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1. 发明公开

EP4033974A1 DETERMINING HEART CONDITION STATUSES USING SUBCUTANEOUS IMPEDANCE MEASUREMENTS 审中-公开
公开(公告)号：EP4033974A1
公开(公告)日：2022-08-03
申请号：EP20803311.8
申请日：2020-09-23
申请人： Medtronic, Inc.
发明人： SARKAR, Shantanu , ZIELINSKI, Todd, M. , LEE, Brian, B. , EISELE III, Val, D. , WARMAN, Eduardo, N.
IPC分类号： A61B5/0537 , A61B5/0538 , A61B5/00

2. 发明授权

EP1123132B1 CIRCUIT FOR IMPLANTABLE DUAL SENSOR MEDICAL ELECTRICAL LEAD 有权
标题翻译：电路是否具有两个传感器植入医疗导线
公开(公告)号：EP1123132B1
公开(公告)日：2005-03-02
申请号：EP99955127.8
申请日：1999-10-22
申请人： Medtronic, Inc.
发明人： ROBERTS, Jonathan, P. , ROLINE, Glenn, M. , LEE, Brian, B.
IPC分类号： A61N1/365
CPC分类号： A61N1/36585
摘要： An implantable dual transducer apparatus for use with an implantable medical device and control method are disclosed. The dual transducer assembly includes two physiologic sensors coupled to the medical device via a pair of lead conductors. Switching circuitry is controlled by the medical device to selectively activate and deactivate the two physiologic sensors by application of a supply voltage of an appropriate polarity. Each sensor of the dual transducer assembly is connected to the pair of lead conductors through a respective power switch. In response to the polarity of the supply voltage applied to the lead conductors, the power switches activate or deactivate their respective sensor in an alternating manner. Selective activation of one of the sensors while concurrently deactivating the other sensor of the dual transducer assembly provides for reduced power consumption and reliable communication of sensor data and other information transmitted over the pair of lead conductors. The power switches may be constructed using diodes, including discrete or substrate diodes, or transistors, such as n-channel and p-channel transistors. A wide variety of physiologic sensors may be incorporated into the dual transducer assembly.

3. 发明授权

EP1959856B1 MEDICAL DEVICE PACKAGING SYSTEM 失效
标题翻译： SYSTEM FOR包装医疗器械的
公开(公告)号：EP1959856B1
公开(公告)日：2013-04-10
申请号：EP06839757.9
申请日：2006-11-08
申请人： Medtronic, Inc.
发明人： PLOMBON, William, J. , LEE, Brian, B. , WENGER, Willaim, K. , KRAUSE, Paul, G. , LU, Steven, N. , MCADAMS, Sean, B. , STYLOS, Lee , SALZER, Judy, B. , MONTGOMERY, Gerald, J.
IPC分类号： A61N1/08 , A61B19/02 , A61N1/375 , A61N1/372
CPC分类号： A61N1/08 , A61B50/30 , A61B2050/0065 , A61N1/372 , A61N1/375 , A61N2001/37294

4. 发明授权

EP1357833B1 SYSTEM AND COMPUTER PROGRAM FOR DERIVING A VIRTUAL ECG OR EGM SIGNAL 有权
标题翻译：系统和计算机程序DIVERT一个虚拟ECG或EGM信号
公开(公告)号：EP1357833B1
公开(公告)日：2006-04-12
申请号：EP01997253.8
申请日：2001-11-16
申请人： MEDTRONIC, INC.
发明人： LEE, Brian, B. , PANKEN, Eric, J. , REINKE, James, D.
IPC分类号： A61B5/04
CPC分类号： A61B5/04011 , A61B5/0402 , G06F19/00
摘要： A system and method for obtaining a virtual physiologic voltage signal between a first predetermined point in a second selected point in the body is disclosed. At least three electrodes are used to measure two voltage signals S1 and S2 in a body. In one embodiment, the signal S1 is measured between a first electrode and a common electrode, and the signal S2 is measured between a second electrode and the common electrode. A selected point within the body may be chosen to define a pair of virtual electrodes existing between this selected point and the common electrode. An approximation of the voltage signal S as could be measured between electrodes positioned at these virtual electrode locations may be derived as a function of S1, S2, and theta, wherein theta is the angle between the directional vector U1 for the signal S1 and the directional vector U for the signal S. According to the inventive system and method, the signal value for S is also dependent on the distances between the electrode pairs, on the angle beta between directional vectors U1 and U2, and on the distance between the virtual electrodes. The current invention may be utilized with electrodes that are positioned either externally on the surface of, or implanted within, a body. According to one aspect of the invention, a user may employ a user interface to select the values of theta, beta, and the electrode spacings. Alternatively, ones of these parameters may be predetermined by the system. In another embodiment, the system could derive the signal S over a predetermined range of values for the angle theta. The system may then select the angle of theta resulting in the derived signal S that exhibits a desired waveform morphology.

5. 发明公开

EP1601283A2 METHOD AND APPARATUS FOR MONITORING HEART FUNCTION IN A SUBCUTANEOUSLY IMPLANTED DEVICE 审中-公开
标题翻译：方法和设备的用于监测心功能的皮下植入设备
公开(公告)号：EP1601283A2
公开(公告)日：2005-12-07
申请号：EP04715125.3
申请日：2004-02-26
申请人： MEDTRONIC, INC.
发明人： LEE, Brian, B.
IPC分类号： A61B5/00
CPC分类号： A61N1/36514 , A61B5/0031 , A61B5/0205 , A61B5/0215 , A61B5/0452 , A61B5/7232 , A61N1/05 , A61N1/3702
摘要： A minimally invasive, implantable monitor (10) and associated method for chronically monitoring a patient's hemodynamic function based on signals sensed by one or more acoustical sensors (22, 22A, 23A, 23B). The monitor may be implanted subcutaneously or submuscularly in relation to the heart to allow acoustic signals generated by heart or blood motion to be received by a passive or active acoustical sensor. Circuitry (32) for filtering and amplifying and digitizing acoustical data is included, and sampled data may be continuously or intermittently written to a looping memory buffer (38). ECG electrodes (14, 16) and associated circuitry (30, 39) may be included to simultaneously record ECG data. Upon a manual or automatic trigger event acoustical and ECG data may be stored in long-term memory (41) for future uploading to an external device (62). The external device may present acoustical data visually and acoustically with associated ECG data to allow interpretation of both electrical and mechanical heart function.

6. 发明公开

EP2632325A1 POSTURE-INDUCED CHANGES TO PHYSIOLOGICAL PARAMETERS 有权
标题翻译：态度变化引起的生理参数
公开(公告)号：EP2632325A1
公开(公告)日：2013-09-04
申请号：EP11718867.2
申请日：2011-04-29
申请人： Medtronic, Inc.
发明人： CORBUCCI, Giorgio , LEE, Brian, B.
IPC分类号： A61B5/024 , A61B5/029
CPC分类号： A61B5/0205 , A61B5/02028 , A61B5/024 , A61B5/02438 , A61B5/029 , A61B5/1116 , A61B5/4878 , A61B5/686 , A61B5/7246 , A61B5/7282 , A61N1/3627 , A61N1/36535 , A61N1/36585 , A61N1/3702 , A61N1/37247
摘要： Methods and devices for analyzing posture-induced changes to physiological parameters of a patient (e.g., ejection time, heart rate, etc.) to provide an assessment of one or more conditions of the patient.

7. 发明公开

EP1549213A1 METHODS AND APPARATUS FOR CARDIAC R-WAVE SENSING IN A SUBCUTANEOUS ECG WAVEFORM 有权转让
标题翻译： DEVICE对于R波的心脏的IN A皮肤下的ECG波形检测
公开(公告)号：EP1549213A1
公开(公告)日：2005-07-06
申请号：EP03749329.3
申请日：2003-09-02
申请人： Medtronic, Inc.
发明人： CAO, Jian , LEE, Brian, B. , KANE, Michael, R. , HURD, Spencer, R.
IPC分类号： A61B5/0456 , A61B5/0468
CPC分类号： A61B5/0468 , A61B5/04325 , A61B5/0456 , A61B5/7203 , A61B5/7221
摘要： The present invention uses a R-wave sensing algorithm that uniquely combines an automatic threshold adjustment method with a new noise rejection technique. This algorithm has significant advantages in avoiding the sensing of T-waves, P-waves, and noise/artifacts. Detecting the presence of noise bursts uses features that determine if an R-R interval adjacent to or within the noise signal is valid. Circuitry that discriminates noise signals from R-waves can use any one of several features including, but not limited to, the following: detection events occurring so close together that they are outside normal physiologic heart rates; frequency content that is wider than that of QRS complexes; amplitudes that are different than the adjacent or encompassing R-waves; and amplitudes that display greater than normal variability. The present invention employs multiple discrete thresholds optionally with different decay constants, alone or in combination with one or more substantially constant magnitude sensing threshold.

8. 发明公开

EP1123132A1 CIRCUIT AND METHOD FOR IMPLANTABLE DUAL SENSOR MEDICAL ELECTRICAL LEAD 有权
标题翻译：电路是否具有两个传感器植入医疗导线
公开(公告)号：EP1123132A1
公开(公告)日：2001-08-16
申请号：EP99955127.8
申请日：1999-10-22
申请人： MEDTRONIC, INC.
发明人： ROBERTS, Jonathan, P. , ROLINE, Glenn, M. , LEE, Brian, B.
IPC分类号： A61N1/365
CPC分类号： A61N1/36585
摘要： An implantable dual transducer apparatus for use with an implantable medical device and control method are disclosed. The dual transducer assembly includes two physiologic sensors coupled to the medical device via a pair of lead conductors. Switching circuitry is controlled by the medical device to selectively activate and deactivate the two physiologic sensors by application of a supply voltage of an appropriate polarity. Each sensor of the dual transducer assembly is connected to the pair of lead conductors through a respective power switch. In response to the polarity of the supply voltage applied to the lead conductors, the power switches activate or deactivate their respective sensor in an alternating manner. Selective activation of one of the sensors while concurrently deactivating the other sensor of the dual transducer assembly provides for reduced power consumption and reliable communication of sensor data and other information transmitted over the pair of lead conductors. The power switches may be constructed using diodes, including discrete or substrate diodes, or transistors, such as n-channel and p-channel transistors. A wide variety of physiologic sensors may be incorporated into the dual transducer assembly.

9. 发明授权

EP2632325B1 POSTURE-INDUCED CHANGES TO PHYSIOLOGICAL PARAMETERS 有权
公开(公告)号：EP2632325B1
公开(公告)日：2019-08-14
申请号：EP11718867.2
申请日：2011-04-29
申请人： Medtronic, Inc.
发明人： CORBUCCI, Giorgio , LEE, Brian, B.
IPC分类号： A61B5/024 , A61B5/029

10. 发明公开

EP2069009A1 IMPLANTABLE MEDICAL DEVICE WITH SENSOR SELF-TEST FEATURE 审中-公开
标题翻译：植入性医疗带传感器自检功能
公开(公告)号：EP2069009A1
公开(公告)日：2009-06-17
申请号：EP07755924.3
申请日：2007-04-24
申请人： MEDTRONIC, INC.
发明人： PANKEN, Eric, J. , MIESEL, Keith, A. , LEE, Brian, B. , DENISON, Timothy, J.
IPC分类号： A61N1/37
CPC分类号： A61N1/3706 , A61B2560/0276 , A61N1/36535 , A61N1/36542 , A61N1/3702
摘要： An implantable medical device (IMD) applies a sensor self-test when a sensing device generates a sensor signal indicating an event, or when the sensor is used to validate an event detected by another device. The event may be based on a sensed condition that triggers an operational adjustment, such as a therapy or diagnostic adjustment within the IMD. A sensor self-test verifies that an implantable sensing device is functional, and can be performed with or without activating the sensor. Activating the sensor may involve, application of an electrical input signal that causes the sensor to generate an output signal. Alternatively, the sensor self-test may be performed without activating the sensor by analyzing the continuity of a signal path between the sensor and sensor interface circuitry. In either case, a sensor self-test verifies proper operation so that operational adjustments can be made with greater confidence.

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