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1. 发明授权

EP0905506B1 Method and apparatus for transferring a liquid specimen into an optical cuvette, and polarimeter using said apparatus 有权
标题翻译：方法和用于光学反应杯供应的液体样品的装置，和旋光仪利用这样的装置
公开(公告)号：EP0905506B1
公开(公告)日：2005-11-30
申请号：EP98118018.5
申请日：1998-09-23
申请人： MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD.
发明人： Kawamura, Tatsurou , Miyazaki, Jinsei
IPC分类号： G01N21/11 , G01N21/21
CPC分类号： G01N21/11 , G01N1/14 , G01N21/21 , G01N2021/054 , G01N2021/115 , G01N2021/218

2. 发明授权

EP0902270B1 Sample cell for polarimetry and polarimeter 有权
标题翻译：极化样品池和旋光
公开(公告)号：EP0902270B1
公开(公告)日：2005-04-20
申请号：EP98116995.6
申请日：1998-09-08
申请人： Matsushita Electric Industrial Co., Ltd.
发明人： Kawamura, Tatsurou , Miyazaki, Jinsei , Kamei, Akihito
IPC分类号： G01N21/21 , G01N33/487 , G01N21/05 , G01N21/11
CPC分类号： G01N21/21

3. 发明公开

EP0957362A2 Dye-labeled protein conjugate and method for preparing the same 有权
标题翻译：色素标记蛋白质复合物和工艺制备它
公开(公告)号：EP0957362A2
公开(公告)日：1999-11-17
申请号：EP99108595.2
申请日：1999-05-07
申请人： Matsushita Electric Industrial Co., Ltd.
发明人： Shigetou, Nobuyuki , Miyazaki, Jinsei , Nakayama, Hiroshi
IPC分类号： G01N33/532 , G01N33/531
CPC分类号： G01N33/531 , G01N33/532
摘要： The present invention provides a dye-labeled protein conjugate in which a protein conjugate is labeled with a large number of dye molecules. In the dye-labeled protein conjugate, a protein conjugate that includes a protein and an antibody bound thereto via a disulfide bond is labeled with a cyanine dye represented by the formula (1) or the formula (2) given below:
where R 1 and R 2 denote hydrogen or an alkyl group, X denotes a halogen, M denotes hydrogen or an alkali metal, and n represents an integer in a range of 1 to 4.

4. 发明公开

EP0359063A2 Antibody having high affinity to methamphetamine and immunogen for obtaining the same 失效
标题翻译：抗体与甲基苯丙胺高亲和性和免疫原适合用于其生产。
公开(公告)号：EP0359063A2
公开(公告)日：1990-03-21
申请号：EP89116185.3
申请日：1989-09-01
申请人： MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD.
发明人： Miyazaki, Jinsei , Taketani, Makoto , Mitsumata, Tadayasu
IPC分类号： G01N33/94 , C12P21/08 , C12N5/00
CPC分类号： G01N33/531 , A61K47/646 , C07K16/44
摘要： In producing an antibody using a low molecular substance as an antigen, it is necessary to immunize with an immunogen which is prepared by binding the antigen to protein. Therefore, it is difficult to produce an antibody having a high affinity to the antigen. According to the present invention, investigations were made, paying attention to the molecular structure, especially the structure at the site binding to protein, of the antigen in production of the immunogen. As the result, there is used a process which comprises preparing an antigen derivative (e.g., aminobutyl amphetamine) using a compound (e.g., amphetamine) having such a structure that an alkyl group of the desired antigen (e.g., methamphetamine) is replaced with hydrogen atom, and then binding the antigen derivative with protein. Immunization using the thus obtained immunogen gives an antibody having a high affinity to methamphetamine and improved sensitivity of immunoassay by about 1000 times. Furthermore, by this immunogen, a monoclonal antibody having a high affinity to methamphetamine can be produced.
摘要翻译：在使用低分子物质作为抗原在抗体产生，有必要在所有的免疫原性是由抗原结合蛋白制备的免疫。因此，难以制造在具有对抗原的高亲和性抗体。。根据本发明，调查在生产免疫原性的被做了，关注的分子结构，在现场结合蛋白爱尤其是结构抗原。其结果，有使用方法，它包括制备抗原衍生物（例如，氨基丁基苯丙胺），使用的化合物（例如，安非他明），其具有检测的结构确实烷基所需抗原的基团（例如，甲基苯丙胺）与氢气置换原子，然后与结合蛋白的抗原衍生物。免疫使用如此获得的免疫原性抗体的给出了约1,000倍不必甲基苯丙胺和改进的免疫测定的灵敏度的高亲和力。进一步，由该免疫原性，能够制造具有对甲基苯丙胺的高亲和性的单克隆抗体。

5. 发明公开

EP0193931A3 Optical high density recording mediums, method for making same and method for recording optical information in the medium 失效
标题翻译：光学高密度记录介质，其制造方法和记录介质中的光学信息的方法
公开(公告)号：EP0193931A3
公开(公告)日：1988-06-29
申请号：EP86102848
申请日：1986-03-05
申请人： MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD.
发明人： Miyazaki, Jinsei , Ando, Eiji , Yoshino, Kimiaki , Morimoto, Kazuhisa
IPC分类号： G11B07/24
CPC分类号： G11B7/26 , G11B7/00455 , G11B7/244 , G11B7/2472 , G11B7/2475 , G11B2007/0013 , Y10S430/146 , Y10S430/163
摘要： An optical recording medium which comprises a substrate and a recording layer of at least two J-aggregates of dyes formed on the substrate is described. The dyes may be photochromic dyes or other types of dyes capable of forming the aggregates which have narrower absorption spectral ranges than original dyes. A plurality of information bits can be written in the recording layer by irradiation of one laser beam spot. The recording layer is formed by an LB film method or a method capable of fluidizing a dye solution in a direction horizontal to the substrate surface. A recording method using the medium is also described.

6. 发明公开

EP0182236A1 Optical recording medium 失效
标题翻译：光学记录载体。
公开(公告)号：EP0182236A1
公开(公告)日：1986-05-28
申请号：EP85114293.5
申请日：1985-11-09
申请人： MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD.
发明人： Yoshino, Kimiaki , Ando, Eiji , Miyazaki, Jinsei , Morimoto, Kazuhisa
IPC分类号： G11B7/24
CPC分类号： B82Y30/00 , G11B7/244 , Y10S430/136 , Y10S430/146 , Y10S430/162 , Y10S430/163
摘要： @ An optical recording medium comprising a substrate and an information recording layer which consists of monolayer assemblies comprising a photochromic compound of which is based on cis-trans isomerization such as an amphipathic derivative of azobenzene, indigo or thioindigo having a long chain substituent, which monolayers are formed on the substrate by the Langmuir-Blodgett method and oriented in a two-dimensional plain. When the recording medium is irradiated by light, light absorption spectrum of the recording layer changes so that information is recorded. Since the photochromic compound is oriented in a monolayer, its photochromism lasts long.

7. 发明公开

EP0957364A3 Dye-labeled protein conjugate and method for preparing the same 有权
标题翻译：色素标记蛋白质复合物和工艺制备它
公开(公告)号：EP0957364A3
公开(公告)日：2000-01-12
申请号：EP99108597.8
申请日：1999-05-07
申请人： Matsushita Electric Industrial Co., Ltd.
发明人： Shigetou, Nobuyuki , Miyazaki, Jinsei , Nakayama, Hiroshi
IPC分类号： G01N33/532 , G01N33/531 , G01N33/58 , G01N33/68
CPC分类号： G01N33/531 , G01N33/532
摘要： The present invention provides a dye-labeled protein conjugate in which a protein conjugate is labeled with a large number of dye molecules. In the dye-labeled protein conjugate, a protein conjugate that includes a protein and an antibody bound thereto via a disulfide bond is labeled with a cyanine dye represented by the formula (1) given below. where R 1 and R 2 denote hydrogen or an alkyl group, X denotes a halogen, M denotes hydrogen or an alkali metal, and n represents an integer in a range of 1 to 4.

8. 发明公开

EP0957361A3 Dye-labeled and polymerized antibody and method for preparing the same 审中-公开
标题翻译：色素标记聚合抗体和其制备方法
公开(公告)号：EP0957361A3
公开(公告)日：2000-01-12
申请号：EP99108594.5
申请日：1999-05-07
申请人： Matsushita Electric Industrial Co., Ltd.
发明人： Shigetou, Nobuyuki , Miyazaki, Jinsei , Hirai, Mahito
IPC分类号： G01N33/532 , G01N33/531 , G01N33/58 , G01N33/68
CPC分类号： G01N33/531 , G01N33/532
摘要： The present invention provides a highly sensitive dye-labeled and polymerized antibody that can detect a target substance even when the target substance has a low concentration. The dye-labeled and polymerized antibody of the present invention comprises a polymerized antibody, which has been polymerized with a polyfunctional reagent, and a cyanine dye for labeling the polymerized antibody represented by the formula (1) or the formula (2) given below: where R 1 and R 2 denote hydrogen or an alkyl group, X denotes a halogen, M denotes hydrogen or an alkali metal, and n represents an integer in a range of 1 to 4.

9. 发明公开

EP0957364A2 Dye-labeled protein conjugate and method for preparing the same 有权
标题翻译： Farbstoff-markierte Proteinkonjugat和Verfahren zu seiner Herstellung
公开(公告)号：EP0957364A2
公开(公告)日：1999-11-17
申请号：EP99108597.8
申请日：1999-05-07
申请人： Matsushita Electric Industrial Co., Ltd.
发明人： Shigetou, Nobuyuki , Miyazaki, Jinsei , Nakayama, Hiroshi
IPC分类号： G01N33/532 , G01N33/531
CPC分类号： G01N33/531 , G01N33/532
摘要： The present invention provides a dye-labeled protein conjugate in which a protein conjugate is labeled with a large number of dye molecules. In the dye-labeled protein conjugate, a protein conjugate that includes a protein and an antibody bound thereto via a disulfide bond is labeled with a cyanine dye represented by the formula (1) given below.
where R 1 and R 2 denote hydrogen or an alkyl group, X denotes a halogen, M denotes hydrogen or an alkali metal, and n represents an integer in a range of 1 to 4.
摘要翻译：本发明提供染料标记的蛋白质缀合物，其中蛋白质缀合物用大量染料分子标记。在染料标记的蛋白质缀合物中，包含蛋白质和通过二硫键结合的抗体的蛋白质缀合物用下面给出的式（1）表示的花青染料标记。其中R1和R2表示氢或烷基，X表示卤素，M表示氢或碱金属，n表示1至4的整数。

10. 发明公开

EP0957363A2 Dye-labeled and polymerized antibody and method for preparing the same 审中-公开
标题翻译：染料标记和聚合抗体及其制备方法
公开(公告)号：EP0957363A2
公开(公告)日：1999-11-17
申请号：EP99108596.0
申请日：1999-05-07
申请人： Matsushita Electric Industrial Co., Ltd.
发明人： Shigetou, Nobuyuki , Miyazaki, Jinsei , Hirai, Mahito
IPC分类号： G01N33/532 , G01N33/531
CPC分类号： G01N33/532 , G01N33/531
摘要： The present invention provides a highly sensitive dye-labeled and polymerized antibody that can detect a target substance even when the target substance has a low concentration. The dye-labeled and polymerized antibody of the present invention comprises a polymerized antibody, which has been polymerized with a polyfunctional reagent, and a cyanine dye for labeling the polymerized antibody represented by the formula (1) given below:

where R 1 and R 2 denote hydrogen or an alkyl group, X denotes a halogen, M denotes hydrogen or an alkali metal, and n represents an integer in a range of 1 to 4.
摘要翻译：本发明提供即使在目标物质浓度低的情况下也能够检测目标物质的高灵敏度的染料标记聚合抗体。本发明的染料标记聚合抗体包含已经与多官能试剂聚合的聚合抗体和用于标记由以下给出的式（1）表示的聚合抗体的花青染料：其中R 1和R 2表示氢或烷基，X表示卤素，M表示氢或碱金属，并且n表示1至4的整数。

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