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    • 2. 发明公开
    • Apparatus and method for obtaining images using coherent anti-stokes Raman scattering
    • 装置和使用相干反斯托克斯拉曼散射成像方法
    • EP2096430A2
    • 2009-09-02
    • EP09153244.0
    • 2009-02-19
    • Gwangju Institute of Science and Technology
    • Kim, Dug YoungCho, Seung Bum
    • G01N21/65
    • G01N21/65G01J3/44G01N2021/653
    • Disclosed is an apparatus and method for obtaining images using coherent anti-stokes Raman scattering. The apparatus for obtaining images using coherent anti-stokes Raman scattering according to the present invention comprises: a pump light source (401) and a stokes light source (402) that irradiate pump light and stokes light on a sample (S) to generate anti-stokes light having anti-stokes frequency; a reference light source (410) that generates reference light; and an image obtaining unit (430) that obtains the images of the sample using a change in phase of the reference light due to a change in the refractive index of the sample in the vicinity of the anti-stokes frequency. Thereby, the present invention provides an apparatus for obtaining images using coherent anti-stokes Raman scattering that is not affected by non-resonant background signals, that has strong resistance against noise even for weak signals, and that has excellent sensitivity and resolution.
    • 公开了一种用于使用相干反斯托克斯拉曼散射获得图像的装置和方法。 对于使用相干反斯托克斯拉曼获取图像散射雅丁到本发明的设备包括:一个泵浦光源(401)和一个斯托克斯光源(402)那样照射到泵浦光,并在样品(S),以产生反斯托克斯光 -stokes具有光反斯托克斯频; (410)做了一个参考光源生成参考光; 以及图像获得单元(430)没有获得用参照光的相位的变化的试样的图像由于在反斯托克斯频率附近的样本的折射率的改变。 由此,本发明提供的装置用于使用相干反斯托克斯拉曼散射并不会受到非共振背景信号获得的图像,并具有针对即使对于弱信号噪声抗性强,并做具有优良的灵敏度和分辨率。