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1. 发明授权

EP1634589B9 AQUEOUS OLANEXIDINE SOLUTION, METHOD OF PREPARING THE SAME, AND DISINFECTANT 有权
标题翻译：水性OLANEXIDIN解决方案，用于生产和消毒剂
公开(公告)号：EP1634589B9
公开(公告)日：2011-08-31
申请号：EP04734736.4
申请日：2004-05-25
申请人： OTSUKA PHARMACEUTICAL CO., LTD. , OTSUKA PHARMACEUTICAL FACTORY, INC.
发明人： MIYATA, Kazuyoshi , INOUE, Yasuhide , HAGI, Akifumi , KIKUCHI, Motoya , OHNO, Hitoshi , HASHIMOTO, Kinji , OHGURO, Kinue, Guran Kawauchi Tower 1304 , SATO, Tetsuya , TSUBOUCHI, Hidetsugu , ISHIKAWA, Hiroshi , OKAMURA, Takashi, Editaun Gomaihama D-10 , IWATA, Koushi, Sanraunjihaitsu 205
IPC分类号： A61K31/155 , A61K9/08 , A61K47/12 , A61K47/10 , A61K47/34 , A61L2/18 , A01N25/02 , A01N37/02 , A01N47/44 , A61P17/00 , A61P31/00
CPC分类号： A61K9/0014 , A01N47/44 , A61K31/155 , A61K31/191 , A61K31/522 , A61K45/06 , A61K47/12 , A61L2/18 , A01N37/36 , A01N25/32 , A01N2300/00 , A61K2300/00
摘要： A disinfectant which contains olanexidine in such a concentration that the disinfectant shows an effective bactericidal activity and which is reduced in side effects such as skin irritation. The disinfectant comprises an aqueous solution which contains olanexidine and gluconic acid, the amount of the latter being at least equimolar with the former, and contains substantially none of acids other than gluconic acid and of salts of the acids (other than gluconic acid).

2. 发明公开

EP1634499A1 AQUEOUS COMPOSITIONS FOR DISINFECTION AND/OR STERILIZATION 审中-公开
标题翻译： WÄSSRIGEZUSAMMENSETZUNGENFÜRDESINFEKTIONS- UND / ODER STERAILISISZWECKE
公开(公告)号：EP1634499A1
公开(公告)日：2006-03-15
申请号：EP04734737.2
申请日：2004-05-25
申请人： OTSUKA PHARMACEUTICAL CO., LTD.
发明人： NISHIBAYASHI, Toru , SATO, Tetsuya , ODOMI, Masaaki; , OHGURO, Kinue; , ISHIKAWA, Hiroshi
IPC分类号： A01N47/44 , A61K31/155 , A61P31/02
CPC分类号： A61K31/155 , A01N47/44 , A01N25/30 , A01N2300/00
摘要： The present invention provides a disinfectant and/or bactericidal aqueous composition containing an olanexidine acid addition salt, and at least one polyoxyethylene-based nonionic surfactant selected from the group consisting of polyoxyethylene higher alkyl ethers and polyoxyethylene alkylphenyl ethers; a disinfectant and/or bactericidal aqueous composition containing an olanexidine acid addition salt at a concentration of 0.05 to 0.5 W/V%, and an alcohol at a concentration of 20 to 80 W/V%, and not containing any surfactants; and a disinfectant and/or bactericidal aqueous composition containing an olanexidine acid addition salt , and at least one member selected from the group consisting of ester-based nonionic surfactants and cyclic oligosaccharides.
摘要翻译：本发明提供一种含有奥拉昔定酸加成盐的消毒剂和/或杀菌水性组合物，以及选自聚氧乙烯高级烷基醚和聚氧乙烯烷基苯基醚的至少一种聚氧乙烯基非离子表面活性剂; 含有浓度为0.05〜0.5W / V％的奥拉西丁酸加成盐的消毒剂和/或杀菌水性组合物，浓度为20〜80W / V％的醇，不含任何表面活性剂; 以及含有奥拉西酸加成盐的消毒剂和/或杀菌水性组合物，以及选自酯类非离子表面活性剂和环状低聚糖中的至少一种。

3. 发明公开

EP2975400A1 METHOD OF MEASURING INSULIN RESISTANCE WITH FATTY ACID COMBUSTION, AND COMPOSITION USED HEREIN 有权
标题翻译：测量胰岛素抵抗与脂肪酸的烧伤和ITS中使用合成方法
公开(公告)号：EP2975400A1
公开(公告)日：2016-01-20
申请号：EP14763271.5
申请日：2014-03-13
申请人： Otsuka Pharmaceutical Co., Ltd.
发明人： INADA, Makoto , KUNIZAKI, Jun-ichi , TOBITA, Kazuki , MOTONARI, Hiroshi , SATO, Tetsuya
IPC分类号： G01N33/497 , A61B5/08 , G01N33/50
CPC分类号： G01N33/5088 , A61B5/0836 , G01N33/497 , G01N2458/15 , G01N2560/00
摘要： This invention provides a method for measuring insulin resistance of a test subject, and a composition suitably used for the method.
A method for measuring insulin resistance of a test subject comprising steps (a) and (b) below, the method using a composition for measuring insulin resistance comprising, as an active ingredient, a C 12-38 fatty acid labeled with at least one isotope of C, wherein the C 12-38 fatty acid is converted in the body into labeled carbon dioxide that is excreted in expired air,
(a) intravenously administering the composition to a test subject and collecting expired air; and
(b) determining the ratio of labeled CO 2 amount to unlabeled CO 2 amount contained in the expired air or the ratio of labeled CO 2 amount to total CO 2 amount contained in the expired air.
摘要翻译：本发明提供了用于测量测试受试者的胰岛素抵抗的方法，和组合物适合用于该方法。一种用于测量包括以下步骤测试受试者的胰岛素抵抗的方法（a）和（b）所示，使用用于测量胰岛素抵抗，其包含作为活性成分的组合物的方法中，用至少一种同位素一个C 12-38脂肪酸 C，worin的C 12-38脂肪酸在体内转化成标记的二氧化碳并在呼气中排出的（a）中静脉内施用组合物至受试者，并收集呼气; 和（b）确定的采矿标记CO 2的量与包含在呼出空气或标记的CO 2的量与包含在呼出空气总CO 2量的比例未标记的CO 2量的比例。

4. 发明公开

EP2033678A1 POWDER INHALER 审中-公开
标题翻译：粉末吸入器
公开(公告)号：EP2033678A1
公开(公告)日：2009-03-11
申请号：EP07767552.8
申请日：2007-06-26
申请人： Otsuka Pharmaceutical Co., Ltd. , Otsuka Techno Corporation
发明人： NISHIBAYASHI, Toru , ADACHI, Shintaro , SATO, Tetsuya , NAKAO, Takaaki
IPC分类号： A61M15/00
CPC分类号： A61M15/0065 , A61M15/0005 , A61M15/0026 , A61M2202/064 , A61M2206/14
摘要： The subject invention provides a powder inhaler enabling the user to complete powder drug inhalation with fewer steps, for improved user convenience.
A powder inhaler of the present invention comprises:
a housing 1A having an admission port 2f on one end;
a supplier having a drug-discharging hole, provided inside the housing 1A with a capacity sufficient to contain plural doses of a fine powder drug;
a drug carrier having a measurement concave portion for receiving a single dose of a drug from the drug-discharging hole, the drug carrier being supported inside the housing 1A while being movable between a drug-receiving position for allowing drug supply from the drug-discharging hole to the measurement concave portion, and a drug-inhalation position for allowing drug inhalation from the measurement concave portion through the admission port;
a cover cap C2 pivotably mounted to the housing 1A; and
a vibrating means 60 brought into operation by pivoting the cover cap C2 so as to vibrate the supplier.
摘要翻译：本发明提供了一种粉末吸入器，使使用者能够以更少的步骤完成粉末药物吸入，从而提高了使用者的便利性。本发明的粉末吸入器包括：壳体1A，其一端具有进入口2f; 具有药物排放孔的供应商，其设置在壳体1A内具有足以容纳多个剂量的细粉药物的容量; 药物载体，其具有用于从药物排出孔接收单剂量药物的测量凹部，药物载体被支撑在壳体1A内部，同时可在用于允许药物从药物排出的供给位置以及药物吸入位置，用于允许药物通过进入口从测量凹部吸入药物; 可枢转地安装到壳体1A的盖帽C2; 以及振动装置60，其通过枢转罩盖C2而进行操作，以使供应商振动。

5. 发明授权

EP2279772B1 POWDER INHALER 有权
标题翻译：干粉吸入器
公开(公告)号：EP2279772B1
公开(公告)日：2016-12-14
申请号：EP09750668.7
申请日：2009-05-22
申请人： Otsuka Pharmaceutical Co., Ltd. , Otsuka Techno Corporation
发明人： SATO, Tetsuya , NISHIBAYASHI, Toru , OGAWA, Yusuke , NAKAO, Takaaki , ADACHI, Shintaro
IPC分类号： A61M11/00 , A61M15/00
CPC分类号： A61M15/0065 , A61M11/002 , A61M15/0026 , A61M15/0075 , A61M2202/064

6. 发明公开

EP1452198A1 POWDER INHALATION DEVICE 审中-公开
标题翻译： PULVERINHALATIONSVORRICHTUNG
公开(公告)号：EP1452198A1
公开(公告)日：2004-09-01
申请号：EP03754018.4
申请日：2003-10-08
申请人： OTSUKA PHARMACEUTICAL CO., LTD. , Otsuka Techno Corporation
发明人： NISHIBAYASHI, Toru Puretamezon Kawauchi 701 , ADACHI, Shintaro Ezansu Nakatani 101 , SATO, Tetsuya
IPC分类号： A61M15/00
CPC分类号： A61M15/0065 , A61M11/002 , A61M15/0025 , A61M15/0068 , A61M15/0075 , A61M2202/064 , A61M2205/0233 , A61M2206/16
摘要： A powder inhalator comprising: a housing; a supply member for holding a powdered drug for a large number of doses and having a drug discharge aperture at its bottom surface; a drug carrier, to which the powdered drug is supplied from the drug discharge aperture of the supply member, and having on its upper surface a measuring recess that has a volume equivalent to one dose of the drug; and an operation member disposed so as to move freely back and forth, and operate the drug carrier; the drug carrier moving in contact with the bottom surface of the supply member to carry the powdered drug loaded into the measuring recess from the position of the drug discharge aperture to an air inhalation channel, wherein the drug carrier is disposed slidably so that the measuring recess moves in a circular manner by sliding the drug carrier.
摘要翻译：一种粉末吸入器，包括：壳体; 供给构件，用于以大量剂量保持粉末状药物，并在其底面具有药物排出口; 药物载体，粉末药物从供给构件的药物排出口供给到药物载体上，并且在其上表面上具有相当于一剂药物的体积的测量凹部; 以及操作构件，其被设置成能够自由地前后移动，并且操作所述药物载体; 所述药物载体与所述供应构件的底表面接触地移动，以将装载到所述测量凹部中的所述粉末药物从所述药物排放孔的位置运送至空气吸入通道，其中所述药物载体可滑动地设置，使得所述测量凹部通过滑动药物载体以圆形方式移动。

7. 发明授权

EP2975400B1 COMPOSITION FOR USE IN A METHOD FOR MEASURING SUGAR/FATTY ACID COMBUSTION RATIO 有权
公开(公告)号：EP2975400B1
公开(公告)日：2019-09-04
申请号：EP14763271.5
申请日：2014-03-13
申请人： Otsuka Pharmaceutical Co., Ltd.
发明人： INADA, Makoto , KUNIZAKI, Jun-ichi , TOBITA, Kazuki , MOTONARI, Hiroshi , SATO, Tetsuya
IPC分类号： G01N33/497 , A61B5/08 , G01N33/50

8. 发明授权

EP2841431B1 DIHYDRATE OF BENZOTHIOPHENE COMPOUND AND PROCESS FOR PRODUCING THE SAME 有权转让
标题翻译： DIHYDRATE的苯并噻吩和方法及其制造
公开(公告)号：EP2841431B1
公开(公告)日：2017-01-04
申请号：EP13722129.7
申请日：2013-04-23
申请人： Otsuka Pharmaceutical Co., Ltd.
发明人： YAMASHITA, Hiroshi , SATO, Tetsuya , MINOWA, Takuya , HOSHIKA, Yusuke , TOYOFUKU, Hidekazu , YAMAGUCHI, Tatsuya , SOTA, Masahiro , KAWANO, Shuuji , NAKAMURA, Takayuki , ETO, Ryohei , IKEBUCHI, Takuma , MORIYAMA, Kei , ITO, Nobuaki
IPC分类号： C07D409/12 , A61K31/4704 , A61P25/00
CPC分类号： C07D409/12

9. 发明授权

EP1634589B1 AQUEOUS OLANEXIDINE SOLUTION, METHOD OF PREPARING THE SAME, AND DISINFECTANT 有权
标题翻译：水性奥兰西丁溶液，其制备方法和消毒剂
公开(公告)号：EP1634589B1
公开(公告)日：2011-02-23
申请号：EP04734736.4
申请日：2004-05-25
申请人： OTSUKA PHARMACEUTICAL CO., LTD. , OTSUKA PHARMACEUTICAL FACTORY, INC.
发明人： MIYATA, Kazuyoshi , INOUE, Yasuhide , HAGI, Akifumi , KIKUCHI, Motoya , OHNO, Hitoshi , HASHIMOTO, Kinji , OHGURO, Kinue, Guran Kawauchi Tower 1304 , SATO, Tetsuya , TSUBOUCHI, Hidetsugu , ISHIKAWA, Hiroshi , OKAMURA, Takashi, Editaun Gomaihama D-10 , IWATA, Koushi, Sanraunjihaitsu 205
IPC分类号： A61K31/155 , A61K9/08 , A61K47/12 , A61K47/10 , A61K47/34 , A61L2/18 , A01N25/02 , A01N37/02 , A01N47/44 , A61P17/00 , A61P31/00
CPC分类号： A61K9/0014 , A01N47/44 , A61K31/155 , A61K31/191 , A61K31/522 , A61K45/06 , A61K47/12 , A61L2/18 , A01N37/36 , A01N25/32 , A01N2300/00 , A61K2300/00
摘要： A disinfectant which contains olanexidine in such a concentration that the disinfectant shows an effective bactericidal activity and which is reduced in side effects such as skin irritation. The disinfectant comprises an aqueous solution which contains olanexidine and gluconic acid, the amount of the latter being at least equimolar with the former, and contains substantially none of acids other than gluconic acid and of salts of the acids (other than gluconic acid).
摘要翻译：一种含有奥兰西丁的消毒剂，其浓度使消毒剂显示出有效的杀菌活性，并且其副作用如皮肤刺激性降低。消毒剂包含含有奥兰西丁和葡糖酸的水溶液，后者的量与前者等摩尔，并且基本上不含除葡糖酸以外的酸和酸的盐（除葡糖酸以外）。

10. 发明公开

EP2279772A1 POWDER INHALER 有权
标题翻译： PULVERINHALATOR
公开(公告)号：EP2279772A1
公开(公告)日：2011-02-02
申请号：EP09750668.7
申请日：2009-05-22
申请人： Otsuka Pharmaceutical Co., Ltd. , Otsuka Techno Corporation
发明人： SATO, Tetsuya , NISHIBAYASHI, Toru , OGAWA, Yusuke , NAKAO, Takaaki , ADACHI, Shintaro
IPC分类号： A61M15/00
CPC分类号： A61M15/0065 , A61M11/002 , A61M15/0026 , A61M15/0075 , A61M2202/064
摘要： An object of the present invention is to provide a powder inhaler that does not require shaking, and that therefore can be operated in an efficient manner.
The powder inhaler of the present invention includes: a housing having a port; a storage member located in the housing for storing a powder medicament; a medicament-delivery member provided in the housing, the medicament-delivery member comprising at least one concave portion for receiving medicament, and capable of taking, relative to the storage member, a receiving position wherein the concave portion receives a predetermined amount of powder medicament from the storage member, and an inhalation position wherein the powder medicament can be inhaled through the admission port; a stirring member for stirring the powder medicament stored in the storage member; an operation button provided in the housing and being capable of moving between the initial position and a depressed position, while the operation button reciprocates between the initial position and the depressed position, the concave portion in the medicament-delivery member moves from the receiving position to the inhalation position and the stirring member operates.
摘要翻译：本发明的目的是提供一种不需要振动的粉末吸入器，因此可以有效地操作。本发明的粉末吸入器包括：具有端口的壳体; 位于所述壳体中用于储存粉末药剂的存储构件; 药物输送部件，其设置在所述壳体内，所述药剂输送部件包括至少一个用于接收药物的凹部，并且能够相对于所述存储部件取出接收位置，其中所述凹部接收预定量的粉末药物以及吸入位置，其中所述粉末药物可以通过所述入口吸入; 用于搅拌存储在所述存储部件中的粉末药剂的搅拌部件; 设置在壳体中并且能够在初始位置和踩下位置之间移动的操作按钮，同时操作按钮在初始位置和踩下位置之间往复运动，药物输送构件中的凹部从接收位置移动到吸入位置和搅拌构件工作。

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