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1. 发明公开

EP2618145A1 METHOD FOR QUANTITATIVE MEASUREMENT OF GASTRIC ACIDITY USING 13C CARBONATE SALT 有权
标题翻译： VERFAHREN ZUR QUANTITATIVEN MAGENSAUREMESSUNG MITHILFE VON 13C-CARBONAT-SALZ
公开(公告)号：EP2618145A1
公开(公告)日：2013-07-24
申请号：EP11818231.0
申请日：2011-08-18
申请人： Otsuka Pharmaceutical Co., Ltd.
发明人： INADA, Makoto , KUNIZAKI, Jun-ichi , TOBITA, Kazuki , AKAMATSU, Suguru , IIZUKA, Shinji
IPC分类号： G01N33/497 , A61B10/00 , A61K49/00
CPC分类号： G01N33/497 , A61B2010/0087 , A61K49/0004 , A61K49/1815 , C12Q1/26 , G01N33/004 , Y02A50/243 , Y10T436/204998
摘要： The present invention provides a method for measuring the gastric acidity of a mammal using a 13 C-labeled carbonate compound. Specifically, the present invention relates to a method for measuring the gastric acidity of a mammal including the following steps:
(1) using, as a test sample, expired air of a mammalian subject excreted at any point in time within 30 minutes after oral administration of a predetermined amount of a 13 C-labeled carbonate compound, measuring behavior of 13 CO 2 in the expired air;
(2) comparing the behavior of 13 CO 2 (measured 13 CO 2 behavior) obtained in step (1) with the behavior of corresponding 13 CO 2 (reference 13 CO 2 behavior) that has been obtained beforehand in a control mammal; and
(3) determining the gastric acidity of the mammalian subject based on a difference between the reference 13 CO 2 behavior and the measured 13 CO 2 behavior obtained above.
摘要翻译：本发明提供了使用13 C-标记的碳酸酯化合物测量哺乳动物胃酸度的方法。具体地，本发明涉及一种测定哺乳动物胃酸度的方法，包括以下步骤：（1）使用作为测试样品的哺乳动物受试者在口服给药后30分钟内任何时间点排出的呼吸空气的预定量的13 C标记的碳酸盐化合物，测量呼气中的13 CO 2的行为; （2）将步骤（1）中获得的13 CO 2（测量的13 CO 2行为）的行为与对照哺乳动物中预先获得的相应的13 CO 2（参考13 CO 2行为）的行为进行比较; 和（3）基于参考13 CO 2行为与上述获得的13 CO 2行为之间的差异来确定哺乳动物受试者的胃酸度。

2. 发明授权

EP2975400B1 COMPOSITION FOR USE IN A METHOD FOR MEASURING SUGAR/FATTY ACID COMBUSTION RATIO 有权
公开(公告)号：EP2975400B1
公开(公告)日：2019-09-04
申请号：EP14763271.5
申请日：2014-03-13
申请人： Otsuka Pharmaceutical Co., Ltd.
发明人： INADA, Makoto , KUNIZAKI, Jun-ichi , TOBITA, Kazuki , MOTONARI, Hiroshi , SATO, Tetsuya
IPC分类号： G01N33/497 , A61B5/08 , G01N33/50

3. 发明授权

EP2618145B1 METHOD FOR QUANTITATIVE MEASUREMENT OF GASTRIC ACIDITY USING 13C CARBONATE SALT 有权
标题翻译：方法定量胃酸MEASUREMENT USING 13C碳酸盐
公开(公告)号：EP2618145B1
公开(公告)日：2016-11-23
申请号：EP11818231.0
申请日：2011-08-18
申请人： Otsuka Pharmaceutical Co., Ltd.
发明人： INADA, Makoto , KUNIZAKI, Jun-ichi , TOBITA, Kazuki , AKAMATSU, Suguru , IIZUKA, Shinji
IPC分类号： G01N33/497 , A61B10/00 , A61K49/00 , G01N33/00
CPC分类号： G01N33/497 , A61B2010/0087 , A61K49/0004 , A61K49/1815 , C12Q1/26 , G01N33/004 , Y02A50/243 , Y10T436/204998
摘要： The present invention provides a method for measuring the gastric acidity of a mammal using a 13 C-labeled carbonate compound. Specifically, the present invention relates to a method for measuring the gastric acidity of a mammal including the following steps: (1) using, as a test sample, expired air of a mammalian subject excreted at any point in time within 30 minutes after oral administration of a predetermined amount of a 13 C-labeled carbonate compound, measuring behavior of 13 CO 2 in the expired air; (2) comparing the behavior of 13 CO 2 (measured 13 CO 2 behavior) obtained in step (1) with the behavior of corresponding 13 CO 2 (reference 13 CO 2 behavior) that has been obtained beforehand in a control mammal; and (3) determining the gastric acidity of the mammalian subject based on a difference between the reference 13 CO 2 behavior and the measured 13 CO 2 behavior obtained above.

4. 发明公开

EP2975400A1 METHOD OF MEASURING INSULIN RESISTANCE WITH FATTY ACID COMBUSTION, AND COMPOSITION USED HEREIN 有权
标题翻译：测量胰岛素抵抗与脂肪酸的烧伤和ITS中使用合成方法
公开(公告)号：EP2975400A1
公开(公告)日：2016-01-20
申请号：EP14763271.5
申请日：2014-03-13
申请人： Otsuka Pharmaceutical Co., Ltd.
发明人： INADA, Makoto , KUNIZAKI, Jun-ichi , TOBITA, Kazuki , MOTONARI, Hiroshi , SATO, Tetsuya
IPC分类号： G01N33/497 , A61B5/08 , G01N33/50
CPC分类号： G01N33/5088 , A61B5/0836 , G01N33/497 , G01N2458/15 , G01N2560/00
摘要： This invention provides a method for measuring insulin resistance of a test subject, and a composition suitably used for the method.
A method for measuring insulin resistance of a test subject comprising steps (a) and (b) below, the method using a composition for measuring insulin resistance comprising, as an active ingredient, a C 12-38 fatty acid labeled with at least one isotope of C, wherein the C 12-38 fatty acid is converted in the body into labeled carbon dioxide that is excreted in expired air,
(a) intravenously administering the composition to a test subject and collecting expired air; and
(b) determining the ratio of labeled CO 2 amount to unlabeled CO 2 amount contained in the expired air or the ratio of labeled CO 2 amount to total CO 2 amount contained in the expired air.
摘要翻译：本发明提供了用于测量测试受试者的胰岛素抵抗的方法，和组合物适合用于该方法。一种用于测量包括以下步骤测试受试者的胰岛素抵抗的方法（a）和（b）所示，使用用于测量胰岛素抵抗，其包含作为活性成分的组合物的方法中，用至少一种同位素一个C 12-38脂肪酸 C，worin的C 12-38脂肪酸在体内转化成标记的二氧化碳并在呼气中排出的（a）中静脉内施用组合物至受试者，并收集呼气; 和（b）确定的采矿标记CO 2的量与包含在呼出空气或标记的CO 2的量与包含在呼出空气总CO 2量的比例未标记的CO 2量的比例。

5. 发明授权

EP2887066B1 COMPOSITION FOR USE IN A METHOD FOR MEASURING CARBOHYDRATE METABOLISM ABILITY 有权转让
公开(公告)号：EP2887066B1
公开(公告)日：2020-08-05
申请号：EP13831608.8
申请日：2013-08-20
申请人： OTSUKA PHARMACEUTICAL CO., LTD.
发明人： INADA, Makoto , KUNIZAKI, Jun-ichi , TOBITA, Kazuki , AKAMATSU, Suguru
IPC分类号： G01N33/497 , G01N33/58 , A61B5/083

6. 发明授权

EP2011518B1 TEST AGENT FOR DIAGNOSING DYSPEPSIA 有权
标题翻译：检测手段于诊断消化功能紊乱
公开(公告)号：EP2011518B1
公开(公告)日：2014-06-18
申请号：EP07741475.3
申请日：2007-04-12
申请人： Otsuka Pharmaceutical Co., Ltd.
发明人： INADA, Makoto , KUNIZAKI, Jun-ichi , IKEI, Nobuhiro , NATSUME, Kuniaki
IPC分类号： A61K49/00 , C07D239/46 , G01N33/497
CPC分类号： C07D239/46 , A61K49/0004 , G01N33/497 , Y10T436/204998

7. 发明公开

EP2011518A1 TEST AGENT FOR DIAGNOSING DYSPEPSIA 有权
标题翻译： TESTMITTEL ZUR DIAGNOSE VONVERDAUUNGSSTÖRUNGEN
公开(公告)号：EP2011518A1
公开(公告)日：2009-01-07
申请号：EP07741475.3
申请日：2007-04-12
申请人： Otsuka Pharmaceutical Co., Ltd.
发明人： INADA, Makoto , KUNIZAKI, Jun-ichi , IKEI, Nobuhiro , NATSUME, Kuniaki
IPC分类号： A61K49/00 , C07D239/46
CPC分类号： C07D239/46 , A61K49/0004 , G01N33/497 , Y10T436/204998
摘要： The present invention provides a composition for measuring the gastric-emptying function and a method for measuring the gastric-emptying function effectively usable in diagnosing dyspepsia. The present invention also provides a dyspepsia diagnostic agent, a method for diagnosing dyspepsia, and a method for measuring the treatment effect on a patient suffering from gastrointestinal disorders caused by insufficiencies in the gastric-emptying function (including a pharmacotherapy). One of the main features of the composition for measuring the gastric-emptying function of the present invention is that a pyrimidine compound, which is converted to a labeled CO 2 gas in the body and excreted in expired air, labeled with an isotope of C or O, is used as an active ingredient. The method of the present invention can be conducted by orally administering the composition to a subject, and measuring the amount or behavior of the labeled CO 2 excreted in expired air.
摘要翻译：本发明提供了一种用于测量胃排空功能的组合物和用于测量有效可用于诊断消化不良的胃排空功能的方法。本发明还提供消化不良诊断剂，诊断消化不良的方法，以及测定由胃排空功能不足引起的胃肠道疾病患者（包括药物治疗）的治疗效果的测定方法。用于测量本发明的胃排空功能的组合物的主要特征之一是将嘧啶化合物转化为体内标记的CO 2气体并在呼出空气中排出，用C或C的同位素标记 O被用作活性成分。本发明的方法可以通过向受试者口服施用该组合物，并测量在呼出空气中排出的标记的CO 2的量或行为。

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