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1. 发明授权

EP2944699B1 METHOD OF SELECTIVELY DETERMINING GLYCATED HEMOGLOBIN 有权
标题翻译：选择性测定糖化血红蛋白的方法
公开(公告)号：EP2944699B1
公开(公告)日：2017-10-18
申请号：EP15174619.5
申请日：2001-07-12
申请人： ARKRAY, Inc.
发明人： YONEHARA, Satoshi
IPC分类号： C12Q1/37 , C12Q1/26 , G01N33/72
CPC分类号： C12Q1/26 , C12Q1/37 , G01N33/723 , G01N33/725

2. 发明公开

EP3001190A1 METHOD FOR DETECTING PHENOTHIAZINE-DERIVATIVE COLOR AND COLOR-DEVELOPER REAGENT USED THEREIN 有权
标题翻译：用于检测表没食子儿茶素衍生物的显色剂和显色剂的方法
公开(公告)号：EP3001190A1
公开(公告)日：2016-03-30
申请号：EP15191515.4
申请日：2008-01-30
申请人： ARKRAY, Inc.
发明人： YONEHARA, Satoshi , INAMURA, Norio
IPC分类号： G01N31/00 , G01N21/78 , G01N31/22 , C09B11/08 , C09B21/00 , C09B29/15 , C09B29/50 , C09B67/22 , C09B67/46 , G01N21/77
CPC分类号： G01N31/22 , C09B11/08 , C09B21/00 , C09B29/103 , C09B29/366 , C09B67/0033 , C09B67/0041 , C09B67/0089 , G01N21/78 , G01N2021/7783 , Y10T436/141111 , Y10T436/145555
摘要： The present invention provides a phenothiazine-derivative color-measuring method that can detect a phenothiazine-derivative color even at a wavelength longer than the wavelength that exhibits maximum absorption. A phenothiazine-derivative color is detected, by adding a 5-hydroxy-1-(4-sulfophenyl)-4-(4-sulfophenylazo)pyrazole-3-carboxylic acid salt, 6-hydroxy-5-(4-sulfophenylazo)-2-naphthalenesulfonic acid salt, 3-hydroxy-4-(4-sulfonaphthylazo)-2,7-naphthalenedisulfonic acid salt, or 7-hydroxy-8-(4-sulfonaphthylazo)-1,3-naphthalenedisulfonic acid salt to the reaction system containing a phenothiazine-derivative color, and then measuring the light absorbance at a wavelength of 610 to 730 nm.
摘要翻译：本发明提供即使在比显示最大吸收的波长更长的波长下也能够检测吩噻嗪衍生物颜色的吩噻嗪衍生物颜色测定方法。通过加入5-羟基-1-（4-磺基苯基）-4-（4-磺基苯基偶氮）吡唑-3-羧酸盐，6-羟基-5-（4-磺基苯偶氮基） - 2-萘磺酸盐，3-羟基-4-（4-磺基萘基偶氮）-2,7-萘二磺酸盐或7-羟基-8-（4-磺基萘基偶氮）-1,3-萘二磺酸盐加入反应体系含有吩噻嗪衍生物颜色，然后测量在610-730nm波长处的吸光度。

3. 发明授权

EP2249163B1 Method of pretreating sample for measurement of glycated amine 有权
标题翻译：一种用于预处理样品糖化胺的测定方法
公开(公告)号：EP2249163B1
公开(公告)日：2012-06-27
申请号：EP10008376.5
申请日：2002-10-09
申请人： ARKRAY, Inc.
发明人： YONEHARA, Satoshi , KOMORI, Tsuguki
IPC分类号： C12Q1/26 , C12Q1/37 , C12Q1/28 , G01N33/48 , G01N33/50 , G01N33/72
CPC分类号： C12Q1/26 , C12Q1/37 , G01N33/723 , G01N2333/906

4. 发明授权

EP1950309B1 ALBUMIN-DENATURING AGENT 有权
标题翻译：白蛋白变性
公开(公告)号：EP1950309B1
公开(公告)日：2011-08-17
申请号：EP06822508.5
申请日：2006-10-27
申请人： ARKRAY, Inc.
发明人： YONEHARA, Satoshi , INAMURA, Norio
IPC分类号： C12Q1/00 , G01N33/48 , G01N33/66 , G01N33/68
CPC分类号： C12Q1/37 , G01N33/68 , G01N2333/76 , G01N2400/00
摘要： Disclosed is an albumin-denaturing agent which is helpful for achieving a high-efficiency decomposition of albumin with a protease. The albumin-denaturing agent comprises a tertiary ammonium having a hydrocarbon group harboring 12 to more carbon atoms or a salt thereof. Albumin in a sample is decomposed with a protease in the presence of the albumin-denaturing agent, a glycosylated part in the resulting albumin decomposition product is reacted with FAOD, and the oxidation/reduction reaction between the glycosylated part and FAOD is then determined, whereby the ratio of the amount of glycosylated albumin to that of albumin (GA (%)) can be determined.

5. 发明授权

EP2108952B1 Method for detection of a target compound based on a redox-reaction of a phenothiazine dye 有权转让
标题翻译：一种用于基于一个Phenothiazinfarbstoffs的氧化还原反应检测靶化合物的方法
公开(公告)号：EP2108952B1
公开(公告)日：2015-10-28
申请号：EP08704155.4
申请日：2008-01-30
申请人： ARKRAY, Inc.
发明人： YONEHARA, Satoshi , INAMURA, Norio
IPC分类号： C09B21/00 , C09B29/10 , C09B29/36 , C09B67/00 , G01N31/22 , G01N21/78 , G01N21/77 , C09B11/08 , C09B29/15 , C09B29/50 , C09B67/22 , C09B67/46
CPC分类号： G01N31/22 , C09B11/08 , C09B21/00 , C09B29/103 , C09B29/366 , C09B67/0033 , C09B67/0041 , C09B67/0089 , G01N21/78 , G01N2021/7783 , Y10T436/141111 , Y10T436/145555

6. 发明公开

EP2144055A1 METHOD OF ANALYZING HEMOGLOBIN BY CAPILLARY ELECTROPHORESIS AND ADDITIVE TO BE USED THEREIN 有权
标题翻译：血红蛋白分析方法毛细管以及它在SANTANDER添加剂
公开(公告)号：EP2144055A1
公开(公告)日：2010-01-13
申请号：EP08751963.3
申请日：2008-04-23
申请人： Arkray, Inc.
发明人： NAKAYAMA, Yusuke , YONEHARA, Satoshi
IPC分类号： G01N27/447
CPC分类号： G01N27/44747
摘要： The present invention provides a method for analyzing hemoglobin by capillary electrophoresis, that allows the apparatus to be smaller in size, allows a highly precise analysis to be obtained, and allows the analysis to be performed in a short period of time. The analytical method of the present invention are methods for analyzing hemoglobin by capillary electrophoresis, comprising: a sample-providing step of providing a sample containing hemoglobin; a capillary tube-providing step of providing a capillary tube containing a buffer solution; and an electrophoresis step of carrying out electrophoresis of the sample, by introducing the sample into the buffer solution in the capillary tube, and applying a voltage across both ends of the capillary tube; wherein the electrophoresis is carried out following at least one of modes (A) and (B) below: (A) the electrophoresis is carried out with a surfactant (a) added to the buffer solution, the surfactant (a) being a non-ionic surfactant having an alkyl group as a hydrophobic portion and a sugar as a hydrophilic portion; and (B) the electrophoresis is carried out with a surfactant (b) added to the sample, the surfactant (b) being a betaine-type amphoteric surfactant.
摘要翻译：本发明提供了用于通过毛细管电泳法分析血红蛋白的方法，确实允许所述装置在尺寸上较小，使得能够获得高精度的分析，并允许在很短的时间周期中进行的分析。本发明的分析方法是用于通过毛细管电泳法分析血红蛋白的方法，包括：提供含有血红蛋白的试样的样品提供步骤; 一个毛细管准备提供毛细管含有缓冲溶液的步骤; 并进行样品的电泳，通过将样品引入毛细管中的缓冲溶液中，并施加在整个毛细管的两端的电压的电泳工序; worin电泳进行以下模式中的下面的至少一种（A）和（B）：（A）的电泳与表面活性剂开展的（a）加入到该缓冲液中，表面活性剂（a）是一个非具有烷基作为疏水性部分和糖作为亲水部分离子表面活性剂; 和（B）的电泳与表面活性剂（b）中加入到样品中，表面活性剂（b）是甜菜碱型两性表面活性剂开展。

7. 发明公开

EP1985670A1 LIQUID REAGENT OF COLOR FORMER AND METHOD OF STABILIZING THE SAME 有权转让
标题翻译： FLÜSSIGESREAGENS EINES FARBBILDNERS UND VERFAHREN ZUR STABILISIERUNG DESSELBIGEN
公开(公告)号：EP1985670A1
公开(公告)日：2008-10-29
申请号：EP07707001.9
申请日：2007-01-18
申请人： Arkray, Inc.
发明人： YONEHARA, Satoshi , INAMURA, Norio
IPC分类号： C09B67/00 , C09B21/00 , G01N31/22
CPC分类号： C09B69/04 , C09B67/0076 , G01N31/22 , Y10T436/10 , Y10T436/17 , Y10T436/173845 , Y10T436/25 , Y10T436/2525
摘要： A liquid reagent in which a methylene blue compound color former is stably stored in a liquid state; and a method of stabilizing a methylene blue compound color former in a liquid state. A methylene blue compound color former is stabilized by causing it to coexist with either a quaternary ammonium compound having a C 12 or higher hydrocarbon chain or a salt thereof in a liquid medium. Examples of the methylene blue compound color former include 10-(carboxymethylaminocarbonyl)-3,7-bis(dimethylamino) phenothiazine.
摘要翻译：其中亚甲基蓝化合物成色剂以液态稳定储存的液体试剂; 以及稳定液态的亚甲蓝化合物着色剂的方法。亚甲蓝化合物着色剂通过在液体介质中与具有C 12或更高级烃链的季铵化合物或其盐共存而稳定。亚甲基蓝化合物显色剂的实例包括10-（羧甲基氨基羰基）-3,7-双（二甲基氨基）吩噻嗪。

8. 发明公开

EP2944699A1 METHOD OF SELECTIVELY DETERMINING GLYCATED HEMOGLOBIN 有权
标题翻译： VERFAHREN ZUR SELEKTIVEN BESTIMMUNG VON GLYKIERTEMHÄMOGLOBIN
公开(公告)号：EP2944699A1
公开(公告)日：2015-11-18
申请号：EP15174619.5
申请日：2001-07-12
申请人： ARKRAY, Inc.
发明人： YONEHARA, Satoshi
IPC分类号： C12Q1/26 , G01N33/72
CPC分类号： C12Q1/26 , C12Q1/37 , G01N33/723 , G01N33/725
摘要： A method of determining glycated hemoglobin is provided, by which a ratio of the glycated hemoglobin in a sample can be determined accurately and easily. The ratio of glycated hemoglobin can be determined by hemolyzing whole blood using a non-ionic surfactant; degrading glycated hemoglobin in the hemolyzed whole blood selectively with a protease to give a glycated hemoglobin degradation product; causing a redox reaction between a glycation site of the glycated hemoglobin degradation product and a fructosyl amino acid oxidoreductase; and determining the redox reaction to determine an amount of the glycated hemoglobin; wherein the protease is a metalloproteinase capable of selectively degrading the glycated hemoglobin.
摘要翻译：提供了测定糖化血红蛋白的方法，通过该方法可以准确且容易地测定样品中糖化血红蛋白的比例。糖化血红蛋白的比例可以通过使用非离子表面活性剂溶血全血来测定; 用蛋白酶选择性地降解溶血全血中的糖化血红蛋白，得到糖化血红蛋白降解产物; 引起糖化血红蛋白降解产物的糖化位点与果糖基氨基酸氧化还原酶之间的氧化还原反应; 并测定氧化还原反应以确定糖化血红蛋白的量; 其中所述蛋白酶是能够选择性降解糖化血红蛋白的金属蛋白酶。

9. 发明授权

EP2144055B1 METHOD OF ANALYZING HEMOGLOBIN BY CAPILLARY ELECTROPHORESIS AND ADDITIVE TO BE USED THEREIN 有权
标题翻译：血红蛋白分析方法毛细管以及它在SANTANDER添加剂
公开(公告)号：EP2144055B1
公开(公告)日：2014-03-12
申请号：EP08751963.3
申请日：2008-04-23
申请人： ARKRAY, Inc.
发明人： NAKAYAMA, Yusuke , YONEHARA, Satoshi
IPC分类号： G01N27/447
CPC分类号： G01N27/44747

10. 发明授权

EP2116611B1 MEASUREMENT METHOD FOR HBA1C 有权
标题翻译：法测量的A1C
公开(公告)号：EP2116611B1
公开(公告)日：2013-08-14
申请号：EP08704157.0
申请日：2008-01-30
申请人： ARKRAY, Inc.
发明人： YONEHARA, Satoshi , INAMURA, Norio
IPC分类号： C12Q1/26 , C12Q1/37 , G01N33/72
CPC分类号： C12Q1/26 , C12Q1/37 , G01N33/721 , G01N2333/805 , Y10T436/19 , Y10T436/25

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