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1. 发明授权

EP2510951B1 MOLECULAR PROBE FOR IMAGING OF PANCREATIC ISLET, AND USE THEREOF 有权转让
标题翻译：分子探针用于成像朗格汉斯群岛及其用途
公开(公告)号：EP2510951B1
公开(公告)日：2016-07-13
申请号：EP10836003.3
申请日：2010-12-08
申请人： Kyoto University , ARKRAY, Inc.
发明人： SAJI, Hideo , INAGAKI, Nobuya , TOYODA, Kentaro , KIMURA, Hiroyuki , HIRAO, Konomu , NAGAKAWA, Kenji , MATSUDA, Hirokazu
IPC分类号： A61K51/08 , G01N33/74 , C07K1/13 , C07K14/605 , G01T1/161
CPC分类号： G01N33/74 , A61K51/088 , C07K14/605

2. 发明授权

EP2418216B1 MOLECULAR PROBE FOR IMAGING OF PANCREATIC ISLET AND PRECURSOR THEREOF, AND USE OF THE MOLECULAR PROBE OR THE PRECURSOR 有权转让
标题翻译：分子探针朗格汉斯群岛成像和PRE体和分子探针或先行者的使用
公开(公告)号：EP2418216B1
公开(公告)日：2015-10-28
申请号：EP10808203.3
申请日：2010-08-09
申请人： Kyoto University , ARKRAY, Inc.
发明人： INAGAKI, Nobuya , SAJI, Hideo , TOYODA, Kentaro , KIMURA, Hiroyuki , OGAWA, Yu , HIRAO, Konomu , NAGAKAWA, Kenji , MATSUDA, Hirokazu
IPC分类号： C07K14/47 , A61K51/00 , G01T1/161
CPC分类号： C07K14/57563 , A61K51/08 , Y02P20/55

3. 发明公开

EP2335739A1 MOLECULAR PROBE PRECURSOR FOR IMAGING OF PANCREATIC ISLET, AND USE THEREOF 有权转让
标题翻译：麦克卢瑟尔SONDENVORLÄUFERZUR BILDGEBUNG DER LANGERHANS-INSELN UND VERFAHRENDAFÜR
公开(公告)号：EP2335739A1
公开(公告)日：2011-06-22
申请号：EP09814677.2
申请日：2009-09-18
申请人： Kyoto University , ARKRAY, Inc.
发明人： INAGAKI, Nobuya , SAJI, Hideo , TOYODA, Kentaro , KIMURA, Hiroyuki , HIRAO, Konomu , NAGAKAWA, Kenji
IPC分类号： A61K49/00 , C07K14/00
摘要： A precursor of a molecular probe for imaging of pancreatic islets is provided. The precursor includes a polypeptide represented by any one of the following formulae (1) to (12), or a polypeptide having a homology with the foregoing polypeptide:
*-DLSKQMEEEAVRLFIEWLK* NGGPSSGAPPPS-NH 2 (1)
*-LSKQMEEEAVRLFIEWLK* NGGPSSGAPPPS-NH 2 (2)
*-SKQMEEEAVRLFIEWLK* NGGPSSGAPPPS-NH 2 (3)
*-KQMEEEAVRLFIEWLK* NGGPSSGAPPPS-NH 2 (4)
*-DLSK* QMEEEAVRLFIEWLKNGGPSSGAPPPS-NH 2 (5)
*-LSW QMEEEAVRLFIEWLKNGGPSSGAPPPS-NH 2 (6)
*-SK* QMEEEAVRLFIEWLKNGGPSSGAPPPS-NH 2 (7)
*-K* QMEEEAVRLFIEWLKNGGPSSGAPPPS-NH 2 (8)
DLSK* QMEEEAVRLFIEWLK* NGGPSSGAPPPS-NH 2 (9)
LSK* QMEEEAVRLFIEWLK* NGGPSSGAPPPS-NH 2 (10)
SK* QMEEEAVRLFIEWLK* NGGPSSGAPPPS-NH 2 (11)
K* QMEEEAVRLFIEWLK* NGGPSSGAPPPS-NH 2 (12)
摘要翻译：提供了用于胰岛成像的分子探针的前体。前体包括由下式（1）至（12）中的任一个表示的多肽或与前述多肽具有同源性的多肽：* -DLSKQMEEEAVRLFIEWLK * NGGPSSGAPPPS-NH 2（1）* -LSKQMEEEAVRLFIEWLK * NGGPSSGAPPPS-NH 2（2）* -SKQMEEEAVRLFIEWLK * NGGPSSGAPPPS-NH 2（3）* -KQMEEEAVRLFIEWLK * NGGPSSGAPPPS-NH 2（4）* -DLSK * QMEEEAVRLFIEWLKNGGPSSGAPPPS-NH 2（5）* -LSW QMEEEAVRLFIEWLKNGGPSSGAPPPS-NH 2（6）* -SK * QMEEEAVRLFIEWLKNGGPSSGAPPPS-NH 2（7）* -K * QMEEEAVRLFIEWLKNGGPSSGAPPPS-NH 2（8）DLSK * QMEEEAVRLFIEWLK * NGGPSSGAPPPS-NH 2（9）LSK * QMEEEAVRLFIEWLK * NGGPSSGAPPPS-NH 2（10）SK * QMEEEAVRLFIEWLK * NGGPSSGAPPPS-NH 2 11）K * QMEEEAVRLFIEWLK * NGGPSSGAPPPS-NH 2（12）

4. 发明授权

EP2474326B1 MOLECULAR PROBE FOR IMAGING ISLETS OF LANGERHANS, AND USE THEREFOR 有权转让
公开(公告)号：EP2474326B1
公开(公告)日：2020-04-08
申请号：EP10813687.0
申请日：2010-08-31
申请人： Kyoto University , ARKRAY, Inc.
发明人： INAGAKI, Nobuya , SAJI, Hideo , TOYODA, Kentaro , KIMURA, Hiroyuki , OGAWA, Yu , HIRAO, Konomu , NAGAKAWA, Kenji , MATSUDA, Hirokazu
IPC分类号： A61K51/08 , A61K101/02

5. 发明授权

EP2484386B1 MOLECULAR PROBE FOR PANCREATIC ISLETS IMAGING AND USE OF SAID PROBE 有权转让
公开(公告)号：EP2484386B1
公开(公告)日：2019-04-17
申请号：EP10820575.8
申请日：2010-09-29
申请人： Kyoto University , ARKRAY, Inc.
发明人： SAJI, Hideo , INAGAKI, Nobuya , TOYODA, Kentaro , KIMURA, Hiroyuki , HIRAO, Konomu , NAGAKAWA, Kenji , MATSUDA, Hirokazu
IPC分类号： A61K51/08 , A61K101/02 , C07K14/605

6. 发明公开

EP2660249A1 PEPTIDE DERIVATIVE AND USE THEREOF 有权转让
标题翻译： PEPTIDDERIVAT UND SEINE VERWENDUNG
公开(公告)号：EP2660249A1
公开(公告)日：2013-11-06
申请号：EP11830776.8
申请日：2011-10-07
申请人： Kyoto University , Arkray, Inc.
发明人： SAJI, Hideo , INAGAKI, Nobuya , TOYODA, Kentaro , KIMURA, Hiroyuki , HIRAO, Konomu , MATSUDA, Hirokazu
IPC分类号： C07K14/46 , G01N33/53 , G01N33/536
CPC分类号： C07K14/57563 , A61K51/088 , G01N33/534 , G01N33/74 , G01N2800/042
摘要： A new peptide derivative is provided. The peptide derivative is represented by the following general formula (I),

where polypeptide ExP is a polypeptide that contains completely or partially the amino acid sequence of exendin-4, and the -L-Z group represents a group represented by the following formula (II) that is bound to an amino acid side chain of, or the α-amino group at the N-terminus of, the polypeptide ExP,
摘要翻译：提供了一种新的肽衍生物。肽衍生物由以下通式（I）表示，其中多肽ExP是完全或部分含有毒蜥外泌肽-4的氨基酸序列的多肽，-LZ基团表示由下式（II）表示的基团，其与多肽ExP的N-末端的氨基酸侧链或N-氨基结合，

7. 发明公开

EP2474326A1 MOLECULAR PROBE FOR IMAGING ISLETS OF LANGERHANS, AND USE THEREFORE 有权转让
标题翻译： MOLEKULARE SONDE ZUR BILDGEBUNG DER LANGERHANS-INSELN UND IHRE VERWENDUNG
公开(公告)号：EP2474326A1
公开(公告)日：2012-07-11
申请号：EP10813687.0
申请日：2010-08-31
申请人： Kyoto University , Arkray, Inc.
发明人： INAGAKI, Nobuya , SAJI, Hideo , TOYODA, Kentaro , KIMURA, Hiroyuki , OGAWA, Yu , HIRAO, Konomu , NAGAKAWA, Kenji
IPC分类号： A61K49/00 , C07K14/00
摘要： To provide a molecular probe for imaging of pancreatic islets. A molecular probe for use in imaging of pancreatic islets is provided. The molecular probe includes any one of the following polypeptides: polypeptides represented by the following formulae (1), (5), and (9); and polypeptides having homology with the foregoing polypeptides:
Z-DLSXQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH 2 (1)
Z-DLSKQMEEEAVRLFIEWLXNGGPSSGAPPPS-NH 2 (5)
B-DLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH 2 (9)

where X in the formulae (1) and (5) and B- in the formula (9) indicate that an amino group is labeled with a group represented by the formula (I) below having an aromatic ring,

where A represents either an aromatic hydrocarbon group or an aromatic heterocyclic group, R 1 represents a substituent that contains radioactive iodine, R 2 represents either a hydrogen atom or a substituent different from that represented by R 1 , and R 3 represents any one of a bond, a methylene group, and an oxymethylene group.
摘要翻译：提供胰岛成像的分子探针。提供了一种用于胰岛成像的分子探针。分子探针包括以下多肽之一：由下式（1），（5）和（9）表示的多肽; 和与前述多肽具有同源性的多肽：Z-DLSXQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH 2（1）Z-DLSKQMEEEAVRLFIEWLXNGGPSSGAPPPS-NH 2（5）B-DLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH 2（9）其中式（1）和（5）中的X和B - 在式（9）中表示氨基被具有芳环的式（I）表示的基团标记，其中A表示芳香族烃基或芳香族杂环基，R 1表示含有放射性碘，R 2表示氢原子或与R 1表示的不同的取代基，R 3表示键，亚甲基和氧亚甲基中的任一个。

8. 发明授权

EP2335739B1 MOLECULAR PROBE PRECURSOR FOR IMAGING OF PANCREATIC ISLET, AND USE THEREOF 有权转让
公开(公告)号：EP2335739B1
公开(公告)日：2020-04-08
申请号：EP09814677.2
申请日：2009-09-18
申请人： Kyoto University , ARKRAY, Inc.
发明人： INAGAKI, Nobuya , SAJI, Hideo , TOYODA, Kentaro , KIMURA, Hiroyuki , HIRAO, Konomu , NAGAKAWA, Kenji
IPC分类号： A61K51/08 , A61K101/02 , A61P3/10 , A61K49/00 , C07K14/00

9. 发明授权

EP2660249B1 PEPTIDE DERIVATIVE AND USE THEREOF 有权转让
公开(公告)号：EP2660249B1
公开(公告)日：2019-07-10
申请号：EP11830776.8
申请日：2011-10-07
申请人： Kyoto University , ARKRAY, Inc.
发明人： SAJI, Hideo , INAGAKI, Nobuya , TOYODA, Kentaro , KIMURA, Hiroyuki , HIRAO, Konomu , MATSUDA, Hirokazu
IPC分类号： C07K14/46 , G01N33/53 , G01N33/536

10. 发明公开

EP2418216A1 MOLECULAR PROBE FOR IMAGING OF PANCREATIC ISLET AND PRECURSOR THEREOF, AND USE OF THE MOLECULAR PROBE OR THE PRECURSOR 有权转让
标题翻译：分子探针朗格汉斯群岛成像和PRE体和分子探针或先行者的使用
公开(公告)号：EP2418216A1
公开(公告)日：2012-02-15
申请号：EP10808203.3
申请日：2010-08-09
申请人： Kyoto University , Arkray, Inc.
发明人： INAGAKI, Nobuya , SAJI, Hideo , TOYODA, Kentaro , KIMURA, Hiroyuki , OGAWA, Yu , HIRAO, Konomu , NAGAKAWA, Kenji , MATSUDA, Hirokazu
IPC分类号： C07K14/47 , A61K51/00 , G01T1/161
CPC分类号： C07K14/57563 , A61K51/08 , Y02P20/55
摘要： A precursor of molecular probe for imaging of pancreatic islets is provided. A polypeptide represented by any one of the following formulae (1) to (4), or a polypeptide having a homology with the foregoing polypeptide.
*-DLSK* QMEEEAVRLFIEWLK* NGGPSSGAPPPSK-NH 2 (1)
*-LSK* QMEEEAVRLFIEWLK* NGGPSSGAPPPSK-NH 2 (2)
*-SK* QMEEEAVRLFIEWLK* NGGPSSGAPPPSK-NH 2 (3)
*-K* QMEEEAVRLFIEWLK* NGGPSSGAPPPSK-NH 2 (4),

in the foregoing formulae (1) to (4) *- indicates that an α-amino group at an N-terminus is protected by a protecting group or modified with a modifying group having no electric charge; K* indicates that an amino group of a side chain of a lysine is protected by a protecting group; and -NH 2 indicates that a carboxyl group at a C-terminus is amidated.
摘要翻译：提供了一种用于胰岛成像用分子探针的前体。通过满足下式中的任一个表示的多肽（1）〜（4），或者具有与上述多肽的同源性的多肽。 * * -DLSK * QMEEEAVRLFIEWLK NGGPSSGAPPPSK-NH 2（1）* * -LSK * QMEEEAVRLFIEWLK NGGPSSGAPPPSK-NH 2（2）* -SK * * QMEEEAVRLFIEWLK NGGPSSGAPPPSK-NH 2（3）* -K * * QMEEEAVRLFIEWLK NGGPSSGAPPPSK-NH 2（（4）在前述式餐饮（1）至4）* - 表示没有在N末端至±氨基被保护基保护或与具有不带电荷的修饰基改性; K *表示没有到氨基酸赖氨酸被保护基团保护的侧链的基团; 和NH 2表示并在C末端的羧基被酰胺化。

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