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1. 发明公开

EP2477706A2 IMPROVED PURIFICATION OF MULTI-SPECIFIC RECEPTORS 审中-公开
标题翻译：多特异性受体改善AUFREINGUNG
公开(公告)号：EP2477706A2
公开(公告)日：2012-07-25
申请号：EP10754335.7
申请日：2010-09-16
申请人： Mipsalus Aps
发明人： KROGH, Nicolas, Otto , GREGORIUS, Klaus
IPC分类号： B01D15/38
CPC分类号： A61K31/74 , B01D15/1807 , B01D15/3804 , B01J20/26 , B01J20/268
摘要： Disclosed is a method for preparing a composition enriched for receptors (typically molecular impringet polymers, MIPs) that bind an agent, where said receptors each specifically bind at least two discrete sites on said agent, by subjecting a sample of receptors to a first step of affinity purification with the agent where one binding site on the agent is non-accessible for binding to the receptors and subsequently subjecting the purified receptors to at least one further step of affinity purification with the agent where a second binding site on the agent is non-accessible. Also disclosed is a method for treatment, amelioration or prophylaxis of a disease selected from the group consisting of phenylketonuria (PKU, Følling's disease), hyperphenylalaninemia (HPA), alcaptonuria (black urine disease), tyrosinemia, hypertyrosinemia, myasthenia gravis, histidinemia, urocanic aciduria, maple syrup urine disease (MSUD), isovaleric acidemia (isovaleryl-CoA dehydrogenase deficiency), homocystinuria, propionic acidemia, methylmalonic acidemia, and glutaric aciduria Type 1 (GA-I), galactosemia, comprising administering to the gastrointestinal tract of a patient in need thereof an effective amount of a composition of molecular imprinted polymers (MIPs), said composition being capable of binding a symptom provoking agent of said disease.

2. 发明公开

EP3645160A1 MOLECULAR IMPRINTED POLYMERS TARGETING PHENYLALANINE 审中-公开
公开(公告)号：EP3645160A1
公开(公告)日：2020-05-06
申请号：EP18735562.3
申请日：2018-06-29
申请人： Mipsalus APS
发明人： GREGORIUS, Klaus , KROGH, Nicolas, Otto
IPC分类号： B01J20/26 , A61K31/787

3. 发明公开

EP2819778A1 PREPARATION OF MOLECULAR IMPRINTED POLYMERS BY CROSS-LINKING 有权转让
标题翻译： MANUFACTURING分子印迹聚合物NETWORKING
公开(公告)号：EP2819778A1
公开(公告)日：2015-01-07
申请号：EP12708277.4
申请日：2012-02-28
申请人： Mipsalus Aps
发明人： GREGORIUS, Klaus , NICHOLLS, Ian, Alan , KROGH, Nicolas, Otto
IPC分类号： B01J20/26 , C08F8/00 , C08J3/24 , B01D15/38 , B82Y40/00
CPC分类号： C08J9/36 , B01D15/3804 , B01D15/3852 , B01J20/268 , B01J20/285 , B01J20/3007 , B01J20/3057 , B01J20/3085 , B01J2220/82 , B82Y30/00 , C08J2300/00
摘要： Provided is an improved method for preparation of insoluble molecular imprinted polymers (MIPs), the method comprising : a) providing soluble or semi-soluble MIPs that 1) substantially all bind template agents and 2) have sizes which enable their separation in a chromatographic step utilizing packed bed chromatography, b) cross-linking the template agent binding soluble MIPs provided in step a so as to obtain insoluble template agent binding MIPs, and c) optionally isolating, concentrating or purifying the MIPs obtained by the cross-linking in step b. In an interesting embodiment, step a includes an affinity purification procedure, which ensures that the MIPs provided in step a are indeed all binders of the template.

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