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1. 发明公开

EP1962692A1 TRANSDUCER CUFF FOR GUIDANCE AND APPLICATION OF HIGH INTENSITY FOCUSED ULTRASOUND FOR CONTROL OF BLEEDING DUE TO SEVERED LIMBS 有权
标题翻译： UMRICHTERMANSCHETTE持有和聚焦超声高强度应用控制DUE肢解出血
公开(公告)号：EP1962692A1
公开(公告)日：2008-09-03
申请号：EP06832153.8
申请日：2006-12-07
申请人： Koninklijke Philips Electronics N.V.
发明人： FRASER, John , ROUTH, Helen , AYATI, Shervin , PETRUZZELLO, John
IPC分类号： A61B8/06 , A61N7/02 , A61B17/132 , A61B17/135 , A61B8/00
CPC分类号： A61B8/06 , A61B5/6843 , A61B8/4227 , A61B8/4281 , A61B8/4483 , A61B17/1355 , A61N7/02 , A61N2007/0065 , A61N2007/0095 , A61N2007/027
摘要： An ultrasonic diagnostic and therapy system is described for stopping the bleeding of severely damaged blood vessels or vessels severed in a limb amputation. A cuff (30) is attached to the stump of the severed limb which contains a diagnostic transducer array (52, 54, 56) and a HIFU transducer (42, 44). The diagnostic transducer surveys the tissue of the severed limb, searching for a Doppler flow signal. When a Doppler flow signal is detected, the range to and coordinates of the sample volume where the flow was detected are determined, as well as the flow velocity. This information is supplied to a HIFU therapy transducer controller, which controls the HIFU transducer to transmit focused ultrasound to the sample volume of the flow locus, the center of the lumen of a blood vessel. The focused ultrasound heats and coagulates blood in the severed vessel to stem the bleeding. Heat dissipation due to the blood flow is reduced by tracking and continuously heating the same bolus of blood as it flows, or by heating a significant length of the blood vessel instead of a fixed spot in the vessel .

2. 发明公开

EP1962690A1 METHOD AND APPARATUS FOR GUIDANCE AND APPLICATION OF HIGH INTENSITY FOCUSED ULTRASOUND FOR CONTROL OF BLEEDING DUE TO SEVERED LIMBS 失效转让
标题翻译：设备领导和高强度的应用聚焦超声治疗控制出血引起的断肢
公开(公告)号：EP1962690A1
公开(公告)日：2008-09-03
申请号：EP06832151.2
申请日：2006-12-07
申请人： Koninklijke Philips Electronics N.V.
发明人： PETRUZZELLO, John , ROUTH, Helen , FRASER, John , AYATI, Shervin
IPC分类号： A61B8/00 , A61B8/06 , A61N7/02 , A61B17/132 , A61B17/135
CPC分类号： A61B8/06 , A61B5/6843 , A61B8/4227 , A61B8/4281 , A61B8/4483 , A61B17/1325 , A61B17/135 , A61B17/1355 , A61N7/02 , A61N2007/0065 , A61N2007/027
摘要： An ultrasonic diagnostic and therapy system is described for stopping the bleeding of severely damaged blood vessels or vessels severed in a limb amputation. A cuff (30) is attached to the stump of the severed limb which contains a diagnostic transducer array and a HIFU transducer (42, 44). The diagnostic transducer surveys the tissue of the severed limb, searching for a Doppler flow signal. When a Doppler flow signal is detected, the range to and coordinates of the sample volume where the flow was detected are determined, as well as the flow velocity. This information is supplied to a HIFU therapy transducer controller, which controls the HIFU transducer to transmit focused ultrasound to the sample volume of the flow locus, the center of the lumen of a blood vessel. The focused ultrasound heats and coagulates blood in the severed vessel to stem the bleeding. Heat dissipation due to the blood flow is reduced by tracking and continuously heating the same bolus of blood as it flows, or by heating a significant length of the blood vessel instead of a fixed spot in the vessel.

3. 发明公开

EP1926528A1 COMBINATION IMAGING AND THERAPY TRANSDUCER WITH THERAPY TRANSDUCER AMPLIFIER 审中-公开
标题翻译：组合影像与治疗学转换器，转换器治疗放大器
公开(公告)号：EP1926528A1
公开(公告)日：2008-06-04
申请号：EP06795787.8
申请日：2006-08-25
申请人： Koninklijke Philips Electronics N.V.
发明人： POWERS, Jeffry, E. , FRASER, John , AVERKIOU, Michalakis
IPC分类号： A61N7/00 , A61B17/22 , A61B8/14 , A61B19/00
CPC分类号： A61B17/22004 , A61B8/0833 , A61B8/14 , A61B8/4405 , A61B8/481 , A61B17/2256 , A61B2017/22028 , A61B2090/378 , G01S15/8918 , G01S15/8977
摘要： A combined ultrasound imaging and therapy transducer (10) includes a linear array of imaging transducer elements (14). First and second linear arrays of therapy transducer elements (18, 20) extend longitudinally along respective first and second sides of the imaging transducer elements and are canted inwardly toward each other. The imaging and therapy transducer is used with an ultrasound imaging system to locate clots in a region of interest. After the region of interest has been perfused with a microbubble contrast agent, the therapy transducer elements are driven by an amplifier located in the transducer to dissolve the clot. The use of the imaging transducer elements and the therapy transducer elements can be interleaved so that the therapy can be conditioned on an ultrasound image showing substantial destruction of the contrast agent microbubbles, re-perfusion of microbubbles in the region of interest, or the continued presence of the clot.

4. 发明公开

EP2164398A2 WIRELESS ULTRASOUND PROBE WITH AUDIBLE INDICATOR 审中-公开
标题翻译：发声指示灯无线超声波探头
公开(公告)号：EP2164398A2
公开(公告)日：2010-03-24
申请号：EP08751281.0
申请日：2008-05-21
申请人： Koninklijke Philips Electronics N.V.
发明人： POLAND, McKee , CUSCUNA, Dino , WILSON, Martha , GARNER, David , GADES, Anthony , HALEY, Denise , RUST, David , FRASER, John , MESAROS, Robert
IPC分类号： A61B8/00 , A61B5/00
CPC分类号： A61B8/00 , A61B8/4427 , A61B8/4433 , A61B8/4444 , A61B8/4472 , A61B8/565 , G01S7/52079 , G01S7/5208 , G01S15/899
摘要： A wireless ultrasound probe has a probe case enclosing a transducer array, an acquisition circuit, a transceiver and a battery. The probe also includes a loudspeaker which produces audible sounds during use of the probe. The loudspeaker, which may be a piezoelectric loudspeaker, issues an alert when battery power is low or signal strength of the wireless transmission is poor or nonexistent. The loudspeaker can provide user feedback to the actuation of a button or control on the probe. The loudspeaker can provide haptic feedback during use of the probe, and can be used to produce audio Doppler tones or heart sounds during probe use.

5. 发明公开

EP1915221A2 ULTRASOUND TRANSDUCER ARRAYS 有权
标题翻译： ULTRASCHALLWANDLERARRAYS
公开(公告)号：EP1915221A2
公开(公告)日：2008-04-30
申请号：EP06780137.3
申请日：2006-07-19
申请人： Koninklijke Philips Electronics N.V.
发明人： FRASER, John , DUFORT, Benoit
IPC分类号： B06B1/02
CPC分类号： B06B1/0207
摘要： A transducer array of micromachined ultrasonic transducer elements is connected to a microbeamformer. Driver circuits of the microbeamformer have a first output coupled to a first electrode of a respective transducer element and a second output coupled to a second electrode of the respective transducer element. The driver circuits apply first and second time varying voltage signals to the electrodes, with one voltage signal being time inverted relative to the other. The peak-to-peak voltage applied to the transducer element is 1.75 to 2.0 times the peak-to-peak voltage of either the first or the second time varying voltage signal.
摘要翻译：微机械超声换能器元件的换能器阵列连接到微波束成形器。微波束形成器的驱动器电路具有耦合到相应换能器元件的第一电极的第一输出和耦合到相应换能器元件的第二电极的第二输出。驱动器电路将第一和第二时变电压信号施加到电极，其中一个电压信号相对于另一个时间反转。施加到换能器元件的峰峰值电压是第一或第二时变电压信号的峰 - 峰电压的1.75至2.0倍。

6. 发明授权

EP1962692B1 TRANSDUCER CUFF FOR GUIDANCE AND APPLICATION OF HIGH INTENSITY FOCUSED ULTRASOUND FOR CONTROL OF BLEEDING DUE TO SEVERED LIMBS 有权
标题翻译： UMRICHTERMANSCHETTE持有和聚焦超声高强度应用控制DUE肢解出血
公开(公告)号：EP1962692B1
公开(公告)日：2011-08-17
申请号：EP06832153.8
申请日：2006-12-07
申请人： Koninklijke Philips Electronics N.V.
发明人： FRASER, John , ROUTH, Helen , AYATI, Shervin , PETRUZZELLO, John
IPC分类号： A61B8/06 , A61N7/02 , A61B17/132 , A61B17/135 , A61B8/00
CPC分类号： A61B8/06 , A61B5/6843 , A61B8/4227 , A61B8/4281 , A61B8/4483 , A61B17/1355 , A61N7/02 , A61N2007/0065 , A61N2007/0095 , A61N2007/027
摘要： An ultrasonic diagnostic and therapy system is described for stopping the bleeding of severely damaged blood vessels or vessels severed in a limb amputation. A cuff (30) is attached to the stump of the severed limb which contains a diagnostic transducer array (52, 54, 56) and a HIFU transducer (42, 44). The diagnostic transducer surveys the tissue of the severed limb, searching for a Doppler flow signal. When a Doppler flow signal is detected, the range to and coordinates of the sample volume where the flow was detected are determined, as well as the flow velocity. This information is supplied to a HIFU therapy transducer controller, which controls the HIFU transducer to transmit focused ultrasound to the sample volume of the flow locus, the center of the lumen of a blood vessel. The focused ultrasound heats and coagulates blood in the severed vessel to stem the bleeding. Heat dissipation due to the blood flow is reduced by tracking and continuously heating the same bolus of blood as it flows, or by heating a significant length of the blood vessel instead of a fixed spot in the vessel .

7. 发明公开

EP1962691A2 METHOD AND APPARATUS FOR GUIDANCE AND APPLICATION OF HIGH INTENSITY FOCUSED ULTRASOUND FOR CONTROL OF BLEEDING DUE TO SEVERED LIMBS 审中-公开
标题翻译：管理和高强度使用方法和设备聚焦超声治疗控制出血引起的断肢
公开(公告)号：EP1962691A2
公开(公告)日：2008-09-03
申请号：EP06832155.3
申请日：2006-12-07
申请人： Koninklijke Philips Electronics N.V.
发明人： ROUTH, Helen , FRASER, John , PETRUZZELLO, John , AYATI, Shervin
IPC分类号： A61B8/00
CPC分类号： A61B8/4227 , A61B8/06 , A61B8/4281 , A61B8/4483 , A61N7/02 , A61N2007/0065 , A61N2007/0078 , A61N2007/0095 , A61N2007/027
摘要： An ultrasonic diagnostic and therapy system is described for stopping the bleeding of severely damaged blood vessels or vessels severed in a limb amputation. A cuff is attached to the stump of the severed limb which contains a diagnostic transducer array and a HIFU transducer. The diagnostic transducer surveys the tissue of the severed limb, searching for a Doppler flow signal. When a Doppler flow signal is detected, the flow velocity and range and coordinates of the sample volume are determined. This information is supplied to a HIFU therapy transducer controller, which controls the HIFU transducer to transmit focused ultrasound to the sample volume of the flow locus. The focused ultrasound heats and coagulates blood in the severed vessel to stem the bleeding. Heat dissipation is reduced by tracking and continuously heating the same bolus of blood as it flows, or by heating a significant length of the blood vessel.

8. 发明公开

EP1926437A2 COMBINATION IMAGING AND THERAPY TRANSDUCER 审中-公开
标题翻译：组合成像和治疗CONVERTER
公开(公告)号：EP1926437A2
公开(公告)日：2008-06-04
申请号：EP06795785.2
申请日：2006-08-25
申请人： Koninklijke Philips Electronics N.V.
发明人： POWERS, Jeffry, E. , FRASER, John , AVERKIOU, Michalakis
IPC分类号： A61B8/14 , A61B17/22 , A61N7/00
CPC分类号： A61B8/14 , A61B8/0833 , A61B8/4405 , A61B8/481 , A61B17/22004 , A61B17/2256 , A61B2017/22028 , A61B2090/378 , A61N7/00 , G01S15/8918 , G01S15/899
摘要： A combined ultrasound imaging and therapy transducer (10) includes a linear array of imaging transducer elements (14) . First and second linear arrays of therapy transducer elements (18, 20) extend longitudinally along respective first and second sides of the imaging transducer elements and are canted inwardly toward each other. The imaging and therapy transducer is used with an ultrasound imaging system to locate clots in a region of interest . After the region of interest has been perfused with a microbubble contrast agent, the therapy transducer elements are driven by an amplifier located in the transducer to dissolve the clot. The use of the imaging transducer elements and the therapy transducer elements can be interleaved so that the therapy can be conditioned on an ultrasound image showing substantial destruction of the contrast agent microbubbles, re-perfusion of microbubbles in the region of interest, or the continued presence of the clot.

9. 发明授权

EP1962690B1 APPARATUS FOR GUIDANCE AND APPLICATION OF HIGH INTENSITY FOCUSED ULTRASOUND FOR CONTROL OF BLEEDING DUE TO SEVERED LIMBS 失效转让
标题翻译：设备领导和高强度的应用聚焦超声治疗控制出血引起的断肢
公开(公告)号：EP1962690B1
公开(公告)日：2013-08-14
申请号：EP06832151.2
申请日：2006-12-07
申请人： Koninklijke Philips Electronics N.V.
发明人： PETRUZZELLO, John , ROUTH, Helen , FRASER, John , AYATI, Shervin
IPC分类号： A61B8/00 , A61B8/06 , A61N7/02 , A61B17/132 , A61B17/135
CPC分类号： A61B8/06 , A61B5/6843 , A61B8/4227 , A61B8/4281 , A61B8/4483 , A61B17/1325 , A61B17/135 , A61B17/1355 , A61N7/02 , A61N2007/0065 , A61N2007/027

10. 发明公开

EP2400894A1 ULTRASONIC VASCULAR FLOW SENSOR WITH TRIANGULAR SENSOR GEOMETRY 审中-公开
标题翻译：三角传感器几何超声血管血流传感器
公开(公告)号：EP2400894A1
公开(公告)日：2012-01-04
申请号：EP10704598.1
申请日：2010-02-10
申请人： Koninklijke Philips Electronics N.V.
发明人： ERKAMP, Ramon , COHEN-SOLAL, Eric , RAJU, Balasundara , FRASER, John
IPC分类号： A61B8/06 , B06B1/06
CPC分类号： A61B8/06 , A61B8/4236 , A61B8/4483 , A61B8/4494 , B06B1/0629
摘要： An ultrasonic blood flow sensor includes a plurality of adjacent triangular shaped transducer elements which transmit ultrasound waves into a blood vessel and receive reflected ultrasound waves from the blood flow in the vessel. Preferably the transducer elements are paired in pairs of transmit and receive elements. The elements are fixed in a matrix which may be attached in acoustic coupling contact with the skin The matrix retains adjacent transducer elements slightly spaced apart so that the matrix of transducer elements may bend and conform to the shape of the skin surface. The spacing between the triangular elements is neither parallel nor orthogonal to the length dimension of the matrix so that a blood vessel will not be aligned with a space between transducer elements when the matrix is affixed across the location of a blood vessel. In addition the geometry of the elements creates a beam pattern that provide more overlap between transmit and receive beam profiles, thereby increasing the area of sensor coverage.

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