODUCING THE SAME 有权转让
标题翻译：袋用于生产医用液体容器与过程
公开(公告)号：EP1875889B1
公开(公告)日：2014-11-26
申请号：EP06745438.9
申请日：2006-04-19
申请人： Otsuka Pharmaceutical Factory, Inc.
发明人： TATEISHI, Isamu , MORI, Hitoshi , MORIMOTO, Yasushi
IPC分类号： A61J1/10 , B32B27/32
CPC分类号： B32B27/32 , A61J1/10 , A61M2207/00 , Y10T428/1352 , Y10T428/1379 , Y10T428/1383

7. 发明公开

EP2080501A1 DRUG SOLUTION HAVING REDUCED DISSOLVED OXYGEN CONTENT, METHOD OF PRODUCING THE SAME AND DRUG SOLUTION CONTAINING UNIT HAVING REDUCED DISSOLVED OXYGEN CONTENT 有权转让
标题翻译： ARZNEILÖSUNGBÜNDELMIT VERRINGERTEMGELÖSTEMSAUERSTOFFGEHALT
公开(公告)号：EP2080501A1
公开(公告)日：2009-07-22
申请号：EP07830562.0
申请日：2007-10-25
申请人： OTSUKA PHARMACEUTICAL FACTORY, INC.
发明人： SUMIYOSHI, Nobuaki , TATEISHI, Isamu , MORI, Hitoshi , MORIMOTO, Yasushi
IPC分类号： A61J1/00 , A61K9/08
CPC分类号： A61J1/10 , A61J1/2093 , A61K9/08
摘要： It is an object of the present invention to provide a drug solution which has a reduced dissolved oxygen content and is less susceptible to oxidative degradation and highly stable over time, a production method therefor, and a drug solution containing pack which is capable of maintaining the dissolved oxygen content of a drug solution at a reduced level, less susceptible to oxidative degradation of the drug solution and highly stable over time. To achieve the aforementioned object, the reduced-dissolved-oxygen-content drug solution is produced by filling and sealing the drug solution in a drug solution container (15) formed of a plastic material having an oxygen permeability of not lower than 200 cm 3 /m 2 ·24h·atm at 25°C at 60%RH within 12 hours after a steam sterilization process or a hot water sterilization process and having a steady-state oxygen permeability of not higher than 100 cm 3 /m 2 ·24h·atm at 25°C at 60%RH, subjecting the drug solution container to the steam sterilization process or the hot water sterilization process, and storing the drug solution container in an environment having deoxidization means for reducing the dissolved oxygen concentration of the drug solution to not higher than 2 ppm when the oxygen permeability of the plastic material reaches the steady-state level.
摘要翻译：本发明的目的是提供一种药物溶液，其溶解氧含量降低，并且不易氧化降解，随时间稳定性高，其制备方法和药物溶液包含能够维持药物溶液的氧含量降低，对药物溶液的氧化降解敏感，并且随着时间的推移高度稳定。为了实现上述目的，通过将药液填充并密封在由氧透过度不低于200cm 3 / cm 2的塑料材料形成的药液容器（15）中来制造还原溶解氧含量药物溶液，在蒸汽灭菌处理或热水杀菌处理后的12小时内，在25℃，60％RH下，m 2·24h·atm，稳态透氧度不高于100cm 3 / m 2·24h·atm 在25℃，60％RH下，对药液容器进行蒸汽灭菌处理或热水灭菌处理，并将药液容器保存在具有用于将药液的溶解氧浓度降低的脱氧装置的环境中当塑料材料的透氧性达到稳态水平时，高于2ppm。

8. 发明授权

EP1820521B1 MEDICAL TUBE 有权
标题翻译：医疗管
公开(公告)号：EP1820521B1
公开(公告)日：2011-12-28
申请号：EP05809722.1
申请日：2005-11-25
申请人： Mitsui Chemicals, Inc. , OTSUKA PHARMACEUTICAL FACTORY, INC.
发明人： IGARASHI, Kouichi , SHIROKUMA, Sadamu , MORI, Ryoji , TATEISHI, Isamu , MORI, Hitoshi , ISHII, Rie
IPC分类号： A61L29/04 , A61M1/14 , A61M5/14 , A61M25/00 , C08L23/12 , C08L23/16
CPC分类号： A61M39/08 , A61L29/041 , A61M25/0009 , C08L23/10 , C08L23/12 , C08L23/14 , C08L23/142 , Y10T428/13 , Y10T428/1397 , C08L2666/06
摘要： This invention provides a medical tube comprising a propylene polymer composition (A). The propylene polymer composition (A) contains a polymer comprising propylene units, and at least a part of the propylene unit-containing polymer has an isotactic structure. The content of the propylene unit based on 100% by mole in total of all the structural units of the propylene unit-containing polymer contained in the composition (A) is 65 to 82% by mole. The medical tube satisfies the following (a1), (a2) and (b1): (a1) a tensile modulus of elasticity of 5 to 25 MPa as measured according to JIS K 6301; (a2) a needle penetration temperature of 120ºC or above as measured according to JIS K 7196; and (b1) a distance (H) of not more than 60 mm as determined by preparing a tube having a size of 2.1 mm in inner diameter, 3.5 mm in outer diameter, and 20 cm in length from the composition (A), inserting both ends of the tube into a tool having a hollow hole having a size of 10 mm in diameter x 5 mm in height, forming a loop, pulling down both ends of the tube, and measuring the distance (H) from the upper surface of the tool to the upper end of the loop at the time when the loop has kinked.

9. 发明公开

EP1875889A1 HOUSING BODY FOR MEDICAL LIQUID CONTAINER AND PROCESS FOR PRODUCING THE SAME 有权转让
标题翻译：袋用于生产医用液体容器与过程
公开(公告)号：EP1875889A1
公开(公告)日：2008-01-09
申请号：EP06745438.9
申请日：2006-04-19
申请人： OTSUKA PHARMACEUTICAL FACTORY, INC.
发明人： TATEISHI, Isamu , MORI, Hitoshi , MORIMOTO, Yasushi
IPC分类号： A61J1/10
CPC分类号： B32B27/32 , A61J1/10 , A61M2207/00 , Y10T428/1352 , Y10T428/1379 , Y10T428/1383
摘要： An object of this invention is to provide a drug solution container package, which can restrain degradation of a drug solution, proliferation of microbes, etc. accompanying the transmission of oxygen in a high degree while maintaining characteristics required of plastic drug solution containers such as heat resistance, impact resistance, pliability, transparency, and resistance against elution of plastic forming material, and to provide a method for manufacturing the drug solution container package. In the present invention, to achieve the above object, a drug solution is contained and sealed in a plastic drug solution container having an oxygen gas transmission rate (25°C, 60%RH) of not less than 200cm 3 /m 2 · 24h · atm within twelve hours after being subject to steam sterilization or hot water sterilization, and having an oxygen gas transmission rate (25°C, 60%RH) of not more than 100cm 3 /m 2 ·24h·atm when the oxygen gas transmission rate is in a steady state, and thereafter the plastic drug solution container is steam sterilized or hot water sterilized and then are contained and sealed along with an oxygen scavenger in an outer pouch having an oxygen barrier property.
摘要翻译：本发明的一个目的是提供一种药液容器包装，同时保持特性所需的塑料药液容器的能有效抑制药物溶液的降解，微生物的增殖等伴随在高度氧气的传输：如热性，耐冲击性，柔软性，透明性，以及对塑料成形材料的耐溶出性，以及一种用于制造该药物溶液容器包装的方法。在本发明中，为了达到上述目的，药液容纳并密封在塑料药液容器，其具有在不小于200厘米3 / m 2的氧气透过率（25℃，60％RH）·24 ·12小时内大气压经受蒸汽灭菌或热水灭菌，并且具有不大于百厘米3 /米2·24小时的氧气透过率（25℃，60％RH）·大气压的氧气传输当后率是在稳定状态，并且此后的塑料药液容器进行蒸汽消毒或热水灭菌，然后被包含在具有阻氧性外袋密封地连同氧清除剂的。

10. 发明公开

EP1803552A1 GAS BARRIER FILM FOR MEDICAL USE AND MEDICAL BAGS MADE BY USING THE SAME 失效转让
标题翻译： GASSPERRFOLIE ZUR MEDIZINISCHEN VERWENDUNG UNDEE VERWENDEND MEDIZINISCHE BEUTEL
公开(公告)号：EP1803552A1
公开(公告)日：2007-07-04
申请号：EP05793171.9
申请日：2005-10-13
申请人： OTSUKA PHARMACEUTICAL FACTORY, INC.
发明人： MORI, Hitoshi , MORIMOTO, Yasushi , KONISHI, Kenji , TATEISHI, Isamu
IPC分类号： B32B9/04 , A61J1/10 , A61L31/00
CPC分类号： A61J1/10 , A61M2207/00 , B32B7/12 , B32B25/08 , B32B25/14 , B32B27/08 , B32B27/16 , B32B27/32 , B32B27/325 , B32B27/34 , B32B27/36 , B32B2255/10 , B32B2255/20 , B32B2274/00 , B32B2307/306 , B32B2307/31 , B32B2307/412 , B32B2307/514 , B32B2307/558 , B32B2307/7242 , B32B2439/46 , B32B2439/80 , Y10T428/13 , Y10T428/1303 , Y10T428/1307 , Y10T428/1334 , Y10T428/1352 , Y10T428/1359 , Y10T428/1379 , Y10T428/2495 , Y10T428/2817 , Y10T428/31725 , Y10T428/31765 , Y10T428/31786 , Y10T428/31797 , Y10T428/31855 , Y10T428/31909
摘要： The object of the present invention is to provide a gas barrier film suitable for medical uses, which is excellent in gas and vapor properties and can prevent ingredients of an adhesive and the like from eluting even after heating and sterilizing treatment, and a medical bag using the gas barrier film. A medical gas barrier film of the present invention comprises a multilayer gas barrier film 10 including a deposition oriented polyester layer 11 having a deposited layer 13 of an inorganic oxide on one surface, an oriented polyamide layer 15 adhered to the surface of the deposited layer 13 and a polyethylene layer 17 adhered to the surface on the opposite side to an adhered surface 15a of the oriented polyamide layer 15, and a multilayer substrate film 22 including a cyclic olefin polymer layer 25, an elastomer layers 24, 26 and a heat sealing layer 23, and the multilayer substrate film 22 is adhered to an other surface 11b on the opposite side of the deposited layer of the deposition oriented polyester layer 11.
摘要翻译：本发明的目的是提供一种适用于医疗用途的气体阻隔膜，其气体和蒸汽性能优异，并且即使在加热灭菌处理之后也可以防止粘合剂等的成分洗脱，以及使用阻气膜。本发明的医疗用气体阻隔膜包括：多层阻气膜10，其包括在一个表面上具有无机氧化物的沉积层13的沉积取向聚酯层11，附着到沉积层13的表面的取向聚酰胺层15 以及与取向聚酰胺层15的粘合面15a相反一侧的表面粘附的聚乙烯层17，以及包含环状烯烃聚合物层25，弹性体层24,26和热封层 23，并且多层基板膜22粘附到沉积取向聚酯层11的沉积层的相对侧上的另一个表面11b。

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