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1. 发明授权

EP2883058B1 BIOMARKERS FOR TYPE 2 DIABETES 有权
标题翻译： 2型糖尿病的生物标志物
公开(公告)号：EP2883058B1
公开(公告)日：2018-01-03
申请号：EP13748063.8
申请日：2013-08-13
申请人： Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) , Deutsche Diabetes-Forschungsgesellschaft E.V. - Träger Des Deutschen Diabetes-Zentrums Düsseldorf , Eberhard Karls Universität Tübingen Medizinische Fakultät
发明人： RATHMANN, Wolfgang , HERDER, Christian , ILLIG, Thomas , ADAMSKI, Jerzy , WANG-SATTLER, Rui , YU, Zhongao , WICHMANN, H.-Erich , HÄRING, Hans-Ulrich , PETERS, Annette , MEISINGER, Christine , HRABÉ DE ANGELIS,Martin , RODEN, Michael , MEITINGER, Thomas
IPC分类号： G01N33/68 , G01N33/92
CPC分类号： G01N33/487 , G01N24/08 , G01N30/02 , G01N30/72 , G01N30/7206 , G01N33/49 , G01N33/6893 , G01N33/92 , G01N2030/025 , G01N2030/027 , G01N2030/8813 , G01N2500/10 , G01N2800/042 , G01N2800/50
摘要： The present invention relates to a method of identifying a predisposition for developing type 2 diabetes mellitus in a subject, said method comprising the step of assessing in a sample obtained from said subject the amount of one or more metabolite(s) selected from (a) a first group comprising the metabolites glycine, lysoPhosphatidylcholine acyl C18:2, lysoPhosphatidylcholine acyl C17:0, lysoPhosphatidylcholine acyl C18:0, lysoPhosphatidylcholine acyl C18:1, phosphatidylcholine acyl-alkyl C34:2, phosphatidylcholine acyl-alkyl C36:2, phosphatidylcholine acyl-alkyl C36:3 and isobaric metabolites having the same molecular mass as glycine, lysoPhosphatidylcholine acyl C18:2, lysoPhosphatidylcholine acyl C17:0, lysoPhosphatidylcholine acyl C18:0, lysoPhosphatidylcholine acyl C18:1, phosphatidylcholine acyl-alkyl C34:2, phosphatidylcholine acyl-alkyl C36:2 or phosphatidylcholine acyl-alkyl C36:3 but different chemical formula; and/or (b) a second group comprising the metabolite acetylcarnitine C2 and an isobaric metabolite having the same molecular weight as acetylcarnitine C2 but different chemical formula; wherein a decrease in the amount of a metabolite selected from said first group or an increase in the amount of a metabolite selected from said second group as compared to the amount of the corresponding metabolite(s) of a control is indicative of a predisposition to develop type 2 diabetes mellitus. Further, the invention relates to a method of identifying a compound capable of preventing type 2 diabetes mellitus and diseases associated therewith or serving as a lead compound for developing a compound capable of preventing type 2 diabetes mellitus and diseases associated therewith and a method of selecting a therapy to prevent type 2 diabetes mellitus. Also, the invention relates to a kit.

2. 发明公开

EP2883058A1 BIOMARKERS FOR TYPE 2 DIABETES 有权
标题翻译：生物标志物FÜRTYP-2-DIABETES
公开(公告)号：EP2883058A1
公开(公告)日：2015-06-17
申请号：EP13748063.8
申请日：2013-08-13
申请人： Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) , Deutsche Diabetes-Forschungsgesellschaft E.V. , Eberhard Karls Universität Tübingen Medizinische Fakultät
发明人： RATHMANN, Wolfgang , HERDER, Christian , ILLIG, Thomas , ADAMSKI, Jerzy , WANG-SATTLER, Rui , YU, Zhongao , WICHMANN, H.-Erich , HÄRING, Hans-Ulrich , PETERS, Annette , MEISINGER, Christine , HRABÉ DE ANGELIS,Martin , RODEN, Michael , MEITINGER, Thomas
IPC分类号： G01N33/68 , G01N33/92
CPC分类号： G01N33/487 , G01N24/08 , G01N30/02 , G01N30/7206 , G01N33/49 , G01N33/6893 , G01N33/92 , G01N2030/025 , G01N2030/027 , G01N2500/10 , G01N2800/042 , G01N2800/50
摘要： The present invention relates to a method of identifying a predisposition for developing type 2 diabetes mellitus in a subject, said method comprising the step of assessing in a sample obtained from said subject the amount of one or more metabolite(s) selected from (a) a first group comprising the metabolites glycine, lysoPhosphatidylcholine acyl C18:2, lysoPhosphatidylcholine acyl C17:0, lysoPhosphatidylcholine acyl C18:0, lysoPhosphatidylcholine acyl C18:1, phosphatidylcholine acyl-alkyl C34:2, phosphatidylcholine acyl-alkyl C36:2, phosphatidylcholine acyl-alkyl C36:3 and isobaric metabolites having the same molecular mass as glycine, lysoPhosphatidylcholine acyl C18:2, lysoPhosphatidylcholine acyl C17:0, lysoPhosphatidylcholine acyl C18:0, lysoPhosphatidylcholine acyl C18:1, phosphatidylcholine acyl-alkyl C34:2, phosphatidylcholine acyl-alkyl C36:2 or phosphatidylcholine acyl-alkyl C36:3 but different chemical formula; and/or (b) a second group comprising the metabolite acetylcarnitine C2 and an isobaric metabolite having the same molecular weight as acetylcarnitine C2 but different chemical formula; wherein a decrease in the amount of a metabolite selected from said first group or an increase in the amount of a metabolite selected from said second group as compared to the amount of the corresponding metabolite(s) of a control is indicative of a predisposition to develop type 2 diabetes mellitus. Further, the invention relates to a method of identifying a compound capable of preventing type 2 diabetes mellitus and diseases associated therewith or serving as a lead compound for developing a compound capable of preventing type 2 diabetes mellitus and diseases associated therewith and a method of selecting a therapy to prevent type 2 diabetes mellitus. Also, the invention relates to a kit.
摘要翻译：本发明涉及鉴定受试者中2型糖尿病发病倾向的方法，所述方法包括以下步骤：在从所述受试者获得的样品中评估选自（a）的一种或多种代谢物的量，第一组包括代谢物甘氨酸，溶血磷脂酰胆碱酰基C18：2，溶血磷脂酰胆碱酰基C17：0，溶血磷脂酰胆碱酰基C18：0，溶血磷脂酰胆碱酰基C18：1，磷脂酰胆碱酰基 - 烷基C34：2，磷脂酰胆碱酰基 - 烷基C36：2，磷脂酰胆碱酰基 - 烷基C36：3和具有与甘氨酸相同分子量的等压代谢物，溶血磷脂酰胆碱酰基C18：2，溶血磷脂酰胆碱酰基C17：0，溶血磷脂酰胆碱酰基C18：0，溶血磷脂酰胆碱酰基C18：1，磷脂酰胆碱酰基 - 烷基C34：2，磷脂酰胆碱酰基 - 烷基C36：2或磷脂酰胆碱酰基 - 烷基C36：3但化学式不同; 和/或（b）包含代谢物乙酰肉碱C2和具有与乙酰肉碱C2分子量相同但不同化学式的等压代谢物的第二组; 其中与对照的相应代谢物的量相比，选自所述第一组的代谢物的量的减少或选自所述第二组的代谢物的量的增加表明发生倾向 2型糖尿病此外，本发明涉及鉴定能够预防2型糖尿病和与之相关的疾病或作为用于开发能够预防2型糖尿病和相关疾病的化合物的铅化合物的化合物的方法，以及选择治疗预防2型糖尿病。此外，本发明涉及一种试剂盒。

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