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1. 发明授权

EP1294769B1 ANTIBODIES THAT IMMUNOSPECIFICALLY BIND TO BLYS 有权转让
标题翻译：免疫特异性结合抗体BLYS
公开(公告)号：EP1294769B1
公开(公告)日：2011-01-05
申请号：EP01946365.2
申请日：2001-06-15
申请人： HUMAN GENOME SCIENCES, INC. , Cambridge Antibody Technology LTD
发明人： RUBEN, Steven, M. , BARASH, Steven, C. , CHOI, Gil, H. , VAUGHAN, Tristan, , HILBERT, David
IPC分类号： C07K14/52 , A61K47/48 , G01N33/564 , A61K49/00 , C07K16/28 , C07K14/705
CPC分类号： C07K14/70575 , A61K47/6849 , A61K49/0004 , A61K2039/505 , C07K14/52 , C07K16/2875 , C07K2317/21 , C07K2317/622 , G01N33/564
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to BLyS. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated with aberrant BLyS expression or inappropriate function of BLyS comprising antibodies or fragments or variants thereof or related molecules that immunospecifically bind to BLyS. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant BLyS expression or inappropriate BLyS function comprising administering to an animal an effective amount of oune or more antibodies or fragments or variants thereof or related molecules that immunospecifically bind to BLyS.

2. 发明授权

EP1534752B1 ANTIBODIES THAT SPECIFICALLY BIND TO CHEMOKINE BETA-4 有权
标题翻译：具体趋化因子β-4结合抗体
公开(公告)号：EP1534752B1
公开(公告)日：2011-08-03
申请号：EP03721955.7
申请日：2003-04-30
申请人： Human Genome Sciences, Inc.
发明人： ROSEN, Craig, A. , RUBEN, Steven, M.
IPC分类号： C07K16/00 , C07K16/24
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies and related molecules that specifically bind to CK-B4. Such antibodies have uses, for example, in the prevention and treatment of cancer as well as immune system diseases and disorders including cancers, as well as immune system diseases and disorders including autoimmune diseases, inflammatory disorders, immunodeficiencies, infections, HIV, arthritis, allergy, psoriasis, dermatitis, and inflammatory bowel disease. The invention also relates to nucleic acid molecules encoding anti-CK-B4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancers, as well as immune system diseases and disorders including autoimmune disease, inflammatory disorders, immunodeficiencies, infections, HIV, arthritis, allergy, psoriasis, dermatitis, and inflammatory bowel disease, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that specifically bind to CK-B4.

3. 发明授权

EP1036164B1 CHEMOKINE ALPHA-5 有权
标题翻译： CHEMOKIN ALPHA-5
公开(公告)号：EP1036164B1
公开(公告)日：2010-06-30
申请号：EP98958066.7
申请日：1998-11-18
申请人： HUMAN GENOME SCIENCES, INC.
发明人： WEI, Ying-Fei , NI, Jian , LI, Yi , ROSEN, Craig, A. , RUBEN, Steven, M.
IPC分类号： C12N5/10 , C12N15/12 , C12N15/19 , C12N15/63 , C12N15/64 , A61K38/16 , A61K38/19 , C07K14/00 , C07K14/47 , C07K14/52
CPC分类号： C07K14/521 , A61K38/00 , C07K14/522 , C07K2319/00 , C12N2799/026 , Y02A50/423 , Y10T436/143333
摘要： The present invention relates to a novel CKalpha-5 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CKalpha-5 protein. CKalpha-5 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Antibodies and fragments thereof that specifically bind to CKalpha-5 polypeptides are also disclosed, as are compositions and methods for making such antibodies. The invention further relates to screening methods for identifying agonists and antagonists of CKalpha-5 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

4. 发明授权

EP1385864B1 Anti-VEGF-2 antibodies 有权
标题翻译：抗VEGF-2抗体
公开(公告)号：EP1385864B1
公开(公告)日：2010-06-09
申请号：EP02726730.1
申请日：2002-04-12
申请人： HUMAN GENOME SCIENCES, INC.
发明人： ROSEN, Craig, A. , ALBERT, Vivian, R. , RUBEN, Steven, M. , WAGER, Ruth, E.
IPC分类号： C07K16/22
CPC分类号： C07K16/22 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/52 , C07K16/24 , C07K2317/21 , C07K2317/622 , C12N2799/026 , G01N33/574 , G01N33/74 , Y02A50/41 , Y02A50/422 , Y10S435/81
摘要： Disclosed are human VEGF-2 antibodies, antibody fragments, or variants thereof. Also provided are processes for producing such antibodies. The present invention relates to methods and compositions for preventing, treating or ameliorating a disease or disorder comprising administering to an animal, preferably a human, an effective amount of one or more VEGF-2 antibodies or fragments or variants thereof.

5. 发明授权

EP1007670B1 TWO HUMAN G-PROTEIN COUPLED RECEPTORS: EBV-INDUCED GPCR 2 (EBI-2) AND EDG-1-LIKE GPCR 失效
标题翻译：两种人G蛋白偶联受体蛋白质：EBV诱导GPCR2（EBI-2）和EGD-1样GPCR
公开(公告)号：EP1007670B1
公开(公告)日：2007-08-15
申请号：EP98920965.5
申请日：1998-05-07
申请人： HUMAN GENOME SCIENCES, INC.
发明人： RUBEN, Steven, M. , LI, Yi
IPC分类号： C12N15/12 , C12Q1/68 , C07K14/705 , C07K16/28
CPC分类号： C07K14/705
摘要： Two human G-protein coupled receptor polypeptides and DNA (RNA) encoding each of such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides. Also disclosed are diagnostic methods for detecting a mutation in the nucleic acid sequence of each of the G-protein coupled receptors.

6. 发明公开

EP1534336A2 ANTIBODIES THAT IMMUNOSPECIFICALLY BIND TO TRAIL RECEPTORS 审中-公开
标题翻译：免疫学特异性结合于TRAIL受体的抗体
公开(公告)号：EP1534336A2
公开(公告)日：2005-06-01
申请号：EP03788476.4
申请日：2003-08-15
申请人： Human Genome Sciences, Inc.
发明人： SALCEDO, Theodora , RUBEN, Steven, M. , ROSEN, Craig, A. , ALBERT, Vivian, A.
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/2878 , A61K39/39558 , A61K2039/505 , C07K2317/622 , C07K2317/73 , C07K2317/92 , A61K2300/00
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR4.
摘要翻译：本发明涉及免疫特异性结合TRAIL受体TR4的抗体和相关分子。这样的抗体例如用于预防和治疗癌症和其他增殖性疾病。本发明还涉及编码抗TR4抗体的核酸分子，包含这些核酸的载体和宿主细胞及其制备方法。本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是癌症和其它过度增殖性病症的方法和组合物，所述方法和组合物包含向动物，优选人施用有效量的一种或多种抗体或片段或其变体或相关分子，其免疫特异性结合TRAIL受体TR4。

7. 发明公开

EP1379264A1 HUMAN SECRETED PROTEINS 审中-公开
标题翻译：人类分泌的蛋白质
公开(公告)号：EP1379264A1
公开(公告)日：2004-01-14
申请号：EP02723499.6
申请日：2002-03-19
申请人： Human Genome Sciences, Inc.
发明人： ROSEN, Craig, A. , RUBEN, Steven, M.
IPC分类号： A61K38/00 , C07K1/00
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating gastrointestinal diseases, disorders, and/or conditions related thereto. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及人分泌的多肽和编码所述多肽的分离的核酸分子，可用于诊断和治疗与其相关的胃肠疾病，病症和/或病症。结合这些多肽的抗体也包含在本发明中。本发明还包括载体，宿主细胞和用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

8. 发明公开

EP1313503A1 HUMAN TUMOR NECROSIS FACTOR RECEPTORS TR21 AND TR22 审中-公开
标题翻译：人肿瘤坏死因子受体TR21和TR22（02年4月2日）
公开(公告)号：EP1313503A1
公开(公告)日：2003-05-28
申请号：EP01959117.1
申请日：2001-07-23
申请人： Human Genome Sciences, Inc.
发明人： ZENG, ZhiZhen , RUBEN, Steven, M. , ROSEN, Craig, A.
IPC分类号： A61K39/00 , A61K39/395 , C07K1/00 , C07K16/00 , C12N5/06 , C12N5/10 , C12N5/16 , G01N33/574
CPC分类号： C07K14/7151 , A61K38/00 , A61K2039/505 , C07K16/2878 , C07K2317/622 , C07K2319/30 , G01N2333/70578
摘要： The present invention relates to two novel proteins, TR21 and TR22, which are members of the tumor necrosis factor (TNF) receptor. In particular, isolated nucleic acid molecules are provided encoding the human TR21 and TR22 protein. TR21 and TR22 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to secreening methods for identifying agonists and antagonists of TR21 and TR22 activity; and methods of treating immune disorders by administering TR21 and TR22 polynucleotides, polypeptides, agonists, and antagonists.

9. 发明公开

EP1282644A1 TM4SF RECEPTOR POLYNUCLEOTIDES, POLYPEPTIDES, AND ANTIBODIES 审中-公开
标题翻译： TM4SF受体多核苷酸，多肽和抗体
公开(公告)号：EP1282644A1
公开(公告)日：2003-02-12
申请号：EP01923180.2
申请日：2001-04-05
申请人： Human Genome Sciences, Inc.
发明人： SHI, Yanggu , RUBEN, Steven, M.
IPC分类号： C07K14/705 , A01K67/027 , C12N15/12
CPC分类号： C07K14/705 , A61K38/00 , A61K48/00
摘要： The present invention relates to novel human TM4SF polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human TM4SF polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human TM4SF polypeptides.
摘要翻译：本发明涉及新的人TM4SF多肽和含有编码这些多肽的基因的编码区的分离的核酸。还提供了用于生产人TM4SF多肽的载体，宿主细胞，抗体和重组方法。本发明进一步涉及用于诊断和治疗与这些新型人TM4SF多肽有关的病症的诊断和治疗方法。

10. 发明公开

EP1261742A2 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
标题翻译： NUCLEIC，蛋白质和抗体
公开(公告)号：EP1261742A2
公开(公告)日：2002-12-04
申请号：EP01916069.6
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES, INC.
发明人： ROSEN, Craig, A. , BARASH, Steven, C. , RUBEN, Steven, M.
IPC分类号： C12Q1/68 , C07H21/02
摘要： The present invention relates to novel immune/hematopoietic-related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as 'immune/hematopoietic antigens', and the use of such immune/hematopoietic antigens for detecting immune/hematopoietic-related diseases and/or disorders, particularly the presence of cancer and cancer metastases of cells of hematopoietic origin. More specifically, isolated immune/hematopoietic associated nucleic acid molecules are provided encoding novel immune/hematopoietic associated polypeptides. Novel immune/hematopoietic polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human immune/hematopoietic associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the immune system or cells and tissues associated with hematopoiesis, including cancers of cells of hematopoietic origin, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.

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