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1. 发明公开

EP2477706A2 IMPROVED PURIFICATION OF MULTI-SPECIFIC RECEPTORS 审中-公开
标题翻译：多特异性受体改善AUFREINGUNG
公开(公告)号：EP2477706A2
公开(公告)日：2012-07-25
申请号：EP10754335.7
申请日：2010-09-16
申请人： Mipsalus Aps
发明人： KROGH, Nicolas, Otto , GREGORIUS, Klaus
IPC分类号： B01D15/38
CPC分类号： A61K31/74 , B01D15/1807 , B01D15/3804 , B01J20/26 , B01J20/268
摘要： Disclosed is a method for preparing a composition enriched for receptors (typically molecular impringet polymers, MIPs) that bind an agent, where said receptors each specifically bind at least two discrete sites on said agent, by subjecting a sample of receptors to a first step of affinity purification with the agent where one binding site on the agent is non-accessible for binding to the receptors and subsequently subjecting the purified receptors to at least one further step of affinity purification with the agent where a second binding site on the agent is non-accessible. Also disclosed is a method for treatment, amelioration or prophylaxis of a disease selected from the group consisting of phenylketonuria (PKU, Følling's disease), hyperphenylalaninemia (HPA), alcaptonuria (black urine disease), tyrosinemia, hypertyrosinemia, myasthenia gravis, histidinemia, urocanic aciduria, maple syrup urine disease (MSUD), isovaleric acidemia (isovaleryl-CoA dehydrogenase deficiency), homocystinuria, propionic acidemia, methylmalonic acidemia, and glutaric aciduria Type 1 (GA-I), galactosemia, comprising administering to the gastrointestinal tract of a patient in need thereof an effective amount of a composition of molecular imprinted polymers (MIPs), said composition being capable of binding a symptom provoking agent of said disease.

2. 发明公开

EP3645160A1 MOLECULAR IMPRINTED POLYMERS TARGETING PHENYLALANINE 审中-公开
公开(公告)号：EP3645160A1
公开(公告)日：2020-05-06
申请号：EP18735562.3
申请日：2018-06-29
申请人： Mipsalus APS
发明人： GREGORIUS, Klaus , KROGH, Nicolas, Otto
IPC分类号： B01J20/26 , A61K31/787

3. 发明公开

EP2819778A1 PREPARATION OF MOLECULAR IMPRINTED POLYMERS BY CROSS-LINKING 有权转让
标题翻译： MANUFACTURING分子印迹聚合物NETWORKING
公开(公告)号：EP2819778A1
公开(公告)日：2015-01-07
申请号：EP12708277.4
申请日：2012-02-28
申请人： Mipsalus Aps
发明人： GREGORIUS, Klaus , NICHOLLS, Ian, Alan , KROGH, Nicolas, Otto
IPC分类号： B01J20/26 , C08F8/00 , C08J3/24 , B01D15/38 , B82Y40/00
CPC分类号： C08J9/36 , B01D15/3804 , B01D15/3852 , B01J20/268 , B01J20/285 , B01J20/3007 , B01J20/3057 , B01J20/3085 , B01J2220/82 , B82Y30/00 , C08J2300/00
摘要： Provided is an improved method for preparation of insoluble molecular imprinted polymers (MIPs), the method comprising : a) providing soluble or semi-soluble MIPs that 1) substantially all bind template agents and 2) have sizes which enable their separation in a chromatographic step utilizing packed bed chromatography, b) cross-linking the template agent binding soluble MIPs provided in step a so as to obtain insoluble template agent binding MIPs, and c) optionally isolating, concentrating or purifying the MIPs obtained by the cross-linking in step b. In an interesting embodiment, step a includes an affinity purification procedure, which ensures that the MIPs provided in step a are indeed all binders of the template.

4. 发明授权

EP1988993B1 IMPROVED PREPARATION OF MOLECULAR IMPRINTED POLYMERS 有权转让
公开(公告)号：EP1988993B1
公开(公告)日：2019-04-17
申请号：EP07702501.3
申请日：2007-02-21
申请人： Mipsalus Aps
发明人： KRISTENSEN, Jesper Svenning , NIELSEN, Klaus Gregorius , KROGH, Nicolas Otto
IPC分类号： B01J20/26 , A61K31/74 , C08J9/02

5. 发明公开

EP1988993A2 IMPROVED PREPARATION OF MOLECULAR IMPRINTED POLYMERS 有权转让
标题翻译： VERBESSERTE HERSTELLUNG VON MOLEKULARGEPRÄGTENPOLYMEREN
公开(公告)号：EP1988993A2
公开(公告)日：2008-11-12
申请号：EP07702501.3
申请日：2007-02-21
申请人： Mipsalus Aps
发明人： KRISTENSEN, Jesper Svenning , NIELSEN, Klaus Gregorius , KROGH, Nicolas Otto
IPC分类号： B01J20/26 , A61K31/74 , C08J9/02
CPC分类号： B01J20/26 , A61K31/74 , A61K47/58 , A61K47/593 , B01J20/268 , B01J20/3057
摘要： One aspect is a method for improved preparation of molecular imprinted polymer (MIP) particles, where initial compositions comprising insoluble MIP particles are enriched for those MIP particles that bind a particular target molecule, thus excluding non-binding and weakly binding particles from the final composition. Enrichment is typically accomplished via use of chromatographic methods capable of separating particulate material or by means of agglutination. Another aspect is preparation of improved insoluble MIPs by use of extended micronization of raw MIP particles with a view to expose a large number of binding sites per mass unit of MIP particles. In preferred embodiments the two aspects are combined. The resulting improved MIPs may be used for diagnostic, analytical and therapeutic purposes, notably as orally administered drugs which can bind substances such as cholesterol and bile acids and bile acid salts in the gastrointestinal tract.
摘要翻译：一个方面是用于改进分子印迹聚合物（MIP）颗粒的制备的方法，其中包含不溶性MIP颗粒的初始组合被富集用于结合特定靶分子的那些MIP颗粒，从而从最终组合物排除非结合和弱结合的颗粒。富集通常通过使用能够分离颗粒材料或通过凝集的色谱方法来完成。另一方面是通过使用原始MIP颗粒的延长微粉化来制备改进的不溶性MIP，以期暴露每质量单位MIP颗粒的大量结合位点。在优选实施例中，组合了两个方面。所得到的改进的MIP可用于诊断，分析和治疗目的，特别是作为可以在胃肠道中结合物质如胆固醇和胆汁酸和胆汁酸盐的口服给药的药物。

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