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1. 发明授权

EP0798288B1 TRICICLIC COMPOUNDS 失效
标题翻译：三元化合物
公开(公告)号：EP0798288B1
公开(公告)日：2001-05-16
申请号：EP96935342.4
申请日：1996-10-16
申请人： KYOWA HAKKO KOGYO CO., Ltd.
发明人： YOSHIDA, Makoto , SASAKI, Shin-ichi , AONO, Shigeru , FUJIWARA, Shigeki , TAKAI, Haruki , YAMAGATA, Tsuyoshi , NAGASAHIMA, Ken , KARASAWA, Akira
IPC分类号： C07C235/16 , C07D221/06 , C07D307/93 , C07D313/12 , C07D333/78 , C07D337/12 , C07D491/044 , C07D495/04 , A61K31/35 , A61K31/38 , A61K31/435
CPC分类号： C07D491/04 , C07C235/16 , C07C2603/16 , C07C2603/18 , C07C2603/32 , C07D221/16 , C07D307/93 , C07D313/12 , C07D333/80 , C07D337/12 , C07D493/04 , C07D495/04
摘要： Triciclic compounds represented by general formula (I) which are useful as a remedy for urinary incontinence, wherein R1 represents hydrogen, etc.; and -X1-X2-X3- represents -CR?2=CR3-CR4=CR5¿- (wherein R?2, R3, R4 and R5¿ represent each hydrogen, etc.); and Y represents -CH¿2?O- etc.
摘要翻译：用作尿失禁治疗药的有用的通式（I）所示的三元系化合物，其中R1表示氢等。 -X 1 -X 2 -X 3 - 表示-CR 2 = CR 3 -CR 4 = CR 5 - （其中R 2，R 3，R 4和R 5'各自代表氢等）。 Y代表-CH 2 O-等。

2. 发明公开

EP0979821A1 TRICYCLIC COMPOUNDS 失效
标题翻译：三环化合物
公开(公告)号：EP0979821A1
公开(公告)日：2000-02-16
申请号：EP98914022.3
申请日：1998-04-15
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： YOSHIDA, Makoto , SEISHI, Takashi , AONO, Shigeru , TAKAI, Haruki , SUZUKI, Koji , YAMAGATA, Tsuyoshi , ATSUKI, Kaoru , KARASAWA, Akira , KUMAZAWA, Toshiaki
IPC分类号： C07D313/12 , C07D333/06 , C07D333/12 , C07D495/04 , A61K31/335 , A61K31/38 , A61K31/435
CPC分类号： C07D495/04 , C07D313/12 , C07D337/12
摘要： The present invention provides tricyclic compounds which are useful for the treatment of pollakiuria and urinary incontinence and which are represented by general formula (I):
(wherein R 1 represents hydrogen, substituted or unsubstituted lower alkyl, etc.; X 1 -X 2 -X 3 represents CR 5 =CR 6 -CR 7 =CR 8 (wherein R 5 , R 6 , R 7 and R 8 , which may be the same or different, each represents hydrogen, substituted or unsubstituted lower alkyl, hydroxy, substituted or unsubstituted lower alkoxy, etc.), N(O)m=CR 5 -CR 6 -CR 7 (wherein R 5 , R 6 and R 7 have the same significances as defined above, and m represents 0 or 1), S-CR 7 =CR 8 (wherein R 7 and R 8 have the same significances as defined above), etc.;
and when R 2 represents hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy, a substituted or unsubstituted N-substituted heterocyclic group,
(wherein n is 0 or 1; R 3 and R 4 , which may be the same or different, each represents hydrogen, substituted or unsubstituted lower alkyl, trifluoromethyl, etc., or R 3 and R 4 may be combined together to form cyclic alkyl; and Q represents hydroxy, halogen, etc.), etc., Y represents -CH 2 SO 2 -, -SCH 2 -, -SOCH 2 -, -SO 2 CH 2 -, etc.) and pharmaceutically acceptable salts thereof.
摘要翻译：本发明提供了可用于治疗尿频和尿失禁的三环化合物，其由通式（I）表示：（其中R 1表示氢，取代或未取代的低级烷基等; X 1 -X 2 -X 3表示CR 5 （其中R5，R6，R7和R8可以相同或不同，各自代表氢，取代的或未取代的低级烷基，羟基，取代的或未取代的低级烷氧基等），N（O）= CR6- m = CR 5 -CR 6 -CR 7（其中R 5，R 6和R 7具有与上述定义相同的含义，并且m表示0或1），S-CR 7 = CR 8（其中R 7和R 8具有与上述定义相同的含义）等 ;当R2代表氢时，取代或未取代的低级烷基，取代或未取代的低级烷氧基，取代或未取代的N-取代的杂环基，（其中n是0或1; R3和R4可以相同或不同，各自代表氢，取代或未取代的低级烷基，t 三氟甲基等，或者R3和R4可以结合在一起形成环烷基; Q表示羟基，卤素等）等，Y表示-CH 2 SO 2 - ， - SCH 2 - ， - SOCH 2 - ，-SO 2 CH 2 - 等）及其药学上可接受的盐。

3. 发明公开

EP0798288A1 TRICICLIC COMPOUNDS 失效
标题翻译：三环化合物
公开(公告)号：EP0798288A1
公开(公告)日：1997-10-01
申请号：EP96935342.4
申请日：1996-10-16
申请人： Kyowa Hakko Kogyo Co., Ltd.
发明人： YOSHIDA, Makoto , SASAKI, Shin-ichi , AONO, Shigeru , FUJIWARA, Shigeki , TAKAI, Haruki , YAMAGATA, Tsuyoshi , NAGASAHIMA, Ken , KARASAWA, Akira
IPC分类号： C07C235/16 , C07D221/06 , C07D307/93 , C07D313/12 , C07D333/78 , C07D337/12 , C07D491/044 , C07D495/04 , A61K31/35 , A61K31/38 , A61K31/435
CPC分类号： C07D491/04 , C07C235/16 , C07C2603/16 , C07C2603/18 , C07C2603/32 , C07D221/16 , C07D307/93 , C07D313/12 , C07D333/80 , C07D337/12 , C07D493/04 , C07D495/04
摘要： The present invention relates to tricyclic compounds represented by general formula (I) which are useful as therapeutic agents for urinary incontinence:
wherein R 1 represents hydrogen and the like; -X 1 -X 2 -X 3 -represents -CR 2 =CR 3 -CR 4 =CR 5 - (wherein R 2 , R 3 , R 4 , and R 5 represent hydrogen and the like) and the like; and Y represents -CH 2 O- and the like.

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