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1. 发明公开

EP1467760A2 SYSTEMS AND METHODS FOR PHOTODYNAMIC THERAPY 审中-公开
标题翻译：系统和光动力治疗方法
公开(公告)号：EP1467760A2
公开(公告)日：2004-10-20
申请号：EP03704019.3
申请日：2003-01-23
申请人： Light Sciences Corporation
发明人： CHEN, James , CHRISTOPHERSEN, Julene , YEO, Nick , HEACOCK, Greg
IPC分类号： A61K41/00
CPC分类号： A61K41/0057 , A61B5/0059 , A61B5/411 , A61F9/0079 , A61F9/008 , A61F9/009 , A61F2009/00863 , A61K41/0061 , A61K41/0071 , A61K41/0076 , A61N5/0601 , A61N5/062 , A61N2005/0651 , A61N2005/0652
摘要： Systems and methods for performing photodynamic therapy wherein a photoreactive agent is delivered locally and activated with an external non-invasive energy source are provided. In one embodiment, a low energy light source is used to initiate fluorescence in target tissue containing photoreactive agent. The characteristic fluorescence of the abnormal target tissue is used to generate a map that is then used to direct targeted activation energy to the target tissue without collateral damage to healthy tissue.

2. 发明授权

EP1131100B1 THERAPEUTIC COMPOSITIONS FOR METABOLIC BONE DISORDERS OR BONE METASTASES COMPRISING A PHOTOSENSITIZER AND A BISPHOSPHONATE 有权
标题翻译：治疗组合物骨代谢紊乱与骨转移含有光敏剂和双膦酸盐
公开(公告)号：EP1131100B1
公开(公告)日：2003-03-12
申请号：EP00903278.0
申请日：2000-01-14
申请人： Light Sciences Corporation
发明人： CHEN, James
IPC分类号： A61K41/00 , A61K31/661 , A61K31/663 , A61P19/08
CPC分类号： A61K41/0057 , A61K41/0033 , A61K41/0071
摘要： The present invention is drawn to methods and compositions useful for targeting and treating target tissues affected by or involved in metabolic bone disorders and bone metastases with photodynamic therapy (PDT) in a mammalian subject. The compositions are bisphosphonates, pyrophosphates or bisphosphonate-like compounds conjugated to photosensitive agents which are optionally further conjugated to ligands which are target tissue specific antibodies, peptides or polymers. The methods of PDT treatment utilize these compositions to target the tissues or cells of a mammalian subject to be treated. The methods comprise irradiating at least a portion of the subject with light at a wavelength absorbed by said photosensitizing agent that under conditions of activation during photodynamic therapy using a relatively low fluence rate, but an overall high total fluence dose results in minimal collateral tissue damage.

3. 发明公开

EP1287602A1 CONTACTLESS ENERGY TRANSFER APPARATUS 审中-公开
标题翻译：接触能量传输设备
公开(公告)号：EP1287602A1
公开(公告)日：2003-03-05
申请号：EP01928415.7
申请日：2001-04-10
申请人： Light Sciences Corporation
发明人： CHEN, James , HUSTON, Darrin , WILKERSON, Brian
IPC分类号： H02K35/02 , H01M10/46
CPC分类号： A61N1/08 , A47J36/02 , A47J36/26 , A61F2250/0001 , A61N1/3787 , H01F38/12 , H01F38/14 , H01M10/46 , H01M10/48 , H02K5/1282 , H02K7/1807 , H02K7/1876 , H02K21/12 , H02K21/24 , H02K35/02 , H05B6/1236 , Y02B40/123
摘要： A flux generator base unit (20) electromagnetically coupled with a receiving unit to transfer energy into the receiving unit. The base unit (20) includes one or more permanent magnets (42) that produce a magnetic flux, which passes through a receiver coil (30) in the receiving unit. The receiver coil (30) is either disposed in a separate housing (29) that is electrically connected with a portable device, or integrated into the housing of the portable device. Either the permanent magnets (42) or a flux shunt (214) is moved in the base unit to produce the varying magnetic flux that is coupled to the receiver coil. As a result of the varying magnetic field experienced by the receiver coil, an electric current is induced in the receiver coil, which is conditioned (e.g., rectified, filtered, and regulated) by a conditioning circuit (34) to charge a battery or energize electronics contained in the portable device.

4. 发明公开

EP1644082A2 LIGHT GENERATING DEVICE THAT SELF CENTERS WITHIN A LUMEN TO RENDER PHOTODYNAMIC THERAPY 审中-公开
标题翻译： LIGHTS令人信服的器件; 导致管腔以自我为中心，光动力治疗
公开(公告)号：EP1644082A2
公开(公告)日：2006-04-12
申请号：EP04778803.9
申请日：2004-07-08
申请人： Light Sciences Corporation
发明人： CHEN, James , GUO, Zihong , LICHTTENEGGERE, Gary , SHINE, David , BURWELL, Phillip
IPC分类号： A61N5/067
CPC分类号： A61N5/0601 , A61M2025/1047 , A61N5/062 , A61N2005/0652 , A61N2005/1003
摘要： A light generating device (1) for illuminating tissue adjacent to a body lumen while a distal end (5) of the device is centered in the lumen, to render photodynamic therapy. The device can either occlude or displace bodily fluid, both without the use of a balloon. In one embodiment, a flushing lumen (4B) has a port adjacent to an array of light sources(10) , to displace bodily fluid that might otherwise absorb light. Another embodiment employs a centering (45) member that moves between a first position and a second position. The centering member centers the device in the lumen and preferably is formed of a shape memory material. In yet another embodiment, the device includes an outer sheath and an inner member that are independently positionable, enabling the centering member to be selectively positionable. The centering member can be non porous, such that the centering member also occludes fluid flow.

5. 发明公开

EP1267935A2 NOVEL TREATMENT FOR EYE DISEASE 审中-公开
标题翻译：治疗眼疾
公开(公告)号：EP1267935A2
公开(公告)日：2003-01-02
申请号：EP01901987.6
申请日：2001-01-12
申请人： Light Sciences Corporation
发明人： CHEN, James
IPC分类号： A61K47/48 , A61K41/00
CPC分类号： A61K41/0057 , A61K41/0071 , A61K41/0076 , A61K47/62 , A61K47/6843 , A61K47/6847 , Y10S514/912
摘要： This invention discloses methods, kits, and instructions to treat neovasculature diseases of the eye through the administration of a targeted photosensitizing agent and subsequent exposure to light of specific wavelength sufficient to photoactivate photosensitizing agent. The photosensitizing agent is bound to a composition that mediates site specific delivery to a neovasculature target tissue of a therapeutically effective amount of a photosensitizing agent that is activated by a relatively low fluence rate of light over a prolonged period of time. Diseases treatable under this invention, include: diabetic retinopathy; macular degeneration; and malignant uveal melanomas.

6. 发明公开

EP1212057A1 EXTENDED DURATION LIGHT ACTIVATED CANCER THERAPY 审中-公开
标题翻译：中长期光动力治疗癌症
公开(公告)号：EP1212057A1
公开(公告)日：2002-06-12
申请号：EP00957944.2
申请日：2000-08-31
申请人： Light Sciences Corporation
发明人： CHEN, James , SINGHAL, Anil
IPC分类号： A61K31/40
CPC分类号： A61K41/0057 , A61K41/0071 , A61N5/062
摘要： The present invention is drawn to methods and compounds for photodynamic therapy (PDT) of a target tissue or compositions in a mammalian subject, using a light source that preferably transmits light to a treatment site transcutaneously. The method provides for administering to the subject a therapeutically effective amount of a photosensitizing agent. This photosensitizing agent preferentially associates with the target tissue. Light at a wavelength or waveband corresponding to that which is absorbed by the photosensitizing agent is then administered. The light intensity is relatively low, but a high total fluence is employed to ensure the activation of the photosensitizing agent. Transcutaneous PDT is useful in the treatment of specifically selected target tissues, such as vascular endothelial tissue, the abnormal vascular walls of tumors, solid tumors of the head and neck, tumors of the gastrointestinal tract, tumors of the liver, tumors of the breast, tumors of the prostate, tumors of the lung, nonsolid tumors, malignant cells of the hematopoietic and lymphoid tissue and other lesions in the vascular system or bone marrow, and tissue or cells related to autoimmune and inflammatory disease.

7. 发明公开

EP1131100A2 THERAPEUTIC COMPOSITIONS FOR METABOLIC BONE DISORDERS OR BONE METASTASES 有权
标题翻译：治疗组合物骨代谢紊乱与骨转移
公开(公告)号：EP1131100A2
公开(公告)日：2001-09-12
申请号：EP00903278.0
申请日：2000-01-14
申请人： Light Sciences Corporation
发明人： CHEN, James
IPC分类号： A61K41/00
CPC分类号： A61K41/0057 , A61K41/0033 , A61K41/0071
摘要： The present invention is drawn to methods and compositions useful for targeting and treating target tissues affected by or involved in metabolic bone disorders and bone metastases with photodynamic therapy (PDT) in a mammalian subject. The compositions are bisphosphonates, pyrophosphates or bisphosphonate-like compounds conjugated to photosensitive agents which are optionally further conjugated to ligands which are target tissue specific antibodies, peptides or polymers. The methods of PDT treatment utilize these compositions to target the tissues or cells of a mammalian subject to be treated. The methods comprise irradiating at least a portion of the subject with light at a wavelength absorbed by said photosensitizing agent that under conditions of activation during photodynamic therapy using a relatively low fluence rate, but an overall high total fluence dose results in minimal collateral tissue damage.

8. 发明公开

EP1648562A2 DEVICE FOR DISTAL PROTECTION AND TREATMENT OF BLOOD VESSELS 有权
标题翻译： DEVICE远端保护和治疗血管
公开(公告)号：EP1648562A2
公开(公告)日：2006-04-26
申请号：EP04756854.8
申请日：2004-07-09
申请人： Light Sciences Corporation
发明人： CHEN, James , SHINE, David , LICHTTENEGGER, Gary , ZIHONG, Guo , BURWELL, Phillip , DALY, Steven
IPC分类号： A61N5/067
CPC分类号： A61N5/062 , A61B2017/22051 , A61N5/0601 , A61N2005/0652
摘要： Light generating devices for illuminating portions of vascular tissue to administer photodynamic therapy, and usable with, or including a distal protection device. A first device includes a hollow tip, a flushing lumen, a guidewire lumen, and at least one of a light source, and a hollow light transmissive shaft that is adapted to accommodate a light source. If desired, the device can include a balloon, so that a portion of a body lumen between the balloon and the distal protection device is isolated when the balloon is inflated. A second device includes inner and outer catheters, the outer catheter including a balloon, and the inner catheter including a light source and distal protection device comprising a shape memory polymer. Yet another device is a catheter having two balloons and a sleeve extending therebetween. Within the sleeve, the catheter includes a light source and an expanding member.

9. 发明公开

EP1237625A1 ILLUMINATING DEVICE FOR TREATING EYE DISEASE 审中-公开
标题翻译：照明装置用于眼科疾病医疗的治疗
公开(公告)号：EP1237625A1
公开(公告)日：2002-09-11
申请号：EP00982460.8
申请日：2000-12-05
申请人： Light Sciences Corporation
发明人： CHEN, James , WISCOMBE, Brent
IPC分类号： A61N5/00
CPC分类号： A61N5/062 , A61N2005/0642 , A61N2005/0648 , A61N2005/0651
摘要： A photodynamic therapy (PDT) device (20) utilizes a non-coherent light source (22) to activate a photoreactive agent for treating a diseased site in a patient's eye (10). When activated, the photoreactive agent causes a desired change in the diseased tissue of the treatment site. In one embodiment, the photoreactive agent is preferentially absorbed by the diseased tissue at the treatment site, and the light from the PDT device (20) is directed generally at the site. In another embodiment, the photoreactive agent is less selectively absorbed by the diseased tissue, and the light from the PDT device (20) is focused onto the diseased treatment site. The device preferably focuses the light emitted by a source using totally internally reflective (TIR) lenses (14), convergent lenses (24), divergent lenses, and/or deformable lenses. One embodiment incorporates a plurality of light sources of different wavebands, including a waveband that does not activate the photoreactive agent, so that the light source can be used to precisely target the focal point at the desired treatment site. Once targeted, a light source is energized to produce light in a waveband that activates the photoreactive agent and can penetrate different depths of tissue. The PDT device (20) can be incorporated into a headset or in an ophthalmic slit lamp.

10. 发明公开

EP1140176A1 TRANSCUTANEOUS PHOTODYNAMIC TREATMENT OF TARGETED CELLS 审中-公开
标题翻译： DUAL共轭皮光动力FOR脂质体系统肿瘤靶向治疗
公开(公告)号：EP1140176A1
公开(公告)日：2001-10-10
申请号：EP00902416.7
申请日：2000-01-14
申请人： Light Sciences Corporation
发明人： CHEN, James
IPC分类号： A61K41/00
CPC分类号： A61K41/0057 , A61K41/0061 , A61K41/0071 , A61K47/6817 , A61K47/6835 , A61K47/6849 , A61K47/6867 , A61N5/062
摘要： The present invention is drawn to methods and compounds for photodynamic therapy (PDT) of a target tissue or compositions in a mammalian subject, using a light source that preferably transmits light to a treatment site transcutaneously. The method provides for administering to the subject a therapeutically effective amount of a targeted substance, which is either a targeted photosensitizing agent, or a photosensitizing agent delivery system, or a targeted prodrug. This targeted substance preferably selectively binds to the target tissue. Light at a wavelength or waveband corresponding to that which is absorbed by the targeted substance is then administered. The light intensity is relatively low, but a high total fluence is employed to ensure the activation of the targeted photosensitizing agent or targeted prodrug product. Transcutaneous PDT is useful in the treatment of specifically selected target tissues, such as vascular endothelial tissue, the abnormal vascular walls of tumors, solid tumors of the head and neck, tumors of the gastrointestinal tract, tumors of the liver, tumors of the breast, tumors of the prostate, tumors of the lung, nonsolid tumors, malignant cells of the hermatopoietic and lymphoid tissue and other lesions in the vascular system or bone marrow, and tissue or cells related to autoimmune and inflammatory disease.

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