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1. 发明公开

EP1270728A4 PROCESS FOR PRODUCING AVERMECTIN DERIVATIVE 有权
标题翻译：工艺生产除虫菌素衍生物
公开(公告)号：EP1270728A4
公开(公告)日：2004-11-24
申请号：EP01906278
申请日：2001-02-23
申请人： KYOWA HAKKO KOGYO KK , KITASATO INST
发明人： ENDO HIROFUMI , YAMAGUCHI HIROYUKI , KANDA YUTAKA , HASHIMOTO SHINICHI , OMURA SATOSHI , IKEDA HARUO
IPC分类号： C07C327/30 , C12N1/21 , C12N15/52 , C12N15/53 , C12N15/54 , C12P19/62 , C12N9/00
CPC分类号： C12N15/52 , C07C327/30
摘要： 22,23-Dihydroavermectin B1a, which is useful in drugs, veterinary drugs and pesticides, can be produced by direct fermentation. Thus, the troublesome and difficult industrial steps of purifying avermectin B1a and chemically modifying avermectin B1a involved in the conventional are can be omitted and therefore 22,23-dihydroavermectin B1a can be industrially produced while largely saving the cost and time. Moreover, a preparation containing 22,23-dihydroavermectin B1a alone, which is highly efficacious as a drug, can be produced.

2. 发明公开

EP0887351A4 DC 107 DERIVATIVES (2) 失效
标题翻译： DC 107-DERIVATE
公开(公告)号：EP0887351A4
公开(公告)日：2001-06-06
申请号：EP97947917
申请日：1997-12-12
申请人： KYOWA HAKKO KOGYO KK
发明人： KANDA YUTAKA , ARAI HITOSHI , YAMAGUCHI HIROYUKI , ASHIZAWA TADASHI , IKEDA SHUN-ICHI , MURAKATA CHIKARA , TAMAOKI TATSUYA
IPC分类号： C07D513/08 , C07D513/18 , C07D513/20 , C07H15/26 , C07H17/02 , A61K31/425 , A61K31/70 , C07D519/00 , C07H17/00
CPC分类号： C07D513/08 , C07H15/26 , C07H17/02
摘要： DC 107 derivatives represented by general formula (I) or pharmacologically acceptable salts thereof, each having antibacterial and antitumor activities, wherein R1 represents CO(CR4AR4B)n1[O(CH2)p1]n2OR5, wherein n1 represents an integer of 1 or 2; R?4A and R4B¿ are the same or different and each represents hydrogen or lower alkyl; p1 and n2 are each an integer of 1 to 10; and R5 represents hydrogen, lower alkyl, etc.; or formula (II), (wherein A?1, A2, A3 and A4¿ are the same or different and each represents hydrogen, hydroxy, etc.); R2 represents hydrogen or COR6 (wherein R6 represents lower alkyl, aralkyl, optionally substituted aryl, etc.); R3 represents lower alkyl, lower alkenyl, aralkyl having optionally substituted aryl, alicyclic alkanoyloxy-alkyl, -CH¿2OCOR?7, etc., or R3 may form a bond together with Y; Y forms a bond together with R3 or Z; Z represents hydrogen or may form a bond together with Y; and W represents oxygen or NR8.

3. 发明公开

EP0280741A4 MITOMYCIN DERIVATIVES. 失效
标题翻译：丝裂霉素衍生物。
公开(公告)号：EP0280741A4
公开(公告)日：1990-02-21
申请号：EP87905655
申请日：1987-08-28
申请人： KYOWA HAKKO KOGYO KK
发明人： KONO MOTOMICHI , SAITO YUTAKA , KANDA YUTAKA , KASAI MASAJI - - MATSUGAOKA , SATO AKIRA , MORIMOTO MAKOTO , ASHIZAWA TADASHI
IPC分类号： C07D487/14 , C07D487/22 , C07H19/06 , C07J43/00 , A61K31/40 , C07H19/067 , C07H19/073
CPC分类号： C07D487/14 , C07H19/06 , C07J43/003
摘要： Mitomycin derivatives having a novel substituted dithioethylamino group at 7-position. These compounds are better than mitomycin C with respect to an oncostatic activity and toxicity. Specifically, compounds showing a wider effective administration region against sarcoma 180A, a higher life prolonging effect gainst P388, and a less marrow depressing effect are disclosed. Some of them have a high water solubitity which is advantageous in forming a pharmaceutical preparation, thus facilitating preparation of excellent oncostatic agents.

4. 发明公开

EP1227097A4 UCS1025 DERIVATIVES 审中-公开
标题翻译： UCS1025衍
公开(公告)号：EP1227097A4
公开(公告)日：2003-04-02
申请号：EP00969907
申请日：2000-10-19
申请人： KYOWA HAKKO KOGYO KK
发明人： AKAMA TSUTOMU , ASAI AKIRA , AGATSUMA TSUTOMU , NARA SHINJI , YAMASHITA YOSHINORI , MIZUKAMI TAMIO , IKEDA SHUN-ICHI , SAITOH YUTAKA , KANDA YUTAKA
IPC分类号： A61P31/04 , A61P35/00 , C07D487/04 , C07D487/14 , C07D487/16 , C07D491/14 , C07D491/147 , C07D491/16 , C07D498/08 , A61K31/407 , A61K31/4162 , A61K31/4439
CPC分类号： C07D487/04 , C07D487/14 , C07D491/14
摘要： UCS1025 derivatives represented by general formula (I) which have an antitumor activity or an antibacterial activity or pharmacologically acceptable salts thereof, (I) wherein R1 represents hydrogen, lower alkyl, etc.; R2 represents hydrogen, or forms a bond, etc. together with R3 or forms -O(C=O)-, etc. together with R4; R3 represents hydrogen or forms a bond, etc. together with R2; R4 represents hydrogen or forms -(C=O)O-, etc. together with R2; R5 represents hydrogen, or forms a bond together with R6; R6 represents hydroxy, or forms a bond together with R5; R7 represents hydrogen, or forms =O together with R8; R8 represents hydroxy or forms =O together with R7; --- represents a single or double bond; and a represents a single bond (i.e., the two carbon atoms bonded to a form a single bond to each other) or an oxygen atom.

5. 发明公开

EP0670314A4 FARNESYLTRANSFERASE INHIBITOR. 失效
标题翻译： FARNESYLTRANSFERASE抑制剂。
公开(公告)号：EP0670314A4
公开(公告)日：1996-04-10
申请号：EP94927069
申请日：1994-09-20
申请人： KYOWA HAKKO KOGYO KK
发明人： KANDA YUTAKA , SAITOH YUTAKA , AKASAKA KAZUHITO , MIZUKAMI TAMIO , NAKANO HIROFUMI
IPC分类号： A61K31/495 , A61K31/54 , C07D241/08 , C07D513/08
CPC分类号： C07D513/08 , A61K31/495 , A61K31/54 , C07D241/08
摘要： A farnesyltransferase inhibitor and an antitumor drug each containing a piperazinedione derivative represented by general formula (I) as the active ingredient, wherein R?1 and R2¿ are the same or different from each other and each represents lower alkyl, lower alkoxyalkyl, or (un)substituted aryl or aralkyl; R?3 and R4¿ are the same or different from each other and each represents mercapto, lower alkanoylthio, aroylthio, lower alkoxycarbonylthio or aryloxycarbonylthio, or R?3 and R4¿ are combined with each other to represent a disulfide bond; and R?5 and R6¿ are the same or different from each other and each represents hydrogen, lower alkyl, lower alkoxyalkyl, hydroxyalkyl, lower alkanoyloxyalkyl, aroyloxyalkyl, aralkyloxyalkyl or aralkyl.
摘要翻译：一种法呢基转移酶抑制剂和抗肿瘤药，其各自含有通式（I）表示的哌嗪二酮衍生物作为活性成分，其中R 1和R 2彼此相同或不同，各自表示低级烷基，低级烷氧基烷基，或（未）取代的芳基或芳烷基; R 3和R 4彼此相同或不同，并且各自表示巯基，低级烷酰硫基，芳酰硫基，低级烷氧基羰基硫基或芳氧基羰硫基，或R 3和R 4彼此结合以表示二硫键 R 5和R 6彼此相同或不同，各自表示氢，低级烷基，低级烷氧基烷基，羟烷基，低级烷酰氧基烷基，芳氧基烷基，芳烷氧基烷基或芳烷基。

6. 发明公开

EP1666064A4 REMEDY FOR DISEASES ASSOCIATED WITH IMMUNOGLOBULIN GENE TRANSLOCATION 审中-公开
标题翻译：代理疾病的诊治免疫球蛋白基因易位有关
公开(公告)号：EP1666064A4
公开(公告)日：2008-12-17
申请号：EP04772374
申请日：2004-08-23
申请人： KYOWA HAKKO KOGYO KK
发明人： SHIOTSU YUKIMASA , SOGA SHIRO , KANDA YUTAKA , AKINAGA SHIRO
IPC分类号： A61K45/00 , A61K31/00 , A61K31/365 , A61K31/4025 , A61P35/00 , A61P35/02 , A61P43/00 , C07D313/00 , G01N33/50
CPC分类号： A61K31/365 , A61K31/00 , C07D313/00
摘要： A drug containing, as the active ingredient, a compound having an Hsp90 inhibitory effect or a pharmacologically acceptable salt thereof is used as a remedy for diseases associated with the translocation of immunoglobulin gene. In the diseases associated with the translocation of immunoglobulin gene, abnormally accelerated expression of a partner gene of the translocation of immunoglobulin gene participates in the onset and progress of symptoms. By administering a compound having an Hsp90 inhibitory effect or a pharmacologically acceptable salt thereof, the decomposition of a protein encoded by the partner gene is promoted and thus the diseases can be treated.

7. 发明公开

EP1650194A4 PROTEIN KINASE INHIBITOR 审中-公开
标题翻译： PROTEINKINASEINHIBITOR
公开(公告)号：EP1650194A4
公开(公告)日：2008-10-01
申请号：EP04771303
申请日：2004-07-30
申请人： KYOWA HAKKO KOGYO KK
发明人： SHIOTSU YUKIMASA , UMEHARA HIROSHI , KANAI FUMIHIKO , NARA SHINJI , OHTA YOSHIHISA , KANDA YUTAKA , AKINAGA SHIRO , NAOE TOMOKI , KIYOI HITOSHI , NAKAZATO TOMOYUKI , TASHIRO SATOSHI
IPC分类号： C07D231/56 , A61K31/416 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K31/547 , A61P35/00 , A61P35/02 , A61P43/00 , C07D401/06
CPC分类号： C07D231/56
摘要： An inhibitor against protein kinases excluding c-jun N-terminal kinase, which contains as an active ingredient either an indazole derivative represented by the formula (I): (wherein R1 represents (un)substituted aryl or (un)substituted heterocyclic group) or a pharmacologically acceptable salt of the derivative.

8. 发明公开

EP1500698A4 CELL WITH DEPRESSION OR DELETION OF THE ACTIVITY OF PROTEIN PARTICIPATING IN GDP-FUCOSE TRANSPORT 无效
标题翻译：具有降低的细胞或GDP-FUCOSETRANSPORT缔约方蛋白的删除ACTIVITY
公开(公告)号：EP1500698A4
公开(公告)日：2006-02-15
申请号：EP03720896
申请日：2003-04-09
申请人： KYOWA HAKKO KOGYO KK
发明人： KANDA YUTAKA , SATOH MITSUO , MORI KATSUHIRO
IPC分类号： A61P9/00 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/00 , C07K14/47 , C07K16/18 , C07K16/28 , C12N15/82 , C12P21/08 , C12N5/10 , A01H5/00 , A01K67/027 , A61K39/395 , C12N15/09
CPC分类号： C12N15/8245 , A61K2039/505 , C07K14/47 , C07K16/18 , C07K16/2866 , C07K2317/24 , C07K2317/732
摘要： A cell in which the activity of a protein participating in the transport of an intracellular sugar nucleotide GDP-fucose into Golgi bodies is depressed or deleted compared with its parent strain cells; a process for producing an antibody composition with the use of the above cell; a transgenic nonhuman animal or plant the genome of which has been modified so as to depress or delete the activity of a protein participating in the transport of an intracellular sugar nucleotide GDP-fucose into Golgi bodies, or offspring thereof; a process for producing an antibody composition from the above animal or plant; and a drug containing the antibody composition.

9. 发明公开

EP1331266A4 CELLS PRODUCING ANTIBODY COMPOSITIONS 有权
标题翻译：抗体组合物产生细胞
公开(公告)号：EP1331266A4
公开(公告)日：2005-07-13
申请号：EP01974718
申请日：2001-10-05
申请人： KYOWA HAKKO KOGYO KK
发明人： KANDA YUTAKA , SATOH MITSUO , NAKAMURA KAZUYASU , UCHIDA KAZUHISA , SHINKAWA TOYOHIDE , YAMANE NAOKO , HOSAKA EMI , YAMANO KAZUYA , YAMASAKI MOTOO , HANAI NOBUO
IPC分类号： A61K39/395 , C07K16/00 , C07K16/06 , C07K16/18 , C07K16/28 , C07K16/32 , C12N5/10 , C12N9/04 , C12N9/10 , C12N9/12 , C12N9/88 , C12N9/90 , C12P21/00 , C12P21/08 , C12N15/10 , A01K67/00 , C12N9/00 , C12N15/52 , G01N33/53
CPC分类号： C07K16/3084 , A61K2039/505 , C07K16/00 , C07K16/065 , C07K16/18 , C07K16/2866 , C07K16/32 , C07K2317/24 , C07K2317/41 , C07K2317/732 , C07K2319/30 , C12N9/0006 , C12N9/1051 , C12N9/1241 , C12N9/90 , C12P21/005
摘要： Cells to be used in producing antibody compositions, for example, an antibody having a high antibody-dependent cellular cytotoxic activity which is useful in various diseases, an antibody fragment or a fused protein having the Fc domain of the antibody; a process for producing an antibody composition by using these cells; antibody compositions; and uses thereof. In the above-described antibody compositions, the ratio of sugar chains, which are free from fucose bonded to N-acetylglucosamine at the sugar chain reducing end, to the total N-glycoside linkage complex sugar chains bonded to the Fc domain amounts to 20% or more. Moreover, novel GDP-mannose 4,6-dehydrogenase, GDP-keto-6-deoxymannose 3,5-epimerase 4-reductase, GDP-beta-L-fucose pyrophosphorylase, alpha-1,6-fucosyltransferase and DNAs encoding the same are provided.

10. 发明公开

EP1145713A4 TELOMERASE INHIBITORS 审中-公开
标题翻译：端粒酶抑制剂
公开(公告)号：EP1145713A4
公开(公告)日：2003-08-06
申请号：EP00900346
申请日：2000-01-12
申请人： KYOWA HAKKO KOGYO KK
发明人： YAMASHITA YOSHINORI , ASAI AKIRA , HASEGAWA ATSUHIRO , AKINAGA SHIRO , ISHIDA HIROYUKI , MIZUKAMI T , YAMAGUCHI HIROYUKI , AKAMA TSUTOMU , ENDO KAORI , NARA SHINJI , KANDA YUTAKA
IPC分类号： A61K31/00 , A61K31/409 , A61P35/00 , A61P43/00 , C07D487/22 , A61K31/454 , A61K31/5377
CPC分类号： C07D487/22 , A61K31/00 , A61K31/409
摘要： Telomerase inhibitors containing as the active ingredient porphyrin derivatives represented by general formula (I), N-(lower alkyl)-substituted derivatives thereof (wherein the lower alkyl is located on the nitrogen atom of the pyrrole ring of the porphyrin ring) or metal coordinates thereof or pharmacologically acceptable salts thereof: (I) wherein R?1, R2, R3, R4, R5, R6, R7 and R8¿ are the same or different and each represents hydrogen, formyl, optionally substituted lower alkyl, optionally substituted lower alkenyl, carboxy, optionally substituted lower alkoxycarbonyl, CONR9R10 (wherein R?9 and R10¿ are the same or different and each represents hydrogen or optionally substituted lower alkyl), sulfo, lower alkoxysulfonyl or cyano.

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