专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP0689549A1 NEUE HARNSTOFFDERIVATE, IHRE HERSTELLUNG UND VERWENDUNG 失效
标题翻译：新的脲衍生物，生产和使用
公开(公告)号：EP0689549A1
公开(公告)日：1996-01-03
申请号：EP94911129.0
申请日：1994-03-09
申请人： HOECHST AKTIENGESELLSCHAFT
发明人： KLINGLER, Otmar , JABLONKA, Bernd , JUST, Melitta , ZOLLER, Gerhard , BREIPOHL, Gerhard , KNOLLE, Jochen , KÖNIG, Wolfgang , STILZ, Hans-Ulrich
IPC分类号： C07D215 , A61K31 , A61K38 , A61P7 , A61P35 , A61P43 , C07C275 , C07C309 , C07C311 , C07C335 , C07D211 , C07D263 , C07D453 , C07D471 , C07K5
CPC分类号： C07K5/06026 , A61K38/00 , C07C275/40 , C07D263/32 , C07K5/06113 , C07K5/0806 , C07K5/0821
摘要： Urea derivates are disclosed having the general formula (I), in which A, B, W, Z, R, R?1, R2, R3¿ and r have the meaning given in the description, as well as a process for preparing the same and their use as inhibitors of thrombocyte aggregation, carcinom cell metastasis and osteoclast binding to bone surface.

2. 发明授权

EP0823898B1 HYDANTOINDERIVATE ALS ZWISCHENPRODUKTE FÜR PHARMAZEUTISCHE WIRKSTOFFE 失效
标题翻译：海因中间产品用于药物
公开(公告)号：EP0823898B1
公开(公告)日：2003-02-26
申请号：EP96914914.5
申请日：1996-04-15
申请人： HOECHST AKTIENGESELLSCHAFT
发明人： ZOLLER, Gerhard , KLINGLER, Otmar , KNOLLE, Jochen , STILZ, Hans, Ulrich , WEHNER, Volkmar
IPC分类号： C07D233/76 , C07D233/80
CPC分类号： C07D233/76

3. 发明公开

EP0729460A1 SUBSTITUIERTE 5-RING-HETEROCYCLEN, IHRE HERSTELLUNG UND IHRE VERWENDUNG 失效
标题翻译：取代的5元杂环，其生产和使用
公开(公告)号：EP0729460A1
公开(公告)日：1996-09-04
申请号：EP94930215.0
申请日：1994-10-24
申请人： HOECHST AKTIENGESELLSCHAFT , Merlin, Jacques
发明人： ZOLLER, Gerhard , KLINGLER, Otmar , JABLONKA, Bernd , JUST, Melitta , BREIPOHL, Gerhard , KNOLLE, Jochen , KÖNIG, Wolfgang , STILZ, Hans-Ulrich
IPC分类号： A61K31 , A61P7 , A61P35 , C07D233 , C07D277 , C07D401 , C07D473 , C07K5 , A61K38
CPC分类号： C07D233/76 , A61K38/00 , C07D401/12 , C07K5/021 , C07K5/06139 , C07K5/0821
摘要： The present invention pertains to 5-ring heterocycles of general formula (I), wherein W, Y, Z, B, D, E and R as well as b, c, d, e, f, g and h are as indicated in the description; to methods for preparing them, and to their use as inhibitors of platelet aggregation, metastasizing of carcinomatous cells and the attachment of osteoclasts to the bone surface.

4. 发明公开

EP0688314A1 PRODRUG-DERIVATE VON ENZYMINHIBITOREN MIT HYDROXYLGRUPPEN, VERFAHREN ZU DEREN HERSTELLUNG UND IHRE VERWENDUNG 失效
标题翻译：酶抑制剂与羟基，制造方法的相同，它们的用途前药衍生物
公开(公告)号：EP0688314A1
公开(公告)日：1995-12-27
申请号：EP94909071.0
申请日：1994-02-25
申请人： HOECHST AKTIENGESELLSCHAFT
发明人： BUDT, Karl-Heinz , STOWASSER, Bernd , PEYMAN, Anuschirwan , KNOLLE, Jochen , WINKLER, Irvin , BERSCHEID, Hans-Gerd
IPC分类号： C07D295 , A61K31 , A61K38 , A61P31 , A61P37 , A61P43 , C07C317 , C07C323 , C07D207 , C07D213 , C07D215 , C07D235 , C07D277 , C07D401 , C07F9 , C07K5 , C07K7
CPC分类号： C07K7/02 , A61K38/00 , C07C317/44 , C07C323/52 , C07F9/5304 , C07K5/0207 , C07K5/021
摘要： The invention concerns prodrugs of enzyme inhibitors in which at least one OH-group in the enzyme inhibitor has been converted into a derivative by means of a grouping of the formula (III, IV or V) in which the groups R?11 to R25¿ and s, 1, m, o, q and r are as defined in the description. Such prodrugs exhibit an improved solubility in water and improved pharmaco-kinetic characteristics.

5. 发明授权

EP0688315B1 PYRROLIDIN- UND OXAZOLIDIN DERIVATE , IHRE HERSTELLUNG UND IHRE VERWENDUNG ALS THROMBOCYTEN-AGGREGATIONS-HEMMER 失效
标题翻译：吡咯烷和恶唑烷衍生物，它们的生产和它们作为血小板聚集抑制剂
公开(公告)号：EP0688315B1
公开(公告)日：1999-05-06
申请号：EP94908350.5
申请日：1994-02-19
申请人： HOECHST AKTIENGESELLSCHAFT
发明人： KLINGLER, Otmar , BREIPOHL, Gerhard , ZOLLER, Gerhard , JABLONKA, Bernd , JUST, Melitta , KNOLLE, Jochen , KÖNIG, Wolfgang
IPC分类号： C07D207/40 , A61K31/40 , C07D401/12 , C07D403/12 , A61K31/445
CPC分类号： C07K5/0821 , A61K38/00

6. 发明授权

EP0689549B1 NEUE HARNSTOFFDERIVATE, IHRE HERSTELLUNG UND VERWENDUNG 失效
标题翻译：新的脲衍生物，生产和使用
公开(公告)号：EP0689549B1
公开(公告)日：1998-06-17
申请号：EP94911129.8
申请日：1994-03-09
申请人： HOECHST AKTIENGESELLSCHAFT
发明人： KLINGLER, Otmar , JABLONKA, Bernd , JUST, Melitta , ZOLLER, Gerhard , BREIPOHL, Gerhard , KNOLLE, Jochen , KÖNIG, Wolfgang , STILZ, Hans-Ulrich
IPC分类号： C07K5/06 , C07K5/08 , C07C275/40 , C07C275/42 , C07D263/32 , A61K38/04
CPC分类号： C07K5/06026 , A61K38/00 , C07C275/40 , C07D263/32 , C07K5/06113 , C07K5/0806 , C07K5/0821

7. 发明公开

EP0688315A1 NEUE HETEROCYCLEN, IHRE HERSTELLUNG UND IHRE VERWENDUNG 失效
标题翻译：新的杂环化合物，其生产和使用
公开(公告)号：EP0688315A1
公开(公告)日：1995-12-27
申请号：EP94908350.0
申请日：1994-02-19
申请人： HOECHST AKTIENGESELLSCHAFT
发明人： KLINGLER, Otmar , BREIPOHL, Gerhard , ZOLLER, Gerhard , JABLONKA, Bernd , JUST, Melitta , KNOLLE, Jochen , KÖNIG, Wolfgang
IPC分类号： C07D233 , A61K31 , A61P7 , A61P9 , A61P35 , C07D207 , C07D271 , C07D401 , C07D403 , C07K5 , A61K38
CPC分类号： C07K5/0821 , A61K38/00
摘要： The invention concerns heterocyclic compounds of the general formula (I) in which A, B, R, R2, R3, W, Y, Z1, Z2 and r are as defined in the description, methods of preparing them and their use as inhibitors of thrombocyte aggregation, the metastization of carcinoma cells and the binding of osteoclasts on bone surfaces.

8. 发明授权

EP0729460B1 SUBSTITUIERTE 5-RING-HETEROCYCLEN, IHRE HERSTELLUNG UND IHRE VERWENDUNG 失效
标题翻译：取代的5元杂环，其生产和使用
公开(公告)号：EP0729460B1
公开(公告)日：2002-05-15
申请号：EP94930215.2
申请日：1994-10-24
申请人： HOECHST AKTIENGESELLSCHAFT
发明人： ZOLLER, Gerhard , KLINGLER, Otmar , JABLONKA, Bernd , JUST, Melitta , BREIPOHL, Gerhard , KNOLLE, Jochen , KÖNIG, Wolfgang , STILZ, Hans-Ulrich
IPC分类号： C07D233/76 , A61K31/415 , C07D401/12
CPC分类号： C07D233/76 , A61K38/00 , C07D401/12 , C07K5/021 , C07K5/06139 , C07K5/0821
摘要： The present invention pertains to 5-ring heterocycles of general formula (I), wherein W, Y, Z, B, D, E and R as well as b, c, d, e, f, g and h are as indicated in the description; to methods for preparing them, and to their use as inhibitors of platelet aggregation, metastasizing of carcinomatous cells and the attachment of osteoclasts to the bone surface.

9. 发明授权

EP0680468B1 SUBSTITUIERTE AMINOVERBINDUNGEN, IHRE HERSTELLUNG UND IHRE VERWENDUNG ALS HEMMSTOFFE DER THROMBOZYTENAGGREGATION 失效
标题翻译：氨基酸取代债券，生产及其作为血小板聚集抑制剂的
公开(公告)号：EP0680468B1
公开(公告)日：1998-06-24
申请号：EP94905012.4
申请日：1994-01-07
申请人： HOECHST AKTIENGESELLSCHAFT
发明人： ZOLLER, Gerhard , JABLONKA, Bernd , JUST, Melitta , KLINGLER, Otmar , BREIPOHL, Gerhard , KNOLLE, Jochen , KÖNIG, Wolfgang
IPC分类号： C07C275/24 , C07D233/76 , C07C271/22 , C07C279/18 , A61K31/17 , A61K31/27 , A61K31/415 , A61K31/155
CPC分类号： C07D233/78 , C07C275/24

10. 发明公开

EP0823898A1 HYDANTOINDERIVATE ALS ZWISCHENPRODUKTE FÜR PHARMAZEUTISCHE WIRKSTOFFE 失效
标题翻译：海因中间产品用于药物
公开(公告)号：EP0823898A1
公开(公告)日：1998-02-18
申请号：EP96914914.0
申请日：1996-04-15
申请人： HOECHST AKTIENGESELLSCHAFT
发明人： ZOLLER, Gerhard , KLINGLER, Otmar , KNOLLE, Jochen , STILZ, Hans, Ulrich , WEHNER, Volkmar
IPC分类号： C07D233
CPC分类号： C07D233/76
摘要： The present invention concerns hydantoine derivatives of general formula (I) in which: R stands for cyano, C(=NH)-O-(C1-C6)-alkyl, C(=NH)-NH-X, CH2-NH-X, or NH-X1; X stands for hydrogen, (C¿1?-C6) alkyl, (C1-C6) alkylcarbonyl, (C1-C6)-alkoxycarbonyl, (C1-C18)-alkylcarbonyloxy-(C1-C6)-alkoxycarbonyl, optionally substituted (C6-C14)-arylcarbonyl, optionally substituted (C6-C14)-aryloxycarbonyl, (C6-C14)-aryl-(C1-C6)-alkoxycarbonyl which can also be substituted in the aryl group, (R?5O)¿2P(O), cyano, hydroxy, (C1-C6)-alkoxy, (C6-C14)-aryl-(C1-C6)-alkoxy which can also be substituted in the aryl group, or amino; X1 has one of the meanings of X or stands for R'-NH-C(=N-R'), R' and R' independently of one another having one of the meanings of X; R1 stands for (C¿1?-C8)-alkyl, C6-C14)-aryl-(C1-C8)-alkyl optionally substituted in the aryl group, or (C3-C8)-cycloalkyl; R?2¿ stands for hydrogen, (C¿1?-C8)-alkyl, optionally substituted (C6-C14)-aryl, (C6-C14)-aryl-(C1-C8)-alkyl optionally substituted in the aryl group or (C3-C8)-cycloalkyl; R?3¿ stands for hydrogen or CH¿2?-CO-OR?4; R4¿ stands for hydrogen, (C¿1?-C6)-alkyl, (C6-C14)-aryl-(C1-C6)-alkyl optionally substituted in the aryl group, or optionally substituted (C6-C14)-aryl; R?5¿ stands for hydrogen, (C¿1?-C8)-alkyl, optionally substituted (C6-C14)-aryl or (C6-C14)-aryl-(C1-C8)-alkyl which can also be substituted in the aryl group. The follwing other conditions also apply; if R?3¿ stands for hydrogen, R may not stand for CN, NH¿2? or CH2-NH2: if the compounds of general formula (I) are present in racemic form with respect to the asymmetric centre in the hydantoine ring and R?3¿ stands for methoxycarbonyl methyl, R1 for methyl and R2 for hydrogen or methyl, R may not stand for CN or C(=NH)-OC¿2?H5; and if the compounds of general formula (I) are present in racemic form with respect to asymmetric centre in the hydantoine ring and R?3¿ standssfor methoxycarbonyl methyl or hydroxycarbonyl methyl, R1 for methyl and R2 for hydrogen or methyl, R may not stand for NH¿2?, CH2-NH2, C(=NH)-NH2, tert-butyloxycarbonylaminomethyl or benzyloxycarbonylguanidino. The invention also concerns the salts of the said hydantoine derivatives.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式