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1. 发明公开

EP2691676A1 INJECTION OF MULTIPLE VOLUMES INTO OR OUT OF DROPLETS 有权转让
标题翻译：注射多卷或液滴
公开(公告)号：EP2691676A1
公开(公告)日：2014-02-05
申请号：EP12762825.3
申请日：2012-03-28
申请人： Gnubio, Inc. , Abate, Adam , Kiani, Sepehr , Hung, Tony , Mary, Pascaline , Esmail, Adnan, Moez
发明人： ABATE, Adam , KIANI, Sepehr , HUNG, Tony , MARY, Pascaline , ESMAIL, Adnan, Moez
IPC分类号： F16K31/48
CPC分类号： B01L3/5027 , B01F13/0071 , B01F13/0076 , B01L3/502784 , B01L2300/0816 , B01L2300/0867 , B01L2300/1861 , B01L2400/0424 , B01L2400/0436 , B01L2400/0442 , F04B19/006 , F16K99/0019
摘要： The present invention generally pertains to a system for performing injection of multiple substantially controlled volumes into or out of a droplet, and methods and kits comprising the same. The system of the present invention comprises at least one microfluidic channel, one or more injection channels, an injection inlet associated with each of the one or more injection channels, and a mechanism for disrupting an interface between a droplet and a fluid and/or emulsion, wherein the at least one microfluidic channel comprises one or more droplets are flowing therein, and wherein each of the one or more injection channels comprises at least one fluid and/or emulsion therein.

2. 发明公开

EP2691540A1 MANAGING VARIATION IN SPECTROSCOPIC INTENSITY MEASUREMENTS THROUGH THE USE OF A REFERENCE COMPONENT 有权
标题翻译：变化管理在强度光谱测量使用参考COMPONENT
公开(公告)号：EP2691540A1
公开(公告)日：2014-02-05
申请号：EP12764041.5
申请日：2012-03-28
申请人： Gnubio Inc. , Abate, Adam , Emhoff John, Lawrence , Hung, Tony , Esmail, Adnan, Moez , Kiani, Sepehr , Mary, Pascaline
发明人： ABATE, Adam , EMHOFF, John, Lawrence , HUNG, Tony , ESMAIL, Adnan, Moez , KIANI, Sepehr , MARY, Pascaline
IPC分类号： C12Q1/68
CPC分类号： G01N21/6486 , C12Q1/6806 , G01N21/255 , G01N21/76 , G01N2201/06113 , G01N2201/062 , C12Q2545/101 , C12Q2563/107 , C12Q2563/159 , C12Q2563/161 , C12Q2565/629
摘要： The present invention generally pertains to methods and kits for managing the variation in spectroscopic intensity measurements through the use of a reference component. The reference component may comprise a reference spectroscopic substance and may be contained together with a sample of interest in a sample to be tested, wherein the sample of interest may comprise a sample spectroscopic substance. Each sample to be tested may be uniquely identified and, hence, "barcoded" by combinations of different colors and concentrations of spectroscopic substances, contained therein.

3. 发明授权

EP2691676B1 INJECTION OF MULTIPLE VOLUMES INTO OR OUT OF DROPLETS 有权转让
公开(公告)号：EP2691676B1
公开(公告)日：2019-03-27
申请号：EP12762825.3
申请日：2012-03-28
申请人： Bio-Rad Laboratories, Inc. , Abate, Adam , Kiani, Sepehr , Hung, Tony , Mary, Pascaline , Esmail, Adnan, Moez
发明人： ABATE, Adam , KIANI, Sepehr , HUNG, Tony , MARY, Pascaline , ESMAIL, Adnan, Moez
IPC分类号： F16K31/48 , B01F13/00 , B01L3/00 , F04B19/00 , F16K99/00

4. 发明公开

EP2691752A1 SCALABLE SPECTROSCOPIC DETECTION AND MEASUREMENT 审中-公开
标题翻译：可扩展的光谱检测和测量
公开(公告)号：EP2691752A1
公开(公告)日：2014-02-05
申请号：EP12765764.1
申请日：2012-03-27
申请人： Gnubio, Inc. , Tracy, David , Stokes, Peter, Lewis , Kiani, Sepehr
发明人： TRACY, David , STOKES, Peter, Lewis , KIANI, Sepehr
IPC分类号： G01J3/12
CPC分类号： G01J3/42 , G01J3/0208 , G01J3/021 , G01J3/0216 , G01J3/0248 , G01J3/0291 , G01J3/06 , G01J3/08 , G01J3/10 , G01J3/14 , G01J3/18 , G01J3/2803 , G01J3/44 , G01J3/4406 , G01N15/1434 , G01N15/1459 , G01N15/1484 , G01N21/6456
摘要： The present invention generally pertains to a system, method and kit for the detection and measurement of spectroscopic properties of light from a sample, or the scalable detection and measurement of spectroscopic properties of light from each sample present among multiple samples, simultaneously, wherein the system comprises: an optical train comprising a dispersing element; and an image sensor. The light detected and measured may comprise light scattered from a sample, emitted as chemiluminescence by a chemical process within a sample, selectively absorbed by a sample, or emitted as fluorescence from a sample following excitation.

5. 发明公开

EP3155086A1 SIZE ALTERNATING INJECTION INTO DROPS TO FACILITATE SORTING 有权转让
标题翻译：在GROPSEN WECHSELNDE INJEKTION IN TROPFEN ZUR ERLEICHTERUNG DER SORTIERUNG
公开(公告)号：EP3155086A1
公开(公告)日：2017-04-19
申请号：EP15809718.8
申请日：2015-06-16
申请人： Gnubio Inc.
发明人： ABATE, Adam R. , KIANI, Sepehr
IPC分类号： C12M1/14
CPC分类号： B01L3/502784 , B01L3/0241 , B01L2200/0652 , B01L2300/0654 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2400/0424 , B01L2400/0436 , C12M47/04 , C12Q1/6806
摘要： This invention pertains to a new microfluidic device and the method of using it to sort droplets. The method comprises (a) providing a plurality of droplets flowing in a microfluidic channel, wherein the plurality of droplets comprise desired droplets and undesired droplet (b) identifying desired droplets in the plurality of droplets, (c) changing volume of the desired droplets relative to volume of the undesired droplets such that at least some of the desired droplets have a different volume than the undesired droplets, and (d) passively sorting the desired droplets having the different volume from the undesired droplets.
摘要翻译：本发明涉及一种新的微流体装置及其使用它来分选液滴的方法。该方法包括（a）提供在微流体通道中流动的多个液滴，其中所述多个液滴包含所需液滴和不希望的液滴（b）识别所述多个液滴中的所需液滴，（c）改变所需液滴的体积相对至少一些期望的液滴具有与不需要的液滴不同的体积，和（d）被动地将具有不同体积的所需液滴与不期望的液滴分离。

6. 发明公开

EP2931259A1 METHOD FOR MAINTAINING HETEROGENEOUS CONCENTRATIONS OF MOLECULES IN EMULSION DROPLETS 审中-公开
标题翻译：方法用于维持分子的异质浓度乳滴
公开(公告)号：EP2931259A1
公开(公告)日：2015-10-21
申请号：EP13862508.2
申请日：2013-12-16
申请人： Gnubio Inc.
发明人： HUNG, Tony , BLOUWOLFF, Joshua , KIANI, Sepehr
IPC分类号： A61K9/10
CPC分类号： B01J19/0046 , A61K9/107 , B01J2219/00599 , B01J2219/00722 , C40B50/08
摘要： The present invention provides a method for maintaining heterogeneous concentrations of transitory target molecules in emulsion droplets by using one of a number of means to associate them to other, non-transitory molecules within the emulsion droplets contained in a microfluidic device. The present invention further provides a method for ensuring that the concentration and speciation of molecules will remain constant when stored in emulsion droplets. This results in emulsion droplets having heterogeneous concentrations of molecules, thereby improving the performance and applicability of droplet-based microfluidics.

7. 发明公开

EP3215855A1 DROPLET VELOCITY DETECTION 审中-公开
标题翻译：液滴速度检测
公开(公告)号：EP3215855A1
公开(公告)日：2017-09-13
申请号：EP15857631.4
申请日：2015-11-04
申请人： Gnubio Inc.
发明人： WEBER, Aaron , HUNG, Tony , KIANI, Sepehr
IPC分类号： G01P3/36
CPC分类号： G01P5/18 , G01P5/20 , G01P5/26
摘要： Methods and systems are provided for measuring a velocity of a droplet passing through a microfluidic channel.
摘要翻译：提供了用于测量通过微流体通道的液滴速度的方法和系统。

8. 发明公开

EP3052236A1 MICROFLUIDIC CARTRIDGE DEVICE AND METHODS OF USE AND ASSEMBLY 有权转让
标题翻译：微流体卡盒的装置和方法使用和安排
公开(公告)号：EP3052236A1
公开(公告)日：2016-08-10
申请号：EP14848694.7
申请日：2014-09-30
申请人： GnuBIO, Inc.
发明人： KIANI, Sepehr , HUNG, Tony , STOKES, Peter , SHARPE, Julia , ABATE, Adam , ESMAIL, Adnan
IPC分类号： B01L3/00
CPC分类号： B01L3/502738 , B01L3/50273 , B01L3/502784 , B01L2200/025 , B01L2200/0621 , B01L2200/0684 , B01L2200/10 , B01L2200/16 , B01L2300/021 , B01L2300/0654 , B01L2300/0672 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2400/0487 , B01L2400/0638 , B01L2400/0655 , B01L2400/0683 , B01L2400/0688 , F16K99/00 , F16K99/0015 , F16K99/0059
摘要： Methods and systems for controlling fluid flow through a cartridge for use in an assay of a fluid sample for detection of a target analyte. In one aspect, the cartridge includes a microfluidic device having a network of microfluidic channels, one or more reservoirs and one or more actuatable valves for controlling fluid flow from the reservoirs through the microfluidic channels. In some embodiments, the valve includes a deformable membrane movable between a closed configuration in which the membrane seals against the microfluidic device inhibiting fluid flow and an open configuration moved away from the microfluidic device to allow fluid flow through the microfluidic channels. Other valve embodiments utilize frangible membranes or user-removable membrane.

9. 发明公开

EP2948703A1 SYSTEM AND METHOD FOR PERFORMING DROPLET INFLATION 有权转让
标题翻译：系统和方法用于进行DROP通货膨胀
公开(公告)号：EP2948703A1
公开(公告)日：2015-12-02
申请号：EP14743656.2
申请日：2014-01-27
申请人： GnuBIO, Inc.
发明人： HUNG, Tony , ESMAIL, Adnan , KIANI, Sepehr
IPC分类号： F16K31/48
CPC分类号： B01L3/502715 , B01L3/502784 , B01L2200/06 , B01L2200/0605 , B01L2300/0645 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/161 , B01L2300/1861 , B01L2400/0415 , B01L2400/0448 , B01L2400/0487
摘要： The present invention generally pertains to a system for performing droplet inflation, and methods and kits comprising the same. The system comprises at least one microfluidic channel comprising one or more droplets flowing therein, one or more fluid reservoirs, one or more inflators, one or more inflator nozzles, and at least one mechanism for disrupting an interface between a droplet and a fluid. The present invention provides for the inflation of a relatively controlled volume of fluid into a droplet resulting in an increase in the volume of the droplet relative to its volume prior to inflation and, accordingly, dilution of the concentration of species, if any, previously present and emulsified in the droplet.

10. 发明公开

EP3160649A2 FLOATING THERMAL CONTACT ENABLED PCR 有权转让
标题翻译：浮动热接触启用PCR
公开(公告)号：EP3160649A2
公开(公告)日：2017-05-03
申请号：EP15815117.5
申请日：2015-06-30
申请人： Gnubio Inc.
发明人： POSSINGER, Christopher , KIANI, Sepehr
IPC分类号： B01L7/00
摘要： The present invention generally pertains to a system which utilizes floating thermal contact to enable PCR, in a thermal management device. Comprised of multiple thermal zones attached to a framework, each zone an individually actuated, isolated sub-assembly. The actuation of each zone ensures physical contact with an uneven, yet flat microfluidic chip to achieve effective, conductive heat transfer. The isolation of each zone serves to insulate the thermal zones from each other and minimize undesired heat transfer between adjacent zones, so that each zone is at a proper, uniform temperature.
摘要翻译：本发明总体上涉及在热管理装置中利用浮动热接触来启用PCR的系统。由连接到框架上的多个热区组成，每个区域都是独立启动的隔离子组件。每个区域的致动确保与不均匀但平坦的微流体芯片的物理接触，以实现有效的导热传递。每个区域的隔离用于将热区域彼此隔离并且使相邻区域之间的不期望的热传递最小化，使得每个区域处于适当的均匀温度。

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