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1. 发明授权

EP0306969B1 A process for producing an alpha-acyloxy-alpha beta-unsaturated carbonyl compound and a 20-acyl-oxy-17(20)-methylen-21-al-steroid compound 失效
标题翻译：一种用于制备α-酰氧基α-β-不饱和化合物和20-酰氧基-17（20） - 亚甲基-21-人 - 甾类衍生物的过程。
公开(公告)号：EP0306969B1
公开(公告)日：1994-11-30
申请号：EP88114770.6
申请日：1988-09-09
申请人： NIPPON ZEON CO., LTD.
发明人： Watanbe, Kiyoshi , Kataoka, Hideaki , Goto, Kuniaki
IPC分类号： C07J13/00 , C07C69/24 , C07C69/145 , C07C67/30 , C07J75/00
CPC分类号： C07J75/00 , C07C67/313 , C07J1/0048 , C07J13/005 , C07J13/007

2. 发明公开

EP0133548A1 Process for producing alpha,beta-unsaturated ketones 失效
标题翻译：一种用于α，β-不饱和酮的制备方法。
公开(公告)号：EP0133548A1
公开(公告)日：1985-02-27
申请号：EP84109131.7
申请日：1984-08-01
申请人： NIPPON ZEON CO., LTD.
发明人： Kataoka, Hideaki , Yamada, Toshiro , Goto, Kuniaki , Tsuji, Jiro
IPC分类号： C07C45/67 , C07C49/00
CPC分类号： C07C49/203 , C07C45/673 , C07C45/676 , C07C49/603 , C07C49/647
摘要： A process for producing alpha, beta-unsaturated ketones represented by the following general formula
wherein R, represents a hydrocarbon radical, R 2 represents an organic radical bonded through a carbon-carbon bond, R 3 and R 4 represent a hydrogen atom or a hydrocarbon radical, and R 1 , R 2 , R 3 and R 4 may be straight-chained or form a ring in arbitrary combinations, which comprises contacting an alpha-disubstituted-beta-keto acid ester represented by the general formula
wherein R,, R 2 , R 3 and R 4 are as defined, and R 5 , R 6 , R 7 and R 8 represent a hydrogen atom or a hydrocarbon radical, with a catalyst consisting essentially of (a) a compound of a platinum-group metal and optionally (b) a monodentate ligand (b).

3. 发明公开

EP0306969A3 A process for producing an alpha-acyloxy-alpha beta-unsaturated carbonyl compound and a 20-acyl-oxy-17(20)-methylen-21-al-steroid compound 失效
标题翻译：一种制备阿尔法 - 乙酰氧基 - 不饱和碳酸酯化合物的方法和20-乙酰氧基-17（20） - 甲基-21-AL-甾体化合物
公开(公告)号：EP0306969A3
公开(公告)日：1990-03-07
申请号：EP88114770.6
申请日：1988-09-09
申请人： NIPPON ZEON CO., LTD.
发明人： Watanbe, Kiyoshi , Kataoka, Hideaki , Goto, Kuniaki
IPC分类号： C07J13/00 , C07C69/24 , C07C69/145 , C07C67/30 , C07J75/00
CPC分类号： C07J75/00 , C07C67/313 , C07J1/0048 , C07J13/005 , C07J13/007
摘要： There are disclosed a process for producing an α-acyloxy-α,β-unsaturated carbonyl compound represented by the general formula (VI):
wherein Ri, R 2 and R4 are independently hydrogen atoms or substituted or unsubstituted hydrocarbon residues, or Ri, R 2 and R 4 , when taken together with one another in an optional combination, form a ring, R 3 is a substituted or unsubstituted hydrocarbon residue, and indicates that the configuration may be either E-configuration or Z-configuration, in particular, a 20-acyloxy-17(20)-methylen-21-al-steroid represented by the partial structural formula (II): wherein R is a hydrocarbon residue, and indicates that the configuration of the acyloxy group and the formyl group bonded to the carbon atom at the 20-position may be either E-configuration or Z-configuration, which comprises oxidizing a propargyl ester represented by the general formula (V):
wherein Ri, R 2 , R 3 and R 4 have the same meanings as defined above; an al-steroid compound having the above partial structural formula which is an intermediate for producing a 21-acyloxy-20-keto-delta16-steroid being extremely useful as an intermediate for important corticoids as drugs and obtained by being subjected said al-steroid to isomerization reaction; and a process for producing a 21-acyloxy-20-keto- delta 16 -steroid which comprises oxidation reaction and isomerization reaction.

4. 发明授权

EP0133548B1 Process for producing alpha,beta-unsaturated ketones 失效
标题翻译：生产ALPHA，BETA不饱和酮的方法
公开(公告)号：EP0133548B1
公开(公告)日：1987-04-22
申请号：EP84109131.7
申请日：1984-08-01
申请人： NIPPON ZEON CO., LTD.
发明人： Kataoka, Hideaki , Yamada, Toshiro , Goto, Kuniaki , Tsuji, Jiro
IPC分类号： C07C45/67 , C07C49/00
CPC分类号： C07C49/203 , C07C45/673 , C07C45/676 , C07C49/603 , C07C49/647

5. 发明公开

EP0306969A2 A process for producing an alpha-acyloxy-alpha beta-unsaturated carbonyl compound and a 20-acyl-oxy-17(20)-methylen-21-al-steroid compound 失效
标题翻译：一种用于制备α-酰氧基α-β-不饱和化合物和20-酰氧基-17（20） - 亚甲基-21-人 - 甾类衍生物的过程。
公开(公告)号：EP0306969A2
公开(公告)日：1989-03-15
申请号：EP88114770.6
申请日：1988-09-09
申请人： NIPPON ZEON CO., LTD.
发明人： Watanbe, Kiyoshi , Kataoka, Hideaki , Goto, Kuniaki
IPC分类号： C07J13/00 , C07C69/24 , C07C69/145 , C07C67/30 , C07J75/00
CPC分类号： C07J75/00 , C07C67/313 , C07J1/0048 , C07J13/005 , C07J13/007
摘要： There are disclosed a process for producing an α-acyloxy-α,β-unsaturated carbonyl compound represented by the general formula (VI):
wherein Ri, R 2 and R4 are independently hydrogen atoms or substituted or unsubstituted hydrocarbon residues, or Ri, R 2 and R 4 , when taken together with one another in an optional combination, form a ring, R 3 is a substituted or unsubstituted hydrocarbon residue, and indicates that the configuration may be either E-configuration or Z-configuration, in particular, a 20-acyloxy-17(20)-methylen-21-al-steroid represented by the partial structural formula (II):
wherein R is a hydrocarbon residue, and indicates that the configuration of the acyloxy group and the formyl group bonded to the carbon atom at the 20-position may be either E-configuration or Z-configuration, which comprises oxidizing a propargyl ester represented by the general formula (V):
wherein Ri, R 2 , R 3 and R 4 have the same meanings as defined above; an al-steroid compound having the above partial structural formula which is an intermediate for producing a 21-acyloxy-20-keto-delta16-steroid being extremely useful as an intermediate for important corticoids as drugs and obtained by being subjected said al-steroid to isomerization reaction; and a process for producing a 21-acyloxy-20-keto- delta 16 -steroid which comprises oxidation reaction and isomerization reaction.
摘要翻译：有游离缺失盘的处理在阿尔法酰氧基-α，由通式（VI）表示β-不饱和羰基化合物制备： worin R1，R2和R4为氢原子或unabhängigsubstituiertem奥德unsubstituiertem烃残基，或R1 ，R2和R4，当与在和任意组合彼此结合在一起形成一个环，R 3是一个substituiertem奥德unsubstituiertem烃残基，@@@表示DASS模具结构可以是E构型或Z构型，特别是，20酰氧基 - 17（20）亚甲基 - 21-AL-类固醇由部分结构式（II）表示： worin R是烃残基，并且表示@@@做的酰氧基的构和在20位键合到碳原子上的甲酰基可以是E构型或Z构型，该方法包括氧化由通式（V）表示的炔丙基酯： worin R1，R2，R3和 R4具有相同的含义如上所定义; 到人类固醇化合物，其具有的所有这些是用于制造21 - 酰氧基-20-酮基 - 德尔塔中间上述部分结构式<1> <6>类固醇是作为中间体用于重要肾上腺皮质激素作为药物非常有用的，并通过而获得进行说人类固醇至异构化反应; 以及一种用于制造21 - 酰氧基-20-酮基 - 德尔塔的处理<1> <6>类固醇，其包括氧化反应和异构化反应。

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