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1. 发明公开

EP2148193A1 ELECTROPHORESIS CHIP, ELECTROPHORESIS DEVICE, AND SAMPLE ANALYZING METHOD BY CAPILLARY ELECTROPHORESIS METHOD 审中-公开
标题翻译： ELEKTROPHORESE-CHIP，ELEKTROPHORESEVORRICHTUNG SOWIE VERFAHREN ZUR ANALYZE VON PROBEN DURCH KAPILLARELEKTROPHORESE
公开(公告)号：EP2148193A1
公开(公告)日：2010-01-27
申请号：EP08752216.5
申请日：2008-04-28
申请人： National Institute of Advanced Industrial Science and Technology , Arkray, Inc.
发明人： TANAKA, Yoshide , NAKAYAMA, Yusuke , YONEHARA, Satoshi
IPC分类号： G01N27/447 , G01N37/00
CPC分类号： G01N27/44791 , G01N27/44743
摘要： An electrophoresis chip that can be small and simple and that can analyze a sample with high accuracy is provided. The electrophoresis chip includes an upper substrate 4, a lower substrate 1, an introduction reservoir 2a, a recovery reservoir 2b and a capillary channel for sample analysis 3x.
The introduction reservoir 2a and the recovery reservoir 2b are formed in the lower substrate 1. The introduction reservoir 2a and the recovery reservoir 2b are in communication with each other via the capillary channel for sample analysis 3x. The introduction reservoir 2a receives a sample to be measured.
The sample is electrophoretically introduced directly into the capillary channel for sample analysis 3x by creating a potential difference between the introduction reservoir 2a and the recovery reservoir 2b, and is also analyzed in the capillary channel for sample analysis 3x during the separation of the sample while the sample is being continuously supplied.
摘要翻译：提供可以小而简单并且可以高精度地分析样品的电泳芯片。电泳芯片包括上基板4，下基板1，导入槽2a，回收槽2b和用于样品分析的毛细通道3x。引入储存器2a和回收储存器2b形成在下基板1中。引入储存器2a和回收储存器2b经由用于样本分析3x的毛细通道彼此连通。引入容器2a接收要测量的样品。通过在引入容器2a和回收容器2b之间产生电位差，将样品电泳引入毛细通道3x进行样品分析，并在样品分离过程中在毛细管通道中进行样品分析3x分析，同时样品不断供应。

2. 发明公开

EP2060912A1 METHOD FOR ANALYSIS OF SAMPLE BY CAPILLARY ELECTROPHORESIS 有权转让
标题翻译：毛细管电泳分析样品的方法
公开(公告)号：EP2060912A1
公开(公告)日：2009-05-20
申请号：EP07806228.8
申请日：2007-08-29
申请人： National Institute of Advanced Industrial Science and Technology , Arkray, Inc.
发明人： TANAKA, Yoshihide, c/o Kansai Center of Nat. Inst. , NAKAYAMA, Yusuke , YONEHARA, Satoshi , WAKIDA, Shinichi, c/o Kansai Center of Nat. Inst.
IPC分类号： G01N27/447
CPC分类号： G01N27/447 , G01N27/44756
摘要： A process for analyzing a sample by a capillary electrophoresis method is provided that allows the apparatus to be reduced in size, allows a high analytical precision to be obtained, and can be carried out easily. The aanalytical process of the present invention is a process for analyzing a sample by a capillary electrophoresis method. The process includes a step of preparing a capillary channel to be used for the capillary electrophoresis method and a step of electrophoresing a complex of a sample and an anionic group-containing compound that are bonded together, in the capillary channel, wherein the capillary channel includes an A layer that is coated on an inner wall thereof and a B layer that is coated on the A layer. A layer: a spacer layer formed of at least one selected from the group consisting of polydiallyldimethylammoniumchloride, a nonpolar polymer, and a cationic group-containing compound, wherein the polydiallyldimethylammoniumchloride is coated on the inner wall of the capillary channel by physical adsorption when the layer includes the polydiallyldimethylammoniumchloride, and at least one of the nonpolar polymer and the cationic group-containing compound is coated on the inner wall of the capillary channel by covalent bond when the layer includes at least one of the nonpolar polymer and the cationic group-containing compound
B layer: an anionic layer formed of an anionic group-containing compound
摘要翻译：提供了一种通过毛细管电泳方法分析样品的方法，该方法允许装置尺寸减小，可以获得高分析精度，并且可以容易地进行。本发明的分析过程是用毛细管电泳法分析样品的过程。该方法包括准备用于毛细管电泳方法的毛细管通道的步骤以及在毛细管通道中电泳样品和包含阴离子基团的化合物的复合物的步骤，其中毛细管通道包括涂覆在其内壁上的A层和涂覆在A层上的B层。层：由选自聚二烯丙基二甲基氯化铵，非极性聚合物和含阳离子基团的化合物组成的组中的至少一种形成的间隔层，其中聚二烯丙基二甲基氯化铵通过物理吸附涂布在毛细管通道的内壁上，包括聚二烯丙基二甲基氯化铵，并且当所述层包含非极性聚合物和含阳离子基团的化合物中的至少一种时，非共极聚合物和含阳离子基团的化合物中的至少一种通过共价键被涂布在毛细管通道的内壁上 B层：由含阴离子基团的化合物形成的阴离子层

3. 发明授权

EP2312308B1 APPARATUS AND METHOD FOR ANALYSIS BY CAPILLARY ELECTROPHORETIC METHOD 有权转让
标题翻译：设备和方法分析毛细管电泳
公开(公告)号：EP2312308B1
公开(公告)日：2016-08-31
申请号：EP09800373.4
申请日：2009-07-17
申请人： ARKRAY, Inc. , National Institute of Advanced Industrial Science and Technology
发明人： SUGIYAMA, Koji , HIGASHIISOKAWA, Yukio , NAKAYAMA, Yusuke , TANAKA, Yoshihide
IPC分类号： G01N27/447 , B01D57/02 , G01N33/49 , G01N33/72 , C07K1/26
CPC分类号： G01N27/44791 , B01D57/02 , C07K1/26 , G01N27/403 , G01N27/44721 , G01N33/6893 , G01N33/721 , G01N33/726 , G01N2800/042

4. 发明授权

EP2144055B1 METHOD OF ANALYZING HEMOGLOBIN BY CAPILLARY ELECTROPHORESIS AND ADDITIVE TO BE USED THEREIN 有权
标题翻译：血红蛋白分析方法毛细管以及它在SANTANDER添加剂
公开(公告)号：EP2144055B1
公开(公告)日：2014-03-12
申请号：EP08751963.3
申请日：2008-04-23
申请人： ARKRAY, Inc.
发明人： NAKAYAMA, Yusuke , YONEHARA, Satoshi
IPC分类号： G01N27/447
CPC分类号： G01N27/44747

5. 发明公开

EP2144056A1 ELECTROPHORESIS CHIP AND ELECTROPHORESIS APPARATUS 审中-公开
标题翻译： ELEKTROPHORESE-CHIP UND ELEKTROPHORESEVORRICHTUNG
公开(公告)号：EP2144056A1
公开(公告)日：2010-01-13
申请号：EP08751964.1
申请日：2008-04-23
申请人： Arkray, Inc.
发明人： SUGIYAMA, Koji , YONEHARA, Satoshi , NAKAYAMA, Yusuke
IPC分类号： G01N27/447 , G01N37/00
CPC分类号： G01N27/44791 , B01L3/50273 , B01L2300/0867 , B01L2300/0887 , B01L2300/16 , B01L2400/0421 , C07K1/26
摘要： An electrophoresis chip that enables an apparatus to be small, analysis time to be short and glycosylated hemoglobin to be analyzed highly accurately is provided. The electrophoresis chip includes an upper substrate 4, a lower substrate 1, a first introduction reservoir 2a, a first recovery reservoir 2b and a capillary channel for sample analysis 3x; the first introduction reservoir 2a and the first recovery reservoir 2b are formed in the lower substrate 1; and the first introduction reservoir 2a and the first recovery reservoir 2b are in communication with each other via the capillary channel for sample analysis 3x.
摘要翻译：提供能够使装置小型，分析时间短，要高精度地分析糖基化血红蛋白的电泳芯片。电泳芯片包括上基板4，下基板1，第一引入槽2a，第一回收槽2b和用于样品分析的毛细通道3x; 第一引入槽2a和第一回收槽2b形成在下基板1中; 并且第一引入槽2a和第一回收槽2b经由用于样品分析3x的毛细通道彼此连通。

6. 发明公开

EP4343323A1 HEMOGLOBIN A1C MEASUREMENT METHOD, HEMOGLOBIN ANALYZER, AND NON-TRANSITORY COMPUTER-READABLE RECORDING MEDIUM 审中-实审
公开(公告)号：EP4343323A1
公开(公告)日：2024-03-27
申请号：EP23174366.7
申请日：2023-05-19
申请人： ARKRAY, Inc.
发明人： NAKAYAMA, Yusuke
IPC分类号： G01N30/88 , G16H50/20 , G01N30/86
摘要： There is provided a stable glycohemoglobin measurement method. In the method, a processor (100A) executes a process to separate hemoglobin in blood to acquire a hemoglobin A1c peak derived from stable glycohemoglobin, hemoglobin A peaks including fractions derived from hemoglobin A, and hemoglobin-derived peaks fractionated other than the hemoglobin A peaks and find the value of the stable glycohemoglobin by performing a correction calculation to lower, based on the area of a peak selected from among the hemoglobin-derived peaks fractionated other than the hemoglobin A peaks, a value obtained by dividing the area of the hemoglobin A1c peak by the areas of the hemoglobin A peaks.

7. 发明公开

EP2315015A1 ANALYSIS DEVICE BY CAPILLARY ELECTROPHORESIS METHOD 审中-公开
标题翻译： ANALYSATOR MIT KAPILLARELEKTROPHORESEVERFAHREN
公开(公告)号：EP2315015A1
公开(公告)日：2011-04-27
申请号：EP09800372.6
申请日：2009-07-17
申请人： ARKRAY, Inc.
发明人： SUGIYAMA, Koji , HIGASHIISOKAWA, Yukio , NAKAYAMA, Yusuke
IPC分类号： G01N27/447
CPC分类号： G01N27/44791 , C07K1/26 , G01N27/44721
摘要： A capillary electrophoresis analysis apparatus, for analyzing protein in blood by a capillary electrophoresis method, is provided that allows the whole apparatus to be small, operation to be simple, manufacturing cost to be inexpensive, and analysis to be performed highly accurately.
A capillary electrophoresis analysis apparatus of the present invention is one for analyzing protein in blood by a capillary electrophoresis method. The capillary electrophoresis analysis apparatus comprises an electrophoresis chip, a voltage application unit, and an absorbance measurement unit. The electrophoresis chip comprises a substrate, a plurality of liquid reservoirs, and a capillary channel. The voltage application unit comprises an electrode. The plural liquid reservoirs are formed in the substrate. The plural liquid reservoirs are in communication with one another via the capillary channel. The capillary channel includes a capillary channel for sample analysis.
摘要翻译：提供一种毛细管电泳分析装置，其通过毛细管电泳方法分析血液中的蛋白质，其允许整个装置小，操作简单，制造成本便宜，并且要高精度地进行分析。本发明的毛细管电泳分析装置是通过毛细管电泳法分析血液中的蛋白质的装置。毛细管电泳分析装置包括电泳芯片，电压施加单元和吸光度测定单元。电泳芯片包括基底，多个液体储存器和毛细通道。电压施加单元包括电极。多个液体储存器形成在基板中。多个液体储存器经由毛细通道彼此连通。毛细通道包括用于样品分析的毛细管通道。

8. 发明公开

EP3839498A1 FILTER DEVICE, COLUMN, AND LIQUID CHROMATOGRAPHY DEVICE 审中-实审
公开(公告)号：EP3839498A1
公开(公告)日：2021-06-23
申请号：EP20214728.6
申请日：2020-12-16
申请人： ARKRAY, Inc.
发明人： NAKAYAMA, Yusuke , TAKAGI, Takeshi , KUGA, Akira
IPC分类号： G01N30/60
摘要： A filter device includes a first filter(48), a first retaining member(44) that has a hollow shape, the first filter(48) being fitted inside the first retaining member(44), a second filter(50) that has a smaller pore size than the first filter(48), a second retaining member(46) that is disposed downstream of the first filter(48) and that has a hollow shape, the second filter(50) being fitted inside the second retaining member(46), a spacer(56) that has a hollow shape, that is disposed between the first retaining member(44) and the second retaining member(46), that maintains a non-contact state between the first filter(48) and the second filter(50), and that includes a first contact portion(58) contacting the first filter(48).

9. 发明授权

EP2144057B1 METHOD FOR ANALYZING A SAMPLE CONTAINING GLYCOSYLATED HEMOGLOBIN AND GLUCOSE 有权转让
公开(公告)号：EP2144057B1
公开(公告)日：2019-04-10
申请号：EP08751965.8
申请日：2008-04-23
申请人： ARKRAY, Inc.
发明人： NAKAYAMA, Yusuke , SUGIYAMA, Koji
IPC分类号： G01N27/447 , G01N37/00 , B01D57/02 , B01L3/00

10. 发明公开

EP2144057A1 ANALYSIS CHIP AND ANALYSIS APPARATUS 有权转让
标题翻译： ANALYSECHIP UNDANALYSEGERÄT
公开(公告)号：EP2144057A1
公开(公告)日：2010-01-13
申请号：EP08751965.8
申请日：2008-04-23
申请人： Arkray, Inc.
发明人： NAKAYAMA, Yusuke , SUGIYAMA, Koji
IPC分类号： G01N27/447 , G01N37/00
CPC分类号： G01N27/44791 , B01D57/02 , G01N27/44704
摘要： An analysis chip that enables an apparatus to be small, analysis to be simple, analysis time to be short and analysis of both glycosylated hemoglobin and glucose to be highly accurate is provided. The electrophoresis chip includes an upper substrate 4, a lower substrate 1, a first introduction reservoir 2a, a first recovery reservoir 2b and a capillary channel for sample analysis 3x; the first introduction reservoir 2a and the first recovery reservoir 2b are formed in the lower substrate 1; and the first introduction reservoir 2a and the first recovery reservoir 2b are in communication with each other via the capillary channel for sample analysis 3x.
摘要翻译：提供一种分析芯片，使装置小型化，分析简单，分析时间短，糖基化血红蛋白和葡萄糖分析精度高。电泳芯片包括上基板4，下基板1，第一引入槽2a，第一回收槽2b和用于样品分析的毛细通道3x; 第一引入槽2a和第一回收槽2b形成在下基板1中; 并且第一引入槽2a和第一回收槽2b经由用于样品分析3x的毛细通道彼此连通。

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