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1. 发明公开

EP3214437A1 SAMPLE SUPPORTING BODY AND METHOD OF MANUFACTURING SAMPLE SUPPORTING BODY 有权
标题翻译：样品支撑体和制造样品支撑体的方法
公开(公告)号：EP3214437A1
公开(公告)日：2017-09-06
申请号：EP16841742.6
申请日：2016-08-26
申请人： Hamamatsu Photonics K.K.
发明人： NAITO Yasuhide , KOTANI Masahiro , OHMURA Takayuki
IPC分类号： G01N27/62
CPC分类号： H01J49/0418 , B01L3/5027 , B01L2300/0819 , G01N27/62
摘要： A sample support (2) according to an aspect is a sample support for a surface-assisted laser desorption/ionization method, and includes: a substrate (21) in which a plurality of through-holes (S) passing from one surface (21a) thereof to the other surface (21b) thereof are provided; and a conductive layer (23) that is formed of a conductive material and covers at least the one surface (21a). The through-holes (S) have a width (d3) of 1 to 700 nm, and the substrate (21) has a thickness (d1) of 1 to 50 µm.
摘要翻译：根据一个方面的样品架（2）是用于表面辅助激光解吸/电离方法的样品架，并且包括：基板（21），其中从一个表面（21a）通过的多个通孔（S））被提供到其另一表面（21b）; 以及由导电材料形成并至少覆盖所述一个表面（21a）的导电层（23）。通孔（S）的宽度（d3）为1〜700nm，基板（21）的厚度（d1）为1〜50μm。

2. 发明公开

EP4135004A1 SAMPLE SUPPORT, IONIZATION METHOD, AND MASS SPECTROMETRY METHOD 审中-实审转让
公开(公告)号：EP4135004A1
公开(公告)日：2023-02-15
申请号：EP21796331.3
申请日：2021-04-15
申请人： Hamamatsu Photonics K.K. , Taiyo Nippon Sanso Corporation , National University Corporation Fukushima University
发明人： KOTANI, Masahiro , OHMURA Takayuki , WAKIMURA Akari , TERAUCHI Tsutomu , TAIRA Shu , NAITO Yasuhide
IPC分类号： H01J49/04 , G01N27/62
摘要： A sample support is a sample support used for ionizing components of a sample, and includes: a substrate including a first surface, a second surface on a side opposite to the first surface, and a plurality of through holes opening to the first surface and the second surface; a conductive layer provided at least on the first surface; and a derivatizing agent provided to the plurality of through holes to derivatize the components.

3. 发明公开

EP3719489A1 LASER DESORPTION/IONIZATION METHOD, MASS SPECTROMETRY METHOD, SAMPLE SUPPORT BODY, AND MANUFACTURING METHOD OF SAMPLE SUPPORT BODY 审中-公开
公开(公告)号：EP3719489A1
公开(公告)日：2020-10-07
申请号：EP18884280.1
申请日：2018-10-05
申请人： Hamamatsu Photonics K.K.
发明人： NAITO Yasuhide , OHMURA Takayuki , KOTANI Masahiro
IPC分类号： G01N27/62 , G01N27/64 , H01J49/04 , H01J49/16
摘要： A laser desorption/ionization method, includes: a first step of preparing a sample support body including a substrate on which a plurality of through holes opening to a first surface and a second surface facing each other are formed, a conductive layer provided on at least the first surface, and a solvent provided in the plurality of through holes with refractoriness in a vacuum; a second step of mounting a sample on a mounting surface of a mounting portion, and of disposing the sample support body on the sample such that the second surface is in contact with the sample; and a third step of ionizing a component of the sample that is mixed with the solvent and is moved to the first surface side from the second surface side through the through hole by irradiating the first surface with laser beam while applying a voltage to the conductive layer, in a state in which the sample is disposed between the mounting portion and the sample support body.

4. 发明公开

EP3686590A1 LASER DESORPTION/IONIZATION METHOD AND MASS SPECTROMETRY METHOD 有权
公开(公告)号：EP3686590A1
公开(公告)日：2020-07-29
申请号：EP18859270.3
申请日：2018-08-03
申请人： Hamamatsu Photonics K.K.
发明人： NAITO Yasuhide , OHMURA Takayuki , KOTANI Masahiro
IPC分类号： G01N27/62 , H01J49/04 , H01J49/10 , H01J49/16
摘要： A laser desorption/ionization method includes a first process of preparing a sample support body (1). The sample support body (1) includes a substrate (2), an ionization substrate (3), and a support (5) that supports the ionization substrate (3) with respect to the substrate (2) such that a first surface (3a) of the ionization substrate (3) is separated from the substrate (2). A plurality of through-holes (3c) are formed at least in measurement regions (R) of the ionization substrate (3). A conductive layer (4) is provided on peripheral edges of the through-holes (3c) at least on the second surface (3b). Further, the laser desorption/ionization method includes a second process of dropping the sample (S) on the measurement regions (R) of the ionization substrate (3), and a third process of, after the sample (S) has infiltrated into the ionization substrate (3), ionizing components of the sample (S) by applying a laser beam (L) to the second surface (3b) while applying a voltage to the conductive layer (4).

5. 发明公开

EP3686588A1 LASER DESORPTION/IONIZATION METHOD AND MASS SPECTROMETRY METHOD 审中-公开
公开(公告)号：EP3686588A1
公开(公告)日：2020-07-29
申请号：EP18858094.8
申请日：2018-08-06
申请人： Hamamatsu Photonics K.K.
发明人： NAITO Yasuhide , KOTANI Masahiro , OHMURA Takayuki
IPC分类号： G01N27/62 , H01J49/16
摘要： A laser desorption/ionization method, includes: a first step of preparing a sample support body including a substrate on which plurality of through holes opening to a first surface and a second surface facing each other are formed, and a conductive layer provided on at least the first surface; a second step of mounting a sample on a mounting surface of a mounting portion, and of disposing the sample support body on the sample such that the second surface is in contact with the sample; a third step of introducing a matrix solution into the plurality of through holes; and a fourth step of ionizing a component of the sample that is mixed with the matrix solution and is moved to the first surface side from the second surface side through the through hole by irradiating the first surface with laser light while a voltage is applied to the conductive layer, in a state where the sample is disposed between the mounting portion and the sample support body.

6. 发明公开

EP3214436A1 SURFACE-ASSISTED LASER DESORPTION/IONIZATION METHOD, MASS SPECTROMETRY METHOD AND MASS SPECTROMETRY DEVICE 有权
标题翻译：表面辅助激光解吸/电离方法，质谱法和质谱仪
公开(公告)号：EP3214436A1
公开(公告)日：2017-09-06
申请号：EP16841741.8
申请日：2016-08-26
申请人： Hamamatsu Photonics K.K.
发明人： NAITO Yasuhide , KOTANI Masahiro , OHMURA Takayuki
IPC分类号： G01N27/62
摘要： A surface-assisted laser desorption/ionization method according to an aspect includes: a first process of preparing a sample support (2) having a substrate (21) in which a plurality of through-holes (S) passing from one surface (21a) thereof to the other surface (21b) thereof are provided and a conductive layer (23) that covers at least the one surface (21a); a second process of placing a sample (10) on a sample stage (1) and arranging the sample support (2) on the sample (10) such that the other surface (21b) faces the sample (10); and a third process of applying a laser beam (L) to the one surface (21a) and ionizing the sample (10) moved from the other surface (21b) side to the one surface (21 a) side via the through-holes (S) due to a capillary phenomenon.
摘要翻译：根据一个方面的表面辅助激光解吸/电离方法包括：制备具有基板（21）的样品支架（2）的第一工艺，在所述基板中，从一个表面（21a）穿过的多个通孔（S）和至少覆盖所述一个面（21a）的导电层（23），其中，（10）放置在样品台（1）上并将样品支架（2）布置在样品（10）上使得另一表面（21b）面向样品（10）的第二过程; 以及对所述一个面（21a）照射激光（L），并使从所述另一个面（21b）侧向所述一个面（21a）侧移动的样本（10）经由所述贯通孔 S）由于毛细管现象。

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