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1. 发明授权

EP0154343B1 Adsorbent 失效
标题翻译：吸附剂
公开(公告)号：EP0154343B1
公开(公告)日：1991-06-19
申请号：EP85102587.4
申请日：1985-03-07
申请人： Research Development Corporation of Japan , MITSUBISHI KASEI CORPORATION
发明人： Kiniwa, Hideaki
IPC分类号： B01J20/26 , B01J20/32 , C07B57/00 , G01N30/48
CPC分类号： C08G69/08 , B01J20/29 , B01J20/321 , B01J20/3212 , B01J20/3274 , B01J20/3282 , Y10T428/249953 , Y10T428/3175

2. 发明公开

EP0300448A3 Separation medium 失效
标题翻译：分离介质
公开(公告)号：EP0300448A3
公开(公告)日：1989-03-29
申请号：EP88111685.9
申请日：1988-07-20
申请人： MITSUBISHI KASEI CORPORATION
发明人： Kusano, Hiroshi , Kiniwa, Hideaki , Shimura, Akihiro , Annaka, Masahiko
IPC分类号： B01J20/32 , C07B57/00
CPC分类号： B01J20/287 , B01J20/223 , B01J20/28004 , B01J20/28016 , B01J20/28057 , B01J20/28078 , B01J20/29 , B01J20/3092 , B01J20/3204 , B01J20/3246 , B01J20/3259 , B01J20/3261 , B01J20/3263 , B01J20/3265 , B01J2220/52 , B01J2220/54 , B01J2220/58 , C07C227/34
摘要： A separation medium useful as an adsorbent of liquid chromatography for optical resolution of racemic mixtures is disclosed, which comprises a reversed phase support coated with an optically active amino acid derivative represented by formula (I):
wherein R₁ represents a straight or branched alkyl group having from 1 to 3 carbon atoms; and R₂ and R₃ each represents a straight or branched alkyl group having from 4 to 12 carbon atoms which may contain an aromatic group or an unsaturated alkyl group. The separation medium is applicable to optical resolution of a wide range of DL-amino acids and exhibits excellent durability.

3. 发明公开

EP0373626A3 Cell culture carriers 失效
标题翻译：细胞培养载体
公开(公告)号：EP0373626A3
公开(公告)日：1991-01-16
申请号：EP89123054.2
申请日：1989-12-13
申请人： MITSUBISHI KASEI CORPORATION
发明人： Kiniwa, Hideaki , Kubota, Hirohisa
IPC分类号： C12N5/00
CPC分类号： C12N5/0075 , C12N2533/30
摘要： This invention relates to cell culture carriers consisting of a porous support, at least a part of which surface being coated with a water-insoluble polymer constituted by (meth)acrylic acid ester and/or (meth)acrylamides and a cross-linking agent, and having a positively chargeable chemical moiety on the polymer surface. The present carriers have enabled the high-density cell culture in any type of the culture methods.

4. 发明公开

EP0373626A2 Cell culture carriers 失效
标题翻译： Trägerzur Zellkultur。
公开(公告)号：EP0373626A2
公开(公告)日：1990-06-20
申请号：EP89123054.2
申请日：1989-12-13
申请人： MITSUBISHI KASEI CORPORATION
发明人： Kiniwa, Hideaki , Kubota, Hirohisa
IPC分类号： C12N5/00
CPC分类号： C12N5/0075 , C12N2533/30
摘要： This invention relates to cell culture carriers consisting of a porous support, at least a part of which surface being coated with a water-insoluble polymer constituted by (meth)acrylic acid ester and/or (meth)acrylamides and a cross-linking agent, and having a positively chargeable chemical moiety on the polymer surface. The present carriers have enabled the high-density cell culture in any type of the culture methods.
摘要翻译：本发明涉及由多孔载体组成的细胞培养载体，其至少一部分表面涂覆有由（甲基）丙烯酸酯和/或（甲基）丙烯酰胺和交联剂构成的水不溶性聚合物，并且在聚合物表面上具有带正电的化学部分。目前的载体使得能够以任何类型的培养方法进行高密度细胞培养。

5. 发明公开

EP0300448A2 Separation medium 失效
标题翻译： Trennungsmittel。
公开(公告)号：EP0300448A2
公开(公告)日：1989-01-25
申请号：EP88111685.9
申请日：1988-07-20
申请人： MITSUBISHI KASEI CORPORATION
发明人： Kusano, Hiroshi , Kiniwa, Hideaki , Shimura, Akihiro , Annaka, Masahiko
IPC分类号： B01J20/32 , C07B57/00
CPC分类号： B01J20/287 , B01J20/223 , B01J20/28004 , B01J20/28016 , B01J20/28057 , B01J20/28078 , B01J20/29 , B01J20/3092 , B01J20/3204 , B01J20/3246 , B01J20/3259 , B01J20/3261 , B01J20/3263 , B01J20/3265 , B01J2220/52 , B01J2220/54 , B01J2220/58 , C07C227/34
摘要： A separation medium useful as an adsorbent of liquid chromatography for optical resolution of racemic mixtures is disclosed, which comprises a reversed phase support coated with an optically active amino acid derivative represented by formula (I):
wherein R₁ represents a straight or branched alkyl group having from 1 to 3 carbon atoms; and R₂ and R₃ each represents a straight or branched alkyl group having from 4 to 12 carbon atoms which may contain an aromatic group or an unsaturated alkyl group.
The separation medium is applicable to optical resolution of a wide range of DL-amino acids and exhibits excellent durability.
摘要翻译：公开了一种可用作外消旋混合物的光学拆分的液相色谱吸附剂的分离介质，其包含涂覆有由式（I）表示的光学活性氨基酸衍生物的反相载体：其中R 1表示直链或支链具有1至3个碳原子的烷基; 并且R 2和R 3各自表示可以含有芳基或不饱和烷基的具有4至12个碳原子的直链或支链烷基。分离介质适用于宽范围的DL-氨基酸的光学拆分，并表现出优异的耐久性。

6. 发明授权

EP0288006B1 Process for producing crosslinked polymer particles 失效
标题翻译：一种用于交联聚合物颗粒的制备方法。
公开(公告)号：EP0288006B1
公开(公告)日：1994-03-23
申请号：EP88106224.4
申请日：1988-04-19
申请人： MITSUBISHI KASEI CORPORATION
发明人： Kusano, Hiroshi , Kiniwa, Hideaki , Shimura, Akihiro , Annaka, Masahiko
IPC分类号： C08F291/00 , C08F257/02
CPC分类号： C08F257/02 , C08F291/00 , C08F2/16

7. 发明公开

EP0288006A2 Process for producing crosslinked polymer particles 失效
标题翻译： Verfahren zur Herstellung von vernetzten Polymerteilchen。
公开(公告)号：EP0288006A2
公开(公告)日：1988-10-26
申请号：EP88106224.4
申请日：1988-04-19
申请人： MITSUBISHI KASEI CORPORATION
发明人： Kusano, Hiroshi , Kiniwa, Hideaki , Shimura, Akihiro , Annaka, Masahiko
IPC分类号： C08F291/00 , C08F257/02
CPC分类号： C08F257/02 , C08F291/00 , C08F2/16
摘要： A process for producing crosslinked polymer particles which comprises a first step of polymerizing a polymerizable monomer containing from 0.1 to 2.0% by weight, based on the entire polymerizable monomer, of a crosslinkable monomer in a medium in which the polymerizable monomer is soluble but the resulting polymer is insoluble, to obtain crosslinked polymer particles having a particle size of from 0.8 to 10 µm, and a second step of letting the crosslinked polymer particles absorb from 1 to 50 times by weight of a polymerizable monomer containing from 2 to 100% by weight, based on the entire polymerizable monomer, of a crosslinkable monomer in an aqueous medium, followed by polymerization to obtain crosslinked polymer particles having a particle size of from 1 to 30 µm and a crosslinking degree of from 1.0 to 98%.
摘要翻译：一种生产交联聚合物颗粒的方法，包括使可聚合单体在可聚合单体溶解的介质中聚合可聚合单体的第一步骤，所述可聚合单体基于整个可聚合单体聚合0.1至2.0重量％的可交联单体，聚合物不溶，得到粒径为0.8〜10μm的交联聚合物粒子，第2工序是使交联聚合物粒子以1〜50重量％的比例吸收1〜50重量％的含有2〜100重量％基于整个可聚合单体的可交联单体在水性介质中的重量，随后聚合以获得粒径为1至30μm和交联度为1.0至98％的交联聚合物颗粒。

8. 发明公开

EP0154343A2 Adsorbent 失效
标题翻译：吸附剂
公开(公告)号：EP0154343A2
公开(公告)日：1985-09-11
申请号：EP85102587.4
申请日：1985-03-07
申请人： Research Development Corporation of Japan , MITSUBISHI KASEI CORPORATION
发明人： Kiniwa, Hideaki
IPC分类号： B01J20/26 , B01J20/32 , C07B57/00 , G01N30/48
CPC分类号： C08G69/08 , B01J20/29 , B01J20/321 , B01J20/3212 , B01J20/3274 , B01J20/3282 , Y10T428/249953 , Y10T428/3175
摘要： A method of adsorbing a substance such as an optically active substance, comprising contacting a solution of the substance in a solvent with an adsorbent, consisting of a cross-linked, polymer comprising an optically active, synthetic.poly(amino acid)represent by the general formula (I):
wherein R stands for an organic group, R' stands for hydrogen or an alkyl group and n is an integer of at least 5, which may be protected at a terminal amino group and a carrier polymer supporting said synthetic poly(amino acid) thereon, said carrier polymer having affinity for said solvent.
The adsorbing is especially useful for optical resolution of racemic mixtures.
摘要翻译：吸附物质如光学活性物质的方法，包括使物质在溶剂中的溶液与吸附剂接触，所述吸附剂由交联的聚合物组成，所述聚合物包含光学活性的合成的聚（氨基酸）通式（I）：其中R代表有机基团，R'代表氢或烷基，并且n是至少为5的整数，其可以在末端氨基处被保护，并且载体聚合物支持所述合成聚（氨基酸），所述载体聚合物对所述溶剂具有亲和力。吸附对于外消旋混合物的光学拆分特别有用。

9. 发明公开

EP0366042A3 Adsorbent for optical resolution and resolution method employing it 失效
标题翻译：用于光学解决方案和解决方案的使用者
公开(公告)号：EP0366042A3
公开(公告)日：1991-08-21
申请号：EP89119647.9
申请日：1989-10-23
申请人： MITSUBISHI KASEI CORPORATION
发明人： Nishikaji, Takashi , Kiniwa, Hideaki , Kurata, Tsunehiko
IPC分类号： C08F291/00 , C08F265/04 , C08F257/00 , C08F299/00 , B01D15/08
CPC分类号： C08F291/00 , B01J20/261 , B01J20/264 , B01J20/267 , B01J20/28004 , B01J20/28057 , B01J20/29 , B01J20/3092 , B01J20/321 , B01J20/3278 , B01J2220/54 , B01J2220/58 , C08F257/02 , C08F265/04 , C08F220/00 , C08F226/02
摘要： An adsorbent for optical resolution obtained by graft polymerizing an optically active vinyl monomer of the formula:
wherein X is -CONH-, -COO- or -NHCOO-, R¹ is a hydrogen atom or a methyl group, and each of R² to R⁴ which are different from one another, is a hydrogen atom, a hydrocarbon group or an alkoxycarbonyl group, or R² and R³ together form a ring, to a crosslinked polymer carrier having groups to which said monomer is graft polymerizable.

10. 发明授权

EP0300448B1 Separation medium 失效
标题翻译：分离介质
公开(公告)号：EP0300448B1
公开(公告)日：1991-04-24
申请号：EP88111685.9
申请日：1988-07-20
申请人： MITSUBISHI KASEI CORPORATION
发明人： Kusano, Hiroshi , Kiniwa, Hideaki , Shimura, Akihiro , Annaka, Masahiko
IPC分类号： B01J20/32 , C07B57/00
CPC分类号： B01J20/287 , B01J20/223 , B01J20/28004 , B01J20/28016 , B01J20/28057 , B01J20/28078 , B01J20/29 , B01J20/3092 , B01J20/3204 , B01J20/3246 , B01J20/3259 , B01J20/3261 , B01J20/3263 , B01J20/3265 , B01J2220/52 , B01J2220/54 , B01J2220/58 , C07C227/34

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