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1. 发明授权

EP3077987B1 FLUORESCENCE IMAGE PROCESSING APPARATUS AND METHOD 有权
标题翻译：荧光图像处理装置和方法
公开(公告)号：EP3077987B1
公开(公告)日：2017-07-05
申请号：EP14803161.0
申请日：2014-11-28
申请人： Koninklijke Philips N.V.
发明人： VINK, Jelte Peter , VAN LEEUWEN, Marinus Bastiaan
IPC分类号： G06T5/00 , G06T5/40 , G06T5/20 , G06T7/00
CPC分类号： G06T7/136 , G06K9/0014 , G06T5/002 , G06T5/008 , G06T5/20 , G06T5/40 , G06T7/11 , G06T7/194 , G06T2207/10056 , G06T2207/10064 , G06T2207/30024
摘要： A fluorescence image processing apparatus for enhancing a fluorescence image includes an image segmentation unit, a background determination unit a background reduction unit, and an image enhancement unit. The background and the area of interest of a glass slide are first segmented and then this segmentation is used to enhance the contrast between both areas.
摘要翻译：用于增强荧光图像的荧光图像处理装置包括图像分割单元，背景确定单元，背景缩小单元和图像增强单元。首先对载玻片的背景和感兴趣区域进行分割，然后使用该分割来增强两个区域之间的对比度。

2. 发明公开

EP2719095A1 CODED-LIGHT DETECTION SYSTEM INCLUDING A CAMERA, LIGHT SENSOR AND AUGMENTED INFORMATION DISPLAY 审中-公开
标题翻译：检测系统于相机和先进的信息显示编码的光，光线感应器
公开(公告)号：EP2719095A1
公开(公告)日：2014-04-16
申请号：EP12729721.6
申请日：2012-05-28
申请人： Koninklijke Philips N.V.
发明人： DE BRUIJN, Frederik Jan , DE BEIJER, Arnoldus Antonius , FERI, Lorenzo , DAMKAT, Chris , MUIJS, Remco Theodorus Johannes , VINK, Jelte Peter
IPC分类号： H04B10/00
CPC分类号： H04B10/11 , H04B10/1121 , H04B10/116
摘要： There is disclosed a sensing device (100) adapted to receive light emitted from a plurality of light sources (A, B), each of the plurality of light sources (A, B) emitting light comprising a light source identifier. The sensing device (100) comprises a sensing module(110) comprising a light selection unit (114) configured to receive at least a portion of the light emitted from the plurality of light sources (A, B) and a light selection unit (114) configured to receive at least a portion of the light emitted from the plurality of light sources (A, B). The light selection unit (114) is adapted to selectively convey a selected portion of light received by the light selection unit (114) to a second photo sensor unit (116). The light selection unit (114) is arranged relatively to the first photo sensor unit (112), or vice versa, in such a way that the selected portion of light is associated with a photo sensor of a plurality of photo sensors of the first photo sensor unit (114) detecting light.

3. 发明公开

EP3127084A1 EXAMINING DEVICE FOR PROCESSING AND ANALYZING AN IMAGE 有权转让
标题翻译： UNTERSUCHUNGSVORRICHTUNG ZUR VERARBEITUNG UNDANALYZE EINES BILDES
公开(公告)号：EP3127084A1
公开(公告)日：2017-02-08
申请号：EP15713742.3
申请日：2015-03-31
申请人： Koninklijke Philips N.V.
发明人： VAN LEEUWEN, Marinus Bastiaan , VINK, Jelte Peter
IPC分类号： G06T7/00 , G06K9/32
摘要： The present invention relates to an examining device (1) for processing and analyzing an image of a bio sample, an examining method for processing and analyzing an image of a bio sample, a computer program element for controlling such device (1), and a corresponding computer readable medium. The examining device (1) for processing and analyzing an image of a bio sample comprises an interface unit, an image analyzing unit, and a display unit. The interface unit is configured to provide an image of a bio sample. The image analyzing unit is configured to indicate a region of interest in the image as reference region, to extract a characteristic of the reference region from the image and to analyze the image for alternative regions with a similar characteristic. The display unit is configured to display the result of the analysis for alternative regions with a similar characteristic.
摘要翻译：本发明涉及用于处理和分析生物样品的图像的检查装置（1），用于处理和分析生物样品的图像的检查方法，用于控制这种装置（1）的计算机程序元件，以及相应的计算机可读介质。用于处理和分析生物样品的图像的检查装置（1）包括接口单元，图像分析单元和显示单元。接口单元被配置为提供生物样品的图像。图像分析单元被配置为指示图像中的感兴趣区域作为参考区域，以从图像中提取参考区域的特征并且分析具有相似特征的替代区域的图像。显示单元被配置为显示具有类似特征的替代区域的分析结果。

4. 发明公开

EP2904373A1 COMBINED SAMPLE EXAMINATIONS 有权转让
标题翻译： KOMBINIERTE PROBENUNTERSUCHUNGEN
公开(公告)号：EP2904373A1
公开(公告)日：2015-08-12
申请号：EP13802437.7
申请日：2013-09-25
申请人： Koninklijke Philips N.V.
发明人： VINK, Jelte Peter , WIMBERGER-FRIEDL, Reinhold , VAN DE STOLPE, Anja
IPC分类号： G01N1/28
CPC分类号： G06T3/40 , C12Q1/686 , G01N1/28 , G01N2001/282 , G01N2001/2886 , G06T2207/10004
摘要： The invention relates to a method and an apparatus (1000) for the examination of a sample, for example a slice of biological tissue (11) on a microscope slide (10). The method comprises the generation of an image (I) of the sample (11), the analysis of said image with respect to at least one sample-parameter, the selection of an image-ROI (region of interest) (RI) in said image (I), and the isolation of a corresponding sample-ROI (RS) from the sample (11). Molecular assays are then executed with the isolated sample-ROI (RS), and the data obtained from these assays are linked to the sample-parameter. The sample-parameter may particularly relate to the local amount of a particular cell-type or tissue-type.
摘要翻译：本发明涉及一种用于检查样品的方法和装置（1000），例如在显微镜载片（10）上的生物组织切片（11）。该方法包括生成样本（11）的图像（I），相对于至少一个样本参数对所述图像的分析，所述图像的ROI（感兴趣区域）（RI）的选择在所述图像（I）和从样本（11）中分离相应的样本 - ROI（RS）。然后用分离的样品-RV（RS）进行分子测定，并且从这些测定获得的数据与样品参数相关联。样品参数可以特别涉及特定细胞类型或组织型的局部量。

5. 发明授权

EP3127084B1 EXAMINING DEVICE FOR PROCESSING AND ANALYZING AN IMAGE 有权转让
公开(公告)号：EP3127084B1
公开(公告)日：2020-07-15
申请号：EP15713742.3
申请日：2015-03-31
申请人： Koninklijke Philips N.V.
发明人： VAN LEEUWEN, Marinus Bastiaan , VINK, Jelte Peter
IPC分类号： G06T7/00 , G06T7/73 , G06K9/00 , G06K9/32

6. 发明授权

EP3063736B1 REGISTRATION OF TISSUE SLICE IMAGE 有权转让
公开(公告)号：EP3063736B1
公开(公告)日：2019-10-09
申请号：EP14793074.7
申请日：2014-10-30
申请人： Koninklijke Philips N.V.
发明人： VINK, Jelte Peter , VAN LEEUWEN, Marinus Bastiaan
IPC分类号： G06T7/00 , G06T7/33 , G06T7/11

7. 发明公开

EP3323107A1 INFORMATION TRANSFORMATION IN DIGITAL PATHOLOGY 有权转让
公开(公告)号：EP3323107A1
公开(公告)日：2018-05-23
申请号：EP16738751.3
申请日：2016-07-12
申请人： Koninklijke Philips N.V.
发明人： VINK, Jelte Peter , VLUTTERS, Ruud , PIERIK, Anke , HULSKEN, Bas , WIMBERGER-FRIEDL, Reinhold , NEERKEN, Sieglinde
IPC分类号： G06T7/00 , G06T11/00
CPC分类号： G06T19/00 , G06T7/0012 , G06T7/11 , G06T7/30 , G06T7/337 , G06T11/00 , G06T2200/24 , G06T2207/20104 , G06T2207/30024 , G06T2207/30096 , G06T2207/30204 , G06T2219/004
摘要： The present invention relates to an illustration of an annotation (22) at a sample slide (14). It is the intention for the invention to copy the annotation (22) provided at a reference slide (12) to the sample slide (14). Typically, a reference image (26) of the reference slide (12) is provided, in particular by scanning the reference slide (12). The reference image (26) therefore has the information about a reference slice (16) which is carried by the reference slide (12). Furthermore, the reference slide (12) has been marked with a region of interest (20) and the annotation (22), which can be associated with the region of interest (20). If such reference slide (12) is scanned, the respective reference image (26) comprises the information about the marked region of interest (20) as well as the annotation (22), too. Furthermore, the sample slide (14) carrying a sample slice (18) can be scanned, in order to provide a sample image (28). The sample slice (18) and the reference slice (16) are cut from the same object (10) of a biological material. In particular, the sample slice (16) has been cut directly after a cut of a material block has been preformed to provide the reference slice (18). Since the reference slice (16) and the sample slice (18) are from the same object (10), their features are very likely that the reference image (26) and the sample image (28) are very similar. Due to this similarity, the annotation (22) of the reference slide (12) is copied on a basis of an image recognition between reference image (26) and the sample image (28) to the sample slide (14).

8. 发明公开

EP3103100A1 METHOD FOR REGISTERING AND VISUALIZING AT LEAST TWO IMAGES 有权转让
标题翻译： VERFAHREN ZUR REGISTRIERUNG UND VISUALISIERUNG MINDESTENS ZWEIER BILDER
公开(公告)号：EP3103100A1
公开(公告)日：2016-12-14
申请号：EP15701777.3
申请日：2015-01-29
申请人： Koninklijke Philips N.V.
发明人： VAN LEEUWEN, Marinus Bastiaan , VINK, Jelte Peter
IPC分类号： G06T3/00
摘要： The present invention relates to a method for registering and visualizing at least two images, the method comprising the steps of: measuring (S1) a navigation speed used by a user during a scrollable and/or zoomable visualization of a first image of the at least two images and comparing the navigation speed with a navigation speed threshold value; visualizing (S2) the first image by solving deformations of the first image using a first level of computational load, if the navigation speed is below the navigation speed threshold value; and visualizing (S3) the first image by solving deformations of the first image using a second level of computational load, if the navigation speed is above the navigation speed threshold value.
摘要翻译：本发明涉及一种用于登记和可视化至少两个图像的方法，所述方法包括以下步骤：测量（S1）用户在所述至少一个第一图像的可滚动和/或可缩放显示期间使用的导航速度将导航速度与导航速度阈值进行比较; 如果导航速度低于导航速度阈值，则通过使用第一级计算负载来解决第一图像的变形来可视化（S2）第一图像; 以及如果所述导航速度高于所述导航速度阈值，则通过使用第二计算负荷水平求解所述第一图像的变形来可视化（S3）所述第一图像。

9. 发明公开

EP3846431A1 A METHOD AND SYSTEM FOR WHOLE SLIDE IMAGING 审中-公开
公开(公告)号：EP3846431A1
公开(公告)日：2021-07-07
申请号：EP19220155.6
申请日：2019-12-31
申请人： Koninklijke Philips N.V.
发明人： SHRESTHA, Prarthana , VINK, Jelte Peter , VAN LIEROP, Maarten , VAN DEN BRAAK, Gert-Jan , REM, Mathijs , DE KLEIJN, Jeroen
IPC分类号： H04N1/60
摘要： A method (and system) is provided obtaining an adapted calibration transformation for whole slide imaging, wherein the adapted calibration transformation is for outputting the color of an empty area of the slide in a whole slide image, WSI, as a desired color. The method comprises first receiving a color target WSI in a device-dependent color space, wherein the color target WSI is a WSI of a color target from a scanner represented in the device-dependent color space. The color target contains at least a white patch and three (near) primary color patches. A calibration transformation is obtained for transforming the device-dependent color space to a device-independent color space. A chromatic adaptation transformation is derived using the color of the white patch in the device-dependent color space, the color of the empty (glass) area in the device-independent color space and the desired empty (glass) color in the target color space. An adapted calibration transformation is obtained by applying the chromatic adaptation transformation to the calibration transformation.

10. 发明授权

EP3103100B1 METHOD FOR REGISTERING AND VISUALIZING AT LEAST TWO IMAGES 有权转让
公开(公告)号：EP3103100B1
公开(公告)日：2019-11-06
申请号：EP15701777.3
申请日：2015-01-29
申请人： Koninklijke Philips N.V.
发明人： VAN LEEUWEN, Marinus Bastiaan , VINK, Jelte Peter
IPC分类号： G06T3/00 , G06F3/0485

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