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1. 发明授权

EP1422523B1 Determination of sample volume adequacy in biosensors 有权
标题翻译：确定在生物传感器中的样品体积的准确度
公开(公告)号：EP1422523B1
公开(公告)日：2007-05-23
申请号：EP02258030.2
申请日：2002-11-21
申请人： LifeScan, Inc.
发明人： Kermani, Mahyar Z. , Teodorczyk, Maria , Guo, Sherry X.
IPC分类号： G01N33/487 , G01N33/49 , G01N27/22 , G01N27/04 , G01R27/26
CPC分类号： G01N27/3274

2. 发明公开

EP1391716A2 Electrochemical test strip with an integrated micro-needle and associated methods 审中-公开
标题翻译： Elektrochemischer Testreifen mit integrierter Mikronadel und entsprechendes Verfahren
公开(公告)号：EP1391716A2
公开(公告)日：2004-02-25
申请号：EP03255247.3
申请日：2003-08-22
申请人： LIFESCAN, INC.
发明人： Teodorczyk, Maria , Kiser, Ernest J. , Olson, Lorin P. , McAllister, Devin , Yuzhakov, Vadim V. , Leong, Koon-wah
IPC分类号： G01N11/00 , G01N33/49 , G01N33/86 , B01L3/00 , G01N27/00
CPC分类号： G01N33/86 , A61B5/150022 , A61B5/150358 , A61B5/150419 , A61B5/150435 , A61B5/150511 , A61B10/0045 , B01L3/5027 , B01L3/502715 , B01L2300/0672 , B01L2300/0825 , B01L2400/0406 , G01N11/00 , G01N27/307 , G01N33/4905 , G01N33/491 , G01N33/5438 , G01N2011/0066
摘要： Methods and devices for electrochemically detecting a change in the viscosity of a fluid are provided. In the subject methods, a fluid sample (e.g., a whole blood sample) is introduced into an electrochemical test strip's electrochemical cell using a micro-needle integrated into one of oppositely spaced apart working and reference electrodes. An electric potential is applied to the electrochemical cell to first achieve a steady state cell current. A decrease in the steady state cell current is then detected and related to a change in viscosity of the sample. In many embodiments, the sample is blood and the change in viscosity is related to the onset of coagulation in the blood sample, and often the PT of the blood sample. An electrochemical test strip includes an electrochemical cell and an integrated micro-needle. The electrochemical cell includes oppositely spaced apart working and reference electrodes and a reagent mixture (e.g., a redox couple and a coagulation catalyzing agent). The micro-needle is integrated into one of the working and reference electrodes of the electrochemical cell.
摘要翻译：提供了用于电化学检测流体粘度变化的方法和装置。在本发明的方法中，将流体样品（例如，全血样品）引入到电化学测试条的电化学电池中，使用集成到相对间隔的工作和参考电极之一中的微针。电化学电位被施加到电化学电池以首先实现稳态电池电流。然后检测稳态电池电流的降低，并与样品的粘度变化相关。在许多实施方案中，样品是血液，并且粘度的变化与血液样品中凝血的开始有关，并且通常与血液样品的PT有关。电化学测试条包括电化学电池和集成微针。电化学电池包括相对间隔的工作和参比电极和试剂混合物（例如，氧化还原对和凝结催化剂）。微针被集成到电化学电池的工作电极和参比电极之一中。

3. 发明公开

EP1318399A2 Passive sample detection to initiate timing of an assay 审中-公开
标题翻译：被动探测器初始分析
公开(公告)号：EP1318399A2
公开(公告)日：2003-06-11
申请号：EP02258481.7
申请日：2002-12-09
申请人： Lifescan, Inc.
发明人： Kermani, Mahyar Z. , Ohara, Timothy , Teodorczyk, Maria
IPC分类号： G01N33/487
CPC分类号： G01N27/3273
摘要： The present invention provides methods and systems for passively and automatically detecting the presence of a sample (the "sample detection phase") upon application of the sample to a biosensor, identifying the sample detection time and then initiating the measurement of a targeted characteristic, e.g. , the concentration of one or more analytes, of the sample (the "measurement phase"), immediately upon sample detection. The subject methods and systems do not employ or involve the application of an electrical signal from an external source to the electrochemical cell for purposes of performing the sample detection phase and are, thus, less complicated and involve fewer steps and components.
摘要翻译：本发明提供了将样品应用于生物传感器时被动地自动检测样品的存在（“样本检测阶段”）的方法和系统，识别样本检测时间，然后开始测量目标特征，例如，样品检测后立即检测样品的一种或多种分析物（“测量阶段”）的浓度。为了执行样品检测阶段的目的，本发明方法和系统不使用或涉及将外部来源的电信号施加到电化学电池，并且因此较不复杂并且涉及更少的步骤和组件。

4. 发明公开

EP2267149A1 A method of discriminating control solution from a physiological sample 有权转让
标题翻译： Verfahren zur Diskriminier derSteuerungslösungeiner physiologischen Probe
公开(公告)号：EP2267149A1
公开(公告)日：2010-12-29
申请号：EP10178905.5
申请日：2007-03-30
申请人： LifeScan, Inc.
发明人： Chatelier, Ronald C. , Hodges, Alastair McIndoe , Teodorczyk, Maria , Dato, Remedios
IPC分类号： C12Q1/00 , G01N33/487 , G01N27/49
CPC分类号： G01N27/3271 , C12Q1/001 , C12Q1/006 , G01N27/3274
摘要： Described herein are systems and methods for distinguishing between a control solution and a blood sample. In one aspect, the methods include using a test strip in which multiple current transients are measured by a meter electrically connected to an electrochemical test strip. The current transients are used to determine if a sample is a blood sample or a control solution based on at least two measured current values, which are summed.
摘要翻译：本文描述了用于区分对照溶液和血液样品的系统和方法。在一个方面，所述方法包括使用测试条，其中通过电连接到电化学测试条的仪表测量多个电流瞬变。目前的瞬变用于确定样品是否是基于至少两个测量电流值的血液样本或对照溶液，这些值是相加的。

5. 发明公开

EP1391716A3 Electrochemical test strip with an integrated micro-needle and associated methods 审中-公开
标题翻译：电化学测试轮胎具有集成的微针和对应的方法
公开(公告)号：EP1391716A3
公开(公告)日：2005-11-16
申请号：EP03255247.3
申请日：2003-08-22
申请人： LIFESCAN, INC.
发明人： Teodorczyk, Maria , Kiser, Ernest J. , Olson, Lorin P. , McAllister, Devin , Yuzhakov, Vadim V. , Leong, Koon-wah
IPC分类号： G01N11/00 , G01N33/49 , G01N33/86 , B01L3/00 , G01N27/00
CPC分类号： G01N33/86 , A61B5/150022 , A61B5/150358 , A61B5/150419 , A61B5/150435 , A61B5/150511 , A61B10/0045 , B01L3/5027 , B01L3/502715 , B01L2300/0672 , B01L2300/0825 , B01L2400/0406 , G01N11/00 , G01N27/307 , G01N33/4905 , G01N33/491 , G01N33/5438 , G01N2011/0066
摘要： Methods and devices for electrochemically detecting a change in the viscosity of a fluid are provided. In the subject methods, a fluid sample (e.g., a whole blood sample) is introduced into an electrochemical test strip's electrochemical cell using a micro-needle integrated into one of oppositely spaced apart working and reference electrodes. An electric potential is applied to the electrochemical cell to first achieve a steady state cell current. A decrease in the steady state cell current is then detected and related to a change in viscosity of the sample. In many embodiments, the sample is blood and the change in viscosity is related to the onset of coagulation in the blood sample, and often the PT of the blood sample. An electrochemical test strip includes an electrochemical cell and an integrated micro-needle. The electrochemical cell includes oppositely spaced apart working and reference electrodes and a reagent mixture (e.g., a redox couple and a coagulation catalyzing agent). The micro-needle is integrated into one of the working and reference electrodes of the electrochemical cell.

6. 发明公开

EP1318399A3 Passive sample detection to initiate timing of an assay 审中-公开
标题翻译：在分析开始评估被动样本
公开(公告)号：EP1318399A3
公开(公告)日：2005-04-20
申请号：EP02258481.7
申请日：2002-12-09
申请人： Lifescan, Inc.
发明人： Kermani, Mahyar Z. , Ohara, Timothy , Teodorczyk, Maria
IPC分类号： G01N33/487
CPC分类号： G01N27/3273
摘要： The present invention provides methods and systems for passively and automatically detecting the presence of a sample (the "sample detection phase") upon application of the sample to a biosensor, identifying the sample detection time and then initiating the measurement of a targeted characteristic, e.g. , the concentration of one or more analytes, of the sample (the "measurement phase"), immediately upon sample detection. The subject methods and systems do not employ or involve the application of an electrical signal from an external source to the electrochemical cell for purposes of performing the sample detection phase and are, thus, less complicated and involve fewer steps and components.

7. 发明公开

EP1398386A1 Mediator stabilized reagent compositions and methods for their use in electrochemical analyte detection assays 有权
标题翻译： Mediator-stableisierende Verbindung und Methoden zur Verwendung zur Detektion elektrochemischer Analyte
公开(公告)号：EP1398386A1
公开(公告)日：2004-03-17
申请号：EP03255680.5
申请日：2003-09-11
申请人： Lifescan, Inc.
发明人： Teodorczyk, Maria , Chatelier, Ronald C. , Hodges, Alastair McIndoe , Ohara, Timothy , Dato, Remy
IPC分类号： C12Q1/00
CPC分类号： C12Q1/005 , C12Q1/004
摘要： Mediator stabilized reagent compositions and methods for their use in electrochemical analyte determination assays are provided. The subject reagent compositions include an enzyme, a redox mediator and a mediator-stabilizing buffer. Optionally, the reagent compositions may further include one or more of a wetting agent, detergent, enzyme cofactor and combinations thereof. Also provided are electrochemical test strips that include the subject reagent compositions, systems and kits that include the same as well as methods for using the same in analyte detection assays. The subject invention finds use in a variety of different applications, including glucose concentration determination applications.
摘要翻译：试剂组合物包含酶，氧化还原介体和介体稳定缓冲液以稳定氧化还原介体。还包括以下独立权利要求：（1）包含试剂组合物的电化学电池; （2）包含电化学电池的电化学测试条; （3）制作电化学试片的方法，涉及使用试剂组成; （4）用于确定样品中分析物浓度的方法，其包括将样品施加到电化学电池，检测由所述电池产生的电信号并将检测到的电信号与样品中分析物的浓度相关联; （5）用于测定生理样品中分析物浓度的试剂盒，其包含电化学测试条和样品获得元素和分析物标准物; 和（6）包括用于读取测试条的电化学测试条和仪表的系统。

8. 发明授权

EP2267149B1 A method of discriminating control solution from a physiological sample 有权转让
标题翻译：从生理样本中区分对照溶液的方法
公开(公告)号：EP2267149B1
公开(公告)日：2018-03-07
申请号：EP10178905.5
申请日：2007-03-30
申请人： LifeScan, Inc.
发明人： Chatelier, Ronald C. , Hodges, Alastair McIndoe , Teodorczyk, Maria , Dato, Remedios
IPC分类号： C12Q1/00 , G01N33/487 , G01N27/49 , G01N27/327
CPC分类号： G01N27/3271 , C12Q1/001 , C12Q1/006 , G01N27/3274
摘要： Described herein are systems and methods for distinguishing between a control solution and a blood sample. In one aspect, the methods include using a test strip in which multiple current transients are measured by a meter electrically connected to an electrochemical test strip. The current transients are used to determine if a sample is a blood sample or a control solution based on at least two characteristics. Further described herein are methods for calculating a discrimination criteria based upon at least two characteristics. Still further described herein are system for distinguishing between blood samples and control solutions.

9. 发明公开

EP2034301A3 Analyte test strip with improved reagent deposition 有权
标题翻译：分析测试条具有改善的Reagenzauftragung
公开(公告)号：EP2034301A3
公开(公告)日：2010-01-13
申请号：EP08252946.2
申请日：2008-09-04
申请人： Lifescan, Inc.
发明人： Teodorczyk, Maria , Dato, Remedios , Leong, Koon-wah
IPC分类号： G01N27/327
CPC分类号： C12Q1/001 , G01N27/3272 , G01N33/521
摘要： An analyte test strip (30) is provided that includes a substrate (5), electrically conductive material (50) and an isolated portion (52,54,56) of the electrically conductive material. The substrate has a generally planar surface that extends from a first end (3) to a second end (4). The electrically conductive material is disposed on the generally planar surface to define a plurality of electrodes (10,12,14) spaced apart from each other. The isolated portion of the electrically conductive material is disposed between at least two electrodes so that the isolated portion is not in electrical communication with the plurality of electrodes.

10. 发明公开

EP1840219A1 Systems and methods of discriminating control solution from a physiological sample 有权转让
标题翻译：系统和方法，用于从血液生理样品区分对照溶液
公开(公告)号：EP1840219A1
公开(公告)日：2007-10-03
申请号：EP07251388.0
申请日：2007-03-30
申请人： LifeScan, Inc.
发明人： Chatelier, Ronald C. , Hodges, Alastair McIndoe , Teodorczyk, Maria , Dato, Remedios
IPC分类号： C12Q1/00 , G01N27/49 , G01N33/487
CPC分类号： G01N27/3271 , C12Q1/001 , C12Q1/006 , G01N27/3274
摘要： Described herein are systems and methods for distinguishing between a control solution and a blood sample. In one aspect, the methods include using a test strip in which multiple current transients are measured by a meter electrically connected to an electrochemical test strip. The current transients are used to determine if a sample is a blood sample or a control solution based on at least two characteristics. Further described herein are methods for calculating a discrimination criteria based upon at least two characteristics. Still further described herein are system for distinguishing between blood samples and control solutions.
摘要翻译：描述为针对控制溶液和血液样品之间进行区分的系统和方法。在一个方面，所述方法包括使用在多个测试条，其电流瞬变通过在电化学测试条电连接到计进行测定。的电流瞬变被用于确定性地雷，如果样品是血液样品或对照溶液基于至少两个特征。进一步描述的是在用于计算基于至少两个特征的判别标准的方法。仍然在顷系统进一步描述用于血液样本和控制解决方案之间进行区分。

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