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1. 发明公开

EP4214331A1 CHEMICAL COMPOSITIONS AND METHODS OF USING THE SAME 审中-实审转让
公开(公告)号：EP4214331A1
公开(公告)日：2023-07-26
申请号：EP21787265.4
申请日：2021-09-16
申请人： Nanostring Technologies, Inc.
发明人： WU, Lidan , KIM, Dae , DUNAWAY, Dwayne L. , HE, Shanshan , LEE, Isabel , BEECHEM, Joseph
IPC分类号： C12Q1/6841

2. 发明公开

EP4168578A1 COMPOSITIONS AND METHODS FOR IN SITU SINGLE CELL ANALYSIS USING ENZYMATIC NUCLEIC ACID EXTENSION 有权转让
公开(公告)号：EP4168578A1
公开(公告)日：2023-04-26
申请号：EP21740355.9
申请日：2021-06-17
申请人： Nanostring Technologies, Inc.
发明人： CHENG, Jonathan , DUNAWAY, Dwayne , GREGORY, Mark , JUNG, Jaemyeong , KHAFIZOV, Rustem , KIM, Dae , PERILLO, Evan , RANE, Tushar , WU, Lidan
IPC分类号： C12Q1/6841 , C12Q1/6806

3. 发明授权

EP3221469B1 ENZYME- AND AMPLIFICATION-FREE SEQUENCING 有权
公开(公告)号：EP3221469B1
公开(公告)日：2020-01-15
申请号：EP15801655.0
申请日：2015-11-19
申请人： Nanostring Technologies, Inc
发明人： BEECHEM, Joseph M. , KHAFIZOV, Rustem
IPC分类号： C12Q1/6869

4. 发明公开

EP3236264A3 PROTEIN DETECTION VIA NANOREPORTERS 审中-公开
公开(公告)号：EP3236264A3
公开(公告)日：2017-11-08
申请号：EP16201369.2
申请日：2010-10-13
申请人： Nanostring Technologies, Inc
发明人： DUNAWAY, Dwayne L
IPC分类号： G01N33/68
CPC分类号： G01N33/5306 , C12Q2537/125 , G01N33/6803 , G01N2333/55 , G01N2458/10
摘要： The invention provides methods, compositions, kits and devices for the detection of proteins. In some embodiments, the invention allows for multiplexed protein detection.

5. 发明公开

EP3177734A1 METHODS FOR DECONVOLUTION OF MIXED CELL POPULATIONS USING GENE EXPRESSION DATA 无效
标题翻译：用基因表达数据解混合细胞群体的方法
公开(公告)号：EP3177734A1
公开(公告)日：2017-06-14
申请号：EP15753257.3
申请日：2015-08-04
申请人： Nanostring Technologies, Inc.
发明人： DANAHER, Patrick John
IPC分类号： C12Q1/68
CPC分类号： G06F19/20 , C12Q1/6813 , C40B30/02 , G06F19/24 , C12Q2537/165
摘要： Body fluid identification by mRNA profiling may allow extraction of contextual ‘activity level’ information from forensic samples. Accordingly, a prototype multiplex digital gene expression method for forensic body fluid/tissue identification is provided, based upon solution hybridization of color-coded (e.g., NanoString®) probes. For example, a model for gene expression in a sample from a single body fluid is provided and extended to mixtures of body fluids. A calculation of maximum likelihood estimates of body fluid quantities in a sample is performed, and use of likelihood ratios to test for the presence of each body fluid in a sample is described. A process/algorithm is described and, unlike conventional algorithms for detecting tissues and cells, may allow for zero false-positive fluid identifications across a plurality of samples. Such a protocol may facilitate routine use of mRNA profiling in casework (e.g., forensic) laboratories that previously has not been as reliable.
摘要翻译：通过mRNA分析鉴定体液可以允许从法医样品中提取上下文“活性水平”信息。因此，基于颜色编码（例如NanoString®）探针的溶液杂交，提供了用于法医体液/组织鉴定的原型多路数字基因表达方法。例如，来自单一体液的样品中的基因表达模型被提供并延伸至体液的混合物。描述了对样本中体液量的最大似然估计值的计算，并且描述了使用似然比来测试样本中每种体液的存在。描述了过程/算法，并且与用于检测组织和细胞的传统算法不同，可以允许跨越多个样本的零假阳性流体识别。这样的协议可以有助于常规使用先前不可靠的个案工作（例如，法医）实验室中的mRNA分析。

6. 发明公开

EP2547795A4 COMPOSITIONS AND METHODS FOR THE DETECTION OF GENOMIC FEATURES 有权
标题翻译：检测基因组特征的组合物和方法
公开(公告)号：EP2547795A4
公开(公告)日：2013-10-09
申请号：EP11756928
申请日：2011-03-16
申请人： NANOSTRING TECHNOLOGIES INC
发明人： HENGEN PAUL NEVIN , GEISS GARY K , ELLIOT NATHAN A , WEBSTER PHILLPPA JANE
IPC分类号： C12Q1/68 , C12N15/11
CPC分类号： C12Q1/6816 , C12Q1/6809 , C12Q1/6827 , C12Q1/6834 , C12Q1/6841 , C12Q2523/303 , C12Q2537/16 , C12Q2565/102 , C12Q2537/125 , C12Q2537/143 , C12Q2539/107 , C12Q2563/155 , C12Q2563/179
摘要： The invention provides compositions and methods for the detection of gene copy number and/or chromosome copy number in a multiplexed reaction. The assays and kits described herein are applicable for the identification, diagnosing, and monitoring of disorders including, but not limited to cancer, developmental and degenerative disease, neurological disorders, and stem cell disorders.

7. 发明公开

EP2155899A2 METHODS AND COMPUTER SYSTEMS FOR IDENTIFYING TARGET-SPECIFIC SEQUENCES FOR USE IN NANOREPORTERS 审中-公开
标题翻译：方法和计算机系统辨识特定序列的目标，使用纳米记者
公开(公告)号：EP2155899A2
公开(公告)日：2010-02-24
申请号：EP08733186.4
申请日：2008-04-10
申请人： Nanostring Technologies, Inc.
发明人： GEISS, Gary, K. , DAHL, Timothy , DAVIDSON, Eric, H.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , G06F19/22 , Y10T436/143333
摘要： The present invention relates to compositions and methods for detection and quantification of individual target molecules in biomolecular samples. In particular, the invention relates to coded, labeled probes that are capable of binding to and identifying target molecules based on the probes' label codes. Methods, computers, and computer program products for identifying target-specific sequences for inclusion in the probes are also provided, as are methods of making and using such probes. The probes can be used in diagnostic, prognostic, quality control and screening applications.

8. 发明公开

EP1963500A2 COMPOSITIONS COMPRISING ORIENTED, IMMOBILIZED MACROMOLECULES AND METHODS FOR THEIR PREPARATION 有权转让
标题翻译：对齐，并固定大分子和组合物的方法用于生产
公开(公告)号：EP1963500A2
公开(公告)日：2008-09-03
申请号：EP06848160.5
申请日：2006-12-22
申请人： Nanostring Technologies, Inc.
发明人： FERREE, Sean M. , DUNAWAY, Dwayne L.
IPC分类号： C12N11/00 , C12N11/04 , C12N11/16
CPC分类号： B82Y5/00 , C12Q1/6834 , C12Q2565/513 , G01N33/54353 , Y10T428/31768 , Y10T428/31971
摘要： The present invention provides methods and compositions that facilitate the identification of structures of a variety of macromolecules. For instance, the present invention provides methods for the selective immobilization of macromolecules in an extended or oriented state. The present invention also provides compositions comprising macromolecules selectively immobilized in extended or oriented states.

9. 发明公开

EP4355907A1 COMPOSITIONS AND METHODS FOR IN SITU SINGLE CELL ANALYSIS USING ENZYMATIC NUCLEIC ACID EXTENSION 审中-实审转让
公开(公告)号：EP4355907A1
公开(公告)日：2024-04-24
申请号：EP22741913.2
申请日：2022-06-17
申请人： Nanostring Technologies, Inc.
发明人： WU, Lidan , KHAFIZOV, Rustem , PERILLO, Evan Paul , DUNAWAY, Dwayne , KIM, Dae , BEECHEM, Joseph M.
IPC分类号： C12Q1/6841 , C12Q1/6806
CPC分类号： C12Q1/6841 , C12Q1/6806

10. 发明公开

EP4226378A1 METHODS, SYSTEMS AND DEVICES FOR PROCESSING SEQUENCE DATA 审中-实审转让
公开(公告)号：EP4226378A1
公开(公告)日：2023-08-16
申请号：EP21802495.8
申请日：2021-10-08
申请人： Nanostring Technologies, Inc.
发明人： ASKOVICH, Peter
IPC分类号： G16B30/00 , G16B50/00

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