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1. 发明授权

EP1860195B1 COMPLEX CRYSTALLINE SUGAR COMPRISING D-PSICOSE AND D-ALLOSE AND PROCESS FOR PRODUCTION OF THE SAME 有权
标题翻译：包含D-半乳糖和D-阿洛糖的复合结晶糖及其生产方法
公开(公告)号：EP1860195B1
公开(公告)日：2018-01-03
申请号：EP06715211.6
申请日：2006-03-03
申请人： National University Corporation Kagawa University , MATSUTANI CHEMICAL INDUSTRY CO., LTD.
发明人： IZUMORI, Ken , TOKUDA, Masaaki , TAKADA, Goro , MORIMOTO, Kenji
IPC分类号： C12P19/02 , C12P19/24 , C12R1/38 , C07H3/02
CPC分类号： C12P19/02 , C12P19/24
摘要： Disclosed is a process for producing a crystalline sugar comprising D-psicose and D-allose. Also disclosed is a process for producing the sugar. A complex crystalline sugar comprising D-psicose and D-allose. The compositional ratio between D-psicose and D-allose in the sugar is about 1:1 to 1:4. A process for producing a complex crystalline sugar comprising D-psicose and D-allose, the process comprising producing a complex crystalline sugar comprising D-psicose and D-allose from a sugar solution containing D-psicose and p-allose and collecting the complex crystalline sugar. The solvent of the sugar solution used in the production of the complex crystalline sugar is water or a mixture of water and ethanol. The sugar solution containing D-psicose and D-allose is produced by a process comprising reacting D-psicose with L-rhamnose isomerase to convert D-psicose into D-allose. The L-rhamnose isomerase is derived from a strain (IPOD FERM BP-08593) belonging to Pseudomonas stutzeri.

2. 发明公开

EP3124028A1 MALARIA TRANSMISSION PREVENTION AGENT HAVING RARE SUGAR AS EFFECTIVE COMPONENT THEREOF AND MALARIAL PARASITE GROWTH REGULATING AGENT 有权
标题翻译：手段预防与稀有糖作为有效的疟疾传播和用于调节疟原虫生长
公开(公告)号：EP3124028A1
公开(公告)日：2017-02-01
申请号：EP15770130.1
申请日：2015-03-20
申请人： National University Corporation Kagawa University , Matsutani Chemical Industry Co., Ltd.
发明人： TOKUDA, Masaaki , ARAI, Meiji , OKUMA, Kazuhiro
IPC分类号： A61K31/7004 , A61P33/06
CPC分类号： A61K31/7004 , Y02A50/411
摘要： Problem: A malaria transmission blocker or a malaria parasite growth inhibitor is provided as a result of finding a drug which inhibits malaria parasite growth in the body of a vector mosquito. Solution: A malaria parasite growth inhibitor or transmission blocker containing a rare sugar such as D-allose or D-psicose as an active ingredient.
摘要翻译：问题：一个疟疾传播阻断剂或疟原虫生长抑制剂被提供为找到一个药物，其在载体蚊子体内抑制疟原虫生长的结果。解决方案：一种疟疾寄生虫生长抑制剂或阻断剂传输包含稀有糖：如D-阿洛糖或D-阿洛酮糖作为有效成分。

3. 发明公开

EP2090180A1 SWEETENER CONTAINING D-PSICOSE AND FOODS AND DRINKS OBTAINED BY USING THE SAME 审中-公开
标题翻译：甜味剂含有D-阿洛酮糖，以及食品和饮料使用相同的获得
公开(公告)号：EP2090180A1
公开(公告)日：2009-08-19
申请号：EP07739604.2
申请日：2007-03-26
申请人： Matsutani Chemical Industry Co., Ltd. , National University Corporation Kagawa University
发明人： FUJIHARA, Hideki , OKUMA, Kazuhiro , IIDA, Tetsuo , IZUMORI, Ken , TOKUDA, Masaaki , FUKADA, Kazuhiro
IPC分类号： A23L1/236 , A23L1/22 , A23C9/13 , A23G4/00 , A23G9/32 , A23G9/44 , A23G9/52 , A23L2/60
CPC分类号： A23C9/13 , A23G3/36 , A23G3/42 , A23G4/06 , A23G4/10 , A23L2/60 , A23L27/33 , A61K8/60 , A61K47/26 , A61Q11/00
摘要： Providing a D-psicose-containing sweetener with the modification of the taste of D-psicose, comprising D-psicose, a sugar alcohol and/or a high intensity sweetener, preferably containing D-psicose as the main component, particularly a low-calorie sweetener and/or a sweetener giving refreshing feel in the oral cavity, as well as foods and drinks obtained by using the D-psicose-containing sweetener with the modification of the taste of D-psicose, and other products given with sweetness. The sugar alcohol is one or more sugar alcohols selected from the group consisting of sorbitol, mannitol, lactitol, maltitol, xylitol and erythritol, while the high intensity sweetener is one or more high intensity sweeteners as selected from aspartame, acesulfame K, sodium cyclamate, sodium saccharin, Sucralose (under trade name), stevia sweetener, dulcin, taumatin, neotame and monellin.
摘要翻译：提供了一个含有D-阿洛酮糖甜味剂与D-阿洛酮糖的味道的修改，包括D-阿洛酮糖，糖醇和/或高强度甜味剂，优选为含有D-阿洛酮糖作为主要成分，特别是一种低热量的甜味剂和/或增甜剂在口腔中给予清凉感，以及食品和通过使用含D-阿洛酮糖甜味剂与D-阿洛酮糖的味道的改性而得到的饮料，并用甜味给予等产品。所述糖醇是选自山梨糖醇，甘露糖醇，乳糖醇，麦芽糖醇，木糖醇和赤藓糖醇中选择的一种或多种糖醇，而所述高强度甜味剂是一种或多种从阿斯巴选定的高强度甜味剂，丁磺氨K，甜蜜素，糖精钠，三氯蔗糖（商品名），甜菊甜味剂，dulcin，索马甜，纽甜和莫内林。

4. 发明授权

EP2098227B1 Noncarious material and anticarious agent containing rare sugar 有权转让
标题翻译：非龋材料和稀有抗龋齿含糖剂
公开(公告)号：EP2098227B1
公开(公告)日：2013-07-24
申请号：EP07739887.3
申请日：2007-03-27
申请人： Matsutani Chemical Industry Co., Ltd. , National University Corporation Kagawa University
发明人： IIDA, Tetsuo , ICHIHARA, Takashi , IZUMORI, Ken , TOKUDA, Masaaki , OGAWA, Takaaki
IPC分类号： A61K31/047 , A61K31/7004 , A61P1/02 , C07H3/02 , A61K8/60 , A61Q11/00
CPC分类号： A61K8/60 , A61K31/047 , A61K31/7004 , A61Q11/00 , C07H3/02

5. 发明公开

EP2111865A1 UTILIZATION OF THE FUNCTION OF RARE SUGAR AS PROMOTER FOR THE MIGRATION OF GLUCOKINASE FROM NUCLEUS TO CYTOPLASM 有权
标题翻译：稀有糖的功能的一种手段用来提高核葡糖激酶的迁移关闭进入细胞质
公开(公告)号：EP2111865A1
公开(公告)日：2009-10-28
申请号：EP07739883.2
申请日：2007-03-27
申请人： National University Corporation Kagawa University , Matsutani Chemical Industry Co., Ltd.
发明人： TOKUDA, Masaaki , IZUMORI, Ken , TOYODA, Yukiyasu , MIWA, Ichitomo
IPC分类号： A61K31/7004 , A23L1/30 , A61P3/04 , A61P3/06 , A61P3/10 , C07H3/02
CPC分类号： A61K31/121 , A23L33/10 , A23V2002/00 , A61K31/7004 , C07H3/02
摘要： Screening for a glucokinase-activating substance among rare sugars and providing a composition for treating disordered conditions in association with glucokinase activity, the composition containing the glucokinase-activating substance as the active ingredient. A promoting agent of glucokinase transfer from nucleus to cytoplasm, the promoting agent containing D-psicose and/or D-tagatose as the active ingredient, or a composition for preventing the onset of disordered conditions in association with glucokinase activity or for therapeutically treating the disordered conditions, which is in a form selected from a group consisting of food additives, food materials, drinks and foods, health drinks and foods, pharmaceutical product and feeds in blend with D-psicose and/or D-tagatose as the active ingredient for use in preventing the onset of disordered conditions in association with glucokinase activity or for therapeutically treating the disordered conditions. The disordered conditions in association with glucokinase activity are selected from impaired glucose tolerance, type 2 diabetes mellitus, insulin resistance, abnormal lipidemia, the metabolic syndrome and obesity. The composition is in a pharmaceutical form, and contains D-psicose and/or D-tagatose together with one or more pharmaceutically acceptable carriers.
摘要翻译：筛选稀有糖中葡萄糖激酶活化物质和用于相关联地葡糖激酶活性，将含有葡萄糖激酶活化物质作为有效成分的组合物来治疗无序条件提供的组合物。甲促销廷从核葡糖激酶转移到细胞质的代理，促销廷剂含有D-阿洛酮糖和/或D-塔格糖作为有效成分的，或用于与葡糖激酶活性或用于治疗性处理无序预防的无序状况的发病相关联的组合物条件下，所有这些是在从包括食品添加剂，食品材料，饮料和食品，保健饮料和食品，药物产品的选择的形式，并用D-阿洛酮糖和/或D-塔格糖作为使用的活性成分馈送到刺眼与葡糖激酶活性或用于治疗性处理无序条件防止无序状况的发作相关联。与葡糖激酶活性相关联的无序条件从葡萄糖耐量降低，2型糖尿病，胰岛素抵抗，血脂异常，代谢综合征和肥胖症。所述组合物为药物剂型，并含有D-阿洛酮糖和/或D-塔格糖与一种或多种药学上可接受的载体在一起。

6. 发明公开

EP2103625A1 THERMOSTABLE L-RIBOSE ISOMERASE, PROCESS FOR PRODUCING THE SAME AND USE THEREOF 有权转让
标题翻译：热稳定剂L-RIBOSE-ISOMERASE，VERFAHREN ZU DEREN HERSTELLUNG UND ANWENDUNG DAVON
公开(公告)号：EP2103625A1
公开(公告)日：2009-09-23
申请号：EP07739605.9
申请日：2007-03-26
申请人： National University Corporation Kagawa University , Rare Sugar Production Technical Research Laboratories, LLC , Fushimi Pharmaceutical Company, Limited , Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo , Matsutani Chemical Industry Co., Ltd.
发明人： IZUMORI, Ken , MORIMOTO, Kenji , TAKATA, Goro , TOKUDA, Masaaki , TSUJISAKA, Yoshio , TAKESHITA, Kei , TSUSAKI, Keiji , OKUMA, Kazuhiro
IPC分类号： C07K14/195 , C12N1/20 , C12N9/90 , C12P19/24
CPC分类号： C12N9/90 , C12P19/24 , C12R1/01
摘要： Object: To provide a thermostable L-ribose isomerase.
Means for Resolution: The thermostable L-ribose isomerase with MW. 32,000 (by SDS-PAGE), optimal temperature of 45°C, optimal pH of pH 9. 0 (glycine-NaOH buffer), and stable physicochemical properties such as temperature stability up to 45°C during thermal treatment at pH 9.0 for 10 minutes, and with an action to isomerize L-ribose to generate L-ribulose or of inversely to isomerize L-ribulose to generate L-ribose. A conversion method between an aldose and a ketose comprising allowing the thermostable L-ribose isomerase as an enzyme derived from (1) Raoultella ornithinolytica strain MB426 (NITE BP-277) to interact with an aldose selected from L-ribose, D-lyxose, D-tallose, D-mannose, L-allose and L-gulose to isomerize the aldose to generate a ketose selected from the individually corresponding L-ribulose, D-xylulose, D-tagatose, D-fructose, L-psicose and L-sorbose or to interact with a ketose selected from L-ribulose, D-xylulose, D-tagatose, D-fructose, L-psicose and L-sorbose to isomerize the ketose to generate an aldose selected from the individually corresponding L-ribose, D-lyxose, D-tallose, D-mannose, L-allose and L-gulose.
摘要翻译：目的：提供热稳定的L-核糖异构酶。解决方法：具有MW的热稳定的L-核糖异构酶。 32,000（通过SDS-PAGE），最适温度为45℃，pH为9.0（甘氨酸 - NaOH缓冲液）的最佳pH，以及稳定的物理化学性质，例如在pH 9.0的热处理期间高达45℃的温度稳定性为10 分钟，并且具有异构化L-核糖以产生L-核酮糖的作用或者与L-核酮糖异构化以产生L-核糖的作用。醛糖和酮糖之间的转化方法，其包括使热稳定的L-核糖异构酶作为源自（1）鸟氨酸龙胆菌株MB426（NITE BP-277）的酶与选自L-核糖，D-赖索糖， D-山梨糖醇，D-甘露糖，L-丙氨酸和L-古洛糖醇，使醛糖异构化，产生选自单独对应的L-核酮糖，D-木酮糖，D-塔格糖，D-果糖，L-灵芝蛋白和L- 山梨糖或与选自L-核酮糖，D-木酮糖，D-塔格糖，D-果糖，L-灵敏糖和L-山梨糖的酮糖相互作用以使酮糖异构化以产生选自相应的L-核糖，D D-糖精，D-托洛糖，D-甘露糖，L-阿洛糖和L-古洛糖。

7. 发明授权

EP2096164B1 MICROORGANISM CAPABLE OF PRODUCING DEOXY POLYOL DEHYDROGENASE AND UTILIZATION OF THE SAME 有权转让
标题翻译：以能力生产DESOXYPOLYOL脱氢酶及其使用微生物
公开(公告)号：EP2096164B1
公开(公告)日：2016-05-11
申请号：EP07739894.9
申请日：2007-03-27
申请人： National University Corporation Kagawa University , Rare Sugar Production Technical Research Laboratories, LLC , Matsutani Chemical Industry Co., Ltd.
发明人： IZUMORI, Ken , MORIMOTO, Kenji , TAKATA, Goro , TOKUDA, Masaaki , TSUJISAKA, Yoshio , TAKESHITA, Kei , TSUSAKI, Keiji , OKUMA, Kazuhiro
IPC分类号： C12N1/20 , A61K8/60 , C12N9/04 , C12P7/18 , C12P19/02 , C12R1/01
CPC分类号： C12R1/01 , A61K8/60 , A61K2800/86 , A61Q19/00 , C12N9/0006 , C12P19/02

8. 发明公开

EP2096164A1 MICROORGANISM CAPABLE OF PRODUCING DEOXY POLYOL DEHYDROGENASE AND UTILIZATION OF THE SAME 有权转让
标题翻译：以能力生产DESOXYPOLYOL脱氢酶及其使用微生物
公开(公告)号：EP2096164A1
公开(公告)日：2009-09-02
申请号：EP07739894.9
申请日：2007-03-27
申请人： National University Corporation Kagawa University , Rare Sugar Production Technical Research Laboratories, LLC , Fushimi Pharmaceutical Company, Limited , Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo , Matsutani Chemical Industry Co., Ltd.
发明人： IZUMORI, Ken , MORIMOTO, Kenji , TAKATA, Goro , TOKUDA, Masaaki , TSUJISAKA, Yoshio , TAKESHITA, Kei , TSUSAKI, Keiji , OKUMA, Kazuhiro
IPC分类号： C12N1/20 , A61K8/60 , C12N9/04 , C12P7/18 , C12P19/02
CPC分类号： C12R1/01 , A61K8/60 , A61K2800/86 , A61Q19/00 , C12N9/0006 , C12P19/02
摘要： Problem: To provide a microorganism with an ability to produce deoxy polyol dehydrogenase.
Means for Resolution: A microorganism belonging to genus Enterobacter with an ability to produce a dehydrogenase for deoxy polyol of the same structure at the positions C2 and C3 as that of ribitol or L-iditol. The bacterial cell IK7 of the genus Enterobacter (accession No. NITE P-271). A method for producing deoxy ketose comprising allowing a culture containing the deoxy polyol dehydrogenase obtained by the culturing of the microorganism of the invention or allowing the deoxy polyol dehydrogenase to react with a solution containing deoxy polyol of the same structure at the positions C2 and C3 as that of ribitol or L-iditol to oxidize deoxy polyol to produce the corresponding deoxy ketose and then collecting the deoxy ketose. The deoxy polyol is 1-deoxy-D-allitol, while the corresponding deoxy ketose is 1-deoxy-L-psicose. Otherwise, the deoxy polyol is L-rhamnitol, while the corresponding deoxy ketose is 1-deoxy-L-fructose.
摘要翻译：问题：在生产脱氧多元醇脱氢酶的能力提供了一个微生物与。用于解决方法：一种微生物，属于肠杆菌属的与在位置C2和C3象核糖醇或L-艾杜糖醇的以产生用于相同的结构的多元醇脱氧脱氢酶的能力。肠杆菌属（保藏号NITE P-271）的细菌细胞IK7。一种生产脱氧酮糖包括允许培养含有由本发明的微生物的培养或允许脱氧多元醇脱氢酶与在位置C2和C3为含有相同的结构的脱氧多羟基化合物的溶液中反应而获得的脱氧多元醇脱氢酶方法确实核糖醇或L-艾杜糖醇的氧化脱氧多羟基化合物，以产生相应脱氧酮糖，然后收集所述脱氧酮糖。脱氧多羟基化合物是1-脱氧-D-蒜糖醇，而相应的脱氧酮糖是1-脱氧-L-阿洛酮糖。否则，脱氧多羟基化合物是L-rhamnitol，而相应的脱氧酮糖是1-脱氧-L-果糖。

10. 发明公开

EP2098227A1 NONCARIOUS MATERIAL AND ANTICARIOUS AGENT CONTAINING RARE SUGAR 有权转让
标题翻译： Nicht-kariöses材料与einen seltenen Zucker enthaltendes反Karies-Mittel
公开(公告)号：EP2098227A1
公开(公告)日：2009-09-09
申请号：EP07739887.3
申请日：2007-03-27
申请人： Matsutani Chemical Industry Co., Ltd. , National University Corporation Kagawa University
发明人： IIDA, Tetsuo , ICHIHARA, Takashi , IZUMORI, Ken , TOKUDA, Masaaki , OGAWA, Takaaki
IPC分类号： A61K31/047 , A61K31/7004 , A61P1/02 , C07H3/02
CPC分类号： A61K8/60 , A61K31/047 , A61K31/7004 , A61Q11/00 , C07H3/02
摘要： Object: To provide a composition for preventing periodontal diseases (prophylactic agent of periodontal diseases), the composition having an excellent cariostatic property, being safe and stable for prolonged use and having less effects on flavor.
Means for Resolution: A non-cariogenic material prepared by blending a rare sugar in the D form as selected from the group consisting of D-psicose, D-sorbose and D-tagatose, a rare sugar in the L form as selected from L-fructose, L-psicose and L-tagatose, or allitol as a rare sugar derivative, singly or in combination. A cariostatic agent comprising D-psicose, D-sorbose, D-tagatose, L-fructose, L-psicose and/or L-tagatose. A cariostatic agent in combination with catechins.
摘要翻译：目的：提供一种用于预防牙周病（牙周病的预防剂）的组合物，该组合物具有优异的抑制性，对于长时间使用是安全和稳定的并且对风味影响较小。解决方法：通过将选自D-木糖，D-山梨糖和D-塔格糖的D-形式的稀有糖混合制备的非致龋物质，L-选择L- 果糖，L-灵巧蛋白和L-塔格糖，或作为稀有糖衍生物的甘醇，单独或组合使用。包含D-灵糖蛋白，D-山梨糖，D-塔格糖，L-果糖，L-灵巧蛋白和/或L-塔格糖的抑制剂。与儿茶素组合的抑制剂。

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