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1. 发明公开

EP0864571A1 APOVINCAMINIC ACID DERIVATIVE AND MEDICINE CONTAINING THE SAME 失效
标题翻译：阿朴氨酸衍生物和含有它的药物
公开(公告)号：EP0864571A1
公开(公告)日：1998-09-16
申请号：EP95938607.9
申请日：1995-11-29
申请人： Hidaka, Hiroyoshi
发明人： HIDAKA, Hiroyoshi , ISHIKAWA, Tomohiko , MURAMATSU, Hiroshi , INOUE, Tsutomu
IPC分类号： C07D461/00 , A61K31/435
CPC分类号： C07D461/00
摘要： This invention relates to an apovincaminic acid derivative represented by the following formula (1):
wherein R 1 represents a lower alkyl group, and R 2 represents an aryl group, which may be substituted by 1 to 5 substituents selected from halogen atoms and lower alkyl, lower alkoxy, lower alkoxycarbonyl, acylamino and nitro groups, a benzyl group, a quinolyl group or a thienyl group, or an acid addition salt thereof; and also to a drug containing the same. This compound has excellent vasodilating activity and platelet aggregation inhibiting activity, and can be used for the treatment of cerebrovascular disorder, thromboembolism and chronic arterial occlusive diseases and also for the improvement of blood flow disturbances.
摘要翻译：本发明涉及由下式（1）表示的阿朴长春蔓宁酸衍生物：其中R 1表示低级烷基，并且R 2表示可以被1-5个选自卤素原子和低级烷基的取代基取代的芳基，低级烷氧基，低级烷氧羰基，酰氨基和硝基，苄基，喹啉基或噻吩基，或其酸加成盐; 还涉及含有它的药物。该化合物具有优异的血管舒张活性和血小板凝聚抑制活性，可用于治疗脑血管障碍，血栓栓塞症和慢性动脉闭塞性疾病，也可用于改善血流紊乱。

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