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1. 发明公开

EP3564655A1 IMAGE PROCESSING METHOD AND IMAGE PROCESSING SYSTEM 审中-公开
公开(公告)号：EP3564655A1
公开(公告)日：2019-11-06
申请号：EP17888370.8
申请日：2017-12-18
申请人： Konica Minolta, Inc.
发明人： KEMMOCHI, Hiroaki , MOTOKUI, Yasuyuki , KOYAMA, Noboru
IPC分类号： G01N21/64 , G01N33/48 , G06T7/00
摘要： The present invention addresses the problem of providing an image processing method and an image processing system by which an entire image of a specimen can be acquired at a high resolution without fading during image-capturing in a fluorescent antibody method. The image processing method comprises: a fluorescent image-capturing step for capturing a fluorescent image of a fluorescently labeled tissue specimen; a creating step for creating a fluorescent whole slide image on the basis of the captured fluorescent image; and a storing step for storing the created fluorescent whole slide image. The fluorescently labelled tissue specimen is formed using, as a staining reagent, fluorescent substance-accumulated nano-particles obtained by binding a biological substance recognition part to fluorescent particles on which a plurality of fluorescent substances are accumulated.

2. 发明公开

EP3702779A1 IMAGE PROCESSING DEVICE, IN-FOCUS POSITION SPECIFYING METHOD, AND IN-FOCUS POSITION SPECIFYING PROGRAM 审中-公开
公开(公告)号：EP3702779A1
公开(公告)日：2020-09-02
申请号：EP18869728.8
申请日：2018-10-18
申请人： Konica Minolta, Inc.
发明人： KEMMOCHI, Hiroaki
IPC分类号： G01N33/48 , G01N21/64 , G06T7/571
摘要： The present invention addresses the problem of providing: an image processing device, an in-focus position specifying method, and an in-focus position specifying program capable of specifying an in-focus position from a fluorescence image and allowing an expression level of a biological material over the entirety of a tissue specimen to be quantitatively analyzed. The present invention is provided with: an input means for inputting a morphology image representing the morphology of cells in a tissue specimen in which a biological material is stained by fluorescent nanoparticles and fluorescence images which represent the same range as that of the morphology image, which represent the expression of the biological material, and in which the focal planes are changed at a predetermined interval in the height direction of the tissue specimen; a first extraction means for extracting cell areas from the morphology image or the fluorescence images; an in-focus plane specifying means for specifying, as an in-focus plane, the focal plane being most focused for each of the cell areas; a coordinate specifying means for specifying coordinates in the in-focus plane of the cell area; a storage means for storing the in-focus plane and the coordinates; a second extraction means for extracting a fluorescent bright point area from a fluorescence image in a focal plane corresponding to the in-focus plane; and a calculation means for calculating the number of fluorescent nanoparticles or a brightness value in the fluorescent bright spot area.

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