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1. 发明授权

EP0630898B1 THROMBOCYTOPENIA REMEDY 失效
标题翻译：补救措施，血小板减少症
公开(公告)号：EP0630898B1
公开(公告)日：2001-11-28
申请号：EP93919687.9
申请日：1993-09-20
申请人： KYOWA HAKKO KOGYO CO., Ltd.
发明人： TAMAOKI, Tatsuya , SHIOTSU, Yukimasa , MURAKATA, Chikara , AKINAGA, Shiro , OKABE, Masami , SAITOH, Yutaka , WATANABE, Junichi , SHIRAKI, Takako
IPC分类号： C07D487/14 , C07D498/22 , C07H19/23 , A61K31/55 , A61K31/40
CPC分类号： C07D498/22 , C07H9/06 , C07H19/044
摘要： A thrombocytopenia remedy containing an indolocarbazole derivative represented by general formula (I) or a pharmacologically acceptable salt thereof as the active ingredient, and a novel indolocarbazole derivative.

2. 发明授权

EP0670317B1 EPOXYCYCLOHEXENEDIONE DERIVATIVE 失效
标题翻译：环氧环己烯衍生物
公开(公告)号：EP0670317B1
公开(公告)日：2000-03-08
申请号：EP94927068.0
申请日：1994-09-20
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： KANEKO, Masami , SAITOH, Yutaka , AKINAGA, Shiro , OKABE, Masami , AKASAKA, Kazuhito , NAKANO, Hirofumi
IPC分类号： C07D303/36 , A61K31/335
CPC分类号： C07D303/36
摘要： An epoxycyclohexenedione derivative represented by general formula (I) or a pharmacologically acceptable salt thereof, wherein R represents C10-C25 linear or branched alkanoyl, C10-C25 linear alkenoyl or a group represented by formula (A), wherein n represents an integer of 1 to 4. This compound has antibacterial and antitumoral activities.
摘要翻译：通式（I）表示的环氧基环己二酮衍生物或其药理学上允许的盐，式中，R表示碳原子数10〜25的直链状或支链状的烷酰基，碳原子数10〜25的直链烯酰基或式（A）所示的基团，到4.这种化合物具有抗菌和抗肿瘤活性。

3. 发明公开

EP0812825A1 PROPENONE DERIVATIVES 失效
标题翻译： PROPENONDERIVATE
公开(公告)号：EP0812825A1
公开(公告)日：1997-12-17
申请号：EP96940153.8
申请日：1996-11-29
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： IKEDA, Shun-ichi , KANAZAWA, Junji , SASAKI, Kimihito , NUKUI, Etsuko , OKABE, Masami , GOMI, Katsushige , SAITO, Hiromitsu , SATO, Soichiro
IPC分类号： C07D209/12 , C07H15/26 , C07F7/10 , A61K31/40 , A61K31/70
CPC分类号： C07F7/0812 , C07D209/12 , C07H15/24
摘要： The present invention relates to propenone derivatives represented by the following formula (I):
wherein R 1 represents substituted lower alkyl or YR 5 (wherein Y represents S or O, and R 5 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or a substituted or unsubstituted cyclic ether residue), R 2 and R 3 represent independently hydrogen, lower alkyl, or substituted or unsubstituted aralkyl, or R 2 and R 3 are combined to represent substituted or unsubstituted methylene or ethylene, R 4 represents hydrogen, hydroxy, lower alkyl, substituted or unsubstituted aralkyl, lower alkoxy, substituted or unsubstituted aralkyloxy, or halogen, and X represents substituted or unsubstituted indolyl, or pharmaceutically acceptable salts thereof.
摘要翻译：本发明涉及由下式（I）表示的丙烯酮衍生物：其中R 1表示取代的低级烷基或YR 5（其中Y表示S或O，R 5表示取代或未取代的）低级烷基，取代或未取代的芳基，取代或未取代的杂芳基或取代或未取代的环状醚残基），R 2和R 3独立地表示氢，低级烷基或取代或未取代的芳烷基或R 2 R 3表示取代或未取代的亚甲基或亚乙基，R 4表示氢，羟基，低级烷基，取代或未取代的芳烷基，低级烷氧基，取代或未取代的芳烷氧基或卤素，X表示取代或未取代的吲哚基或其药学上可接受的盐。

4. 发明公开

EP0670317A1 EPOXYCYCLOHEXENEDIONE DERIVATIVE 失效
标题翻译：环氧环己烯衍生物
公开(公告)号：EP0670317A1
公开(公告)日：1995-09-06
申请号：EP94927068.0
申请日：1994-09-20
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： KANEKO, Masami , SAITOH, Yutaka , AKINAGA, Shiro , OKABE, Masami , AKASAKA, Kazuhito , NAKANO, Hirofumi
IPC分类号： C07D303/36 , A61K31/335
CPC分类号： C07D303/36
摘要： An epoxycyclohexenedione derivative represented by general formula (I) or a pharmacologically acceptable salt thereof, wherein R represents C₁₀-C₂₅ linear or branched alkanoyl, C₁₀-C₂₅ linear alkenoyl or a group represented by formula (A), wherein n represents an integer of 1 to 4. This compound has antibacterial and antitumoral activities.
摘要翻译：由通式（Ⅰ）表示的环氧环己烯二酮衍生物或其药理学上可接受的盐，其中R代表C 10 -C 25直链或支链烷酰基，C 10 -C 25直链烯酰基或式（A）代表的基团，其中n代表整数1 到4.这种化合物具有抗菌和抗肿瘤活性。

5. 发明公开

EP0643966A1 SENSITIVITY ENHANCER FOR ANTINEOPLASIC AGENT 失效
标题翻译： WIRKSTOFF ZUR VERBESSERUNG DES EMPFINDLICHKEITFÜRANTINEOPLASTISCHE WIRKSTOFFE。
公开(公告)号：EP0643966A1
公开(公告)日：1995-03-22
申请号：EP94907663.2
申请日：1994-02-23
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： MURAKATA, Chikara , SAITHO, Yutaka , AKINAGA, Shiro , OKABE, Masami
IPC分类号： A61K31/475 , C07D498/22
CPC分类号： C07D498/22
摘要： The invention provides a sensitivity enhancer for antineoplastic agents which contains as the active ingredient an indolocarbazole derivative represented by general formula (I) or a pharmacologically acceptable salt thereof, wherein R¹ represents hydrogen, lower alkyl or lower alkanoyl; A represents a group represented by general formula (1) (wherein R² represents hydrogen, lower alkyl or lower alkanoyl, and R³ represents hydrogen or lower alkyl) when one of W¹ and W² represents hydrogen and the other thereof represents hydrogen or hydroxy, or alternatively W¹ and W² are combined together to represent oxygen, excluding the case where all of the R¹, R², W¹ and W² are hydrogen atoms and R³ is methyl; or A represents a group represented by general formula (2) [wherein X represents a single bond or -CO-; m represents an integer of 0 to 6; and Y represents hydrogen, OR⁴ (wherein R⁴ represents hydrogen, lower alkyl, aralkyl or CONR⁵R⁶, wherein R⁵ and R⁶ represent each independently hydrogen or lower alkyl, or alternatively R⁵ and R⁶ are combined together to form a heterocyclic group together with the nitrogen atom to which they are bonded), NR⁷R⁸ (wherein R⁷ and R⁸ represent each independently hydrogen or lower alkyl, or alternatively R⁷ and R⁸ are combined together to form a heterocyclic group together with the nitrogen atom to which they are bonded), or (un)substituted aryl] when R¹ represents lower alkyl or lower alkanoyl and one of W¹ and W² represents hydrogen while the other thereof represents hydrogen or hydroxy, or when R¹ represents hydrogen and one of W¹ and W² represents hydrogen while the other thereof represents hydroxy. The invention also provides another indolocarbazole derivative represented by general formula (II) or a pharmacologically acceptable salt thereof, wherein R 1a represents lower alkyl or lower alkanoyl; W represents hydrogen or hydroxy; and R 4a represents lower alkyl.
摘要翻译：本发明提供了抗肿瘤剂的敏感性增强剂，其含有作为活性成分的通式（I）表示的吲哚并咔唑衍生物或其药理学上可接受的盐，其中R 1表示氢，低级烷基或低级烷酰基; 当W 1和W 2之一表示通式（1）表示的基团（其中R 2表示氢，低级烷基或低级烷酰基，R 3表示氢或低级烷基）表示氢，另一个表示氢或羟基，或者W 1和W 2组合在一起代表氧，不包括所有R 1，R 2，W 1和 W 2是氢原子，R 3是甲基; 或A表示由通式（2）表示的基团[其中X表示单键或-CO-; m表示0〜6的整数，并且Y代表氢，OR 4（其中R 4表示氢，低级烷基，芳烷基或CONR 5 R 6，其中R 5和R 6各自独立地表示氢或低级烷基，或者R 5和R 6结合在一起形成与它们所键合的氮原子一起的杂环基），NR 7 R 8（其中R 7和R 8）独立地表示氢或低级烷基，或者R 7和R 8可以结合在一起形成杂环基以及它们所键合的氮原子），或（未取代的芳基），当R 1 >表示低级烷基或低级烷酰基，W 1和W 2中的一个表示氢，而另一个表示氢或羟基，或当R 1表示氢且W 1和W 2中的一个表示氢时，代表氢，而另一个代表羟基。本发明还提供另一种由通式（II）表示的吲哚并咔唑衍生物或其药学上可接受的盐，其中R 1a表示低级烷基或低级烷酰基; W表示氢或羟基; R 4a表示低级烷基。

6. 发明授权

EP0744409B9 PLATELET GROWTH ACCELERATOR 失效
标题翻译：加快幻灯片的增长
公开(公告)号：EP0744409B9
公开(公告)日：2009-08-19
申请号：EP95909967.2
申请日：1995-02-23
申请人： Kyowa Hakko Kogyo Co., Ltd
发明人： YAMASAKI, Motoo , OKABE, Masami , SUZAWA, Toshiyuki , KOBAYASHI, Ken , MARUYAMA, Kumiko
IPC分类号： C07K14/535 , A61K38/19
CPC分类号： C07K14/535 , A61K38/00
摘要： A human granulocyte-colony stimulating polypeptide wherein at least one amino, carboxy, mercapto or guanidino group has been chemically modified by a chemical modifier; a platelet growth accelerator containing the polypeptide; a method of treating thrombocytopenic patients by administering an efficacious dose of the polypeptide; the use of the polypeptide for producing a pharmacological composition efficacious in treating thrombocytopenic patients; and a composition for treating thrombocytopenic patients comprising an efficacious dose of the polypeptide in a pharmacologically acceptable dosage form together with a pharmacologically acceptable carrier.

7. 发明授权

EP0744409B1 PLATELET GROWTH ACCELERATOR 失效
标题翻译：加快幻灯片的增长
公开(公告)号：EP0744409B1
公开(公告)日：2008-08-06
申请号：EP95909967.2
申请日：1995-02-23
申请人： Kyowa Hakko Kogyo Co., Ltd
发明人： YAMASAKI, Motoo , OKABE, Masami , SUZAWA, Toshiyuki , KOBAYASHI, Ken , MARUYAMA, Kumiko
IPC分类号： C07K14/535 , A61K38/19
CPC分类号： C07K14/535 , A61K38/00
摘要： A human granulocyte-colony stimulating polypeptide wherein at least one amino, carboxy, mercapto or guanidino group has been chemically modified by a chemical modifier; a platelet growth accelerator containing the polypeptide; a method of treating thrombocytopenic patients by administering an efficacious dose of the polypeptide; the use of the polypeptide for producing a pharmacological composition efficacious in treating thrombocytopenic patients; and a composition for treating thrombocytopenic patients comprising an efficacious dose of the polypeptide in a pharmacologically acceptable dosage form together with a pharmacologically acceptable carrier.

8. 发明授权

EP0812825B1 PROPENONE DERIVATIVES 失效
标题翻译：丙烯
公开(公告)号：EP0812825B1
公开(公告)日：2004-02-11
申请号：EP96940153.8
申请日：1996-11-29
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： IKEDA, Shun-ichi , KANAZAWA, Junji , SASAKI, Kimihito , NUKUI, Etsuko , OKABE, Masami , GOMI, Katsushige , SAITO, Hiromitsu , SATO, Soichiro
IPC分类号： C07D209/12 , C07H15/26 , C07F7/10 , A61K31/40 , A61K31/70
CPC分类号： C07F7/0812 , C07D209/12 , C07H15/24

9. 发明授权

EP0670317B9 EPOXYCYCLOHEXENEDIONE DERIVATIVE 失效
标题翻译： EPOXYCYCLOHEXENDIONDERIVAT
公开(公告)号：EP0670317B9
公开(公告)日：2001-03-14
申请号：EP94927068.0
申请日：1994-09-20
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： KANEKO, Masami , SAITOH, Yutaka , AKINAGA, Shiro , OKABE, Masami , AKASAKA, Kazuhito , NAKANO, Hirofumi
IPC分类号： C07D303/36 , A61K31/335
CPC分类号： C07D303/36
摘要： An epoxycyclohexenedione derivative represented by general formula (I) or a pharmacologically acceptable salt thereof, wherein R represents C10-C25 linear or branched alkanoyl, C10-C25 linear alkenoyl or a group represented by formula (A), wherein n represents an integer of 1 to 4. This compound has antibacterial and antitumoral activities.

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