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1. 发明公开

EP1251435A2 Knowledge database and method for constructing and merging knowledge database 审中-公开
标题翻译： Wissensbasis und Methode zum Konstruieren und Intergrieren von Wissensbasen
公开(公告)号：EP1251435A2
公开(公告)日：2002-10-23
申请号：EP02003746.1
申请日：2002-02-19
申请人： Hitachi Software Engineering Co., Ltd. , Okubo, Kousaku
发明人： Okubo, Kousaku , Tamura, Takuro , Yamashita, Iwao
IPC分类号： G06F17/30 , G06F19/00
CPC分类号： G06F19/28 , G06F19/24
摘要： Disclosed is a technology capable of acquiring transverse knowledge beyond specialized fields such as medicine and biology. From a knowledge database for accumulating objects as object values, the objects having phrases including terms used in a medical field and/or a biological field, and accumulating relations between the objects, the relations having values, as relation values, for expressing mutual relations between the objects quantitatively, objects related to a query object are extracted based on the relations between the objects, and the query object and the objects extracted are displayed together with the relations therebetween.
摘要翻译：披露了一种能够获得超越专业领域（如医学和生物学）的横向知识的技术。从用于将对象累积为对象值的知识数据库，具有短语的对象包括在医学领域和/或生物领域中使用的术语，并且累积对象之间的关系，具有值的关系作为关系值，用于表示相互关系定量地对象，基于对象之间的关系提取与查询对象相关的对象，并且查询对象和提取的对象与它们之间的关系一起被显示。

2. 发明授权

EP1089211B1 Method and apparatus for displaying gene expression patterns 有权
标题翻译：用于显示的基因表达模式的方法和装置
公开(公告)号：EP1089211B1
公开(公告)日：2005-11-16
申请号：EP00121116.8
申请日：2000-09-28
申请人： HITACHI SOFTWARE ENGINEERING CO., LTD.
发明人： Nozaki, Yasuyuki , Nakashige, Ryo , Watanabe, Tsunehiko , Tamura, Takuro
IPC分类号： G06F19/00
CPC分类号： G06K9/6218 , G06F19/20 , G06F19/24 , G06F19/26 , G06K2209/07

3. 发明公开

EP1089211A3 Method and apparatus for displaying gene expression patterns 有权
标题翻译：用于显示的基因表达模式的方法和装置
公开(公告)号：EP1089211A3
公开(公告)日：2003-09-03
申请号：EP00121116.8
申请日：2000-09-28
申请人： Hitachi Software Engineering Co., Ltd.
发明人： Nozaki, Yasuyuki , Nakashige, Ryo , Watanabe, Tsunehiko , Tamura, Takuro
IPC分类号： G06F19/00
CPC分类号： G06K9/6218 , G06F19/20 , G06F19/24 , G06F19/26 , G06K2209/07
摘要： The present invention aims at finding out and effectively displaying that different genes give the same expression for having the same function at one time point but give different expressions at another time point for having different roles. Furthermore, the present invention aims at automatically extracting brief groups of clusters from the clustering results of gene expression pattern data so that a user can select a desirable level of grouping.

4. 发明公开

EP1132136A2 Microarray, method for producing the same, and method for correcting inter-pin spotting amount error of the same 有权
标题翻译： Microarray sowiedafürgeeignetes Herstellungs- und Aufgabestiftabstandskorrekturverfahren
公开(公告)号：EP1132136A2
公开(公告)日：2001-09-12
申请号：EP01104785.9
申请日：2001-02-27
申请人： Hitachi Software Engineering Co., Ltd.
发明人： Yamamoto, Tomoyuki , Tamura, Takuro
IPC分类号： B01L3/02 , B01J19/00 , G01N21/88
CPC分类号： B01L3/0244 , B01J19/0046 , B01J2219/00387 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00621 , B01J2219/00659 , B01J2219/00695 , B01J2219/00698 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/1067 , G01N2035/1037 , G01N2035/1069
摘要： The present invention has an objective of obtaining more accurate data of microarray experiments by correcting an inter-pin spotting amount error caused upon microarray production using a plurality of pins.
Upon microarray production, samples are immobilized on a microarray support using all pins as controls for correcting the inter-pin spotting amount errors. After the microarray experiments, luminescent intensities of the samples used as control spots for correcting the inter-pin spotting amount errors are measured and used to obtain correction parameters for the inter-pin spotting amount errors of respective pins. These parameters are used to correct luminescent intensities of other samples.
摘要翻译：本发明的目的是通过校正使用多个引脚产生的微阵列产生引起的针间点位量误差来获得更准确的微阵列实验数据。在制备微阵列时，将样品固定在微阵列支架上，使用所有引脚作为校正针间点位量误差的对照。在微阵列实验之后，测量作为用于校正针间点位量误差的对照点的样品的发光强度，并用于获得各针的针间点位量误差的校正参数。这些参数用于校正其他样品的发光强度。

5. 发明公开

EP1089211A2 Method and apparatus for displaying gene expression patterns 有权
标题翻译： Verfahren und Vorrichtung zur Darstellung von Gen-Expressions ustern
公开(公告)号：EP1089211A2
公开(公告)日：2001-04-04
申请号：EP00121116.8
申请日：2000-09-28
申请人： Hitachi Software Engineering Co., Ltd.
发明人： Nozaki, Yasuyuki , Nakashige, Ryo , Watanabe, Tsunehiko , Tamura, Takuro
IPC分类号： G06F19/00
CPC分类号： G06K9/6218 , G06F19/20 , G06F19/24 , G06F19/26 , G06K2209/07
摘要： The present invention aims at finding out and effectively displaying that different genes give the same expression for having the same function at one time point but give different expressions at another time point for having different roles. Furthermore, the present invention aims at automatically extracting brief groups of clusters from the clustering results of gene expression pattern data so that a user can select a desirable level of grouping.
The present invention comprises the steps of: designating a time segment in the time sequential expression pattern data of multiple genes; and clustering the time sequential expression pattern data within the designated time segment based on a predetermined reference value, repeating clustering within the same cluster in a forward or reverse direction along the time axis while changing the reference value, and displaying the results according to a predetermined display format. The present invention also comprises a step of displaying a round number of the cluster groups for each clustering phase, taking a recognition error range in consideration, from the results of the clustering analysis of the gene expression pattern data. The results of clustering analysis are displayed such that only gene groups consisting of at least a predetermined number of gene expression pattern data are displayed.
摘要翻译：本发明旨在找出并有效地显示不同的基因给出在一个时间点具有相同功能的相同表达式，而在另一个时间点给出不同的表达以具有不同的作用。此外，本发明旨在从基因表达模式数据的聚类结果自动提取簇的简要组，以使得用户可以选择期望的分组水平。本发明包括以下步骤：指定多个基因的时间序列表达模式数据中的时间段; 并且基于预定的参考值对所述指定时间段内的所述时间序列表达模式数据进行聚类，在改变所述参考值的同时沿着所述时间轴沿着正向或反向的方向重复在同一簇内的聚类，并且根据预定的参数值显示所述结果显示格式。本发明还包括从基因表达模式数据的聚类分析的结果中，针对每个聚类阶段显示一组群组的轮次，从而考虑识别误差范围。显示聚类分析的结果，使得仅显示由至少预定数量的基因表达模式数据组成的基因组。

6. 发明公开

EP1251435A3 Knowledge database and method for constructing and merging knowledge database 审中-公开
标题翻译：知识库和方法构建和知识基础的intergrieren
公开(公告)号：EP1251435A3
公开(公告)日：2005-08-03
申请号：EP02003746.1
申请日：2002-02-19
申请人： Hitachi Software Engineering Co., Ltd. , Okubo, Kousaku
发明人： Okubo, Kousaku , Tamura, Takuro , Yamashita, Iwao
IPC分类号： G06F17/30 , G06F19/00
CPC分类号： G06F19/28 , G06F19/24
摘要： Disclosed is a technology capable of acquiring transverse knowledge beyond specialized fields such as medicine and biology. From a knowledge database for accumulating objects as object values, the objects having phrases including terms used in a medical field and/or a biological field, and accumulating relations between the objects, the relations having values, as relation values, for expressing mutual relations between the objects quantitatively, objects related to a query object are extracted based on the relations between the objects, and the query object and the objects extracted are displayed together with the relations therebetween.

7. 发明授权

EP1132136B1 Microarray, method for producing the same, and method for correcting inter-pin spotting amount error of the same 有权
标题翻译：微阵列和适于该任务的制造和销间隔的校正方法
公开(公告)号：EP1132136B1
公开(公告)日：2004-09-22
申请号：EP01104785.9
申请日：2001-02-27
申请人： Hitachi Software Engineering Co., Ltd.
发明人： Yamamoto, Tomoyuki , Tamura, Takuro
IPC分类号： B01L3/02 , B01J19/00 , G01N21/88 , G01N35/10
CPC分类号： B01L3/0244 , B01J19/0046 , B01J2219/00387 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00621 , B01J2219/00659 , B01J2219/00695 , B01J2219/00698 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/1067 , G01N2035/1037 , G01N2035/1069

8. 发明公开

EP1132136A3 Microarray, method for producing the same, and method for correcting inter-pin spotting amount error of the same 有权
标题翻译：微阵列和适于该任务的制造和销间隔的校正方法
公开(公告)号：EP1132136A3
公开(公告)日：2003-07-02
申请号：EP01104785.9
申请日：2001-02-27
申请人： Hitachi Software Engineering Co., Ltd.
发明人： Yamamoto, Tomoyuki , Tamura, Takuro
IPC分类号： B01L3/02 , B01J19/00 , G01N21/88 , G01N35/10
CPC分类号： B01L3/0244 , B01J19/0046 , B01J2219/00387 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00621 , B01J2219/00659 , B01J2219/00695 , B01J2219/00698 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/1067 , G01N2035/1037 , G01N2035/1069
摘要： The present invention has an objective of obtaining more accurate data of microarray experiments by correcting an inter-pin spotting amount error caused upon microarray production using a plurality of pins. Upon microarray production, samples are immobilized on a microarray support using all pins as controls for correcting the inter-pin spotting amount errors. After the microarray experiments, luminescent intensities of the samples used as control spots for correcting the inter-pin spotting amount errors are measured and used to obtain correction parameters for the inter-pin spotting amount errors of respective pins. These parameters are used to correct luminescent intensities of other samples.

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