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1. 发明授权

EP0063365B2 1,4-Dihydropyridine derivative and pharmaceutical composition containing same 有权
标题翻译： 1,4-二氢吡啶衍生物和含有它们的药物组合物。
公开(公告)号：EP0063365B2
公开(公告)日：1994-06-15
申请号：EP82103166.3
申请日：1982-04-15
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： Muto, Kenji , Watanabe, Minoru , Hatta, Takao , Sugaya, Toru , Takemoto, Yoshinori , Nakamizo, Nobuhiro
IPC分类号： C07D211/90 , A61K31/445
CPC分类号： C07D211/46 , C07D211/22 , C07D211/90

2. 发明授权

EP0063365B1 1,4-Dihydropyridine derivative and pharmaceutical composition containing same 有权
标题翻译：含有其的1,4-二氢吡啶衍生物和药物组合物
公开(公告)号：EP0063365B1
公开(公告)日：1985-09-04
申请号：EP82103166.3
申请日：1982-04-15
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： Muto, Kenji , Watanabe, Minoru , Hatta, Takao , Sugaya, Toru , Takemoto, Yoshinori , Nakamizo, Nobuhiro
IPC分类号： C07D211/90 , A61K31/445
CPC分类号： C07D211/46 , C07D211/22 , C07D211/90

3. 发明公开

EP0093945A3 1,4-Dihydropyridine derivatives 有权
标题翻译： 1,4-二氢吡啶衍生物
公开(公告)号：EP0093945A3
公开(公告)日：1984-09-12
申请号：EP83104076
申请日：1983-04-26
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： Watanabe, Minoru , Moto, Kenji , Takemoto, Yoshinori , Hatta, Takao , Hashimoto, Tamotsu , Yamada, Koji
IPC分类号： C07D211/94 , C07D405/12 , C07D409/12 , C07D401/12 , A61K31/445
CPC分类号： C07D405/12 , C07C205/56 , C07D211/90 , C07D211/94 , C07D409/12 , Y10S514/929
摘要： Compounds having effects to dilate coronary artery and peripheral blood vessels and to depress the blood pressure, and useful as drugs for cardiovascular disease are represented by the following general formula:
wherein R, represents a hydrogen atom, an alkyl group having 1-5 carbon atoms, an alkenyl group having 2-5 carbon atoms, an aralkyl group having 7-13 carbon atoms or an acyl group having 1-7 carbon atoms, R. and R 3 are the same or different groups and each represents a substituted or unsubstituted alkyl group having 1-5 carbon atoms, an alkenyl group having 2-5 carbon atoms, a disubstituted aminoalkyl group having 1-5 carbon atoms or a substituted or unsubstituted heterocyclic group, R 4 and R 5 are the same or different groups and each represents a hydrogen atom, a halogen atom or a nitro group, and R 6 and R 7 are the same or different groups and each represents an alkyl group having 1-5 carbon atoms; the pharmaceutically acceptable acid addition salt thereof are also effective therapeutic compounds.
摘要翻译：具有扩张冠状动脉和外周血管并降低血压的作用的化合物可用作心血管疾病的药物，其由下列通式表示：其中R 1代表氢原子，具有1-5个碳原子的烷基具有2-5个碳原子的烯基，具有7-13个碳原子的芳烷基或具有1-7个碳原子的酰基，R和R3是相同或不同的基团并且各自表示取代或未取代的烷基具有1-5个碳原子的链烯基，具有2-5个碳原子的链烯基，具有1-5个碳原子的二取代氨基烷基或取代或未取代的杂环基，R 4和R 5是相同或不同的基团并且各自表示氢原子卤素原子或硝基，R6和R7是相同或不同的基团，每个代表具有1-5个碳原子的烷基; 其药学上可接受的酸加成盐也是有效的治疗化合物。

4. 发明授权

EP0093945B1 1,4-Dihydropyridine derivatives 有权
标题翻译： 1,4-二氢吡啶衍生物
公开(公告)号：EP0093945B1
公开(公告)日：1988-11-23
申请号：EP83104076.1
申请日：1983-04-26
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： Watanabe, Minoru , Moto, Kenji , Takemoto, Yoshinori , Hatta, Takao , Hashimoto, Tamotsu , Yamada, Koji
IPC分类号： C07D211/94 , C07D405/12 , C07D409/12 , C07D401/12 , A61K31/445
CPC分类号： C07D405/12 , C07C205/56 , C07D211/90 , C07D211/94 , C07D409/12 , Y10S514/929

5. 发明公开

EP0093945A2 1,4-Dihydropyridine derivatives 有权
标题翻译： -1,4-二氢吡啶衍生物在。
公开(公告)号：EP0093945A2
公开(公告)日：1983-11-16
申请号：EP83104076.1
申请日：1983-04-26
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： Watanabe, Minoru , Moto, Kenji , Takemoto, Yoshinori , Hatta, Takao , Hashimoto, Tamotsu , Yamada, Koji
IPC分类号： C07D211/94 , C07D405/12 , C07D409/12 , C07D401/12 , A61K31/445
CPC分类号： C07D405/12 , C07C205/56 , C07D211/90 , C07D211/94 , C07D409/12 , Y10S514/929
摘要： Compounds having effects to dilate coronary artery and peripheral blood vessels and to depress the blood pressure, and useful as drugs for cardiovascular disease are represented by the following general formula:
wherein R, represents a hydrogen atom, an alkyl group having 1-5 carbon atoms, an alkenyl group having 2-5 carbon atoms, an aralkyl group having 7-13 carbon atoms or an acyl group having 1-7 carbon atoms, R. and R 3 are the same or different groups and each represents a substituted or unsubstituted alkyl group having 1-5 carbon atoms, an alkenyl group having 2-5 carbon atoms, a disubstituted aminoalkyl group having 1-5 carbon atoms or a substituted or unsubstituted heterocyclic group, R 4 and R 5 are the same or different groups and each represents a hydrogen atom, a halogen atom or a nitro group, and R 6 and R 7 are the same or different groups and each represents an alkyl group having 1-5 carbon atoms; the pharmaceutically acceptable acid addition salt thereof are also effective therapeutic compounds.
摘要翻译：具有扩张冠状动脉和外周血管并降低血压的效果的化合物可用作心血管疾病的药物，由以下通式表示：... 其中R1表示氢原子，具有1个 -5个碳原子，具有2-5个碳原子的烯基，具有7-13个碳原子的芳烷基或具有1-7个碳原子的酰基，R2和R3是相同或不同的基团，并且各自表示取代或具有1-5个碳原子的未取代的烷基，具有2-5个碳原子的烯基，具有1-5个碳原子的二取代的氨基烷基或者取代或未取代的杂环基，R4和R5分别相同或不同，氢原子，卤原子或硝基，R 6和R 7相同或不同，各自表示碳原子数为1〜5的烷基。其药学上可接受的酸加成盐也是有效的治疗化合物。

6. 发明公开

EP0063365A1 1,4-Dihydropyridine derivative and pharmaceutical composition containing same 有权
标题翻译： 1,4-二氢吡啶衍生物和含有它们的药物组合物。
公开(公告)号：EP0063365A1
公开(公告)日：1982-10-27
申请号：EP82103166.3
申请日：1982-04-15
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： Muto, Kenji , Watanabe, Minoru , Hatta, Takao , Sugaya, Toru , Takemoto, Yoshinori , Nakamizo, Nobuhiro
IPC分类号： C07D211/90 , A61K31/445
CPC分类号： C07D211/46 , C07D211/22 , C07D211/90
摘要： Compounds having coronary and vasodilator effects, a hypotensive effect, and useful as antianginal drugs and drugs for treating hypertension are represented by the following general formula:
wherein R 1 and R 2 are the same of different groups and each represents a lower alkyl group, one of R 3 and R 4 represents a lower alkyl group and the other represents a group of the general formula:
wherein R 5 represents an aralkyl group or an acyl group and n represents 0 or an integer 1 - 3; the pharmaceutically acceptable acid addition salts thereof are also effective therapeutic compounds.

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