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1. 发明公开

EP3733065A1 METHOD AND SYSTEM FOR CALIBRATING ORTHOGONALLY REDUNDANT SENSOR DEVICES 有权转让
公开(公告)号：EP3733065A1
公开(公告)日：2020-11-04
申请号：EP20179623.2
申请日：2014-11-21
申请人： MEDTRONIC MINIMED, INC.
发明人： VARSAVSKY, Andrea , LI, Xiaolong , LIU, Mike C. , ZHONG, Yuxiang , YANG, Ning
IPC分类号： A61B5/145 , A61B5/1455 , A61B5/1459 , A61B5/1468 , A61B5/1473
摘要： A method of calibrating an orthogonally redundant sensor device for determining the concentration of glucose in a body of a user, said sensor device including at least an electrochemical glucose sensor and an optical glucose sensor, has the steps of receiving a first signal from the electrochemical glucose sensor; receiving a second signal from the optical glucose sensor; performing a respective integrity check on each of said first and second signals; determining whether the first signal can be calibrated, and whether the second signal can be calibrated, wherein said determination is made based on whether the first signal and the second signal pass or fail their respective integrity checks; if it is determined that the first signal can be calibrated, calibrating said first signal to generate an electrochemical sensor glucose (SG) value; if it is determined that the second signal can be calibrated, calibrating said second signal to generate an optical sensor glucose (SG) value; and fusing said electrochemical SG value and said optical SG value to obtain a single, fused sensor glucose value for the orthogonally redundant sensor device. The steps are performed by a microprocessor in a corresponding glucose monitoring system including the sensors and a transmitter.

2. 发明授权

EP3082597B1 METHODS AND SYSTEMS FOR IMPROVING THE RELIABILITY OF ORTHOGONALLY REDUNDANT GLUCOSE SENSORS 有权
公开(公告)号：EP3082597B1
公开(公告)日：2020-07-29
申请号：EP14816501.2
申请日：2014-11-21
申请人： Medtronic MiniMed, Inc.
发明人： VARSAVSKY, Andrea , LI, Xiaolong , LIU, Mike C. , ZHONG, Yuxiang , YANG, Ning
IPC分类号： A61B5/145

3. 发明授权

EP2704633B1 METHOD AND APPARATUS FOR CONTINUOUS ANALYTE MONITORING 有权
公开(公告)号：EP2704633B1
公开(公告)日：2020-12-02
申请号：EP12724437.4
申请日：2012-05-04
申请人： Medtronic MiniMed, Inc.
发明人： ROSE, Jefferson , RAO, Ashwin, K. , YANG, Ning , CHIU, Chia-Hung , LUO, Ying , GOTTLIEB, Rebecca, K.
IPC分类号： A61B5/1473 , A61B5/145 , G01N27/327

4. 发明公开

EP2770907A1 METHOD AND/OR SYSTEM FOR MULTICOMPARTMENT ANALYTE MONITORING 有权
标题翻译：方法和/或系统关于几个主题ANALYTÜBERWACHUNGIN
公开(公告)号：EP2770907A1
公开(公告)日：2014-09-03
申请号：EP12711716.6
申请日：2012-03-08
申请人： Medtronic MiniMed, Inc.
发明人： YANG, Ning , GOTTLIEB, Rebecca, K. , NOGUEIRA, Keith , LI, Xiaolong , LIANG, Bradley , KANNARD, Brian, T.
IPC分类号： A61B5/145 , A61B5/1495
CPC分类号： A61B5/14532 , A61B5/1451 , A61B5/14528 , A61B5/1473 , A61B5/14865 , A61B5/1495 , A61B5/4839 , A61B5/6849 , A61B5/7242 , A61B5/7275 , A61M5/1723 , F04C2270/0421
摘要： Subject matter disclosed herein relates to monitoring and/or controlling levels of an analyte in bodily fluid. In particular, estimation of a concentration of the analyte in a first physiological compartment based upon observations of a concentration of the analyte in a second physiological compartment may account for a latency in transporting the analyte between the first and second physiological compartments.

6. 发明公开

EP3082597A2 METHODS AND SYSTEMS FOR IMPROVING THE RELIABILITY OF ORTHOGONALLY REDUNDANT SENSORS 有权
标题翻译：方法和系统增正交冗余传感器的可靠性
公开(公告)号：EP3082597A2
公开(公告)日：2016-10-26
申请号：EP14816501.2
申请日：2014-11-21
申请人： Medtronic MiniMed, Inc.
发明人： VARSAVSKY, Andrea , LI, Xiaolong , LIU, Mike C. , ZHONG, Yuxiang , YANG, Ning
IPC分类号： A61B5/145
摘要： Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.
摘要翻译：的方法和系统用于传感器校准和葡萄糖传感器（SG）融合有利地用于改善正交冗余葡萄糖传感器装置，其可以包括光学和电化学葡萄糖传感器的准确度和可靠性。校准这两个传感器可以经由固定偏移和/或动态回归方法，这取决于，E. G.，对传感器的稳定性和比的Isig对相关来实现。对于SG融合，respectivement完整性检查可以执行用于SG值从光学和电化学传感器，以及如果完整性检查都通过的SG值来校准。完整性检查可以包括检查损失灵敏度，噪声和漂移。如果完整性检查失败，则电化学和光学传感器之间的在线传感器映射可以之前执行校准。电化学和光学SG值可以被加权（作为respectivement传感器的整体可靠性指数（RI）的函数）和加权的SGs组合以获得一个单一的，稠合的SG值。

7. 发明公开

EP2704633A1 METHOD AND APPARATUS FOR CONTINUOUS ANALYTE MONITORING 有权
标题翻译：方法和装置连续ANALYTÜBERWACHUNG
公开(公告)号：EP2704633A1
公开(公告)日：2014-03-12
申请号：EP12724437.4
申请日：2012-05-04
申请人： Medtronic MiniMed, Inc.
发明人： ROSE, Jefferson , RAO, Ashwin, K. , YANG, Ning , CHIU, Chia-Hung , LUO, Ying , GOTTLIEB, Rebecca, K.
IPC分类号： A61B5/1473 , A61B5/145 , G01N27/327
CPC分类号： A61B5/14735 , A61B5/14532 , G01N27/3272
摘要： Embodiments of the invention provide analyte sensors and sensor systems such as amperometric glucose sensors used in the management of diabetes as well: optimized methods for monitoring analytes using such sensors and sensor systems.

8. 发明公开

EP3082573A1 USE OF ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY (EIS) IN CONTINUOUS GLUCOSE MONITORING 审中-公开
标题翻译：采用电化学阻抗谱（EIS）在连续血糖监测
公开(公告)号：EP3082573A1
公开(公告)日：2016-10-26
申请号：EP14815162.4
申请日：2014-11-26
申请人： Medtronic MiniMed, Inc.
发明人： VARSAVSKY, Andrea , YU, Fei , MILLER, Michael E. , LIANG, Bradley C. , YANG, Ning
IPC分类号： A61B5/00 , A61M5/158 , A61B5/145 , A61B5/1486 , A61B5/1495
CPC分类号： A61B5/1495 , A61B5/0537 , A61B5/0538 , A61B5/14532 , A61B5/1468 , A61B5/1473 , A61B5/14865 , A61B5/6849 , A61B5/7221 , A61B5/7246 , A61M5/14244 , A61M5/14276 , A61M5/1582 , A61M2005/1726 , G01N27/026
摘要： Electrochemical Impedance Spectroscopy (EIS) is used in conjunction with continuous glucose monitors and continuous glucose monitoring (CGM) to enable in-vivo sensor calibration, gross (sensor) failure analysis, and intelligent sensor diagnostics and fault detection. An equivalent circuit model is defined, and circuit elements are used to characterize sensor behavior.

9. 发明授权

EP2770908B1 POLAR PLOT TO REPRESENT GLUCOSE SENSOR PERFORMANCE 有权
公开(公告)号：EP2770908B1
公开(公告)日：2019-07-31
申请号：EP12724442.4
申请日：2012-05-10
申请人： Medtronic MiniMed, Inc.
发明人： GOTTLIEB, Rebecca K. , LUO, Ying , YANG, Ning , CHASE, James Geoffrey
IPC分类号： A61B5/145

10. 发明授权

EP2770907B1 METHOD AND/OR SYSTEM FOR MULTICOMPARTMENT ANALYTE MONITORING 有权
公开(公告)号：EP2770907B1
公开(公告)日：2018-07-25
申请号：EP12711716.6
申请日：2012-03-08
申请人： Medtronic MiniMed, Inc.
发明人： YANG, Ning , GOTTLIEB, Rebecca, K. , NOGUEIRA, Keith , LI, Xiaolong , LIANG, Bradley , KANNARD, Brian, T.
IPC分类号： A61B5/145 , A61B5/1495
CPC分类号： A61B5/14532 , A61B5/1451 , A61B5/14528 , A61B5/1473 , A61B5/14865 , A61B5/1495 , A61B5/4839 , A61B5/6849 , A61B5/7242 , A61B5/7275 , A61M5/1723 , F04C2270/0421
摘要： Subject matter disclosed herein relates to monitoring and/or controlling levels of an analyte in bodily fluid. In particular, estimation of a concentration of the analyte in a first physiological compartment based upon observations of a concentration of the analyte in a second physiological compartment may account for a latency in transporting the analyte between the first and second physiological compartments.

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