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1. 发明公开

EP1261637A1 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
标题翻译：核酸，蛋白质和抗体
公开(公告)号：EP1261637A1
公开(公告)日：2002-12-04
申请号：EP01920103.7
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES, INC.
发明人： ROSEN, Craig, A. , BARASH, Steven, C. , RUBEN, Steven, M.
IPC分类号： C07K14/47 , C12N5/10 , C12N5/16 , C12N15/12 , C12N15/63 , C12N15/64
CPC分类号： Y02A50/475
摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及新蛋白质。更具体而言，提供了编码新多肽的分离的核酸分子。提供了与这些多肽结合的新多肽和抗体。还提供了载体，宿主细胞，以及用于生产人多核苷酸和/或多肽以及抗体的重组和合成方法。本发明进一步涉及用于诊断，治疗，预防和/或预测与这些新多肽有关的病症的诊断和治疗方法。本发明进一步涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明进一步涉及用于抑制或增强本发明多肽的产生和功能的方法和/或组合物。

2. 发明公开

EP1261633A2 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
标题翻译：核酸，蛋白质和抗体
公开(公告)号：EP1261633A2
公开(公告)日：2002-12-04
申请号：EP01908611.5
申请日：2001-01-17
申请人： Human Genome Sciences, Inc.
发明人： ROSEN, Craig, A. , BARASH, Steven, C. , RUBEN, Steven, M.
IPC分类号： C07K14/47 , C12N5/10 , C12N5/16 , C12N15/12 , C12N15/63 , C12N15/64
CPC分类号： Y02A50/475
摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosis, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及新蛋白质。更具体而言，提供了编码新多肽的分离的核酸分子。提供了与这些多肽结合的新多肽和抗体。还提供了载体，宿主细胞，以及用于生产人多核苷酸和/或多肽以及抗体的重组和合成方法。本发明进一步涉及可用于诊断，治疗，预防和/或预测与这些新多肽相关的病症的诊断和治疗方法。本发明进一步涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明进一步涉及用于抑制或增强本发明多肽的产生和功能的方法和/或组合物。

3. 发明公开

EP1255776A1 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
标题翻译：核酸，蛋白质和抗体
公开(公告)号：EP1255776A1
公开(公告)日：2002-11-13
申请号：EP01910337.3
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES, INC.
发明人： ROSEN, Craig, A. , BARASH, Steven, C. , RUBEN, Steven, M.
IPC分类号： C07K14/47 , C12N5/10 , C12N5/16 , C12N15/12 , C12N15/63 , C12N15/64
CPC分类号： Y02A50/475
摘要： The present invention relates to novel pancreatic cancer related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as 'pancreatic cancer antigens', and the use of such pancreatic cancer antigens for detecting disorders of the pancreas, particularly the presence of pancreatic cancer and pancreatic cancer metastases. More specifically, isolated pancreatic cancer associated nucleic acid molecules are provided encoding novel pancreatic cancer associated polypeptides. Novel pancreatic cancer polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human pancreatic cancer associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the pancreas, including pancreatic cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及新的胰腺癌相关多核苷酸和由本文统称为“胰腺癌抗原”的这些多核苷酸编码的多肽，以及这些胰腺癌抗原用于检测胰腺疾病，特别是胰腺癌和胰腺的存在的用途癌症转移。更具体而言，提供了编码新型胰腺癌相关多肽的分离的胰腺癌相关核酸分子。提供了新的胰腺癌多肽和结合这些多肽的抗体。还提供了载体，宿主细胞以及用于产生人胰腺癌相关多核苷酸和/或多肽的重组和合成方法。本发明进一步涉及用于诊断，治疗，预防和/或预测与胰腺相关的疾病（包括胰腺癌）的诊断和治疗方法，以及治疗这些疾病的治疗方法。本发明进一步涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还涉及用于抑制本发明多肽的产生和功能的方法和/或组合物。

4. 发明公开

EP1254272A2 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
公开(公告)号：EP1254272A2
公开(公告)日：2002-11-06
申请号：EP01937134.3
申请日：2001-01-17
申请人： Human Genome Sciences, Inc.
发明人： ROSEN, Craig, A. , BARASH, Steven, C. , RUBEN, Steven, M.
IPC分类号： C12Q1/68 , C07H21/02
摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

5. 发明公开

EP1254248A2 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
标题翻译：核酸，蛋白质和抗体
公开(公告)号：EP1254248A2
公开(公告)日：2002-11-06
申请号：EP01912658.0
申请日：2001-01-17
申请人： Human Genome Sciences, Inc.
发明人： ROSEN, Craig, A. , BARASH, Steven, C. , RUBEN, Steven, M.
IPC分类号： C12P21/06
CPC分类号： Y02A50/475
摘要： The present invention relates to novel ovarian and/or breast cancer related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as 'ovarian and/or breast cancer antigens', and the use of such ovarian and/or breast cancer antigens for detecting disorders of the ovaries and/or breast, particularly the presence of ovarian and/or breast cancer and ovarian and/or breast cancer metastases. More specifically, isolated ovarian and/or breast cancer associated nucleic acid molecules are provided encoding novel ovarian and/or breast cancer associated polypeptides. Novel ovarian and/or breast cancer polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human ovarian and/or breast cancer associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the ovaries and/or breast, including ovarian and/or breast cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及新的卵巢癌和/或乳腺癌相关多核苷酸和由本文统称为“卵巢癌和/或乳腺癌抗原”的这些多核苷酸编码的多肽，以及这些卵巢癌和/或乳腺癌抗原用于检测疾病的卵巢和/或乳房，特别是卵巢和/或乳腺癌和卵巢和/或乳腺癌转移的存在。更具体而言，提供了编码新型卵巢癌和/或乳腺癌相关多肽的分离的卵巢和/或乳腺癌相关核酸分子。提供了新的卵巢和/或乳腺癌多肽以及与这些多肽结合的抗体。还提供了载体，宿主细胞以及用于产生人卵巢癌和/或乳腺癌相关多核苷酸和/或多肽的重组和合成方法。本发明进一步涉及用于诊断，治疗，预防和/或预测与卵巢和/或乳房有关的病症（包括卵巢癌和/或乳腺癌）的诊断和治疗方法，以及用于治疗这些病症的治疗方法。本发明进一步涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还涉及用于抑制本发明多肽的产生和功能的方法和/或组合物。

6. 发明公开

EP1254172A1 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
公开(公告)号：EP1254172A1
公开(公告)日：2002-11-06
申请号：EP01912654.9
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES, INC.
发明人： ROSEN, Craig, A. , BARASH, Steven, C. , RUBEN, Steven, M.
IPC分类号： C07K14/47 , C12N5/10 , C12N5/16 , C12N15/12 , C12N15/63 , C12N15/64
CPC分类号： Y02A50/475
摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

7. 发明公开

EP1254153A2 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
标题翻译：核酸，蛋白质和抗体
公开(公告)号：EP1254153A2
公开(公告)日：2002-11-06
申请号：EP01924081.1
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES, INC.
发明人： ROSEN, Craig, A. , BARASH, Steven, C. , RUBEN, Steven, M.
IPC分类号： C07H21/02 , C07H21/04 , C07K5/00 , C07K14/00 , C12Q1/68 , C12P21/06 , C12N1/20 , C12N15/63 , C12N5/00
CPC分类号： Y02A50/475
摘要： The present invention relates to novel lung related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as 'lung antigens', and the use of such lung antigens for detecting disorders of the lung, particularly the presence of lung cancer and lung cancer metastases. More specifically, isolated lung associated nucleic acid molecules are provided encoding novel lung associated polypeptides. Novel lung polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human lung associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the lung, including lung cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及新的肺相关多核苷酸和由本文统称为“肺抗原”的这些多核苷酸编码的多肽，以及这些肺抗原用于检测肺病症，特别是肺癌和肺癌转移的存在的用途。更具体地说，提供了编码新型肺相关多肽的分离的肺相关核酸分子。提供了新的肺多肽和结合这些多肽的抗体。还提供了载体，宿主细胞以及用于产生人肺相关多核苷酸和/或多肽的重组和合成方法。本发明进一步涉及用于诊断，治疗，预防和/或预测与肺相关的病症（包括肺癌）的诊断和治疗方法，以及用于治疗此类病症的治疗方法。本发明进一步涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还涉及用于抑制本发明多肽的产生和功能的方法和/或组合物。

8. 发明公开

EP1254151A1 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
公开(公告)号：EP1254151A1
公开(公告)日：2002-11-06
申请号：EP01918156.9
申请日：2001-01-17
申请人： Human Genome Sciences, Inc.
发明人： ROSEN, Craig, A. , BARASH, Steven, C. , RUBEN, Steven, M.
IPC分类号： C07H21/02 , C07H21/04 , C07K5/00 , C07K14/00 , C12Q1/68 , C12P21/06 , C12N1/20 , C12N15/63 , C12N5/00
CPC分类号： Y02A50/475
摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

9. 发明公开

EP1254148A1 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
标题翻译： NUCLEIC，蛋白质和抗体
公开(公告)号：EP1254148A1
公开(公告)日：2002-11-06
申请号：EP01903097.2
申请日：2001-01-17
申请人： Human Genome Sciences, Inc.
发明人： ROSEN, Craig, A. , BARASH, Steven, C. , RUBEN, Steven, M.
IPC分类号： C07H21/02 , C07H21/04 , A61K38/00 , C07K14/00 , C12N15/00
CPC分类号： C07K14/47 , A01K2217/05 , C12N2799/026
摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

10. 发明公开

EP1252176A2 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
标题翻译：核酸，蛋白质和抗体
公开(公告)号：EP1252176A2
公开(公告)日：2002-10-30
申请号：EP01912656.4
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES, INC.
发明人： ROSEN, Craig, A. , BARASH, Steven, C. , RUBEN, Steven, M.
IPC分类号： C07K2/00 , C07H21/04 , C12N1/20 , C12N15/00 , C12N5/00 , C12P21/00
CPC分类号： Y02A50/475
摘要： The present invention relates to novel bladder related polynucleotides, the polypeptides encoded by these polynucleotides herein collectively referred to as 'bladder antigens', and antibodies that immunospecifically bind these polypeptides, and the use of such bladder polynucleotides, antigens, and antibodies for detecting, treating, preventing and/or prognosing disorders of the bladder system, including, but not limited to, the presence of bladder cancer and bladder metastases. More specifically, isolated bladder nucleic acid molecules are provided encoding novel bladder polypeptides. Novel bladder polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human bladder polynucleotides, polypeptides, and/or antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the bladder, including bladder cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The invention further relates to methods and/or compositions for inhibiting or promoting the production and/or function of the polypeptides of the invention.
摘要翻译：本发明涉及新的膀胱相关多核苷酸，由本文中这些多核苷酸编码的多肽统称为“膀胱抗原”，以及免疫特异性结合这些多肽的抗体，以及这些膀胱多核苷酸，抗原和抗体用于检测，治疗，预防和/或预测膀胱系统疾病，包括但不限于膀胱癌和膀胱转移的存在。更具体地说，提供了编码新颖膀胱多肽的分离的膀胱核酸分子。提供了新的膀胱多肽和结合这些多肽的抗体。还提供了用于生产人膀胱多核苷酸，多肽和/或抗体的载体，宿主细胞以及重组和合成方法。本发明还涉及用于诊断，治疗，预防和/或预测与膀胱相关的病症（包括膀胱癌）的诊断和治疗方法，以及用于治疗此类病症的治疗方法。本发明进一步涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明进一步涉及用于抑制或促进本发明多肽的产生和/或功能的方法和/或组合物。

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