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1. 发明授权

EP1438571B1 BIOSENSOR-SCHALTKREIS UND EIN AUS EINER MEHRZAHL DIESER BIOSENSOR-SCHALTKREISE BESTEHENDER SENSOR-ARRAY UND BIOSENSOR-ARRAY 有权
标题翻译：生物传感器电路关闭此生物传感器电路的许多现有阵列和生物传感器阵列
公开(公告)号：EP1438571B1
公开(公告)日：2010-09-08
申请号：EP02774406.9
申请日：2002-09-25
申请人： Infineon Technologies AG
发明人： EVERSMANN, Björn-Oliver , JENKNER, Martin , PAULUS, Christian , THEWES, Roland
IPC分类号： G01N27/414
CPC分类号： H03F3/45188 , G01N27/4145 , G01N33/4836 , H03F2203/45352
摘要： The invention relates to a circuit arrangement, a sensor array and a biosensor array. The circuit arrangement comprises a substrate, a sensor element configured on a surface area of the substrate with a physical parameter which can be coupled to a substance to be analyzed; The type of coupling comprises a resistive component and a calibrating device embodied in or on the substrate and arranged in such a way that a modification of the value of the physical parameter of the sensor element can be at least partially compensated therewith. Preferably, the sensor element of the circuit arrangement is provided with an electrically conductive sensor electrode which can be coupled to the substance to be analyzed. The sensor element can also comprise a measuring transistor with a gate connection which is coupled to the electrically conductive sensor electrode.

2. 发明公开

EP1495443A2 EVENTDETECTION-VORRICHTUNG UND VERFAHREN ZUR MESSUNG DER AKTIVITÄT NEURONALER NETZWERKE 审中-公开
标题翻译：事件检测装置和方法测量活动神经元网络
公开(公告)号：EP1495443A2
公开(公告)日：2005-01-12
申请号：EP03720398.1
申请日：2003-03-31
申请人： Infineon Technologies AG
发明人： EVERSMANN, Björn-Oliver , JENKNER, Martin , PAULUS, Christian , THEWES, Roland
IPC分类号： G06N3/04
CPC分类号： G01N33/4833 , G06N3/063
摘要： The invention relates to a device for measuring the activity of neuronal networks using a structured semiconductor substrate comprising a plurality of sensor elements which respectively have at least one electroconductive detection electrode (E) arranged on the surface of the semiconductor substrate for the detection of neuronal signals of the neuronal network. Said sensor elements are arranged in such a way that electrical sensor output signals can be emitted by means of respective sensor outputs (SA) of the sensor elements, according to the detected neuronal signals. The semiconductor substrate also comprises a plurality of amplifying elements (V; TKV) which respectively comprise at least one amplifier input and at least one amplifier output (VA). An amplifying element (V; TKV) is associated with each sensor element, the amplifier input of the amplifying element being electrically connected to the sensor output (SA) of the respective sensor element, and the amplified sensor output signal can be emitted by means of the amplifier output (VA) as an amplifier output signal. Said semiconductor substrate further comprises at least one activity evaluation device comprising at least one evaluation input and at least one evaluation output, the evaluation input (digital out; analog out) being electrically connected to at least one of the amplifier outputs (VA). The activity evaluation device is arranged in such a way that, according to the amplifier output signal, it generates an activity signal which is a measure for the activity of the neuronal network, and emits the same by means of the evaluation output.

3. 发明授权

EP1399262B1 PIPETTENVORRICHTUNG UND VERFAHREN ZU DEREN HERSTELLUNG 有权
公开(公告)号：EP1399262B1
公开(公告)日：2004-10-13
申请号：EP02754726.4
申请日：2002-06-20
申请人： Infineon Technologies AG
发明人： FRITZ, Michaela , DERTINGER, Stephan , FUCHS, Karin , HANEDER, Thomas , HANKE, Hans-Christian , JENKNER, Martin , LEHMANN, Volker , PAULUS, Christian
IPC分类号： B01L3/02 , B01L3/00
CPC分类号： B81C1/00087 , B01L3/0241 , B81B2201/057
摘要： The invention relates to a device, especially for patch-clamping vesicles and/or for dispensing small, defined liquid amounts onto surfaces. The device is characterized in that in a substrate (2) at least one pipette in the form of a through hole (8) with a predetermined diameter is produced, a rim (16) of the through hole (8) protruding from a neighboring surface (4) of the substrate (2) by a predetermined length. The invention further relates to a method for producing the device, comprising the following steps: producing at least one hole (8), forming at least one modified surface layer (12) on at least the inner surfaces of the hole (8), selectively removing the substrate (2), the modified surface layer (12) not being substantially affected so that it protrudes from a surface (4) of the substrate and forms a protruding rim (16), and finishing the hole (8) as a through hole in a suitable process step.
摘要翻译：本发明涉及一种装置，尤其是用于贴片囊泡和/或用于将少量限定的液体量分配到表面上的装置。该装置的特征在于，在基板（2）中制造至少一个具有预定直径的通孔（8）形式的移液管，通孔（8）的边缘（16）从相邻表面（4）的预定长度。本发明还涉及一种用于制造该装置的方法，包括以下步骤：制造至少一个孔（8），在孔（8）的至少内表面上形成至少一个改性表面层（12），选择性地去除基底（2），修饰的表面层（12）基本上不受影响，使得它从基底的表面（4）突出并形成突出边缘（16），并且将孔（8）作为通孔在合适的工艺步骤中钻孔。

4. 发明公开

EP1478737A1 CMOS-PROZESS-KOMPATIBLE HOCH-DK-OBERFLÄCHENBESCHICHTUNG ZUR KAPAZITIVEN DETEKTION UND STIMULATION BIOLOGISCHER GEWEBE 有权
标题翻译：用于电容式检测CMOS工艺兼容的HIGH-DK-表面涂层和生物组织起搏
公开(公告)号：EP1478737A1
公开(公告)日：2004-11-24
申请号：EP03708128.8
申请日：2003-02-24
申请人： Infineon Technologies AG
发明人： GABL, Reinhard , BIRKENMAIER, Tamara , EVERSMANN, Björn-Oliver , FROMHERZ, Peter , JENKNER, Martin , SCHREITER, Matthias , THEWES, Roland , WERSING, Wolfram
IPC分类号： C12N5/06 , G01N33/00 , G01N33/543 , B01L3/00
CPC分类号： C12N5/0619 , G01N33/4833
摘要： The invention relates to a biochip for capacitive stimulation and/or detection of biological tissue (14), having a carrier structure (10), at least one stimulation and/or sensor device that is arranged in or on the carrier structure (10), at least one dielectric layer (12), one of the surfaces of said layer being arranged in the stimulation and/or sensor device while the opposite surface of said layer forms a stimulation and/or sensor surface for capacitive stimulation and/or detection of biological tissue (14), wherein the dielectric layer (12) contains TiO2.

5. 发明公开

EP1428026A1 FLUORESZENZ-BIOSENSORCHIP UND FLUORESZENZ-BIOSENSORCHIP-ANORDNUNG 审中-公开
标题翻译：荧光生物传感器芯片与荧光生物传感器芯片配置
公开(公告)号：EP1428026A1
公开(公告)日：2004-06-16
申请号：EP02758143.8
申请日：2002-08-12
申请人： Infineon Technologies AG
发明人： SCHIENLE, Meinrad , BREDERLOW, Ralf , HOFMANN, Franz , JENKNER, Martin , LUYKEN, R., Johannes , PAULUS, Christian , SCHINDLER-BAUER, Petra , THEWES, Roland
IPC分类号： G01N33/543
CPC分类号： G01N21/6454 , G01N33/54373 , G01N2201/0642
摘要： The invention relates to a fluorescence biosensor chip and to a fluorescence biosensor chip arrangement. Said fluorescence biosensor chip comprises a substrate, at least one detection device which is arranged in or on the substrate and is used to detect electromagnetic radiation, an optical filter layer which is arranged on the substrate, and an immobilisation layer which is arranged on the optical filter layer and is used to immobilise trap molecules. Said detection device, optical filter layer and immobilisation layer are integrated into the fluorescence biosensor chip. The inventive fluorescence biosensor chip arrangement comprises a fluorescence biosensor chip and an electromagnetic source of radiation.

6. 发明授权

EP1478737B1 CMOS-PROZESS-KOMPATIBLE HOCH-DK-OBERFLÄCHENBESCHICHTUNG ZUR KAPAZITIVEN DETEKTION UND STIMULATION BIOLOGISCHER GEWEBE 有权
标题翻译：用于电容式检测CMOS工艺兼容的HIGH-DK-表面涂层和生物组织起搏
公开(公告)号：EP1478737B1
公开(公告)日：2005-08-24
申请号：EP03708128.8
申请日：2003-02-24
申请人： Infineon Technologies AG
发明人： GABL, Reinhard , BIRKENMAIER, Tamara , EVERSMANN, Björn-Oliver , FROMHERZ, Peter , JENKNER, Martin , SCHREITER, Matthias , THEWES, Roland , WERSING, Wolfram
IPC分类号： C12N5/06 , G01N33/00 , G01N33/543 , B01L3/00
CPC分类号： C12N5/0619 , G01N33/4833

7. 发明公开

EP1525470A2 SENSOR-ANORDNUNG 审中-公开
标题翻译：传感器装置
公开(公告)号：EP1525470A2
公开(公告)日：2005-04-27
申请号：EP03747797.3
申请日：2003-07-22
申请人： Infineon Technologies AG
发明人： EVERSMANN, Björn-Oliver , JENKNER, Martin , PAULUS, Christian , STROMBERG, Guido , STURM, Thomas , STÖHR, Annelie
IPC分类号： G01N33/487 , G01N27/414 , H01L27/146
CPC分类号： G01N33/48728 , G01N33/4836 , H01L21/00
摘要： According to the invention, a plurality of cumulative current flows fulfilling a pre-determined selection criterion can be determined from detected cumulative current flows. At least one cumulative current flow fulfilling a pre-determined second selection criterion can be selected from the determined cumulative current flows, as a cumulative current flow representing a sensor signal. The sensor element to which a sensor signal is applied is determined from the selected cumulative current flow.

8. 发明公开

EP1438571A1 BIOSENSOR-SCHALTKREIS UND EIN AUS EINER MEHRZAHL DIESER BIOSENSOR-SCHALTKREISE BESTEHENDER SENSOR-ARRAY UND BIOSENSOR-ARRAY 有权
标题翻译：生物传感器电路关闭此生物传感器电路的许多现有阵列和生物传感器阵列
公开(公告)号：EP1438571A1
公开(公告)日：2004-07-21
申请号：EP02774406.9
申请日：2002-09-25
申请人： Infineon Technologies AG
发明人： EVERSMANN, Björn-Oliver , JENKNER, Martin , PAULUS, Christian , THEWES, Roland
IPC分类号： G01N27/12
CPC分类号： H03F3/45188 , G01N27/4145 , G01N33/4836 , H03F2203/45352
摘要： The invention relates to a circuit arrangement, a sensor array and a biosensor array. The circuit arrangement comprises a substrate, a sensor element configured on a surface area of the substrate with a physical parameter which can be coupled to a substance to be analyzed; The type of coupling comprises a resistive component and a calibrating device embodied in or on the substrate and arranged in such a way that a modification of the value of the physical parameter of the sensor element can be at least partially compensated therewith. Preferably, the sensor element of the circuit arrangement is provided with an electrically conductive sensor electrode which can be coupled to the substance to be analyzed. The sensor element can also comprise a measuring transistor with a gate connection which is coupled to the electrically conductive sensor electrode.

9. 发明公开

EP1399262A1 PIPETTENVORRICHTUNG UND VERFAHREN ZU DEREN HERSTELLUNG 有权
标题翻译：移液器装置和方法及其
公开(公告)号：EP1399262A1
公开(公告)日：2004-03-24
申请号：EP02754726.4
申请日：2002-06-20
申请人： Infineon Technologies AG
发明人： FRITZ, Michaela , DERTINGER, Stephan , FUCHS, Karin , HANEDER, Thomas , HANKE, Hans-Christian , JENKNER, Martin , LEHMANN, Volker , PAULUS, Christian
IPC分类号： B01L3/02 , B01L3/00
CPC分类号： B81C1/00087 , B01L3/0241 , B81B2201/057
摘要： The invention relates to a device, especially for patch-clamping vesicles and/or for dispensing small, defined liquid amounts onto surfaces. The device is characterized in that in a substrate (2) at least one pipette in the form of a through hole (8) with a predetermined diameter is produced, a rim (16) of the through hole (8) protruding from a neighboring surface (4) of the substrate (2) by a predetermined length. The invention further relates to a method for producing the device, comprising the following steps: producing at least one hole (8), forming at least one modified surface layer (12) on at least the inner surfaces of the hole (8), selectively removing the substrate (2), the modified surface layer (12) not being substantially affected so that it protrudes from a surface (4) of the substrate and forms a protruding rim (16), and finishing the hole (8) as a through hole in a suitable process step.

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