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1. 发明公开

EP0990439A1 BISARYL COMPOUNDS AND CANCER REMEDIES CONTAINING THE SAME 失效
标题翻译： DIISE ENTIALTENDE ANTIKREBS-ARZNEIMITTEL BISARYLVERBINDUNGEN
公开(公告)号：EP0990439A1
公开(公告)日：2000-04-05
申请号：EP98921757.5
申请日：1998-05-21
申请人： KYOWA HAKKO KOGYO CO., LTD. , FUJI PHOTO FILM CO., LTD.
发明人： YONETANI, Yoshiyuki , TAKAHASHI, Takeshi , KANDA, Yuko , MIZUKAMI, Tamio , TAMAOKI, Tatsuya , IKEDA, Shun-ichi , TAKASHIMA, Masanobu; Fuji Photo Film Co., Ltd. , ASANUMA, Naoki, Fuji Photo Film Co., Ltd. , INABA, Tadashi, Fuji Photo Film Co., Ltd. , TAKEUCHI, Hiroshi, Fuji Photo Film Co., Ltd. , KAWAMOTO, Hiroshi, Fuji Photo Film Co., Ltd. , TSUKADA, Yoshihisa, Fuji Photo Film Co., Ltd. , SATOMURA, Masato, Fuji Photo Film Co., Ltd. , KITAGUCHI, Hiroshi, Fuji Photo Film Co., Ltd.
IPC分类号： A61K31/10 , A61K31/11 , A61K31/12 , A61K31/135 , A61K31/155 , A61K31/165 , A61K31/18 , A61K31/19 , A61K31/215 , A61K31/335 , A61K31/34 , A61K31/35 , A61K31/40 , A61K31/44 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/505 , A61K31/70 , C07D207/08 , C07D207/408 , C07D211/22 , C07D213/32 , C07D215/08 , C07D233/61
CPC分类号： C07D207/08 , C07C323/16 , C07C323/25 , C07C323/40 , C07D211/58 , C07D211/60 , C07D213/32 , C07D215/06 , C07D233/64 , C07D239/42 , C07D239/58 , C07D251/38 , C07D277/56 , C07D309/38 , C07D317/22 , C07D317/28 , C07D319/06 , C07H5/06 , C07H15/18
摘要： A medicament for treatment of cancer comprising a compound represented by the following general formula (I) or a physiologically acceptable salt thereof:

Ar 1 -S-R 1 -S-Ar 2

wherein R 1 represents a nonmetal bridging group; Ar 1 and Ar 2 independently represent a group selected from the group consisting of an aryl group which has, on its ring, one to three hydroxyl groups optionally substituted with a monovalent group and said aryl group may have one to three substituents other than hydroxyl group on its ring; and a heteroaryl group which has, on its ring, one to three hydroxyl groups optionally substituted with a monovalent group, and said heteroaryl group may have one to three substituents other than hydroxyl group on its ring.
摘要翻译：一种用于治疗癌症的药物，其包含由以下通式（I）表示的化合物或其生理学上可接受的盐：Ar 1 -SR 1 -S-Ar 2其中R 1表示非金属桥接组; Ar 1和Ar 2独立地表示选自以下的基团：其环上具有1〜3个任选被一价基团取代的羟基的芳基，所述芳基可以具有1〜3个取代基其环上除羟基外; 和在其环上具有任选被一价基团取代的一至三个羟基的杂芳基，所述杂芳基可以在其环上具有除了羟基以外的一至三个取代基。

2. 发明公开

EP1097934A1 LK6-A DERIVATIVES 有权
标题翻译： LK6-A-衍生物
公开(公告)号：EP1097934A1
公开(公告)日：2001-05-09
申请号：EP99929753.4
申请日：1999-07-08
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： AKAMA, Tsutomu , NAGATA, Hiroyuki , HASEGAWA, Atsuhiro , UE, Harumi , TAKAHASHI, Isami , SAITOH, Yutaka , MOCHIDA, Kenichi , IKEDA, Shun-ichi , KANDA, Yutaka
IPC分类号： C07D471/06 , A61K31/47
CPC分类号： C07D471/06
摘要： LK6-A derivatives represented by general formula (I) and pharmacologically acceptable salts thereof, which exhibit immunosuppressive, cytostatic and antitumor effects and so on, wherein R 1 is a lower alkanoyl or acryloyl group which may be substituted with, e.g., lower alkoxy, or the like; R 2 is hydrogen, halogeno or the like; R 2' is hydrogen, or R 2' together with R 3 forms a bond; R 3 is optionally substituted lower alkanoyl, or R 3 together with R 2' forms a bond; R 4 and R 5 are each hydrogen, optionally substituted lower alkanoyl or the like; R 6 is hydrogen or the like; and R 7 and R 8 are each hydrogen, optionally substituted lower alkanoyl or the like, with the proviso that LK6-A corresponding to a compound of general formula (I) where R 1 is (E)-methoxyacryloyl; R 2 , R 4 , R 5 , R 6 and R 7 are each hydrogen; R 8 is acetyl; and R 2' and R 3 together form a bond is excepted.
摘要翻译：具有通式（I）表示的LK6-A衍生物及其药理学上可接受的盐，其具有免疫抑制，细胞抑制和抗肿瘤作用等，其中R 1为低级烷酰基或丙烯酰基，其可被例如较低级烷氧基等; R 2是氢，卤素等; R 2是氢，或R 2与R 3一起形成键; R 3是任选取代的低级烷酰基，或R 3与R 2'一起形成键; R 4和R 5各自为氢，任选取代的低级烷酰基等; R 6是氢等; R 7和R 8各自为氢，任选取代的低级烷酰基等，条件是对应于通式（I）的化合物的LK6-A，其中R 1为（E） - 甲氧基丙烯酰基 ; R 2，R 4，R 5，R 6和R 7各自为氢; R 8是乙酰基; 和R 2'和R 3一起形成键。

3. 发明公开

EP0887351A1 DC 107 DERIVATIVES (2) 失效
标题翻译： DC 107-DERIVATE
公开(公告)号：EP0887351A1
公开(公告)日：1998-12-30
申请号：EP97947917.7
申请日：1997-12-12
申请人： Kyowa Hakko Kogyo Co., Ltd.
发明人： KANDA, Yutaka , ARAI, Hitoshi , YAMAGUCHI, Hiroyuki , ASHIZAWA, Tadashi , IKEDA, Shun-ichi , MURAKATA, Chikara , TAMAOKI, Tatsuya
IPC分类号： C07D513/18 , C07D513/20 , C07D519/00 , C07H15/26 , C07H17/00 , A61K31/425 , A61K31/70
CPC分类号： C07D513/08 , C07H15/26 , C07H17/02
摘要： DC107 derivatives represented by formula (I) or pharmaceutically acceptable salts thereof which have antimicrobial activity and antitumor activity are provided:
wherein R 1 represents CO(CR 4A R 4B ) n1 (O(CH 2 ) p1 ) n2 OR 5 {wherein n1 represents an integer of 1 or 2; R 4A and R 4B are the same or different, and each represents hydrogen or lower alkyl; p1 and n2 each represents an integer of 1 to 10; and R 5 represents hydrogen, lower alkyl, or the like), or
(wherein A 1 , A 2 , A 3 , and A 4 are the same or different, and each represents hydrogen, hydroxy, or the like); R 2 represents hydrogen or COR 6 (wherein R 6 represents lower alkyl, aralkyl, substituted or unsubstituted aryl, or the like); R 3 represents lower alkyl, lower alkenyl, aralkyl having substituted or unsubstituted aryl, alicyclic alkanoyloxyalkyl, -CH 2 OCOR 7 , or the like, or is combined with Y to represent a bond; Y is combined together with R 3 to represent a bond or is combined together with Z to represent a bond; Z represents hydrogen, or is combined together with Y to represent a bond; and W represents oxygen, or NR 8 .
摘要翻译：提供了具有抗微生物活性和抗肿瘤活性的由式（I）表示的DC107衍生物或其药学上可接受的盐：其中R 1表示CO（CR 4 R 4）n1（O（CH 2）p1））n2OR <5>其中n1表示1或2的整数; R 4A和R 4B相同或不同，各自表示氢或低级烷基; p1和n2各自表示1〜10的整数， R 5表示氢，低级烷基等）或（其中A 1，A 2，A 3和A 4相同或不同，各自表示氢，羟基等）; R 2表示氢或COR 6（其中R 6表示低级烷基，芳烷基，取代或未取代的芳基等）; R 3表示低级烷基，低级烯基，具有取代或未取代的芳基的芳烷基，脂环族烷酰氧基烷基，-CH 2 OCOR 7等，或与Y结合以表示键; Y与R 3结合以表示键或与Z结合以表示键; Z表示氢，或与Y结合表示键; W表示氧，或NR 8。

4. 发明公开

EP0770601A1 PROPENONE DERIVATIVES 失效
标题翻译：丙烯衍生物
公开(公告)号：EP0770601A1
公开(公告)日：1997-05-02
申请号：EP96912261.3
申请日：1996-04-26
申请人： Kyowa Hakko Kogyo Co., Ltd.
发明人： IKEDA, Shun-ichi , KANAZAWA, Junji , GOMI, Katsushige , SAITO, Hiromitsu , ASHIZAWA, Tadashi
IPC分类号： C07D209/12 , C07D405/10 , A61K31/40
CPC分类号： C07D405/06 , C07D209/12
摘要： The present invention relates to propenone derivatives represented by the following formula (I):
wherein R 1 represents hydrogen or lower alkyl; R 2 and R 3 independently represent hydrogen, lower alkyl, or substituted or unsubstituted aralkyl, or alternatively R 2 and R 3 are combined to form substituted or unsubstituted methylene or ethylene; R 4 represents hydrogen, hydroxy, lower alkyl, substituted or unsubstituted aralkyl, lower alkoxy, substituted or unsubstituted aralkyloxy, or halogen; and X represents substituted or unsubstituted indolyl, with the proviso that when OR 3 is on the position 2 or position 6 of the benzene ring, R 3 is not hydrogen; that when R 4 is on the position 2 or position 6 of the benzene ring, R 4 is not hydroxy; and that the combination of OR 2 , OR 3 , and R 4 is not 3,4-dimethoxy or 3,4,5-trimethoxy; or pharmaceutically acceptable salts thereof.

5. 发明授权

EP0680950B1 PROPENONE DERIVATIVES 失效
标题翻译： PROPENON衍
公开(公告)号：EP0680950B1
公开(公告)日：2001-05-23
申请号：EP95900905.1
申请日：1994-11-16
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： IKEDA, Shun-ichi , KIMURA, Uichiro , ASHIZAWA, Tadashi , GOMI, Katsushige , SAITO, Hiromitsu , KASAI, Masaji
IPC分类号： C07D209/12 , C07D209/30 , C07D401/06 , A61K31/40 , A61K31/44 , C07D405/06
CPC分类号： C07D401/06 , C07D209/12 , C07D209/30 , C07D405/06

6. 发明授权

EP0755928B1 5-AMINOFLAVONE DERIVATIVES 失效
标题翻译： 5-AMINOFLAVONE衍生物
公开(公告)号：EP0755928B1
公开(公告)日：2002-04-10
申请号：EP96901492.7
申请日：1996-01-31
申请人： KYOWA HAKKO KOGYO CO., Ltd.
发明人： AKAMA, Tsutomu , IKEDA, Shun-ichi , ISHIDA, Hiroyuki Oakwood Apartments D205 , KIMURA, Uichiro , GOMI, Katsushige , SAITO, Hiromitsu
IPC分类号： C07D311/30 , A61K31/35
CPC分类号： C07D311/30

7. 发明公开

EP0918058A1 DC 107 DERIVATIVES (1) 失效
标题翻译： DC 107 DERIVATE（1）
公开(公告)号：EP0918058A1
公开(公告)日：1999-05-26
申请号：EP97947916.9
申请日：1997-12-12
申请人： KYOWA HAKKO KOGYO CO., Ltd.
发明人： ARAI, Hitoshi , KANDA, Yutaka , YAMAGUCHI, Hiroyuki , ASHIZAWA, Tadashi , MURAKATA, Chikara , IKEDA, Shun-ichi , TAMAOKI, Tatsuya
IPC分类号： C07D513/18 , C07D519/00 , C07H15/26 , A61K31/425 , A61K31/70
CPC分类号： C07D513/18 , C07H15/26
摘要： DC107 derivatives represented by formula (I) or pharmaceutically acceptable salts thereof which have antimicrobial activity and antitumor activity are provided:
wherein R 1 represents hydrogen, lower alkoxyalkyl, aralkyloxyalkyl, lower alkoxyalkoxyalkyl, lower alkoxyalkoxyalkoxyalkyl, aralkyl, tetrahydropyranyl, COR 4 , or the like; R 2 represents hydrogen or COR 6 ; R 3 represents -CH 2 OCOR 7 , phthalimidomethyl, or the like; and W represents oxygen or NR 8 (wherein R 8 represents hydroxy, lower alkoxy, lower alkenyloxy, aralkyloxy, substituted or unsubstituted arylsulfonylamino, or lower alkoxycarbonylamino).
摘要翻译：提供了具有抗微生物活性和抗肿瘤活性的由式（I）表示的DC107衍生物或其药学上可接受的盐：其中R 1表示氢，低级烷氧基烷基，芳烷氧基烷基，低级烷氧基烷氧基烷基，低级烷氧基烷氧基烷氧基烷基，芳烷基，四氢吡喃基，COR 4等; R 2表示氢或COR 6; R 3表示-CH 2 OCOR 7，邻苯二甲酰亚氨基甲基等; W表示氧或NR 8（其中R 8表示羟基，低级烷氧基，低级烯氧基，芳烷氧基，取代或未取代的芳基磺酰基氨基或低级烷氧基羰基氨基）。

8. 发明公开

EP0812825A1 PROPENONE DERIVATIVES 失效
标题翻译： PROPENONDERIVATE
公开(公告)号：EP0812825A1
公开(公告)日：1997-12-17
申请号：EP96940153.8
申请日：1996-11-29
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： IKEDA, Shun-ichi , KANAZAWA, Junji , SASAKI, Kimihito , NUKUI, Etsuko , OKABE, Masami , GOMI, Katsushige , SAITO, Hiromitsu , SATO, Soichiro
IPC分类号： C07D209/12 , C07H15/26 , C07F7/10 , A61K31/40 , A61K31/70
CPC分类号： C07F7/0812 , C07D209/12 , C07H15/24
摘要： The present invention relates to propenone derivatives represented by the following formula (I):
wherein R 1 represents substituted lower alkyl or YR 5 (wherein Y represents S or O, and R 5 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or a substituted or unsubstituted cyclic ether residue), R 2 and R 3 represent independently hydrogen, lower alkyl, or substituted or unsubstituted aralkyl, or R 2 and R 3 are combined to represent substituted or unsubstituted methylene or ethylene, R 4 represents hydrogen, hydroxy, lower alkyl, substituted or unsubstituted aralkyl, lower alkoxy, substituted or unsubstituted aralkyloxy, or halogen, and X represents substituted or unsubstituted indolyl, or pharmaceutically acceptable salts thereof.
摘要翻译：本发明涉及由下式（I）表示的丙烯酮衍生物：其中R 1表示取代的低级烷基或YR 5（其中Y表示S或O，R 5表示取代或未取代的）低级烷基，取代或未取代的芳基，取代或未取代的杂芳基或取代或未取代的环状醚残基），R 2和R 3独立地表示氢，低级烷基或取代或未取代的芳烷基或R 2 R 3表示取代或未取代的亚甲基或亚乙基，R 4表示氢，羟基，低级烷基，取代或未取代的芳烷基，低级烷氧基，取代或未取代的芳烷氧基或卤素，X表示取代或未取代的吲哚基或其药学上可接受的盐。

9. 发明公开

EP0755928A1 5-AMINOFLAVONE DERIVATIVES 失效
标题翻译： 5-AMINOFLAVONE衍生物
公开(公告)号：EP0755928A1
公开(公告)日：1997-01-29
申请号：EP96901492.7
申请日：1996-01-31
申请人： Kyowa Hakko Kogyo Co., Ltd.
发明人： AKAMA, Tsutomu , IKEDA, Shun-ichi , ISHIDA, Hiroyuki Oakwood Apartments D205 , KIMURA, Uichiro , GOMI, Katsushige , SAITO, Hiromitsu
IPC分类号： C07D311/30 , A61K31/35
CPC分类号： C07D311/30
摘要： The present invention relates to a 5-aminoflavone derivative represented by the formula (I):
wherein X represents substituted lower alkyl, unsubstituted or substituted lower alkoxy, or NR 1 R 2 (wherein R 1 and R 2 are the same or different and represent hydrogen, unsubstituted or substituted lower alkyl, or R 1 and R 2 are taken together to form an unsubstituted or substituted heterocyclic group containing the sandwiched nitrogen atom in the ring), and Y 1 and Y 2 are the same or different and represent hydrogen, halogen, or lower alkyl, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及由式（I）表示的5-氨基黄酮衍生物：其中X代表取代的低级烷基，未取代或取代的低级烷氧基或NR 1 R 2（其中R 1和R 2相同或不同，代表氢，未取代或取代的低级烷基或R 1和R 2一起形成在环中含有夹心的氮原子的未取代或取代的杂环基），并且Y 1和Y 2相同或不同且表示氢，卤素或低级烷基或其药学上可接受的盐其可接受的盐。

10. 发明授权

EP1097934B1 LK6-A DERIVATIVES 有权
标题翻译： LK6-A衍生物
公开(公告)号：EP1097934B1
公开(公告)日：2004-10-13
申请号：EP99929753.4
申请日：1999-07-08
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： AKAMA, Tsutomu , NAGATA, Hiroyuki , HASEGAWA, Atsuhiro , UE, Harumi , TAKAHASHI, Isami , SAITOH, Yutaka , MOCHIDA, Kenichi , IKEDA, Shun-ichi , KANDA, Yutaka
IPC分类号： C07D471/06 , A61K31/47
CPC分类号： C07D471/06

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