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1. 发明授权

EP2770907B1 METHOD AND/OR SYSTEM FOR MULTICOMPARTMENT ANALYTE MONITORING 有权
公开(公告)号：EP2770907B1
公开(公告)日：2018-07-25
申请号：EP12711716.6
申请日：2012-03-08
申请人： Medtronic MiniMed, Inc.
发明人： YANG, Ning , GOTTLIEB, Rebecca, K. , NOGUEIRA, Keith , LI, Xiaolong , LIANG, Bradley , KANNARD, Brian, T.
IPC分类号： A61B5/145 , A61B5/1495
CPC分类号： A61B5/14532 , A61B5/1451 , A61B5/14528 , A61B5/1473 , A61B5/14865 , A61B5/1495 , A61B5/4839 , A61B5/6849 , A61B5/7242 , A61B5/7275 , A61M5/1723 , F04C2270/0421
摘要： Subject matter disclosed herein relates to monitoring and/or controlling levels of an analyte in bodily fluid. In particular, estimation of a concentration of the analyte in a first physiological compartment based upon observations of a concentration of the analyte in a second physiological compartment may account for a latency in transporting the analyte between the first and second physiological compartments.

2. 发明授权

EP2665827B1 LAYERED ENZYME COMPOSITIONS FOR USE WITH ANALYTE SENSORS 有权
标题翻译：用于分析物传感器的分层酶组合物
公开(公告)号：EP2665827B1
公开(公告)日：2017-05-24
申请号：EP12702686.2
申请日：2012-01-20
申请人： Medtronic MiniMed, Inc.
发明人： LI, Xiaolong , SHAH, Rajiv , YANG, Qingling , LI, Yiwen , PHAM, Barry Phong
IPC分类号： C12Q1/00
CPC分类号： C12Q1/00 , C12Q1/005 , C12Q1/006

3. 发明公开

EP3082597A2 METHODS AND SYSTEMS FOR IMPROVING THE RELIABILITY OF ORTHOGONALLY REDUNDANT SENSORS 有权
标题翻译：方法和系统增正交冗余传感器的可靠性
公开(公告)号：EP3082597A2
公开(公告)日：2016-10-26
申请号：EP14816501.2
申请日：2014-11-21
申请人： Medtronic MiniMed, Inc.
发明人： VARSAVSKY, Andrea , LI, Xiaolong , LIU, Mike C. , ZHONG, Yuxiang , YANG, Ning
IPC分类号： A61B5/145
摘要： Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.
摘要翻译：的方法和系统用于传感器校准和葡萄糖传感器（SG）融合有利地用于改善正交冗余葡萄糖传感器装置，其可以包括光学和电化学葡萄糖传感器的准确度和可靠性。校准这两个传感器可以经由固定偏移和/或动态回归方法，这取决于，E. G.，对传感器的稳定性和比的Isig对相关来实现。对于SG融合，respectivement完整性检查可以执行用于SG值从光学和电化学传感器，以及如果完整性检查都通过的SG值来校准。完整性检查可以包括检查损失灵敏度，噪声和漂移。如果完整性检查失败，则电化学和光学传感器之间的在线传感器映射可以之前执行校准。电化学和光学SG值可以被加权（作为respectivement传感器的整体可靠性指数（RI）的函数）和加权的SGs组合以获得一个单一的，稠合的SG值。

4. 发明公开

EP2665828A2 ELECTRODE COMPOSITIONS FOR USE WITH ANALYTE SENSORS 审中-公开
标题翻译：铅化合物与分析物传感器使用
公开(公告)号：EP2665828A2
公开(公告)日：2013-11-27
申请号：EP12704167.1
申请日：2012-01-20
申请人： Medtronic MiniMed, Inc.
发明人： YANG, Qingling , SHAH, Rajiv , LI, Xiaolong , PHAM, Barry Phong , LI, Yiwen
IPC分类号： C12Q1/00
CPC分类号： C12Q1/001 , C12Q1/005
摘要： Embodiments of the invention provide amperometric analyte sensors having optimized elements such as electrodes formed from sputtered platinum compositions as well as layers of material selected to optimize the characteristics of a wide variety of sensor elements and sensors. While embodiments of the innovation can be used in a variety of contexts, typical embodiments of the invention include glucose sensors used in the management of diabetes.

5. 发明公开

EP2665827A1 LAYERED ENZYME COMPOSITIONS FOR USE WITH ANALYTE SENSORS 有权
标题翻译：层状酶组合物与分析物传感器使用
公开(公告)号：EP2665827A1
公开(公告)日：2013-11-27
申请号：EP12702686.2
申请日：2012-01-20
申请人： Medtronic MiniMed, Inc.
发明人： LI, Xiaolong , SHAH, Rajiv , YANG, Qingling , LI, Yiwen , PHAM, Barry Phong
IPC分类号： C12Q1/00
CPC分类号： C12Q1/00 , C12Q1/005 , C12Q1/006
摘要： Embodiments of the invention provide amperometric analyte sensors having optimized elements such as electrodes formed from sputtered platinum compositions as well as layers of material selected to optimize the characteristics of a wide variety of sensor elements and sensors. While embodiments of the innovation can be used in a variety of contexts, typical embodiments of the invention include glucose sensors used in the management of diabetes.

6. 发明公开

EP3733065A1 METHOD AND SYSTEM FOR CALIBRATING ORTHOGONALLY REDUNDANT SENSOR DEVICES 有权转让
公开(公告)号：EP3733065A1
公开(公告)日：2020-11-04
申请号：EP20179623.2
申请日：2014-11-21
申请人： MEDTRONIC MINIMED, INC.
发明人： VARSAVSKY, Andrea , LI, Xiaolong , LIU, Mike C. , ZHONG, Yuxiang , YANG, Ning
IPC分类号： A61B5/145 , A61B5/1455 , A61B5/1459 , A61B5/1468 , A61B5/1473
摘要： A method of calibrating an orthogonally redundant sensor device for determining the concentration of glucose in a body of a user, said sensor device including at least an electrochemical glucose sensor and an optical glucose sensor, has the steps of receiving a first signal from the electrochemical glucose sensor; receiving a second signal from the optical glucose sensor; performing a respective integrity check on each of said first and second signals; determining whether the first signal can be calibrated, and whether the second signal can be calibrated, wherein said determination is made based on whether the first signal and the second signal pass or fail their respective integrity checks; if it is determined that the first signal can be calibrated, calibrating said first signal to generate an electrochemical sensor glucose (SG) value; if it is determined that the second signal can be calibrated, calibrating said second signal to generate an optical sensor glucose (SG) value; and fusing said electrochemical SG value and said optical SG value to obtain a single, fused sensor glucose value for the orthogonally redundant sensor device. The steps are performed by a microprocessor in a corresponding glucose monitoring system including the sensors and a transmitter.

7. 发明授权

EP3082597B1 METHODS AND SYSTEMS FOR IMPROVING THE RELIABILITY OF ORTHOGONALLY REDUNDANT GLUCOSE SENSORS 有权
公开(公告)号：EP3082597B1
公开(公告)日：2020-07-29
申请号：EP14816501.2
申请日：2014-11-21
申请人： Medtronic MiniMed, Inc.
发明人： VARSAVSKY, Andrea , LI, Xiaolong , LIU, Mike C. , ZHONG, Yuxiang , YANG, Ning
IPC分类号： A61B5/145

8. 发明公开

EP2928372A1 MICROARRAY ELECTRODES USEFUL WITH ANALYTE SENSORS AND METHODS FOR MAKING AND USING THEM 有权
标题翻译：微电极阵列分析物传感器和方法进行生产及其用途
公开(公告)号：EP2928372A1
公开(公告)日：2015-10-14
申请号：EP13815240.0
申请日：2013-12-05
申请人： Medtronic MiniMed, Inc.
发明人： PESANTEZ, Daniel E. , LI, Xiaolong , LIANG, Bradley Chi
IPC分类号： A61B5/1486 , G01N27/327
CPC分类号： A61B5/14532 , A61B5/14865 , A61B2562/028 , A61B2562/046 , C12Q1/006
摘要： The invention provides analyte sensors having optimized electrodes and/ or configurations of electrode elements as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.

9. 发明授权

EP3397160B1 RETROSPECTIVE SENSOR CALIBRATION METHODS 有权
公开(公告)号：EP3397160B1
公开(公告)日：2019-11-13
申请号：EP16751064.3
申请日：2016-07-22
申请人： Medtronic MiniMed, Inc.
发明人： NOGUEIRA, Keith , ENGEL, Taly G. , GROSMAN, Benyamin , LI, Xiaolong , LIANG, Bradley C. , SHAH, Rajiv , LIU, Mike C. , TSAI, Andy Y. , VARSAVSKY, Andrea , NISHIDA, Jeffrey
IPC分类号： A61B5/145 , A61B5/1495 , A61B5/053

10. 发明公开

EP2770907A1 METHOD AND/OR SYSTEM FOR MULTICOMPARTMENT ANALYTE MONITORING 有权
标题翻译：方法和/或系统关于几个主题ANALYTÜBERWACHUNGIN
公开(公告)号：EP2770907A1
公开(公告)日：2014-09-03
申请号：EP12711716.6
申请日：2012-03-08
申请人： Medtronic MiniMed, Inc.
发明人： YANG, Ning , GOTTLIEB, Rebecca, K. , NOGUEIRA, Keith , LI, Xiaolong , LIANG, Bradley , KANNARD, Brian, T.
IPC分类号： A61B5/145 , A61B5/1495
CPC分类号： A61B5/14532 , A61B5/1451 , A61B5/14528 , A61B5/1473 , A61B5/14865 , A61B5/1495 , A61B5/4839 , A61B5/6849 , A61B5/7242 , A61B5/7275 , A61M5/1723 , F04C2270/0421
摘要： Subject matter disclosed herein relates to monitoring and/or controlling levels of an analyte in bodily fluid. In particular, estimation of a concentration of the analyte in a first physiological compartment based upon observations of a concentration of the analyte in a second physiological compartment may account for a latency in transporting the analyte between the first and second physiological compartments.

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