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1. 发明公开

EP1820521A1 MEDICAL TUBE 有权
标题翻译： MEDISINISCHER SCHLAUCH
公开(公告)号：EP1820521A1
公开(公告)日：2007-08-22
申请号：EP05809722.1
申请日：2005-11-25
申请人： Mitsui Chemicals, Inc. , OTSUKA PHARMACEUTICAL FACTORY, INC.
发明人： IGARASHI, Kouichi c/o MITSUI CHEMICALS, INC. , SHIROKUMA, Sadamu c/o MITSUI CHEMICALS, INC. , MORI, Ryoji c/o MITSUI CHEMICALS, INC. , TATEISHI, Isamu , MORI, Hitoshi , ISHII, Rie
IPC分类号： A61L29/00 , A61M1/14 , A61M5/14 , A61M25/00 , C08L23/16
CPC分类号： A61M39/08 , A61L29/041 , A61M25/0009 , C08L23/10 , C08L23/12 , C08L23/14 , C08L23/142 , Y10T428/13 , Y10T428/1397 , C08L2666/06
摘要： Medical tubes are well balanced in transparency, flexibility, heat resistance, scratch resistance and rubber elasticity.
The medical tubes including a propylene polymer composition (A) that contains a polymer with propylene units, at least part of the polymer having an isotactic structure and the total of the propylene units of the polymer being in an amount of 65 to 82 mol% (the total of the structural units of the polymer in the composition is 100 mol%), and that satisfies the following (a1), (a2) and (b1):
(a1) the modulus in tension is in the range of 5 to 25 MPa as determined in accordance with JIS K 6301;
(a2) the penetration temperature is 120°C or above as determined in accordance with JIS K 7196; and
(b1) when a tube being made of the composition (A) and having an inner diameter of 2.1 mm, an outer diameter of 3.5mm and a length of 20 cm is looped by inserting both ends thereof into a hollow jig having a hole 10 mm in diameter and 5 mm in height and, then, the both ends of the tube are pulled down until a kink occurs in the loop, the distance H from the upper surface of the jig to the upper end of the loop is not more than 60 mm.
摘要翻译：医疗管在透明度，柔韧性，耐热性，耐刮擦性和橡胶弹性方面均衡。所述医用管包括丙烯聚合物组合物（A），其含有具有丙烯单元的聚合物，所述聚合物的至少一部分具有全同立构结构，所述聚合物的丙烯单元的总量为65〜82摩尔％组合物中的聚合物的结构单元的总和为100摩尔％），满足以下（a1），（a2）和（b1）：（a1）张力的模量为5〜25的范围 MPa，根据JIS K 6301测定; （a2）根据JIS K 7196测定的穿透温度为120℃以上; 和（b1）当由组合物（A）制成并且内径为2.1mm，外径为3.5mm和长度为20cm的管时，将其两端插入具有孔的中空夹具中直径为10毫米，高度为5毫米，然后将管的两端向下拉，直到环中发生扭结，从夹具上表面到环的上端的距离H不大超过60毫米。

2. 发明授权

EP1820521B1 MEDICAL TUBE 有权
标题翻译：医疗管
公开(公告)号：EP1820521B1
公开(公告)日：2011-12-28
申请号：EP05809722.1
申请日：2005-11-25
申请人： Mitsui Chemicals, Inc. , OTSUKA PHARMACEUTICAL FACTORY, INC.
发明人： IGARASHI, Kouichi , SHIROKUMA, Sadamu , MORI, Ryoji , TATEISHI, Isamu , MORI, Hitoshi , ISHII, Rie
IPC分类号： A61L29/04 , A61M1/14 , A61M5/14 , A61M25/00 , C08L23/12 , C08L23/16
CPC分类号： A61M39/08 , A61L29/041 , A61M25/0009 , C08L23/10 , C08L23/12 , C08L23/14 , C08L23/142 , Y10T428/13 , Y10T428/1397 , C08L2666/06
摘要： This invention provides a medical tube comprising a propylene polymer composition (A). The propylene polymer composition (A) contains a polymer comprising propylene units, and at least a part of the propylene unit-containing polymer has an isotactic structure. The content of the propylene unit based on 100% by mole in total of all the structural units of the propylene unit-containing polymer contained in the composition (A) is 65 to 82% by mole. The medical tube satisfies the following (a1), (a2) and (b1): (a1) a tensile modulus of elasticity of 5 to 25 MPa as measured according to JIS K 6301; (a2) a needle penetration temperature of 120ºC or above as measured according to JIS K 7196; and (b1) a distance (H) of not more than 60 mm as determined by preparing a tube having a size of 2.1 mm in inner diameter, 3.5 mm in outer diameter, and 20 cm in length from the composition (A), inserting both ends of the tube into a tool having a hollow hole having a size of 10 mm in diameter x 5 mm in height, forming a loop, pulling down both ends of the tube, and measuring the distance (H) from the upper surface of the tool to the upper end of the loop at the time when the loop has kinked.

3. 发明公开

EP2127866A1 MULTILAYER FILM AND CONTAINER 有权
标题翻译： MEHRLAGIGE FOLIE UNDBEHÄLTER
公开(公告)号：EP2127866A1
公开(公告)日：2009-12-02
申请号：EP08711492.2
申请日：2008-02-18
申请人： OTSUKA PHARMACEUTICAL FACTORY, INC.
发明人： INOUE, Fujio , TATEISHI, Isamu , MORIMOTO, Yasushi
IPC分类号： B32B27/32 , A61J1/05 , B65D65/40
CPC分类号： A61J1/2093 , A61J1/10 , A61J1/2024 , A61M2207/00 , B32B27/08 , B32B27/32 , B32B2250/05 , B32B2270/00 , B32B2307/306 , B32B2307/412 , B32B2307/558 , B32B2307/748 , B32B2439/00 , B32B2439/80 , B65D65/40 , Y10T428/13 , Y10T428/1303 , Y10T428/1352 , Y10T428/1359 , Y10T428/139 , Y10T428/2495 , Y10T428/31913 , Y10T428/31924
摘要： To provide a multilayer film and a container formed of the multilayer film which are excellent in unsealability, transparency, mechanical strength and sterilization heat resistance and are capable of preventing exudation of additives from the film into a liquid contained in the container.
In a multilayer film including a first layer (1), a second layer (2), a third layer (3), a fourth layer (4) and a fifth layer (5) stacked in this order, the first layer (1) is composed of a propylene-ethylene random copolymer and/or a polypropylene homopolymer, and the second layer (2) and the fourth layer (4) are each composed of a mixture of a propylene-ethylene random copolymer and an α-olefin elastomer. The third layer (3) is composed of a mixture of a polycycloolefin and a polyethylene, and the fifth layer (5) is composed of a mixture containing a polypropylene homopolymer and a propylene-ethylene random copolymer in a weight ratio of 90:10 to 10:90. A container is formed of the multilayer film with an outer layer and an inner layer thereof being defined by the first layer (1) and the fifth layer (5), respectively.
摘要翻译：为了提供多层膜和由多层膜形成的容器，其开封性，透明性，机械强度和耐热灭菌性都优异，并且能够防止添加剂从膜中渗出到包含在容器中的液体中。在包括依次堆叠的第一层（1），第二层（2），第三层（3），第四层（4）和第五层（5）的多层膜中，第一层（1）由丙烯 - 乙烯无规共聚物和/或聚丙烯均聚物组成，第二层（2）和第四层（4）由丙烯 - 乙烯无规共聚物和α-烯烃弹性体的混合物组成。第三层（3）由聚环烯烃和聚乙烯的混合物组成，第五层（5）由含有聚丙烯均聚物和丙烯 - 乙烯无规共聚物的混合物组成，其重量比为90:10至 10:90。容器由多层膜形成，其外层和其内层分别由第一层（1）和第五层（5）限定。

4. 发明授权

EP2127866B1 MULTILAYER FILM AND CONTAINER 有权
标题翻译：多层薄膜和容器
公开(公告)号：EP2127866B1
公开(公告)日：2014-10-15
申请号：EP08711492.2
申请日：2008-02-18
申请人： OTSUKA PHARMACEUTICAL FACTORY, INC.
发明人： INOUE, Fujio , TATEISHI, Isamu , MORIMOTO, Yasushi
IPC分类号： B32B27/32 , B32B27/08 , B65D65/40 , A61J1/05
CPC分类号： A61J1/2093 , A61J1/10 , A61J1/2024 , A61M2207/00 , B32B27/08 , B32B27/32 , B32B2250/05 , B32B2270/00 , B32B2307/306 , B32B2307/412 , B32B2307/558 , B32B2307/748 , B32B2439/00 , B32B2439/80 , B65D65/40 , Y10T428/13 , Y10T428/1303 , Y10T428/1352 , Y10T428/1359 , Y10T428/139 , Y10T428/2495 , Y10T428/31913 , Y10T428/31924

6. 发明公开

EP2127629A1 PORT MEMBER FOR INFUSION BAG, AND INFUSION BAG 有权
标题翻译： PORT-ELEMENTFÜREINEN INFUSIONSBEUTEL UND INFUSIONSBEUTEL
公开(公告)号：EP2127629A1
公开(公告)日：2009-12-02
申请号：EP08711653.9
申请日：2008-02-20
申请人： OTSUKA PHARMACEUTICAL FACTORY, INC.
发明人： INOUE, Fujio , TATEISHI, Isamu , TSURUOKA, Tatsuro
IPC分类号： A61J1/10 , A61J1/05 , B65D33/38
CPC分类号： A61J1/1475 , A61J1/10 , A61J1/201 , A61J1/2024 , A61J1/2093 , B65D75/5883 , B65D81/3266
摘要： Provided a port member for an infusion solution bag that is capable of suppressing occurrence of gaps or wrinkles in a sealed portion in a manufacturing process, and preventing damages to resin sheets of a bag body during storage or transportation. A port member for an infusion solution bag includes a tubular body portion having one end sealed by a plug member structured to enable a hollow needle to be pierced into the plug member, and a tubular to-be-sealed portion continuously formed with an other end of the body portion and having an inner space communicated with the inside of the body portion, the to-be-sealed portion being held between and sealed to end portions of resin sheets overlapped together to form a bag body having an inner space for accommodation of at least a medicine, in which the to-be-sealed portion thus sealed has a radially flattened shape.
摘要翻译：提供一种能够抑制制造过程中的密封部分中的间隙或皱纹的发生的输液袋的端口构件，并且防止在储存或运输期间损坏袋体的树脂片。用于输液溶液袋的端口构件包括管状主体部分，其一端由被构造成能够将中空针刺入插塞构件的插塞构件密封，以及连续形成有另一端的管状待密封部所述主体部分具有与所述主体部分的内部连通的内部空间，所述待密封部分保持在所述树脂片材的端部上并被密封在一起，以形成具有用于容纳所述主体部分的内部空间的袋体至少一种药物，其中被密封的被密封部分具有径向平坦的形状。

7. 发明公开

EP2080501A1 DRUG SOLUTION HAVING REDUCED DISSOLVED OXYGEN CONTENT, METHOD OF PRODUCING THE SAME AND DRUG SOLUTION CONTAINING UNIT HAVING REDUCED DISSOLVED OXYGEN CONTENT 有权转让
标题翻译： ARZNEILÖSUNGBÜNDELMIT VERRINGERTEMGELÖSTEMSAUERSTOFFGEHALT
公开(公告)号：EP2080501A1
公开(公告)日：2009-07-22
申请号：EP07830562.0
申请日：2007-10-25
申请人： OTSUKA PHARMACEUTICAL FACTORY, INC.
发明人： SUMIYOSHI, Nobuaki , TATEISHI, Isamu , MORI, Hitoshi , MORIMOTO, Yasushi
IPC分类号： A61J1/00 , A61K9/08
CPC分类号： A61J1/10 , A61J1/2093 , A61K9/08
摘要： It is an object of the present invention to provide a drug solution which has a reduced dissolved oxygen content and is less susceptible to oxidative degradation and highly stable over time, a production method therefor, and a drug solution containing pack which is capable of maintaining the dissolved oxygen content of a drug solution at a reduced level, less susceptible to oxidative degradation of the drug solution and highly stable over time. To achieve the aforementioned object, the reduced-dissolved-oxygen-content drug solution is produced by filling and sealing the drug solution in a drug solution container (15) formed of a plastic material having an oxygen permeability of not lower than 200 cm 3 /m 2 ·24h·atm at 25°C at 60%RH within 12 hours after a steam sterilization process or a hot water sterilization process and having a steady-state oxygen permeability of not higher than 100 cm 3 /m 2 ·24h·atm at 25°C at 60%RH, subjecting the drug solution container to the steam sterilization process or the hot water sterilization process, and storing the drug solution container in an environment having deoxidization means for reducing the dissolved oxygen concentration of the drug solution to not higher than 2 ppm when the oxygen permeability of the plastic material reaches the steady-state level.
摘要翻译：本发明的目的是提供一种药物溶液，其溶解氧含量降低，并且不易氧化降解，随时间稳定性高，其制备方法和药物溶液包含能够维持药物溶液的氧含量降低，对药物溶液的氧化降解敏感，并且随着时间的推移高度稳定。为了实现上述目的，通过将药液填充并密封在由氧透过度不低于200cm 3 / cm 2的塑料材料形成的药液容器（15）中来制造还原溶解氧含量药物溶液，在蒸汽灭菌处理或热水杀菌处理后的12小时内，在25℃，60％RH下，m 2·24h·atm，稳态透氧度不高于100cm 3 / m 2·24h·atm 在25℃，60％RH下，对药液容器进行蒸汽灭菌处理或热水灭菌处理，并将药液容器保存在具有用于将药液的溶解氧浓度降低的脱氧装置的环境中当塑料材料的透氧性达到稳态水平时，高于2ppm。

8. 发明公开

EP2020386A1 MULTI-CHAMBER CONTAINER 审中-公开
标题翻译：多室集装箱
公开(公告)号：EP2020386A1
公开(公告)日：2009-02-04
申请号：EP07737614.3
申请日：2007-03-01
申请人： OTSUKA PHARMACEUTICAL FACTORY, INC.
发明人： INOUE, Fujio , TATEISHI, Isamu , TSURUOKA, Tatsuro , TOGAWA, Akihito
IPC分类号： B65D81/32 , A61J1/05 , B65D33/36 , B65D81/24
CPC分类号： A61J1/2093 , A61J1/10 , A61J1/2024 , B65D1/095 , B65D81/3266 , B65D81/3277
摘要： It is an object of the resent invention to provide a multi-chamber container that has a weak seal portion having an increased joining strength and being easy to be opened when in administration of medicine, and that is provided at low cost. The multi-chamber container includes a medicine accommodation chamber 1, a diluting solution chamber 3 jointed to one side of the medicine accommodation chamber 1 via a partitioning weak seal portion 2, an unoccupied chamber 5 having a port 6 and joined to an opposite side of the medicine accommodation chamber 1 via a discharging weak seal portion 4, a film member 7 attached to the medicine accommodation chamber 1 for increasing a joining strength of each of the discharging weak seal portion 2 and the discharging weak seal portion 4, the discharging weak seal portion 4 having an easy-to-open portion 8 that enables the discharging weak seal portion 4 to easily opened therethrough.
摘要翻译：本发明的目的是提供一种具有弱密封部分的多室容器，其具有增强的接合强度并且在药物给药时易于打开并且以低成本提供。多室容器包括药物容纳室1，经由分隔弱密封部2接合到药物容纳室1的一侧的稀释液室3，具有端口6并且接合到药物容纳室1的相反侧的空室5 药物容纳室1经由排出弱密封部4，附接至药物容纳室1的膜构件7，用于增加排出弱密封部2和排出弱密封部4中的每一个的接合强度，排出弱密封部分4具有使排出弱密封部分4能够容易地打开的易于打开部分8。

9. 发明授权

EP1955686B1 METHOD OF REINFORCING SOFT SEALING PART OF MULTICELL CONTAINER FOR MEDICAL USE 有权
标题翻译：法加固多细胞容器用于医疗目的的软密封部分的
公开(公告)号：EP1955686B1
公开(公告)日：2016-04-20
申请号：EP06833278.2
申请日：2006-11-24
申请人： OTSUKA PHARMACEUTICAL FACTORY, INC.
发明人： INOUE, Fujio , TATEISHI, Isamu , TOGAWA, Akihito , TSURUOKA, Tatsuro
IPC分类号： A61J1/05 , A61J1/10 , B32B7/06 , B32B27/08 , A61J1/20
CPC分类号： A61J1/2093 , A61J1/10 , A61J1/2024
摘要： An object of the invention is to provide a method for reinforcing a weak sealed portion of a multi-chamber medical container by simple processing. The method for reinforcing a weak sealed portion of a multi-chamber medical container according to the invention includes a multi-chamber container forming step for forming a multi-chamber medical container 10 including a first container portion 11 for containing a medicine, a second container portion 12 for containing a medical solution, an empty container portion 13, a pair of lateral side strong sealed portions 16 for forming both side ends of the container portions, a medical solution side weak sealed portion 17 for forming a partition between the first container portion 11 and the second container portion 12, and a discharge side weak sealed portion 18 for forming a partition between the first container portion 11 and the empty container portion 13; and a weak sealed portion reinforcing step for bonding a reinforcement film 20 for reinforcing the discharge side weak sealed portion 18 so as to cover the surface of the first container portion 11 and so as to be spaced in the discharge direction 14 from a first border 19 with the first container portion 11 on the discharge side weak sealed portion 18.

10. 发明授权

EP2080501B1 DRUG SOLUTION CONTAINING PACK WITH REDUCED DISSOLVED OXYGEN CONTENT 有权转让
标题翻译：具有减少溶解氧含量药物捆绑解决方案
公开(公告)号：EP2080501B1
公开(公告)日：2015-06-17
申请号：EP07830562.0
申请日：2007-10-25
申请人： OTSUKA PHARMACEUTICAL FACTORY, INC.
发明人： SUMIYOSHI, Nobuaki , TATEISHI, Isamu , MORI, Hitoshi , MORIMOTO, Yasushi
IPC分类号： A61J1/10 , A61K9/08 , A61J1/20
CPC分类号： A61J1/10 , A61J1/2093 , A61K9/08
摘要： It is an object of the present invention to provide a drug solution which has a reduced dissolved oxygen content and is less susceptible to oxidative degradation and highly stable over time, a production method therefor, and a drug solution containing pack which is capable of maintaining the dissolved oxygen content of a drug solution at a reduced level, less susceptible to oxidative degradation of the drug solution and highly stable over time. To achieve the aforementioned object, the reduced-dissolved-oxygen-content drug solution is produced by filling and sealing the drug solution in a drug solution container (15) formed of a plastic material having an oxygen permeability of not lower than 200 cm 3 /m 2 ·24h·atm at 25°C at 60%RH within 12 hours after a steam sterilization process or a hot water sterilization process and having a steady-state oxygen permeability of not higher than 100 cm 3 /m 2 ·24h·atm at 25°C at 60%RH, subjecting the drug solution container to the steam sterilization process or the hot water sterilization process, and storing the drug solution container in an environment having deoxidization means for reducing the dissolved oxygen concentration of the drug solution to not higher than 2 ppm when the oxygen permeability of the plastic material reaches the steady-state level.

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