专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

EP3112365B1 NUCLEAR MEDICINE DIAGNOSTIC IMAGING AGENT 有权
公开(公告)号：EP3112365B1
公开(公告)日：2018-09-26
申请号：EP16167782.8
申请日：2016-04-29
申请人： KYOTO UNIVERSITY , ARKRAY, Inc.
发明人： SAJI, Hideo , KIMURA, Hiroyuki , MATSUDA, Hirokazu , NAKANISHI, Shuichi
IPC分类号： C07D471/04 , A61K51/04 , C07B59/00
CPC分类号： A61K51/0459 , A61K51/0463 , C07B59/002 , C07D471/04
摘要： Provided is a radioactive labeled compound that can detect a secondary mutation of an epidermal growth factor receptor and which is a compound represented by Formula (1) described below or a pharmaceutically acceptable salt thereof. In Formula (1), L 1 is an alkanediyl group having 1 to 5 carbon atoms or an alkenediyl carbonyl group having 3 to 8 carbon atoms, R 1 is a radioactive halogen atom, or 5- to 7-membered monocyclic nitrogen-containing heterocycloalkyl that may have one substituent, R 2 is a 6- to 8-membered aryl group or nitrogen-containing heteroaryl group with one substituent, R 1 or R 2 contains a radioactive halogen atom or a radioactive carbon atom ( 11 C), and Y is -NH- or -O-.

2. 发明授权

EP2474326B1 MOLECULAR PROBE FOR IMAGING ISLETS OF LANGERHANS, AND USE THEREFOR 有权转让
公开(公告)号：EP2474326B1
公开(公告)日：2020-04-08
申请号：EP10813687.0
申请日：2010-08-31
申请人： Kyoto University , ARKRAY, Inc.
发明人： INAGAKI, Nobuya , SAJI, Hideo , TOYODA, Kentaro , KIMURA, Hiroyuki , OGAWA, Yu , HIRAO, Konomu , NAGAKAWA, Kenji , MATSUDA, Hirokazu
IPC分类号： A61K51/08 , A61K101/02

3. 发明授权

EP2484386B1 MOLECULAR PROBE FOR PANCREATIC ISLETS IMAGING AND USE OF SAID PROBE 有权转让
公开(公告)号：EP2484386B1
公开(公告)日：2019-04-17
申请号：EP10820575.8
申请日：2010-09-29
申请人： Kyoto University , ARKRAY, Inc.
发明人： SAJI, Hideo , INAGAKI, Nobuya , TOYODA, Kentaro , KIMURA, Hiroyuki , HIRAO, Konomu , NAGAKAWA, Kenji , MATSUDA, Hirokazu
IPC分类号： A61K51/08 , A61K101/02 , C07K14/605

4. 发明公开

EP3112365A1 NUCLEAR MEDICINE DIAGNOSTIC IMAGING AGENT 有权
标题翻译： NUKLEARMEDIZINISCHES诊断BILDGEBUNGSMITTEL
公开(公告)号：EP3112365A1
公开(公告)日：2017-01-04
申请号：EP16167782.8
申请日：2016-04-29
申请人： KYOTO UNIVERSITY , ARKRAY, Inc.
发明人： SAJI, Hideo , KIMURA, Hiroyuki , MATSUDA, Hirokazu , NAKANISHI, Shuichi
IPC分类号： C07D471/04 , A61K51/04 , C07B59/00
CPC分类号： A61K51/0459 , A61K51/0463 , C07B59/002 , C07D471/04
摘要： Provided is a radioactive labeled compound that can detect a secondary mutation of an epidermal growth factor receptor and which is a compound represented by Formula (1) described below or a pharmaceutically acceptable salt thereof. In Formula (1), L 1 is an alkanediyl group having 1 to 5 carbon atoms or an alkenediyl carbonyl group having 3 to 8 carbon atoms, R 1 is a radioactive halogen atom, or 5- to 7-membered monocyclic nitrogen-containing heterocycloalkyl that may have one substituent, R 2 is a 6- to 8-membered aryl group or nitrogen-containing heteroaryl group with one substituent, R 1 or R 2 contains a radioactive halogen atom or a radioactive carbon atom ( 11 C), and Y is -NH- or -O-.
摘要翻译：本发明提供能够检测表皮生长因子受体的二次突变的放射性标记化合物，其为由下述式（1）表示的化合物或其药学上可接受的盐。式（1）中，L 1为碳原子数为1〜5的烷二基或碳原子数为3〜8的烯二基羰基，R 1为放射性卤素原子或5〜7元单环含氮杂环烷基可以具有一个取代基，R 2是具有一个取代基的6至8元芳基或含氮杂芳基，R 1或R 2含有放射性卤素原子或放射性碳原子（11 C），Y 是-NH-或-O-。

5. 发明公开

EP2660249A1 PEPTIDE DERIVATIVE AND USE THEREOF 有权转让
标题翻译： PEPTIDDERIVAT UND SEINE VERWENDUNG
公开(公告)号：EP2660249A1
公开(公告)日：2013-11-06
申请号：EP11830776.8
申请日：2011-10-07
申请人： Kyoto University , Arkray, Inc.
发明人： SAJI, Hideo , INAGAKI, Nobuya , TOYODA, Kentaro , KIMURA, Hiroyuki , HIRAO, Konomu , MATSUDA, Hirokazu
IPC分类号： C07K14/46 , G01N33/53 , G01N33/536
CPC分类号： C07K14/57563 , A61K51/088 , G01N33/534 , G01N33/74 , G01N2800/042
摘要： A new peptide derivative is provided. The peptide derivative is represented by the following general formula (I),

where polypeptide ExP is a polypeptide that contains completely or partially the amino acid sequence of exendin-4, and the -L-Z group represents a group represented by the following formula (II) that is bound to an amino acid side chain of, or the α-amino group at the N-terminus of, the polypeptide ExP,
摘要翻译：提供了一种新的肽衍生物。肽衍生物由以下通式（I）表示，其中多肽ExP是完全或部分含有毒蜥外泌肽-4的氨基酸序列的多肽，-LZ基团表示由下式（II）表示的基团，其与多肽ExP的N-末端的氨基酸侧链或N-氨基结合，

6. 发明公开

EP2474326A1 MOLECULAR PROBE FOR IMAGING ISLETS OF LANGERHANS, AND USE THEREFORE 有权转让
标题翻译： MOLEKULARE SONDE ZUR BILDGEBUNG DER LANGERHANS-INSELN UND IHRE VERWENDUNG
公开(公告)号：EP2474326A1
公开(公告)日：2012-07-11
申请号：EP10813687.0
申请日：2010-08-31
申请人： Kyoto University , Arkray, Inc.
发明人： INAGAKI, Nobuya , SAJI, Hideo , TOYODA, Kentaro , KIMURA, Hiroyuki , OGAWA, Yu , HIRAO, Konomu , NAGAKAWA, Kenji
IPC分类号： A61K49/00 , C07K14/00
摘要： To provide a molecular probe for imaging of pancreatic islets. A molecular probe for use in imaging of pancreatic islets is provided. The molecular probe includes any one of the following polypeptides: polypeptides represented by the following formulae (1), (5), and (9); and polypeptides having homology with the foregoing polypeptides:
Z-DLSXQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH 2 (1)
Z-DLSKQMEEEAVRLFIEWLXNGGPSSGAPPPS-NH 2 (5)
B-DLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH 2 (9)

where X in the formulae (1) and (5) and B- in the formula (9) indicate that an amino group is labeled with a group represented by the formula (I) below having an aromatic ring,

where A represents either an aromatic hydrocarbon group or an aromatic heterocyclic group, R 1 represents a substituent that contains radioactive iodine, R 2 represents either a hydrogen atom or a substituent different from that represented by R 1 , and R 3 represents any one of a bond, a methylene group, and an oxymethylene group.
摘要翻译：提供胰岛成像的分子探针。提供了一种用于胰岛成像的分子探针。分子探针包括以下多肽之一：由下式（1），（5）和（9）表示的多肽; 和与前述多肽具有同源性的多肽：Z-DLSXQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH 2（1）Z-DLSKQMEEEAVRLFIEWLXNGGPSSGAPPPS-NH 2（5）B-DLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH 2（9）其中式（1）和（5）中的X和B - 在式（9）中表示氨基被具有芳环的式（I）表示的基团标记，其中A表示芳香族烃基或芳香族杂环基，R 1表示含有放射性碘，R 2表示氢原子或与R 1表示的不同的取代基，R 3表示键，亚甲基和氧亚甲基中的任一个。

7. 发明授权

EP2927239B1 POLYPEPTIDE AND IMAGING METHOD 有权
公开(公告)号：EP2927239B1
公开(公告)日：2019-09-04
申请号：EP13858604.5
申请日：2013-11-29
申请人： Kyoto University , ARKRAY, Inc.
发明人： SAJI, Hideo , INAGAKI, Nobuya , KIMURA, Hiroyuki , TOYODA, Kentaro , MATSUDA, Hirokazu , IOROI, Mikako , KON, Asami
IPC分类号： A61K49/04 , A61K51/08 , B82Y5/00 , C07K14/705 , C07K14/605 , C07K1/13 , G01N33/50

8. 发明授权

EP2510951B1 MOLECULAR PROBE FOR IMAGING OF PANCREATIC ISLET, AND USE THEREOF 有权转让
标题翻译：分子探针用于成像朗格汉斯群岛及其用途
公开(公告)号：EP2510951B1
公开(公告)日：2016-07-13
申请号：EP10836003.3
申请日：2010-12-08
申请人： Kyoto University , ARKRAY, Inc.
发明人： SAJI, Hideo , INAGAKI, Nobuya , TOYODA, Kentaro , KIMURA, Hiroyuki , HIRAO, Konomu , NAGAKAWA, Kenji , MATSUDA, Hirokazu
IPC分类号： A61K51/08 , G01N33/74 , C07K1/13 , C07K14/605 , G01T1/161
CPC分类号： G01N33/74 , A61K51/088 , C07K14/605

9. 发明授权

EP2418216B1 MOLECULAR PROBE FOR IMAGING OF PANCREATIC ISLET AND PRECURSOR THEREOF, AND USE OF THE MOLECULAR PROBE OR THE PRECURSOR 有权转让
标题翻译：分子探针朗格汉斯群岛成像和PRE体和分子探针或先行者的使用
公开(公告)号：EP2418216B1
公开(公告)日：2015-10-28
申请号：EP10808203.3
申请日：2010-08-09
申请人： Kyoto University , ARKRAY, Inc.
发明人： INAGAKI, Nobuya , SAJI, Hideo , TOYODA, Kentaro , KIMURA, Hiroyuki , OGAWA, Yu , HIRAO, Konomu , NAGAKAWA, Kenji , MATSUDA, Hirokazu
IPC分类号： C07K14/47 , A61K51/00 , G01T1/161
CPC分类号： C07K14/57563 , A61K51/08 , Y02P20/55

10. 发明公开

EP3111960A1 NUCLEAR MEDICINE DIAGNOSTIC IMAGING AGENT 有权
标题翻译：核医学诊断成像剂
公开(公告)号：EP3111960A1
公开(公告)日：2017-01-04
申请号：EP16177639.8
申请日：2016-07-01
申请人： KYOTO UNIVERSITY , ARKRAY, Inc.
发明人： SAJI, Hideo , KIMURA, Hiroyuki , MIYAZAKI, Anna , MATSUDA, Hirokazu , NAKANISHI, Shuichi
IPC分类号： A61K51/04
摘要： Provided is a radioactive labeled compound that can detect a secondary mutation of an epidermal growth factor receptor and which is a compound represented by Formula (1) or a pharmaceutically acceptable salt thereof. In Formula (1), R 1 is a group represented by Formula (a), (b) or (c), R 2 is a group represented by Formula (d) or (e), and Y is -NH- or -O-.
摘要翻译：本发明提供能够检测表皮生长因子受体的二次突变的放射性标记化合物，其是由式（1）表示的化合物或其药学上可接受的盐。式（1）中，R 1为式（a），（b）或（c）所示的基团，R 2为式（d）或（e）所示的基团，Y为-NH-或-O- 。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式