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1. 发明公开

EP0106275A3 1,4-Dihydropyridine derivatives 有权
标题翻译： 1,4-二氢吡啶衍生物
公开(公告)号：EP0106275A3
公开(公告)日：1984-05-23
申请号：EP83109968
申请日：1983-10-05
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： Muto, Kenji , Kuroda, Tokuyuki , Karasawa, Akira , Yamada, Koji , Nakamizo, Nobuhiro
IPC分类号： C07D211/90 , A61K31/455 , C07D211/42
CPC分类号： C07D211/42 , C07D211/90
摘要： Disclosed are (±)-2,6-dimethyl-4-(3-nitrophanyl)-1,4-dihydropyridine-3.5-dicarboxylic acid-3-(1-benzyl-3-piperidyl) ester-5-methyl ester, the melting point of the hydrochloride of which is 196 to 202°C (referred to as (±)-α-form], from among the diastereomers of 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydrapyridine-3,5-dicarboxylic acid-3-(1-benzyl-3-piperidyll ester-5-methyl ester represented by the formula:
and an optical isomer having an optical rotation degree of (+) from among (±)-α-form or a salt thereof.
摘要翻译：（±）-2,6-二甲基-4-（3-硝基苯基）-1,4-二氢吡啶-3,5-二羧酸-3-（1-苄基-3-哌啶基）酯-5-甲酯，（±）-2,6-二甲基-4- 在2,6-二甲基-4-（3-硝基苯基）-1,4-二氢吡啶的非对映异构体中，盐酸盐的熔点为196〜202℃（称为（±）-α-型] -3,5-二羧酸-3-（1-苄基-3-哌啶基]酯-5-甲酯和（±）-α-甲基-β-苯基丙氨酸中的旋光度为（+）的光学异构体，形式或其盐。

2. 发明公开

EP0063365A1 1,4-Dihydropyridine derivative and pharmaceutical composition containing same 有权
标题翻译： 1,4-二氢吡啶衍生物和含有它们的药物组合物。
公开(公告)号：EP0063365A1
公开(公告)日：1982-10-27
申请号：EP82103166.3
申请日：1982-04-15
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： Muto, Kenji , Watanabe, Minoru , Hatta, Takao , Sugaya, Toru , Takemoto, Yoshinori , Nakamizo, Nobuhiro
IPC分类号： C07D211/90 , A61K31/445
CPC分类号： C07D211/46 , C07D211/22 , C07D211/90
摘要： Compounds having coronary and vasodilator effects, a hypotensive effect, and useful as antianginal drugs and drugs for treating hypertension are represented by the following general formula:
wherein R 1 and R 2 are the same of different groups and each represents a lower alkyl group, one of R 3 and R 4 represents a lower alkyl group and the other represents a group of the general formula:
wherein R 5 represents an aralkyl group or an acyl group and n represents 0 or an integer 1 - 3; the pharmaceutically acceptable acid addition salts thereof are also effective therapeutic compounds.

3. 发明公开

EP0106276A3 1,4-Dihydropyridine derivatives 有权
标题翻译： 1,4-二氢吡啶衍生物
公开(公告)号：EP0106276A3
公开(公告)日：1984-05-23
申请号：EP83109969
申请日：1983-10-05
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： Watanabe, Minoru , Muto, Kenji , Sugaya, Toru , Kuroda, Tokuyuki , Hashimoto, Tamotsu , Yamada, Koji , Nakamizo, Nobuhiro
IPC分类号： C07D211/90 , C07D405/14 , C07D409/14 , A61K31/455 , C07D211/44 , C07D211/72 , C07D211/46
CPC分类号： C07D405/14 , C07D211/46 , C07D211/72 , C07D211/74 , C07D211/90 , C07D409/14
摘要： A 1,4-dihydropyridine derivative having hypotensive activity is represented by the formula (I):
in which one of R, and R 2 represents an alkyl group or a group of the formula (II):
in which R 5 represents an alkoxy group or a substituted or unsubstituted heterocyclic group and n represents 0 or an integer of 1 - 3, and the other of R, and R 2 represents a group of the formula (III):
in which R 6 represents a substituted or unsubstituted aralkyl group and R 7 , R 8 , R 9 , R 10 , R 11 and R 12 are the same or different groups and each represertts hydrogen or an alkyl group, and two alkyl groups may be attached to one carbon atom on the piperidine ring. When R, is an alkyl group and R a is an unsubstituted aralkyl group, at least one of R 7 , R s , R s , R 10 , R 11 and R 12 represents an alkyl group. Also disclosed are pharmaceutically acceptable acid addition salts of compound (I).

4. 发明公开

EP0106275A2 1,4-Dihydropyridine derivatives 有权
标题翻译： -1,4-二氢吡啶衍生物在。
公开(公告)号：EP0106275A2
公开(公告)日：1984-04-25
申请号：EP83109968.4
申请日：1983-10-05
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： Muto, Kenji , Kuroda, Tokuyuki , Karasawa, Akira , Yamada, Koji , Nakamizo, Nobuhiro
IPC分类号： C07D211/90 , A61K31/455
CPC分类号： C07D211/42 , C07D211/90
摘要： Disclosed are (±)-2,6-dimethyl-4-(3-nitrophanyl)-1,4-dihydropyridine-3.5-dicarboxylic acid-3-(1-benzyl-3-piperidyl) ester-5-methyl ester, the melting point of the hydrochloride of which is 196 to 202°C (referred to as (±)-α-form], from among the diastereomers of 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydrapyridine-3,5-dicarboxylic acid-3-(1-benzyl-3-piperidyll ester-5-methyl ester represented by the formula:
and an optical isomer having an optical rotation degree of (+) from among (±)-α-form or a salt thereof.
摘要翻译：公开了（+/-） - 2,6-二甲基-4-（3-硝基苯基）-1,4-二氢吡啶-3,5-二羧酸-3-（1-苄基-3-哌啶基）酯-5- 甲基酯，其盐酸盐的熔点为196〜202℃（称为（+/-）-α-甲基），2,6-二甲基-4-（3-硝基苯基） - 由下式表示的1,4-二氢吡啶-3,5-二甲酸-3-（1-苄基-3-哌啶基）酯-5-甲酯：旋光度为（+ ）（±）-α型或其盐。

5. 发明授权

EP0063365B2 1,4-Dihydropyridine derivative and pharmaceutical composition containing same 有权
标题翻译： 1,4-二氢吡啶衍生物和含有它们的药物组合物。
公开(公告)号：EP0063365B2
公开(公告)日：1994-06-15
申请号：EP82103166.3
申请日：1982-04-15
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： Muto, Kenji , Watanabe, Minoru , Hatta, Takao , Sugaya, Toru , Takemoto, Yoshinori , Nakamizo, Nobuhiro
IPC分类号： C07D211/90 , A61K31/445
CPC分类号： C07D211/46 , C07D211/22 , C07D211/90

6. 发明授权

EP0063365B1 1,4-Dihydropyridine derivative and pharmaceutical composition containing same 有权
标题翻译：含有其的1,4-二氢吡啶衍生物和药物组合物
公开(公告)号：EP0063365B1
公开(公告)日：1985-09-04
申请号：EP82103166.3
申请日：1982-04-15
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： Muto, Kenji , Watanabe, Minoru , Hatta, Takao , Sugaya, Toru , Takemoto, Yoshinori , Nakamizo, Nobuhiro
IPC分类号： C07D211/90 , A61K31/445
CPC分类号： C07D211/46 , C07D211/22 , C07D211/90

7. 发明公开

EP0106276A2 1,4-Dihydropyridine derivatives 有权
标题翻译： -1,4-二氢吡啶衍生物在。
公开(公告)号：EP0106276A2
公开(公告)日：1984-04-25
申请号：EP83109969.2
申请日：1983-10-05
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： Watanabe, Minoru , Muto, Kenji , Sugaya, Toru , Kuroda, Tokuyuki , Hashimoto, Tamotsu , Yamada, Koji , Nakamizo, Nobuhiro
IPC分类号： C07D211/90 , C07D405/14 , C07D409/14 , A61K31/455
CPC分类号： C07D405/14 , C07D211/46 , C07D211/72 , C07D211/74 , C07D211/90 , C07D409/14
摘要： A 1,4-dihydropyridine derivative having hypotensive activity is represented by the formula (I):
in which one of R, and R 2 represents an alkyl group or a group of the formula (II):
in which R 5 represents an alkoxy group or a substituted or unsubstituted heterocyclic group and n represents 0 or an integer of 1 - 3, and the other of R, and R 2 represents a group of the formula (III):
in which R 6 represents a substituted or unsubstituted aralkyl group and R 7 , R 8 , R 9 , R 10 , R 11 and R 12 are the same or different groups and each represertts hydrogen or an alkyl group, and two alkyl groups may be attached to one carbon atom on the piperidine ring. When R, is an alkyl group and R a is an unsubstituted aralkyl group, at least one of R 7 , R s , R s , R 10 , R 11 and R 12 represents an alkyl group. Also disclosed are pharmaceutically acceptable acid addition salts of compound (I).
摘要翻译：具有降血压活性的1,4-二氢吡啶衍生物由式（I）表示：其中R 1和R 2中的一个表示烷基或式（II）的基团： - （CH 2）n -R5（II）...其中R5表示烷氧基或取代或未取代的杂环基，n表示0或1-3的整数，R1和R2中的另一个表示式（III）的基团：其中R 6表示取代或未取代的芳烷基，且R 7，R 8，R 9，R 10，R 11和R 12为相同或不同的基团，各自表示氢或烷基，两个烷基可以连接到一个碳原子在哌啶环上。当R 1为烷基且R 6为未取代的芳烷基时，R 7，R 8，R 9，R 10，R 11和R 12中的至少一个为烷基。还公开了化合物（I）的药学上可接受的酸加成盐。

8. 发明授权

EP0106275B1 1,4-Dihydropyridine derivatives 有权
公开(公告)号：EP0106275B1
公开(公告)日：1991-03-13
申请号：EP83109968.4
申请日：1983-10-05
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： Muto, Kenji , Kuroda, Tokuyuki , Karasawa, Akira , Yamada, Koji , Nakamizo, Nobuhiro
IPC分类号： C07D211/90 , A61K31/455
CPC分类号： C07D211/42 , C07D211/90

9. 发明授权

EP0106276B1 1,4-Dihydropyridine derivatives 有权
标题翻译： 1,4-二氢吡啶衍生物
公开(公告)号：EP0106276B1
公开(公告)日：1988-10-26
申请号：EP83109969.2
申请日：1983-10-05
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： Watanabe, Minoru , Muto, Kenji , Sugaya, Toru , Kuroda, Tokuyuki , Hashimoto, Tamotsu , Yamada, Koji , Nakamizo, Nobuhiro
IPC分类号： C07D211/90 , C07D405/14 , C07D409/14 , A61K31/455
CPC分类号： C07D405/14 , C07D211/46 , C07D211/72 , C07D211/74 , C07D211/90 , C07D409/14

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