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1. 发明授权

EP0304158B1 Cephalosporins, processes for their preparation and pharmaceutical compositions containing them 失效
标题翻译：头孢菌素类，它们的制备方法和含有它们的药物组合物。
公开(公告)号：EP0304158B1
公开(公告)日：1994-06-22
申请号：EP88306420.6
申请日：1988-07-13
申请人： IMPERIAL CHEMICAL INDUSTRIES PLC , ICI PHARMA
发明人： Arnould, Jean Claude , Jung, Frederick Henri , Boucherot, Dominique , Strawson, Colin John , Davies, David Huw
IPC分类号： C07D501/46 , C07D501/40
CPC分类号： C07D501/46 , C07D501/40

2. 发明公开

EP0304158A1 Cephalosporins, processes for their preparation and pharmaceutical compositions containing them 失效
标题翻译：头孢菌素类，它们的制备方法和含有它们的药物组合物。
公开(公告)号：EP0304158A1
公开(公告)日：1989-02-22
申请号：EP88306420.6
申请日：1988-07-13
申请人： IMPERIAL CHEMICAL INDUSTRIES PLC , ICI PHARMA
发明人： Arnould, Jean Claude , Jung, Frederick Henri , Boucherot, Dominique , Strawson, Colin John , Davies, David Huw
IPC分类号： C07D501/46 , C07D501/40
CPC分类号： C07D501/46 , C07D501/40
摘要： Cephalosporin derivatives having a 3-position substituent of the formula I are described:
wherein R 1 is hydrogen, alkenyl or optionally substituted alkyl, Het is a 5- or 6-membered heterocyclic ring bonded via a carbon atom to the amide linkage, wherein Het is selected from a group of the formulae II - III:
wherein A is CH or a nitrogen atom; B is oxygen, sulphur or a group NR 4 ; one or two of D, E, F and G are nitrogen atoms and the remainder are CH groups: or Het is a pyrazinone, pyridinone, pyridazinone or pyrimidinone ring, or is a thione equivalent of such a ring, said rings having a substituent R 4 on one nitrogen atom, or is pyranone, or pyranthione; the ring Het being fused by any two adjacent carbon atoms to the benzene ring; and Het being attached to the -CH 2 NR'CO- group via a carbon atom;

R 2 is hydroxy or an in vivo hydrolysable ester thereof;
R 3 is ortho to R 2 and is hydroxy or an in vivo hydrolysable ester thereof; and R 4 has various values. The use of such compounds as antibacterial agents is described as are processes for their preparation and intermediates therefor.
摘要翻译：具有下式的3位取代基的头孢菌素衍生物我描述： worin - [R <1>为氢，烯基或任选substituiertem烷基，Het是经由碳原子键合的5-或6-元杂环酰胺键，worin Het是选自式餐饮II的选择 - III： worin A为CH或氮原子; B是氧，硫或基团NR <4>; 一个或两个的D，E，F和G为氮原子，其余的是CH基团：或Het是吡嗪酮，吡啶酮，哒嗪酮或嘧啶酮环，或者是一个硫酮等价搜索一个环的，所述具有取代基R的环 <4>在一个氮原子，或是吡喃酮，或pyranthione; 所述环的Het由任何两个相邻碳原子与苯环稠合; 和Het被附接到经由碳原子的-CH 2 NR <1> CO-基团; [R <2>为羟基或其体内可水解酯; [R <3>是邻至R <2>和是羟基或其体内可水解酯; 且R <4>具有各种值。因为是它们的制备方法及其中间体测试作为抗菌剂的化合物的用途进行说明。

3. 发明公开

EP0070622A1 Derivatives of M.139,603 useful as growth promotors 有权转让
标题翻译：促生长M.139,603的衍生物。
公开(公告)号：EP0070622A1
公开(公告)日：1983-01-26
申请号：EP82303158.8
申请日：1982-06-17
申请人： IMPERIAL CHEMICAL INDUSTRIES PLC
发明人： Davies, David Huw , Smithers, Michael James
IPC分类号： C07D407/14 , C12P17/16 , A23K1/17
CPC分类号： C12R1/465 , C12P17/162
摘要： Novel ether, ester, urethane, thiourethane and carbonate derivatives of the ruminant growth promoters, M. 139,603, M. 139,603-aldehyde and oxime etc. derivatives thereof, all of which are effective in reducing the proportion of methane produced by ruminal fermentation, and increasing the proportion of propionic acid at the expense of acetic acid in the rumen contents; together with processes for their manufacture, compositions containing them, and their use in increasing growth and/ or feed efficiency in ruminant animals.

4. 发明公开

EP0002893A1 Growth promotion means for ruminant animals and method for its production 失效
标题翻译：生长促进反刍动物剂，以及它们的制备方法。
公开(公告)号：EP0002893A1
公开(公告)日：1979-07-11
申请号：EP78300718.0
申请日：1978-12-01
申请人： IMPERIAL CHEMICAL INDUSTRIES PLC
发明人： Davies, David Huw , Norris, Geoffrey Lightfoot Floyd
IPC分类号： A23K1/17 , A23K1/165 , A23K1/18 , C07D493/22 , C12P9/00
CPC分类号： A23K20/195 , Y02P60/56
摘要： This invention relates to the use of aplasmomycin, boromycin and acylated and hydrogenated derivatives thereof for modifying rumen metabolism in domestic ruminant animals, by reducing the proportion of methane formed, and increasing the proportion of propionate at the expense of methane and/or acetate. This modification of rumen metabolism is believed to improve growth in ruminant animals. The disclosure also describes compositions which may be used in the claimed method, an improved process for the production of aplasmomycin, and novel analogs of aplasmomycin and boromycin together with processes for their manufacture.

5. 发明授权

EP0070622B1 Derivatives of M.139,603 useful as growth promotors 有权转让
标题翻译： M.139,603的有用作为增长推广者的衍生物
公开(公告)号：EP0070622B1
公开(公告)日：1987-01-14
申请号：EP82303158.8
申请日：1982-06-17
申请人： IMPERIAL CHEMICAL INDUSTRIES PLC
发明人： Davies, David Huw , Smithers, Michael James
IPC分类号： C07D407/14 , C12P17/16 , A23K1/17
CPC分类号： C12R1/465 , C12P17/162

6. 发明授权

EP0053017B1 Amide derivatives 失效
公开(公告)号：EP0053017B1
公开(公告)日：1985-02-20
申请号：EP81305490.5
申请日：1981-11-20
申请人： IMPERIAL CHEMICAL INDUSTRIES PLC
发明人： Davies, David Huw , Preston, John , Walker, Edward Raymond Halstead , Ratcliffe, Arnold Harry
IPC分类号： C07D401/06 , C07D401/12 , C07D409/12 , C07D405/12 , C07D405/06 , C07D417/06 , C07D411/06 , C07D403/06 , A61K31/395
CPC分类号： C07C255/00 , C07D205/04 , C07D207/16 , C07D209/20 , C07D211/60 , C07D223/06 , C07D239/04 , C07D263/42 , C07D265/06 , C07D277/06 , C07D279/06 , C07D333/24

7. 发明公开

EP0053017A1 Amide derivatives 失效
标题翻译：在一片衍。
公开(公告)号：EP0053017A1
公开(公告)日：1982-06-02
申请号：EP81305490.5
申请日：1981-11-20
申请人： IMPERIAL CHEMICAL INDUSTRIES PLC
发明人： Davies, David Huw , Preston, John , Walker, Edward Raymond Halstead , Ratcliffe, Arnold Harry
IPC分类号： C07D401/06 , C07D401/12 , C07D409/12 , C07D405/12 , C07D405/06 , C07D417/06 , C07D411/06 , C07D403/06 , A61K31/395
CPC分类号： C07C255/00 , C07D205/04 , C07D207/16 , C07D209/20 , C07D211/60 , C07D223/06 , C07D239/04 , C07D263/42 , C07D265/06 , C07D277/06 , C07D279/06 , C07D333/24
摘要： The invention concerns novel amide derivatives of the formula:-
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 10 , R" and R' 6 are various substituents defined hereinafter, Y is carbonyl, thiocarbonyl, sulphonyl or amido, X is carbonyl, hydroxymethylene, thiocarbonyl or oximinomethylene and Q is carbonyl or methylene, or a salt thereof, which are inhibitors of angiotensin converting enzyme and may be used for example, in the treatment of hypertension. The invention also provides pharmaceutical compositions of and processes for the manufacture of the novel amide derivatives
摘要翻译：本发明涉及下式的新型酰胺衍生物：-R 1 -Y-NR 2 -CHR 3 -X-CHR 1 -CHR 4 -CO-NR 5 - CR 6 R 6 -QR 1其中R 1，R 2，R 3，R 4，R 5，R 6， R 1，R 1和R 6是下文定义的各种取代基，Y是羰基，硫代羰基，磺酰基或酰胺基，X是羰基，羟基亚甲基，硫代羰基或肟基亚甲基和Q 是作为血管紧张素转化酶的抑制剂的羰基或亚甲基或其盐，可以用于例如治疗高血压。本发明还提供了用于制备新型酰胺衍生物的药物组合物和方法。

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