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2. 发明授权

EP2900188B1 BIO-ABSORBABLE MEDICAMENT-ELUTING VENTILATION TUBE 有权
公开(公告)号：EP2900188B1
公开(公告)日：2018-12-05
申请号：EP13841828.0
申请日：2013-09-30
申请人： National University of Singapore , Nanyang Technological University
发明人： LIM, Hsueh Yee, Lynne , GAN, Chee Wee , CHOOI, Wai Hon , VENKATRAMAN, Subramanian , NG, Herr Cheun Anthony , WONG, Yee Shan
IPC分类号： A61L29/06 , A61L29/14 , A61L29/16 , A61F11/00 , A61F2/18
CPC分类号： A61F11/002 , A61F2210/0004 , A61F2230/0069 , A61F2250/0067 , A61L29/06 , A61L29/148 , A61L29/16 , A61L2300/406 , A61L2300/41 , C08L67/04
摘要： The present disclosure relates to ventilation tubes used in the treatment of aural maladies such as, for example, otitis media. A bio-absorbable ventilation tube, optionally containing a medicament, is described for use in a land mammal. The bio-absorbable ventilation tube can be customized for both specific treatment and specific degradation rate based in part on the quantity and type of medicament added to a polymer forming the bio-absorbable ventilation tube. A method of preparing the bio-absorbable ventilation tube of the present disclosure is also provided.

3. 发明公开

EP2900188A1 BIO-ABSORBABLE MEDICAMENT-ELUTING VENTILATION TUBE 有权
标题翻译：生物可吸收MEDIKAMENTENELUIERENDER气道
公开(公告)号：EP2900188A1
公开(公告)日：2015-08-05
申请号：EP13841828.0
申请日：2013-09-30
申请人： National University of Singapore , Nanyang Technological University
发明人： LIM, Hsueh Yee, Lynne , GAN, Chee Wee , CHOOI, Wai Hon , VENKATRAMAN, Subramanian , NG, Herr Cheun Anthony , WONG, Yee Shan
IPC分类号： A61F11/00 , A61L27/58 , A61F2/18 , A61L31/12
CPC分类号： A61F11/002 , A61F2210/0004 , A61F2230/0069 , A61F2250/0067 , A61L29/06 , A61L29/148 , A61L29/16 , A61L2300/406 , A61L2300/41 , C08L67/04
摘要： The present disclosure relates to ventilation tubes used in the treatment of aural maladies such as, for example, otitis media. A bio-absorbable ventilation tube, optionally containing a medicament, is described for use in a land mammal. The bio-absorbable ventilation tube can be customized for both specific treatment and specific degradation rate based in part on the quantity and type of medicament added to a polymer forming the bio-absorbable ventilation tube. A method of preparing the bio-absorbable ventilation tube of the present disclosure is also provided.

4. 发明公开

EP2892564A1 HYALURONIC ACID-BASED DRUG DELIVERY SYSTEMS 审中-公开
标题翻译：基于透明质酸的药物递送系统
公开(公告)号：EP2892564A1
公开(公告)日：2015-07-15
申请号：EP13834865.1
申请日：2013-09-06
申请人： Nanyang Technological University
发明人： VENKATRAMAN, Subramanian , HOWDEN, Tina Tzee Ling , WIDJAJA, Leonardus, Kresna
IPC分类号： A61K47/36 , A61K31/728 , A61K9/127 , A61K31/765 , A61K31/722 , A61K31/5575 , A61K31/505 , A61K39/395 , A61K31/7105 , A61K31/711 , A61P27/06
CPC分类号： A61K47/36 , A61K9/0014 , A61K9/0019 , A61K9/06 , A61K9/127 , A61K9/1647 , A61K9/5161 , A61K31/216 , A61K31/513 , A61K31/5575 , A61K31/7105 , A61K31/728 , Y10S977/773 , Y10S977/906 , Y10S977/907
摘要： The present invention relates to novel hyaluronic acid (HA) hydrogels comprising vesicles loaded with a drug or a protein or a nucleic acid. The new HA hydrogels provide sustain release formulations that are useful for several clinical and surgical applications, including but not limited to ophthalmology (e.g. glaucoma, corneal, ocular inflammatory, vitreoretinal and medical retinal diseases) and dermatological conditions.

5. 发明公开

EP2603185A1 A GLAUCOMA VALVE, A CASING FOR CONTAINING A GLAUCOMA VALVE, AND A GLAUCOMA DRAINAGE DEVICE COMPRISING THE VALVE AND/OR THE CASING 有权
标题翻译：青光眼阀，包括与类固醇可降解聚合物
公开(公告)号：EP2603185A1
公开(公告)日：2013-06-19
申请号：EP11816699.0
申请日：2011-08-12
申请人： Nanyang Technological University , Singapore Health Services Pte Ltd
发明人： VENKATRAMAN, Subramanian , SHANG, Lei , BOEY, Yin, Chiang, Freddy , WONG, Tina
IPC分类号： A61F9/007 , A61M27/00
CPC分类号： A61F9/00781 , A61F2210/0004
摘要： Various embodiments of the invention relate to a glaucoma valve, a casing for containing a glaucoma valve and a glaucoma drainage device comprising the glaucoma valve and/or the casing. The valve includes a flow channel having an inlet and an outlet and a valve member connected to the outlet of the flow channel. The valve member may be formed from a degradable polymer or a combination of degradable polymer and non-degradable polymer. Various embodiments of the invention relate to a glaucoma valve, the valve having a first flow channel. The interior of the first flow channel may be coated with a degradable polymer, such that in use, the polymer degrades to allow a greater flow of fluid through the flow channel. In some embodiments, the valve includes a second flow channel, which may be arranged in parallel to the first flow channel. The first flow channel may be completely sealed with the polymer such that in use, the polymer degrades to allow fluid to flow through the first flow channel. Various embodiments relate to a casing for containing a glaucoma valve. The casing may be formed from a degradable polymer, such as a biodegradable polymer.

6. 发明公开

EP2224971A1 A NON-BIODEGRADABLE STENT COMPRISING A BIODEGRADABLE COATING AND METHOD OF COATING THE SAME 有权
标题翻译：可生物降解涂层和涂布方法不是对其进行生物降解的支架
公开(公告)号：EP2224971A1
公开(公告)日：2010-09-08
申请号：EP08845750.2
申请日：2008-10-30
申请人： Nanyang Technological University
发明人： VENKATRAMAN, Subramanian , BOEY, Yin Chiang , KHANOLKAR, Laxmikant
IPC分类号： A61L27/40 , A61F2/82
CPC分类号： A61L31/141 , A61F2/91 , A61F2002/30064 , A61F2250/0067 , A61F2310/0097 , A61L31/10 , A61L2420/08 , C08L67/04
摘要： The present invention relates to the field of non-biodegradable stents, and therein to non-biodegradable stents coated with at least one layer of a biodegradable polymer which maintains mechanical integrity of the coating both in storage and upon balloon expansion and which can optionally release drugs. The at least one polymer layer comprises a biodegradable polymer and a plasticizer. The present invention also relates to a manufacturing method of such a non-biodegradable stent.

7. 发明公开

EP3197999A1 A BIOREACTOR MODULE, A BIOREACTOR SYSTEM AND METHODS FOR THICK TISSUE SEEDING AND CULTIVATION IN AN HIREARCHICAL ORGANIZATION AND PHYSIOLOGICAL MIMIKING CONDITIONS 审中-实审
标题翻译：生物反应器模块，生物反应器系统和用于在分级组织和生理模拟条件下进行组织切片和培养的方法
公开(公告)号：EP3197999A1
公开(公告)日：2017-08-02
申请号：EP15843187.4
申请日：2015-09-23
申请人： Nanyang Technological University , Technion Research & Development Foundation Ltd.
发明人： MACHLUF, Marcelle , SARIG, Udi , GVIRTZ, Maskit , VENKATRAMAN, Subramanian
IPC分类号： C12M3/00 , C12N5/07 , A01N1/02
CPC分类号： C12M21/08 , A01N1/0247 , A61L27/36 , C12M23/22 , C12M25/14 , C12M29/10 , C12M35/02 , C12M35/04 , C12N5/0602 , C12N5/069 , C12N13/00 , C12N2501/115 , C12N2501/165 , C12N2502/00 , C12N2502/28 , C12N2533/50
摘要： The invention provides a bioreactor and methods for tissue cultivation. A bioreactor module comprises a container, a holder adapted to hold a scaffold containing an inherent vascular network, an inlet connectable to a vessel of the inherent vascular network, an inflatable device disposed within the container, and a pair of electrodes attached to opposing walls of the container, wherein the holder is removably receivable in the container and the inflatable device has a conduit extending through a wall of the container. An alternative embodiment provides an in-vitro method for tissue cultivation, comprising seeding an interior and an exterior of a vessel of an inherent vascular network of a scaffold with a first and a second cell type, respectively, and perfusing through the inherent vascular network with culture medium to facilitate compartmentalized co-cultivation of the first and the second cell type in different niches of the tissue. A further embodiment provides an in-vitro method for tissue cultivation, comprising seeding a surface of a scaffold with a predetermined cell type, and perfusing the scaffold with culture medium from an opposite surface of the scaffold through the scaffold and towards the seeded surface to create a nutrient/oxygen gradient and cause migratory diffusion induced penetration of cells towards the opposite surface.
摘要翻译：本发明提供了用于组织培养的生物反应器和方法。生物反应器模块包括容器，适于容纳包含固有血管网络的支架的固定器，可连接到固有血管网络的血管的入口，设置在容器内的可充气装置以及附接到容器的相对壁的一对电极容器，其中保持器可移除地容纳在容器中，并且充气装置具有延伸穿过容器的壁的导管。一个替代实施方案提供了一种用于组织培养的体外方法，包括分别用第一和第二细胞类型在支架的固有血管网的血管的内部和外部接种并通过固有血管网灌注培养基以促进第一种和第二种细胞类型在组织不同生态位上的区室化共培养。进一步的实施方式提供了用于组织培养的体外方法，包括将支架的表面接种预定的细胞类型，并且使用来自支架的相反表面的培养基通过支架并朝向接种表面灌注支架以产生营养/氧气梯度并引起迁移扩散诱导细胞渗透到相对表面。

8. 发明公开

EP3079705A1 MULTILAYERED NANOPARTICLE AND METHODS OF MANUFACTURING AND USING THE SAME 审中-公开
标题翻译： MEHRSCHICHTIGER NANOPARTIKEL SOWIE VERFAHREN ZUR HERSTELLUNG UND VERWENDUNG DAVON
公开(公告)号：EP3079705A1
公开(公告)日：2016-10-19
申请号：EP14870520.5
申请日：2014-12-09
申请人： Nanyang Technological University , Singapore Health Services Pte Ltd
发明人： VENKATRAMAN, Subramanian , WONG, Tzee Ling Tina , NEU, Bjorn
IPC分类号： A61K31/7088 , A61K9/14 , A61K47/30 , A61P27/02 , A61P17/02
CPC分类号： C12N15/113 , A61K9/501 , A61K9/5036 , A61K9/5052 , A61K9/5078 , A61K9/5089 , A61K9/5107 , A61K31/713 , A61K48/0041 , C12N15/111 , C12N2310/14 , C12N2320/32
摘要： The invention relates to a multilayered nanoparticle for delivery of RNA to a cell and methods of manufacturing and using the same. The multilayered nanoparticle has a core nanoparticle coated by alternating positively and negatively charged polymer layers, wherein the at least one of the negatively charged polymer layers is RNA.
摘要翻译：本发明涉及用于将RNA递送至细胞的多层纳米颗粒及其制造和使用方法。多层纳米颗粒具有通过交替的带正电荷和带负电荷的聚合物层涂覆的核心纳米颗粒，其中至少一个带负电荷的聚合物层是RNA。

9. 发明公开

EP2950723A1 A DEVICE AND METHOD FOR FORMING AN ANASTOMOTIC JOINT BETWEEN TWO PARTS OF A BODY 审中-公开
标题翻译：装置及其制造方法之间的两个身体特殊部位吻合
公开(公告)号：EP2950723A1
公开(公告)日：2015-12-09
申请号：EP14746630.4
申请日：2014-01-28
申请人： Nanyang Technological University , Tan Tock Seng Hospital Pte Ltd
发明人： HUANG, Yingying , VENKATRAMAN, Subramanian , CHIA, Sing Joo
IPC分类号： A61B17/11
CPC分类号： A61B17/11 , A61B17/1114 , A61B90/39 , A61B2017/00004 , A61B2017/00884 , A61B2017/00893 , A61B2017/1107 , A61B2017/1132 , A61B2017/1135 , A61B2090/3966
摘要： A device and method for forming an anastomotic joint between two parts of a human or animal body having a hollow connector with at least two proximal arms biased towards an open position; and at least two distal arms biased towards an open position, wherein in use when pressure is applied to the proximal arms to overcome the bias into a position in which the proximal arms are closer to each other; similarly pressure is applied to the distal arms to overcome the bias into a position in which the distal arms are closer to each other; the distal end can be pushed into a passage in the first human or animal body part until the distal arms are located in the first lumen of the first body part and released allowing the distal arms to move to the biased position to urge against the first lumen of the first body part; and the proximal end can be pushed into a passage in the second human or animal body part until the proximal arms are located in the second lumen of the second body part and released allowing the proximal arms to move to the biased position to urge against the second lumen of the second body part.

10. 发明公开

EP3091938A2 EMBOLIC DEVICE, AN APPARATUS FOR EMBOLIZING A TARGET VASCULAR SITE AND A METHOD THEREOF 审中-公开
标题翻译：栓塞设备，设备用于血管栓塞的目标位置及其方法
公开(公告)号：EP3091938A2
公开(公告)日：2016-11-16
申请号：EP15735449.9
申请日：2015-01-08
申请人： Nanyang Technological University , Singapore Health Services Pte Ltd
发明人： VENKATRAMAN, Subramanian , HUANG, Weimin , WONG, Yee Shan , SALVEKAR, Abhijit Vijay , TAY, Kiang Hiong
IPC分类号： A61F2/04 , A61B17/12
CPC分类号： A61B17/12145 , A61B17/12031 , A61B17/1204 , A61B17/12109 , A61B17/12181 , A61B17/1219 , A61B90/39 , A61B2017/00004 , A61B2017/00871 , A61B2017/00893 , A61B2017/00898 , A61B2090/3966
摘要： According to embodiments of the present invention, an embolic device for embolizing a target vascular site is provided. The embolic device includes a biodegradable shape memory element having an original shape and a deformed shape, wherein the biodegradable shape memory element in the deformed shape is in at least one dimension of a smaller size than the biodegradable shape memory element in the original shape, and wherein the biodegradable shape memory element is provided in the deformed shape and configured to resume the original shape in response to an external stimulus being applied to the biodegradable shape memory element in its deformed shape, to embolize the target vascular site and prevent fluid flow through the target vascular site. According to further embodiments of the present invention, an apparatus for embolizing a target vascular site and a method thereof are also provided.

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