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1. 发明公开

EP4168578A1 COMPOSITIONS AND METHODS FOR IN SITU SINGLE CELL ANALYSIS USING ENZYMATIC NUCLEIC ACID EXTENSION 有权转让
公开(公告)号：EP4168578A1
公开(公告)日：2023-04-26
申请号：EP21740355.9
申请日：2021-06-17
申请人： Nanostring Technologies, Inc.
发明人： CHENG, Jonathan , DUNAWAY, Dwayne , GREGORY, Mark , JUNG, Jaemyeong , KHAFIZOV, Rustem , KIM, Dae , PERILLO, Evan , RANE, Tushar , WU, Lidan
IPC分类号： C12Q1/6841 , C12Q1/6806

2. 发明授权

EP3221469B1 ENZYME- AND AMPLIFICATION-FREE SEQUENCING 有权
公开(公告)号：EP3221469B1
公开(公告)日：2020-01-15
申请号：EP15801655.0
申请日：2015-11-19
申请人： Nanostring Technologies, Inc
发明人： BEECHEM, Joseph M. , KHAFIZOV, Rustem
IPC分类号： C12Q1/6869

3. 发明公开

EP4355907A1 COMPOSITIONS AND METHODS FOR IN SITU SINGLE CELL ANALYSIS USING ENZYMATIC NUCLEIC ACID EXTENSION 审中-实审转让
公开(公告)号：EP4355907A1
公开(公告)日：2024-04-24
申请号：EP22741913.2
申请日：2022-06-17
申请人： Nanostring Technologies, Inc.
发明人： WU, Lidan , KHAFIZOV, Rustem , PERILLO, Evan Paul , DUNAWAY, Dwayne , KIM, Dae , BEECHEM, Joseph M.
IPC分类号： C12Q1/6841 , C12Q1/6806
CPC分类号： C12Q1/6841 , C12Q1/6806

4. 发明授权

EP3223947B1 METHODS AND APPARATUSES FOR GENE PURIFICATION AND IMAGING 有权转让
公开(公告)号：EP3223947B1
公开(公告)日：2019-10-30
申请号：EP15816281.8
申请日：2015-11-23
申请人： Nanostring Technologies, Inc.
发明人： DUNAWAY, Dwayne , KHAFIZOV, Rustem , MEI, Qian , DENNIS, Lucas , KROUSE, Michael , BEECHEM, Joseph M. , SPRAGUE, Isaac
IPC分类号： C12Q1/6816 , C12Q1/6825 , B01L3/00

5. 发明公开

EP4029952A1 ENZYME- AND AMPLIFICATION-FREE SEQUENCING 审中-实审转让
公开(公告)号：EP4029952A1
公开(公告)日：2022-07-20
申请号：EP22150167.9
申请日：2015-11-19
申请人： Nanostring Technologies, Inc
发明人： BEECHEM, Joseph M. , KHAFIZOV, Rustem
IPC分类号： C12Q1/6869
摘要： The present invention relates to sequencing probes, methods, kits, and apparatuses that provide enzyme-free, amplification-free, and library-free nucleic acid sequencing that has long-read-lengths and with low error rate. A sequencing probe is used comprising a target binding domain and a barcode domain; wherein said target binding domain comprises at least four nucleotides and is capable of binding a target nucleic acid; wherein said barcode domain comprises a synthetic backbone, said barcode domain comprising at least a first attachment region, said first attachment region comprising a nucleic acid sequence capable of being bound by a first complementary nucleic acid molecule and wherein said nucleic acid sequence of said first attachment region determines the position and identity of a first nucleotide in said target nucleic acid that is bound by a first nucleotide of said target binding domain.

6. 发明公开

EP3696280A1 ENZYME - AND AMPLIFICATION-FREE SEQUENCING 有权
公开(公告)号：EP3696280A1
公开(公告)日：2020-08-19
申请号：EP20151469.2
申请日：2015-11-19
申请人： Nanostring Technologies, Inc
发明人： BEECHEM, Joseph M. , KHAFIZOV, Rustem
IPC分类号： C12Q1/6869
摘要： The present invention relates to sequencing probes, methods, kits, and apparatuses that provide enzyme-free, amplifica-tion-free, and library-free nucleic acid sequencing that has long-read-lengths and with low error rate. A sequencing probe is used comprising a target binding domain and a barcode domain;
wherein said target bind-ing domain comprises at least four nucleotides and is capable of binding a target nucleic acid; wherein said barcode domain comprises a synthetic backbone, said barcode domain comprising at least a first attachment region, said first attachment region comprising a nucleic acid sequence capable of being bound by a first complementary nucleic acid molecule and wherein said nucleic acid sequence of said first attachment region determines the position and identity of a first nucleotide in said target nucleic acid that is bound by a first nucleotide of said target binding domain.

7. 发明公开

EP3458601A1 METHODS FOR DETECTING TARGET NUCLEIC ACIDS IN A SAMPLE 有权
公开(公告)号：EP3458601A1
公开(公告)日：2019-03-27
申请号：EP17726083.3
申请日：2017-05-16
申请人： Nanostring Technologies, Inc.
发明人： KHAFIZOV, Rustem , DUNAWAY, Dwayne L. , GREGORY, Mark
IPC分类号： C12Q1/68

8. 发明公开

EP4324929A1 METHODS FOR DETECTING TARGET NUCLEIC ACIDS IN A SAMPLE 审中-实审转让
公开(公告)号：EP4324929A1
公开(公告)日：2024-02-21
申请号：EP23183318.7
申请日：2017-05-16
申请人： Nanostring Technologies, Inc.
发明人： KHAFIZOV, Rustem , DUNAWAY, Dwayne L. , GREGORY, Mark
IPC分类号： C12Q1/68
摘要： The present invention provides probes, methods, kits, and apparatuses that provide accurate, rapid, and sensitive multiplexed detection, identification, and quantification of target nucleic acids in a sample.

9. 发明公开

EP3794146A1 CHEMICAL COMPOSITIONS AND METHODS OF USING SAME 审中-实审转让
公开(公告)号：EP3794146A1
公开(公告)日：2021-03-24
申请号：EP19732767.9
申请日：2019-05-14
申请人： Nanostring Technologies, Inc.
发明人： DUNAWAY, Dwayne , MANRAO, Elizabeth , BEECHEM, Joseph , KHAFIZOV, Rustem , KORUKONDA, Sanghamithra , DENG, Yi , KIM, Dae , GREGORY, Mark , HOANG, Margaret , WALSH, Matthew , MEREDITH, Gavin , MCELWAIN, Mark , SKENE, Peter , BURKE, Cassandra
IPC分类号： C12Q1/6869 , C12Q1/6874

10. 发明公开

EP3223947A1 METHODS AND APPARATUSES FOR GENE PURIFICATION AND IMAGING 有权转让
标题翻译：用于基因纯化和成像的方法和设备
公开(公告)号：EP3223947A1
公开(公告)日：2017-10-04
申请号：EP15816281.8
申请日：2015-11-23
申请人： Nanostring Technologies, Inc
发明人： DUNAWAY, Dwayne , KHAFIZOV, Rustem , MEI, Qian , DENNIS, Lucas , KROUSE, Michael , BEECHEM, Joseph M. , SPRAGUE, Isaac
IPC分类号： B01L3/00 , C12Q1/68 , C12N15/10 , G01N33/543
摘要： The present disclosure is directed to systems, devices and methods for nucleic acid or protein purification and imaging. A system is provided including a cartridge comprising a sample input area configured to hold a sample, comprising a plurality of hybridized complexes comprising a plurality of target molecules each hybridized with probes and a plurality of non-hybridized probes. The cartridge may also include a first binding chamber configured with first magnetic beads to receive and bind the sample, a first elution channel configured to receive the first magnetic beads and elute the sample from the first magnetic beads, a second binding chamber configured with second magnetic beads to receive and bind the sample, a second elution channel configured to receive the second magnetic beads and elute the sample from the second magnetic beads, and a binding area configured to receive the eluted sample and hold molecules for imaging.
摘要翻译：本公开涉及用于核酸或蛋白质纯化和成像的系统，装置和方法。提供了一种系统，其包括盒体，所述盒体包括被配置为容纳样品的样品输入区域，所述盒体包含多个杂交复合物，所述复合物包含多个各自与探针杂交的靶分子和多个非杂交探针。所述盒还可以包括第一结合室和第二结合室，第一结合室配置有第一磁珠以接收和结合样品，第一洗脱通道配置为接收第一磁珠并从第一磁珠洗脱样品，第二结合室配置有第二磁性用于接收和结合样品的珠子，用于接收第二磁珠并从第二磁珠洗脱样品的第二洗脱通道以及用于接收洗脱样品并保持用于成像的分子的结合区域。

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