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1. 发明公开

EP4327351A1 METHOD TO REDUCE MEASUREMENT BIAS 审中-实审
公开(公告)号：EP4327351A1
公开(公告)日：2024-02-28
申请号：EP22720018.5
申请日：2022-04-22
申请人： Micromass UK Limited
发明人： MOULDS, Richard Barrington , GORDON, David
IPC分类号： H01J49/00

2. 发明公开

EP4052279A1 ION SOURCE 审中-公开
公开(公告)号：EP4052279A1
公开(公告)日：2022-09-07
申请号：EP20796913.0
申请日：2020-10-23
申请人： Micromass UK Limited
发明人： BAJIC, Steve , MOULDS, Richard Barrington , GORDON, David
IPC分类号： H01J49/16 , H01J49/04 , H05B6/10

3. 发明公开

EP3047512A1 MINIATURE ION SOURCE OF FIXED GEOMETRY 有权
标题翻译：与固定几何形状微型离子源
公开(公告)号：EP3047512A1
公开(公告)日：2016-07-27
申请号：EP14772423.1
申请日：2014-09-17
申请人： Micromass UK Limited
发明人： BAJIC, Stevan , GORDON, David , KENNY, Daniel James , MOULDS, Richard Barrington , O'BRIEN, Stephen , TRIVETT, Ian , WHYATT, Kate
IPC分类号： H01J49/16
CPC分类号： H01J49/167 , H01J49/0027 , H01J49/044 , H01J49/165
摘要： A mass spectrometer is disclosed comprising an atmospheric pressure interface comprising a gas cone having an inlet aperture, wherein the gas cone has a first longitudinal axis arranged along an x-axis and an Electrospray ion source comprising a first capillary tube having an outlet and having a second longitudinal axis and a second capillary tube which surrounds the first capillary tube. The mass spectrometer further comprises a desolvation gas supply tube and a first device arranged and adapted to supply an analyte liquid via the first capillary tube so that the liquid exits the outlet of the first capillary tube at a flow rate >200 μL/min. The mass spectrometer further comprises a second device arranged and adapted to supply a nebuliser gas via the second capillary tube at a flow rate in the range 80-150 L/hr, wherein an outlet of the first capillary tube is arranged at a distance x mm along the x-axis as measured from the centre of the gas cone inlet aperture, a distance y mm along a y-axis as measured from the centre of the gas cone inlet aperture and a distance z mm along a z-axis as measured from the centre of the gas cone inlet aperture. The x-axis, the y-axis and the z-axis are mutually orthogonal. The desolvation gas supply tube surrounds the second capillary tube and the mass spectrometer further comprises a third device arranged and adapted to supply a desolvation gas via the desolvation gas supply tube at a flow rate in the range 400-1200 L/hr, a heater arranged and adapted to heat the desolvation gas to a temperature ≥100° C. and a fourth device arranged and adapted to supply a cone gas to the gas cone at a flow rate in the range 40-80 L/hr and wherein x is in the range 2.0-5.0 mm and wherein the ratio z/x is in the range 1-5:1.

4. 发明公开

EP3047506A1 AUTOMATED ADJUSTMENT OF CAPILLARY VOLTAGE BASED ON THE ELUTION CONDITIONS TO RETAIN OPTIMAL IONIZATION CONDITIONS 有权
标题翻译：基于所述保鲜洗脱最佳电离毛细管的自动调整
公开(公告)号：EP3047506A1
公开(公告)日：2016-07-27
申请号：EP14772425.6
申请日：2014-09-17
申请人： Micromass UK Limited
发明人： GORDON, David , HOOPER, Alexander , KENNY, Daniel James , MOULDS, Richard Barrington , PUGH, David , WHYATT, Kate
IPC分类号： H01J49/00 , H01J49/16 , G01N30/72
CPC分类号： H01J49/167 , G01N30/7266 , H01J49/0031 , H01J49/165
摘要： A method of Electrospray ionization is disclosed comprising passing a sample liquid through a liquid chromatography column, monitoring a liquid chromatography back pressure and varying a voltage applied to an Electrospray ionization source electrode in dependence upon said monitored liquid chromatography back pressure.
摘要翻译：电喷雾离子化的方法是游离缺失盘包括使样品液体通过液体层析柱，监测液相色谱背压并改变电压施加到电喷雾在所监测的所述液体色谱背压依赖性电离源电极。

5. 发明授权

EP2419740B1 METHOD TO DETECT AND SEQUENCE POST TRANSLATIONALLY MODIFIED PEPTIDES 有权
标题翻译：方法来检测和PTM肽测序
公开(公告)号：EP2419740B1
公开(公告)日：2013-05-08
申请号：EP10724554.0
申请日：2010-05-28
申请人： Micromass UK Limited
发明人： HUGHES, Christopher, John , MCKENNA, Thérèse , GORDON, David , KENNY, Daniel, James
IPC分类号： G01N33/68 , H01J49/00
CPC分类号： G01N33/6848 , H01J49/0031 , H01J49/0045 , Y10T436/24
摘要： A method of detecting and sequencing post translationally modified peptides is disclosed wherein a negative ion precursor scan is performed. A negative ion high resolution MS scan is then performed and then MRM channels in positive ion mode are determined and monitored. A positive ion MS/MS scan is then performed.

6. 发明公开

EP4169056A1 NEBULISER OUTLET 审中-实审
公开(公告)号：EP4169056A1
公开(公告)日：2023-04-26
申请号：EP21735747.4
申请日：2021-06-23
申请人： Micromass UK Limited
发明人： TRIVETT, Ian David , HESSE, Anthony , WALFORD, Mark , KENNY, Daniel James , GORDON, David , KOZIOL, Stanislaw , TRUDEAU, Steve D. , BOOTH, Alastair , ARYTON, Stephen
IPC分类号： H01J49/04 , H01J49/16 , B33Y80/00

7. 发明公开

EP4053878A1 HIGH FREQUENCY VOLTAGE SUPPLY CONTROL METHOD FOR MULTIPOLE OR MONOPOLE ANALYSERS 审中-公开
公开(公告)号：EP4053878A1
公开(公告)日：2022-09-07
申请号：EP22169733.7
申请日：2014-09-17
申请人： Micromass UK Limited
发明人： GORDON, David , MOULDS, Richard , WORTHINGTON, Kenneth
IPC分类号： H01J49/00 , H01J49/02 , H01J49/42
摘要： A voltage supply system for supplying an RF voltage to an RF resonant load comprising an ion-optical component of a mass spectrometer is disclosed. The system comprises a Direct Digital Synthesiser ("DDS") arranged and adapted to output an RF voltage. The voltage supply system is arranged and adapted: (i) to vary the frequency of the RF voltage output by the Direct Digital Synthesiser, (ii) to determine a first resonant frequency of the RF resonant load comprising the ion-optical component, and (iii) to determine whether or not the generation of an RF voltage at the first resonant frequency by the Direct Digital Synthesiser would also result in the generation of a spur frequency close to the first resonant frequency. If it is determined that a spur frequency would be generated close to the first resonant frequency then the voltage supply system is further arranged and adapted: (iv) to consult a look-up table comprising one or more preferred frequencies, and (v) to direct the Direct Digital Synthesiser to generate an RF voltage at a second frequency which corresponds with one of the preferred frequencies from the look-up table, wherein the second frequency is different to said first resonant frequency.

8. 发明授权

EP2715774B1 ION INLET FOR A MASS SPECTROMETER 有权转让
公开(公告)号：EP2715774B1
公开(公告)日：2019-10-02
申请号：EP12727677.2
申请日：2012-06-01
申请人： Micromass UK Limited
发明人： GORDON, David , KENNY, Daniel James , PRINGLE, Steven Derek
IPC分类号： H01J49/24 , H01J49/06

9. 发明公开

EP3047509A1 ION INLET ASSEMBLY 有权
标题翻译： IONENEINLASSANORDNUNG
公开(公告)号：EP3047509A1
公开(公告)日：2016-07-27
申请号：EP14772190.6
申请日：2014-09-17
申请人： Micromass UK Limited
发明人： GORDON, David , JARRELL, Joseph , KENNY, Daniel James , O'BRIEN, Stephen , TRIVETT, Ian
IPC分类号： H01J49/04 , H01J49/06
CPC分类号： H01J49/0422 , H01J49/0013 , H01J49/04 , H01J49/0495 , H01J49/066
摘要： An ion inlet assembly for connecting to a mass spectrometer housing is disclosed comprising a sampling limiting body (325) having a sampling orifice (329). The sampling limiting body (325) comprises a nickel disk wherein the disk and sampling orifice (329) are made or formed by an electroforming process.

10. 发明公开

EP2715774A2 ION INLET FOR A MASS SPECTROMETER 有权转让
标题翻译： IONENEINLASSFÜREIN MASSENSPEKTROMETER
公开(公告)号：EP2715774A2
公开(公告)日：2014-04-09
申请号：EP12727677.2
申请日：2012-06-01
申请人： Micromass UK Limited
发明人： GORDON, David , KENNY, Daniel James , PRINGLE, Steven Derek
IPC分类号： H01J49/24
摘要： An ion inlet for a mass spectrometer is disclosed comprising a housing having a sampling orifice and an atmospheric pressure orifice. One or more gas outlets are provided in the housing. Gas is drawn through the sampling orifice by a pump so that the gas exits via the one or more gas outlets.
摘要翻译：公开了一种用于质谱仪的离子入口，其包括具有采样孔和大气压力孔的壳体。一个或多个气体出口设置在壳体中。通过泵将气体抽吸通过采样孔，使得气体经由一个或多个气体出口排出。

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