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1. 发明公开

EP1361455A3 Supersensitive nuclear magnetic resonance imaging apparatus 审中-公开
标题翻译：装置具有特别高灵敏度磁共振成像
公开(公告)号：EP1361455A3
公开(公告)日：2004-08-25
申请号：EP02028840.3
申请日：2002-12-23
申请人： Hitachi, Ltd.
发明人： Okada, Michiya , Wakuda, Tsuyoshi , Kakugawa, Shigeru , Morita, Hiroshi , Aihara, Katsuzou
IPC分类号： G01R33/3815 , G01R33/56
CPC分类号： G01R33/3815 , G01R33/465 , G01R33/5604
摘要： Disclosed is to enable to grasp the behavior of protein in the cell by realizing a nuclear magnetic resonance imaging method having spatial resolutions on the scales of cells, and to provide an industrial measure for developing high-quality protein utilizing this technology. In order to realize spatial resolutions in the order of one-tenth the size of the cell, a supersensitive measurement is realized by the combination of the solenoid detector coil and the high magnetic field NMR of not less than 14 Tesla, which has not been used so far. Subsequently, it is combined with the magnetic field uniformity of 0.001 ppm, so that the supersensitive NMR imaging of 0.5 µm, which has been impossible in the related art, is realized. The physico-chemical behavior of protein molecules can easily be clarified, and thus the bioinfomatic network or the process of metabolism of the cell can be brought out.

2. 发明授权

EP1361453B1 Nmr magnet device for solution analysis and nmr apparatus 有权
标题翻译： NMR磁铁溶液分析和NMR仪器
公开(公告)号：EP1361453B1
公开(公告)日：2010-06-02
申请号：EP03009775.2
申请日：2003-05-08
申请人： Hitachi, Ltd.
发明人： Kakugawa, Shigeru , Okada, Michiya , Aihara, Katsuzou , Morita, Hiroshi , Wakuda, Tsuyoshi
IPC分类号： G01R33/38
CPC分类号： G01R33/381 , G01R33/3815

3. 发明公开

EP1361455A2 Supersensitive nuclear magnetic resonance imaging apparatus 审中-公开
标题翻译： Gerätfürdie bildgebende magnetische Resonanz mit besonders hoher Empfindlichkeit
公开(公告)号：EP1361455A2
公开(公告)日：2003-11-12
申请号：EP02028840.3
申请日：2002-12-23
申请人： Hitachi, Ltd.
发明人： Okada, Michiya , Wakuda, Tsuyoshi , Kakugawa, Shigeru , Morita, Hiroshi , Aihara, Katsuzou
IPC分类号： G01R33/3815 , G01R33/56
CPC分类号： G01R33/3815 , G01R33/465 , G01R33/5604
摘要： Disclosed is to enable to grasp the behavior of protein in the cell by realizing a nuclear magnetic resonance imaging method having spatial resolutions on the scales of cells, and to provide an industrial measure for developing high-quality protein utilizing this technology. In order to realize spatial resolutions in the order of one-tenth the size of the cell, a supersensitive measurement is realized by the combination of the solenoid detector coil and the high magnetic field NMR of not less than 14 Tesla, which has not been used so far. Subsequently, it is combined with the magnetic field uniformity of 0.001 ppm, so that the supersensitive NMR imaging of 0.5 µm, which has been impossible in the related art, is realized. The physico-chemical behavior of protein molecules can easily be clarified, and thus the bioinfomatic network or the process of metabolism of the cell can be brought out.
摘要翻译：公开了通过实现在细胞尺度上具有空间分辨率的核磁共振成像方法，能够掌握细胞中的蛋白质的行为，并提供利用该技术开发高质量蛋白质的工业措施。为了实现电池尺寸十分之一的空间分辨率，通过螺线管检测器线圈和尚未使用的不小于14特斯拉的高磁场NMR的组合来实现超敏感测量至今。随后，与0.001ppm的磁场均匀性相结合，实现了现有技术中不可能的0.5μm的超灵敏NMR成像。蛋白质分子的物理化学性质可以很容易地被阐明，从而可以提出生物网络或细胞代谢过程。

4. 发明公开

EP1361453A1 Nmr magnet device for solution analysis and nmr apparatus 有权
标题翻译： NMR-MagnetfürLösungsanalyseund NMR-Gerät
公开(公告)号：EP1361453A1
公开(公告)日：2003-11-12
申请号：EP03009775.2
申请日：2003-05-08
申请人： Hitachi, Ltd.
发明人： Kakugawa, Shigeru , Okada, Michiya , Aihara, Katsuzou , Morita, Hiroshi , Wakuda, Tsuyoshi
IPC分类号： G01R33/38
CPC分类号： G01R33/381 , G01R33/3815
摘要： The invention relates to a split-type magnet device (39) for high-sensitivity NMR apparatus to be used for solution analysis of proteins. The magnet device provides a remarkably uniform magnetic field at the center portion of the device used for sample analysis. The magnet device for NMR apparatus comprises first multilayer coils (1, 2, 3, 4, 5) and second multi-layer coils (1', 2', 3', 4', 5') which face each other with a predetermined distance being provided therebetween, each of the pairs of the first and the second coils being substantially co-axial with respect to a central axis, each of the layers of each of the first and second multilayer coils having at least one coil, wherein the energizing current of at least one of the coils (4,4'; 5,5')constituting the innermost layer of each of the first and the second multilayer coils is in the minus direction if the energizing current of the coil used for generating the main magnetic field for NMR detection in the vicinity of the center portion of the apparatus is in the plus direction.
摘要翻译：本发明涉及用于蛋白质溶液分析的高灵敏度NMR装置的分体型磁体装置（39）。磁体装置在用于样品分析的装置的中心部分提供了非常均匀的磁场。用于NMR装置的磁体装置包括第一多层线圈（1,2,3,4,5）和第二多层线圈（1'，2'，3'，4'，5'），它们以预定的距离设置在它们之间，每对第一和第二线圈相对于中心轴基本上同轴，每个第一和第二多层线圈的每个层具有至少一个线圈，其中激励构成第一和第二多层线圈中的每一个的最内层的至少一个线圈（4,4'; 5,5'）的电流为负方向，如果用于产生主体的线圈的通电电流在装置的中心部附近的NMR检测用磁场处于正方向。

5. 发明授权

EP1361454B1 NMR analyzer comprising a superconducting coil system 有权
标题翻译： NMR分析仪与超导线圈系统
公开(公告)号：EP1361454B1
公开(公告)日：2010-09-08
申请号：EP02028364.4
申请日：2002-12-17
申请人： Hitachi, Ltd.
发明人： Aihara, Katsuzou , Okada, Michiya , Kakugawa, Shigeru , Morita, Hiroshi , Wakuda, Tsuyoshi
IPC分类号： G01R33/3815
CPC分类号： G01R33/34046 , G01R33/34053 , G01R33/3806 , G01R33/3815 , G01R33/44 , G01R33/4808

6. 发明公开

EP1361454A3 NMR analyzer comprising a superconducting coil system 有权
标题翻译： NMR分析仪与超导线圈系统
公开(公告)号：EP1361454A3
公开(公告)日：2004-10-27
申请号：EP02028364.4
申请日：2002-12-17
申请人： Hitachi, Ltd.
发明人： Aihara, Katsuzou , Okada, Michiya , Kakugawa, Shigeru , Morita, Hiroshi , Wakuda, Tsuyoshi
IPC分类号： G01R33/3815
CPC分类号： G01R33/34046 , G01R33/34053 , G01R33/3806 , G01R33/3815 , G01R33/44 , G01R33/4808
摘要： A first room-temperature space is formed penetrating through a cryostat along a center axis of a split-type multi-layer cylindrical superconducting coil system which has a ratio of the maximum empirical magnetic field to the central magnetic filed of not larger than 1.3 and is horizontally arranged such that the center axis of the coil is in the horizontal direction, a room-temperature shim coil system is arranged in said first room-temperature space to improve the homogeneity of the magnetic field, a second room-temperature space is formed penetrating through the cryostat and passing through the center of said split gap in the vertical direction, and a sample to be measured and an NMR probe having a solenoid-type probe coil are inserted in said second room-temperature space. Further, the NMR analyzer has a new function constituted by a system for irradiating and detecting the electromagnetic waves having wavelengths of shorter than 0.1 mm.

7. 发明公开

EP1361454A2 NMR analyzer comprising a superconducting coil system 有权
标题翻译： NMR-Analysator mit supraleitendem Spulensystem
公开(公告)号：EP1361454A2
公开(公告)日：2003-11-12
申请号：EP02028364.4
申请日：2002-12-17
申请人： Hitachi, Ltd.
发明人： Aihara, Katsuzou , Okada, Michiya , Kakugawa, Shigeru , Morita, Hiroshi , Wakuda, Tsuyoshi
IPC分类号： G01R33/3815
CPC分类号： G01R33/34046 , G01R33/34053 , G01R33/3806 , G01R33/3815 , G01R33/44 , G01R33/4808
摘要： A first room-temperature space is formed penetrating through a cryostat along a center axis of a split-type multi-layer cylindrical superconducting coil system which has a ratio of the maximum empirical magnetic field to the central magnetic filed of not larger than 1.3 and is horizontally arranged such that the center axis of the coil is in the horizontal direction, a room-temperature shim coil system is arranged in said first room-temperature space to improve the homogeneity of the magnetic field, a second room-temperature space is formed penetrating through the cryostat and passing through the center of said split gap in the vertical direction, and a sample to be measured and an NMR probe having a solenoid-type probe coil are inserted in said second room-temperature space. Further, the NMR analyzer has a new function constituted by a system for irradiating and detecting the electromagnetic waves having wavelengths of shorter than 0.1 mm.
摘要翻译：第一室温空间形成为沿分离式多层圆柱形超导线圈系统的中心轴穿过低温恒温器，该分离式多层圆柱形超导线圈系统的最大经验磁场与中心磁场的比值不大于1.3，水平布置成使得线圈的中心轴线处于水平方向，室温垫片线圈系统布置在所述第一室温空间中以改善磁场的均匀性，形成第二室温空间穿透通过低温恒温器并沿垂直方向穿过所述分裂间隙的中心，并且将待测量样品和具有螺线管型探针线圈的NMR探针插入所述第二室温空间。此外，NMR分析仪具有由用于照射和检测波长小于0.1mm的电磁波的系统构成的新功能。

8. 发明授权

EP0730284B1 Superconducting magnet formed by laminating hollow conductor plates 失效
标题翻译：超导磁体通过使盘片的层压产生具有中空轮廓
公开(公告)号：EP0730284B1
公开(公告)日：1999-05-26
申请号：EP96102580.6
申请日：1996-02-21
申请人： Hitachi, Ltd.
发明人： Maki, Naoki , Hara, Nobuhiro , Kakugawa, Shigeru , Shibata, Masayuki , Hino, Noriaki , Hattori, Kenichi
IPC分类号： H01F6/00 , H02J15/00
CPC分类号： H01F6/006 , H01F6/00 , H02J15/00 , Y02E40/67 , Y10S505/726 , Y10S505/727 , Y10S505/879

9. 发明公开

EP0730284A1 Superconducting magnet formed by laminating hollow conductor plates 失效
标题翻译： Hohlprofil hergestellten supraleitender Magnet的Durch laminieren von Leitenplattern mit
公开(公告)号：EP0730284A1
公开(公告)日：1996-09-04
申请号：EP96102580.6
申请日：1996-02-21
申请人： HITACHI, LTD.
发明人： Maki, Naoki , Hara, Nobuhiro , Kakugawa, Shigeru , Shibata, Masayuki , Hino, Noriaki , Hattori, Kenichi
IPC分类号： H01F6/00 , H02J15/00
CPC分类号： H01F6/006 , H01F6/00 , H02J15/00 , Y02E40/67 , Y10S505/726 , Y10S505/727 , Y10S505/879
摘要： A laminated superconducting magnet (5) comprises a multilayer short-circuit superconductor group (2) formed by uniting superposed hollow superconducting plates (l, la, lb), and an exciting coil (3) for inducing a current from an external power source (4) to the multilayer short-circuit superconductor group (2) for operation in a permanent current mode.
Even if some of the superconducting plates are quenched, the other normal superconducting plates share the excess current temporarily. Therefore, the entire superconducting magnet is not quenched.
摘要翻译：叠层超导磁体（5）包括通过将叠加的中空超导板（1,1a，1b）和用于从外部电源（1）引起的电流的励磁线圈（3）形成的多层短路超导体组（2） 4）到用于在永久电流模式下操作的多层短路超导体组（2）。即使某些超导板被淬火，其他正常的超导板临时共享过剩电流。因此，整个超导磁体不被淬火。

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