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1. 发明公开

EP1407012A1 METHODS OF CREATING GENETIC DIVERSITY 审中-公开
标题翻译：制备遗传多样性的方法
公开(公告)号：EP1407012A1
公开(公告)日：2004-04-14
申请号：EP02787134.2
申请日：2002-07-17
申请人： Libragen , CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE (CNRS) , Ecole Centrale De Lyon , UNIVERSITE CLAUDE BERNARD - LYON 1
发明人： NALIN, Renaud , DEMANECHE, Sandrine , BERTOLLA, Franck , BURET, François , AURIOL, Philippe , VOGEL, Timothy , SIMONET, Pascal
IPC分类号： C12N15/00 , C12N15/87 , C12N13/00 , A01H1/06 , C12Q1/02
CPC分类号： C12N15/1027
摘要： The present invention relates to methods of creating genetic diversity .The invention also relates to methods of making nucleic acid libraries and their uses to screen for biological activities. The invention can be used to create, improve or modify nucleic acid sequences or repertoire, particularly from non-cultivable microorganisms and finds various applications in the medical, food, agriculture or veterinary industries, for instance. The invention particularly uses and discloses in situ gene shuffling.

2. 发明公开

EP2002002A2 METHOD OF IN VITRO POLYNUCLEOTIDE SEQUENCES SHUFFLING BY RECURSIVE CIRCULAR DNA MOLECULES FRAGMENTATION AND LIGATION 审中-公开
标题翻译： FOR多核苷酸序列在体外改组法通过反复和破碎结扎环状DNA分子
公开(公告)号：EP2002002A2
公开(公告)日：2008-12-17
申请号：EP07734893.6
申请日：2007-04-03
申请人： Libragen
发明人： LEFEVRE, Fabrice , NALIN, Renaud , JARRIN, Cyrille
IPC分类号： C12N15/10
CPC分类号： C12N15/1027
摘要： The present invention relates to a method for in vitro recombining polynucleotides sequences of interest from at least two initial different polynucleotide sequences of interest by cleavage/ligation of circular DNA molecules.

3. 发明授权

EP1278831B1 PROCEDE D'EXTRACTION INDIRECTE D'ADN D'ORGANISMES NON CULTIVABLES 有权
标题翻译：方法对于来自非培养微生物DNA的间接分离
公开(公告)号：EP1278831B1
公开(公告)日：2005-11-30
申请号：EP01921457.6
申请日：2001-04-03
申请人： Libragen
发明人： NALIN, Renaud , ROBE, Patrick , TRAN VAN, Van
IPC分类号： C12N15/10 , C07H21/04 , G01N27/447
CPC分类号： G01N27/44773 , C12N15/1003
摘要： The invention concerns a method for indirectly extracting DNA target with a size greater than 300 kB from non-cultivable organisms contained in an environmental sample which consists in: grinding said sample in liquid medium; recuperating the resulting ground material; separating the organisms from the rest of the ground material by sedimentation on a cushion with density higher than 1; recuperating the organisms isolated at the surface of the cushion and incorporating it in an agarose block; extracting the DNA by lysis in the agarose block; placing the block in an agarose gel which is subjected to at least pulsed field electrophoresis; finally, recuperating the extracted DNA strands.

4. 发明公开

EP2379576A1 HYDROSOLUBLE [6)-O-alpha-D-GLCP-(1->]n-6-O-beta-D-GLCP-(1->-PHENOLIC DERIVATIVES WITH DERMOCOSMETIC, NUTRITIONAL AND THERAPEUTIC APPLICATIONS, AND COMPOSITIONS CONTAINING SAID WATER SOLUBLE COMPOUNDS 审中-公开
标题翻译：水溶性[6）O-A-D-GLC P（1 - >] N-6-O-B-D-GLC P（1 - > - WITH皮肤化妆品，食品关心，治疗应用中，和组合物本水溶性化合物苯酚衍生物
公开(公告)号：EP2379576A1
公开(公告)日：2011-10-26
申请号：EP09795446.5
申请日：2009-12-22
申请人： Libragen
发明人： AURIOL, Daniel , GINOLHAC, Aurélien , LEFEVRE, Fabrice , NALIN, Renaud
IPC分类号： C07H15/203 , C07H15/26 , A61K8/00 , A61K31/7034 , A61P35/00
CPC分类号： C07H15/203 , A61K8/602 , A61K2800/522 , A61Q19/00 , C07H15/26
摘要： The invention relates to [6)-O-α-D-Glcp→]1 →]
n -6-O-β-D-Glcp-(1→-phenolic derivatives. These [6)-O-α-D-Glcp-(1→]
n -6-O-β-D-Glcp-(1→-phenolic derivatives of selected phenolics are new, have a solubility in water higher than that of their parent O-β-D-Glcp- (1→-phenolic derivatives and have useful applications in cosmetic, nutrition and pharmaceutical compositions, such as treating or preventing oxidative stress, a cancer, a cardiovascular disease, a bacterial infection, a viral infection, a fungal infection, a UV- induced erythema, an allergy, a metabolism disorder, diabetes, an obesity, an hormonal disorder, a bone disease, a pain, a brain disease, a mouth or teeth disease, an inflammatory or immune disorder.

5. 发明授权

EP1730296B1 METHODE D'IDENTIFICATION DE FAMILLE DE VOIE METABOLIQUE PAR SELECTION POSITIVE 有权
标题翻译：方法鉴定阳性选择的代谢FAMILY MEANS
公开(公告)号：EP1730296B1
公开(公告)日：2009-06-10
申请号：EP05742624.9
申请日：2005-03-22
申请人： Libragen
发明人： MONSAN, Pierre , BENSOUSSAN, Claude , REULET, Philippe , NALIN, Renaud , ROBE, Patrick , TUPHILE, Karine , GILLET, Benjamin , PUJIC, Pierre
IPC分类号： C12Q1/04
CPC分类号： C12P7/40 , C12N2503/02 , C12P7/02 , C12P13/02 , C12P33/00
摘要： The invention relates to the direct selection of metabolic pathways having a determined function in the transformation of a substrate {Ai} into a target product {B}, which is of interest in the industrial, pharmaceutical or agri-food sectors. More specifically, the invention relates to the detection, within metagenomic libraries, of novel biosynthesis pathways involved in a biochemical reaction having a known product {B}. The selection and characterisation of said novel metabolic pathways enables {B} to be produced enzymatically. The invention provides an alternative to the chemical synthesis of the molecule in question {B}. Moreover, and above all, the invention can be used specifically to target and exploit the only metabolic pathways enabling the transformation of {Ai} into {B}, while eliminating the associated metabolic pathways that can catabolise the target product {B}.

6. 发明公开

EP1730296A1 METHODE D'IDENTIFICATION DE FAMILLE DE VOIE METABOLIQUE PAR SELECTION POSITIVE 有权
标题翻译：方法鉴定阳性选择的代谢FAMILY MEANS
公开(公告)号：EP1730296A1
公开(公告)日：2006-12-13
申请号：EP05742624.9
申请日：2005-03-22
申请人： Libragen
发明人： MONSAN, Pierre , BENSOUSSAN, Claude , REULET, Philippe , NALIN, Renaud , ROBE, Patrick , TUPHILE, Karine , GILLET, Benjamin , PUJIC, Pierre
IPC分类号： C12Q1/04
CPC分类号： C12P7/40 , C12N2503/02 , C12P7/02 , C12P13/02 , C12P33/00
摘要： The invention relates to the direct selection of metabolic pathways having a determined function in the transformation of a substrate {Ai} into a target product {B}, which is of interest in the industrial, pharmaceutical or agri-food sectors. More specifically, the invention relates to the detection, within metagenomic libraries, of novel biosynthesis pathways involved in a biochemical reaction having a known product {B}. The selection and characterisation of said novel metabolic pathways enables {B} to be produced enzymatically. The invention provides an alternative to the chemical synthesis of the molecule in question {B}. Moreover, and above all, the invention can be used specifically to target and exploit the only metabolic pathways enabling the transformation of {Ai} into {B}, while eliminating the associated metabolic pathways that can catabolise the target product {B}.

7. 发明公开

EP2552397A2 COMPOSITION COSMETIQUE ET PHARMACEUTIQUE COMPRENANT DU N-ACETYL-GLUCOSAMINE-6-PHOSPHATE 有权
标题翻译：与N-乙酰氨基葡糖-6-磷酸和维生素A化合物的化妆品和药物组合物
公开(公告)号：EP2552397A2
公开(公告)日：2013-02-06
申请号：EP11720140.0
申请日：2011-04-01
申请人： Libragen
发明人： AURIOL, Daniel , LEFEVRE, Fabrice , NALIN, Renaud , REDZINIAK, Gérard
IPC分类号： A61K8/60 , A61K8/67 , A61K31/07 , A61K31/11 , A61K31/192 , A61K31/203 , A61K31/232 , A61K31/7008 , A61Q19/00 , A61Q19/08 , A61P17/06 , A61P17/16 , A61P19/02 , A61P29/00
CPC分类号： A61K31/07 , A61K8/60 , A61K8/671 , A61K31/11 , A61K31/192 , A61K31/203 , A61K31/232 , A61K31/7008 , A61Q1/14 , A61Q19/08
摘要： The present invention relates to a cosmetic or pharmaceutical composition comprising N-acetylglucosamine-6-phosphate or a salt thereof and, optionally, a compound of the vitamin A family, and also to a device containing same. The composition can be used to treat dry skin, skin aging and wrinkles, to improve elasticity and to tighten the skin, to enhance the synthesis of structural macromolecules, e.g. hyaluronan and collagen, to treat psoriasis, atopic dermatitis or eczema or for treatments associated with surgery.

8. 发明公开

EP2150620A2 METHOD FOR PREPARING C-6 PHOSPHORYLATED D-ALDOHEXOSES AND C-6 PHOSPHORYLATED D-ALDOHEXOSE DERIVATIVES, AND NEW C-6 PHOSPHORYLATED D-ALDOHEXOSE DERIVATIVES 有权
标题翻译：一种用于C-6磷酸化的D-己醛糖的C-6磷酸化的D-己醛糖和其衍生物，和C-6磷酸化的D-己醛糖的新衍生物的制备过程
公开(公告)号：EP2150620A2
公开(公告)日：2010-02-10
申请号：EP08759951.0
申请日：2008-05-23
申请人： Libragen
发明人： AURIOL, Daniel , NALIN, Renaud , LEFEVRE, Fabrice , GINOLHAC, Aurélien , DE GUEMBECKER, Daphné , ZAGO, Caroline
IPC分类号： C12P17/00 , C12P19/02 , C12P19/26 , C12P19/28 , C07D309/10 , C07D309/14 , C07D335/02 , C07H1/02 , C07H5/10 , C07H11/04 , C07H15/04 , C07H15/12 , C07D211/40 , C07D211/54 , C07D211/56 , C07D309/08
CPC分类号： C12P19/02 , C07D211/46 , C07D211/54 , C07D309/10 , C07D309/14 , C07D335/02 , C07H11/04 , C07H15/04 , C12P17/00 , C12P19/26 , C12P19/28
摘要： The present invention concerns a method for preparing C-6 phosphorylated D- aldohexoses and C-6 phosphorylated D-aldohexose derivatives, new C-6 phosphorylated D-aldohexoses derivatives and uses thereof. The method comprises incubating polyphosphate as sole source of phosphate donor and a polyphosphate-glucose phosphotransferase (polyphosphate: D-glucose 6-phosphotransferase, EC 2.7.1.63) in an aqueous solution with aD-aldohexose or a D-aldohexose derivative.

9. 发明公开

EP1539952A1 METHOD FOR THE EXPRESSION OF UNKNOWN ENVIRONMENTAL DNA INTO ADAPTED HOST CELLS 有权
标题翻译： VERFAHREN ZUR EXPRESSION UNBEKANNTER UMGEBUNGS-DNA IN ADAPTIERTE WIRTSZELLEN
公开(公告)号：EP1539952A1
公开(公告)日：2005-06-15
申请号：EP03766202.0
申请日：2003-07-17
申请人： Libragen
发明人： NALIN, Renaud , PUJIC, Petar , TUPHILE, Karine , GILLET, Benjamin
IPC分类号： C12N15/10 , C07K14/00 , C07H21/00
CPC分类号： C07K14/195 , C07H21/00 , C12N9/22 , C12N15/1034 , C12N15/1079 , C12N15/1086 , C12N15/70 , C12N15/76
摘要： The present invention relates to methods for the identification or cloning of polynucleotides encoding a selected phenotype, particularly from environmental DNA. In a specific embodiment, the method comprises (i) cloning environmental DNA fragments into Ecoli cloning vectors to produce a metagenomic library, (ii) identifying or selecting cloning vectors in said library which contain DNA fragments having a particular characteristic of interest, (iii) modifying the identified or selected cloning vectors into shuttle or expression vectors for transfer and integration in a selected host cell, (iv) transferring the modified cloning vectors into said selected host cell and (v) identifying or cloning the DNA fragments contained in said modified cloning vectors which encode said selected phenotype in said selected host cell.
摘要翻译：本发明涉及用于鉴定或克隆编码选择的表型的多核苷酸，特别是来自环境DNA的方法。在一个具体实施方案中，所述方法包括（i）将环境DNA片段克隆到大肠杆菌克隆载体中以产生宏基因组文库，（ii）在所述文库中鉴定或选择含有具有特定特征特征的DNA片段的克隆载体（ iii）将鉴定或选择的克隆载体修饰为穿梭或表达载体以在所选择的宿主细胞中转移或表达，（iv）将修饰的克隆载体转移或表达到所述选择的宿主细胞中，以及（v）鉴定或克隆含有在所述修饰的克隆载体中，所述克隆载体在所述选择的宿主细胞中编码所述选择的表型。

10. 发明授权

EP1539952B1 METHOD FOR THE EXPRESSION OF UNKNOWN ENVIRONMENTAL DNA INTO ADAPTED HOST CELLS 有权
标题翻译：表达未知环境DNA IN方法适应的宿主细胞
公开(公告)号：EP1539952B1
公开(公告)日：2014-08-13
申请号：EP03766202.0
申请日：2003-07-17
申请人： Libragen
发明人： NALIN, Renaud , PUJIC, Petar , TUPHILE, Karine , GILLET, Benjamin
IPC分类号： C12N15/10 , C07K14/00 , C07H21/00
CPC分类号： C07K14/195 , C07H21/00 , C12N9/22 , C12N15/1034 , C12N15/1079 , C12N15/1086 , C12N15/70 , C12N15/76

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