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1. 发明公开

EP2675465A2 TISSUE GRAFTS MODIFIED WITH A CROSS-LINKING AGENT AND METHOD OF MAKING AND USING THE SAME 有权
标题翻译： NETWORKING通过对生产和使用的介质修饰的组织移植和方法
公开(公告)号：EP2675465A2
公开(公告)日：2013-12-25
申请号：EP12746488.1
申请日：2012-02-13
申请人： MIMEDX Group Inc.
发明人： MORSE, Brenda, S. , SITH, Somaly , SPENCER, Randall , DANIEL, John
IPC分类号： A61K35/50
CPC分类号： A61L27/3891 , A61K35/50 , A61L27/3604 , A61L27/3687 , A61L27/3804 , A61L27/3839 , A61L27/3878 , A61L27/3882 , A61L2400/18 , A61L2430/12 , A61L2430/16 , A61L2430/22 , A61L2430/32 , A61L2430/40
摘要： Described herein are tissue grafts derived from the placenta that possess good adhesion to biological tissues and are useful in would healing applications. In one aspect, the tissue graft includes (1) two or more layers of amnion, wherein at least one layer of amnion is cross-linked, (2) two or more layers of chorion, wherein at least one layer of amnion is cross-linked, or (3) one or more layers of amnion and chorion, wherein at least one layer of amnion and/or chorion is cross-linked. In another aspect, the grafts are composed of amnion and chorion cross-linked with one another. In a further aspect, the grafts have one or more layers sandwiched between the amnion and chorion membranes. The amnion and/or the chorion are treated with a cross-linking agent prior to the formation of the graft. Also described herein are methods for making and using the tissue grafts.

2. 发明公开

EP2675279A1 LAMINATED TISSUE GRAFTS COMPOSED OF WHARTON'S JELLY AND METHODS OF MAKING AND USING THE SAME 有权
标题翻译：从华通氏胶和方法层压织物移植的生产和使用
公开(公告)号：EP2675279A1
公开(公告)日：2013-12-25
申请号：EP12747175.3
申请日：2012-02-13
申请人： MIMEDX Group Inc.
发明人： MORSE, Brenda, S. , SITH, Somaly , SPENCER, Randall , DANIEL, John , TOFE, Robert
IPC分类号： A01N63/00
摘要： Described herein are tissue grafts derived from the placenta with improved physical and biological properties. In one aspect, the tissue graft includes a first membrane comprising Wharton's jelly laminated with amnion, chorion, or a combination thereof. The presence of Wharton's jelly in the grafts enhances the performance of allograft amniotic-derived, caderivic allograft, xenograft, or alloplast soft tissue substitutes.

3. 发明授权

EP2793745B1 CROSS-LINKED DEHYDRATED PLACENTAL TISSUE GRAFTS AND METHODS FOR MAKING AND USING THE SAME 有权
公开(公告)号：EP2793745B1
公开(公告)日：2019-07-31
申请号：EP12859455.3
申请日：2012-11-16
申请人： MIMEDX Group Inc.
发明人： KOOB, Thomas J. , DANIEL, John , SPENCER, Randall
IPC分类号： A61F2/02 , A61L27/50

4. 发明公开

EP3146039A1 MICRONIZED WHARTON'S JELLY 审中-实审
标题翻译： MIKRONISIERTE WHARTON-SULZE
公开(公告)号：EP3146039A1
公开(公告)日：2017-03-29
申请号：EP15796851.2
申请日：2015-05-21
申请人： MiMedx Group, Inc.
发明人： SPENCER, Randall , SITH, Somaly
IPC分类号： C12N5/00
CPC分类号： A61K35/51 , A61K9/0019 , A61K35/50 , A61L27/36 , C12N5/0605 , C12N2509/10
摘要： The present invention provides compositions and formulations of micronized Wharton's jelly having a controlled viscosity such that when delivered to the injured region of a subject, it remains substantially localized with little or no migration out of the injured region for the repair and/or regeneration thereof. Micronized Wharton's Jelly can be suspended in a pharmaceutically acceptable aqueous carrier, such as saline, sterile water, or any suitable buffer, to form a suspension or a gelatinous gel composition, or it can be in the form of a paste, suitable for delivery into the space adjacent the articular surface cartilage injured region of a subject. The micronized Wharton's jelly when employed at sufficient concentrations can be hydrated into a gel or paste and administered topically, or it can be injected into the body through the use of a needle and syringe. Accordingly, micronized Wharton's Jelly, compositions, or formulations thereof, can be delivered in a manner that is more convenient than Wharton's jelly that has not been micronized in accordance with the present invention.
摘要翻译：本发明提供了具有受控粘度的微粉化沃顿顿果冻的组合物和制剂，使得当递送至受试者的受损区域时，其保持基本上定位，很少或没有迁移出受损区域用于其修复和/或再生。微粉沃顿的果冻可以悬浮在药学上可接受的水性载体中，例如盐水，无菌水或任何合适的缓冲液，以形成悬浮液或凝胶状凝胶组合物，或者它可以是糊剂的形式，适于递送到邻近被检体的关节面软骨损伤区域的空间。微粉化的Wharton果冻以足够的浓度使用时，可以水合成凝胶或糊状物，并局部给药，也可以通过使用针头和注射器将其注入体内。因此，麦芽糖的果冻，组合物或其制剂可以以比根据本发明未被微粉化的沃顿的果冻更方便的方式递送。

5. 发明公开

EP2585084A2 MICRONIZED PLACENTAL TISSUE COMPOSITIONS AND METHODS FOR MAKING AND USING THE SAME 审中-公开
标题翻译：微粉胎盘组织成分和方法生产和使用
公开(公告)号：EP2585084A2
公开(公告)日：2013-05-01
申请号：EP12746721.5
申请日：2012-02-13
申请人： MIMEDX Group Inc.
发明人： MORSE, Brenda, S. , SITH, Somaly , SPENCER, Randall , RAY, Steven , DANIEL, John
IPC分类号： A61K35/50
CPC分类号： A61K35/50 , A61K8/982 , A61K35/12 , A61L27/3604 , A61L27/3683 , A61L27/3695 , A61L2400/06 , A61L2430/34 , A61P17/02 , A61Q19/00
摘要： Described herein are composition composed of micronized placental components and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the micronized compositions are also described herein.

6. 发明授权

EP3189731B1 PLACENTAL TISSUE GRAFTS AND IMPROVED METHODS OF PREPARING AND USING THE SAME 有权转让
公开(公告)号：EP3189731B1
公开(公告)日：2020-01-29
申请号：EP16203661.0
申请日：2008-09-08
申请人： MiMedx Group, Inc.
发明人： DANIEL, John , TOFE, Robert , SPENCER, Randall , RUSSO, John
IPC分类号： A01N1/00 , A61L27/36 , A61L27/38 , A61K35/28 , A61K35/50 , A61K35/33 , A61K35/19 , A61F2/02 , A61L27/56 , A61K9/70

7. 发明授权

EP2785360B1 PLACENTAL TISSUE GRAFTS PRODUCED BY CHEMICAL DEHYDRATION/FREEZE-DRYING AND METHODS FOR MAKING AND USING SAME 有权转让
公开(公告)号：EP2785360B1
公开(公告)日：2019-06-19
申请号：EP12852862.7
申请日：2012-11-30
申请人： MIMEDX Group Inc.
发明人： DANIEL, John , SPENCER, Randall , RAY, Steven
IPC分类号： A61K35/50 , A01N1/00 , C12N5/071 , A61L27/36

8. 发明公开

EP2785360A1 PLACENTAL TISSUE GRAFTS PRODUCED BY CHEMICAL DEHYDRATION/FREEZE-DRYING AND METHODS FOR MAKING AND USING SAME 有权转让
标题翻译： BY制作了生产和使用胎盘组织移植和方法化学脱水/冷冻干燥
公开(公告)号：EP2785360A1
公开(公告)日：2014-10-08
申请号：EP12852862.7
申请日：2012-11-30
申请人： MIMEDX Group Inc. , Daniel, John , Spencer, Randall , Ray, Steven
发明人： DANIEL, John , SPENCER, Randall , RAY, Steven
IPC分类号： A61K35/50 , A01N1/00 , C12N5/071
CPC分类号： A61L27/3604 , A61K35/50 , A61L27/3687 , A61L27/3691 , A61L2430/02 , A61L2430/12 , A61L2430/16 , A61L2430/20 , A61L2430/34 , A61L2430/38
摘要： Described herein are placental tissue grafts produced by chemical dehydration followed by freeze-drying the placental tissue to produce the tissue graft. The tissue grafts retain their biological properties preferably at the same level as the placental tissues before they are processed. The placental tissue grafts have numerous medical applications. Methods for making the tissue graft compositions are also described herein.

9. 发明公开

EP3689421A1 PLACENTAL TISSUE GRAFTS AND IMPROVED METHODS OF PREPARING AND USING THE SAME 审中-实审
公开(公告)号：EP3689421A1
公开(公告)日：2020-08-05
申请号：EP20153610.9
申请日：2008-09-08
申请人： MiMedx Group, Inc.
发明人： DANIEL, John , TOFE, Robert , SPENCER, Randall , RUSSO, John
IPC分类号： A61P41/00 , A61L27/36 , A61L27/38
摘要： Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located on top of and within the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high levels of laminin-5, a cell adhesion bio-active factor shown to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.

10. 发明公开

EP2904094A2 MICRONIZED COMPOSITIONS COMPOSED OF BONE GRAFTS AND METHODS OF MAKING AND USING THE SAME 有权
标题翻译：从骨移植复合微粉化组合物及其生产及其用途方法
公开(公告)号：EP2904094A2
公开(公告)日：2015-08-12
申请号：EP13844862.6
申请日：2013-10-07
申请人： MIMEDX Group Inc.
发明人： DANIEL, John , SPENCER, Randall , TOFE, Robert
IPC分类号： C12N5/07
CPC分类号： A61L27/3604 , A61L27/3608 , A61L2400/06 , A61L2430/02 , A61L2430/24
摘要： Described herein are compositions composed of micronized particles derived from one or more components present in placental tissue in combination with one or more bone grafts. The compositions have numerous medical applications. Methods for making and using the micronized compositions are also described herein.

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