专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP2967419A1 MEDICAL IMAGING 有权转让
标题翻译： MEDIZINISCHE BILDGEBUNG
公开(公告)号：EP2967419A1
公开(公告)日：2016-01-20
申请号：EP14711591.9
申请日：2014-03-14
申请人： Isis Innovation Limited
发明人： TUNNICLIFFE, Elizabeth , ROBSON, Matthew , BANERJEE, Rajarshi
IPC分类号： A61B5/055 , G01R33/50
CPC分类号： G01R33/50 , A61B5/0044 , A61B5/055 , A61B5/14546 , G01R33/448 , G06T7/0012 , G06T2207/10088 , G06T2207/30048 , G06T2207/30056
摘要： The present disclosure provides systems and methods which may assist in evaluating liver fibrosis/inflammation in the presence of elevated iron using magnetic resonance relaxometry. In a non-limiting embodiment, the systems and methods include: obtaining a measurement of relaxometry data of a subject's liver for extracellular fluid, preferably using a magnetic resonance imaging (MRI) device; determining an iron content for the liver; simulating a measurement of the subject's liver for extracellular fluid for the determined iron content; comparing the measurement of the subject's liver for extracellular fluid to the simulated measurement of the subject's liver for extracellular fluid; and determining from said comparison a value of extracellular fluid in the subject's liver based on a normal iron content for the liver. The simulation can include multi-compartment modeling of various fractions of extracellular fluid in the liver and the impact of iron content in the liver on both the intra- and extracellular relaxation times.
摘要翻译：本公开提供了可以有助于使用磁共振弛豫测定在升高的铁的存在下评估肝纤维化/炎症的系统和方法。在非限制性实施方案中，系统和方法包括：优选使用磁共振成像（MRI）装置获得受试者肝细胞外液的松弛度数据的测量; 测定肝脏的铁含量; 模拟受试者的肝脏对于测定的铁含量的细胞外液的测量; 将受试者肝细胞外液的测量与细胞外液的受试者肝脏的模拟测量进行比较; 并根据所述比较，根据肝脏的正常铁含量确定受试者肝脏中细胞外液的值。模拟可以包括肝脏中细胞外液各种分数的多室建模以及肝中铁含量对细胞内和细胞外松弛时间的影响。

IPRDB

热门服务

关于我们

友情链接

联系方式