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1. 发明公开

EP2204662A1 Device for hyperpolarising and dissolving solid material for NMR analyses 审中-公开
标题翻译： Vorrichtung zur Hyperpolarisation undAuflösungfester ProbenfürNMR-Analysen
公开(公告)号：EP2204662A1
公开(公告)日：2010-07-07
申请号：EP09009604.1
申请日：2001-11-02
申请人： GE Healthcare AS
发明人： Ardenkjaer-Larsen, Jan Henrik , Axelsson, Oskar , Golman, Klaes , Hansson, Georg , Johannesson, Haukur , Servin, Rolf , Thaning, Mikkel , Hansson, Lennart
IPC分类号： G01R33/28 , A61K49/06
CPC分类号： G01R33/282 , G01N1/44 , G01R33/307 , G01R33/5601 , G01R33/62
摘要： The present invention relates to devices and method for melting solid polarised sample while retaining a high level of polarisation. In an embodiment of the present invention a sample is polarised in a sample-retaining cup (9) in a strong magnetic field in a polarising means (3a, 3b, 3c) in a cryostat (2) and then melted inside the cryostat (2) by melting means such as a laser (8) connected by an optical fibre (4) to the interior of the cryostat.
摘要翻译：本发明涉及用于熔化固体极化样品同时保持高水平偏振的装置和方法。在本发明的一个实施例中，样品在低温恒温器（2）中的偏振装置（3a，3b，3c）中的强磁场中在样品保持杯（9）中极化，然后在低温恒温器（2）内熔化）通过诸如通过光纤（4）连接到低温恒温器内部的激光器（8）的熔化装置。

2. 发明授权

EP2119457B1 Method of producing a hyperpolarised contrast agent 有权
标题翻译：一种用于超极化的造影剂的制备方法
公开(公告)号：EP2119457B1
公开(公告)日：2012-10-03
申请号：EP09009608.2
申请日：1998-12-23
申请人： GE Healthcare AS
发明人： Ardenkjaer-Larsen, Jan Henrik , Axelsson, Oskar , Golman, Klaes , Hansson, Georg , Leunbach, Ib , Petersson, Stefan , Wistrand, Lars-Göran
IPC分类号： G01R33/28 , G01R33/56 , A61K49/08 , A61K49/10 , A61K49/18 , G01R33/62
CPC分类号： G01R33/5601 , A61K49/08 , A61K49/10 , A61K49/18 , A61K49/1815 , G01R33/282 , G01R33/62

3. 发明公开

EP2119457A1 Method of magnetic resonance investigation with hyperpolarised contrast agents 有权
标题翻译： Verfahren zur Herstellung eines hyperpolarisierten Kontrastmittels
公开(公告)号：EP2119457A1
公开(公告)日：2009-11-18
申请号：EP09009608.2
申请日：1998-12-23
申请人： GE Healthcare AS
发明人： Ardenkjaer-Larsen, Jan Henrik , Axelsson, Oskar , Golman, Klaes , Hansson, Georg , Leunbach, Ib , Petersson, Stefan , Wistrand, Lars-Göran
IPC分类号： A61K49/06 , A61K49/08 , G01R33/28 , G01R33/62
CPC分类号： G01R33/5601 , A61K49/08 , A61K49/10 , A61K49/18 , A61K49/1815 , G01R33/282 , G01R33/62
摘要： This invention provides a method of magnetic resonance investigation of a sample, preferably of a human or non-human animal body, said method comprising:
(i) producing a hyperpolarised solution of a high T 1 agent by dissolving in a physiologically tolerable solvent a hyperpolarised solid sample of said high T 1 agent;
(ii) where the hyperpolarisation of the solid sample of said high T 1 agent in step (i) is effected by means of a polarising agent, optionally separating the whole, substantially the whole, or a portion of said polarising agent from said high T 1 agent;
(iii) administering said hyperpolarised solution to said sample;
(iv) exposing said sample to a second radiation of a frequency selected to excite nuclear spin transitions in selected nuclei eg the MR imaging nuclei of the high T 1 agent;
(v) detecting magnetic resonance signals from said sample; and
(vi) optionally, generating an image, dynamic flow data, diffusion data, perfusion data, physiological data (eg. pH, pO 2 , pCO 2 , temperature or ionic concentrations) or metabolic data from said detected signals,

wherein said high T 1 agent in said hyperpolarised solution has a T 1 value (at a field strength in the range 0.01-5T and a temperature in the range 20-40°C) of at least 5 seconds.
摘要翻译：本发明提供了一种样品，优选人或非人动物体的磁共振研究方法，所述方法包括：（i）通过将高T 1试剂溶解在生理上可耐受的溶剂中制成超极化溶液所述高T 1试剂的固体样品; （ii）其中步骤（i）中所述高T 1试剂的固体样品的超极化是通过偏振剂进行的，任选地从所述高T分离整个，基本上全部或部分所述偏振剂 1代理; （iii）将所述超极化溶液施用于所述样品; （iv）将所述样品暴露于所选频率的第二辐射，以激发所选择的核中的核自旋跃迁，例如高T 1试剂的MR成像核; （v）检测来自所述样品的磁共振信号; 和（vi）可选地，从所述检测到的信号生成图像，动态流动数据，扩散数据，灌注数据，生理数据（例如pH，pO 2，pCO 2，温度或离子浓度）或代谢数据，其中所述高T 所述超极化溶液中的一种试剂具有至少5秒的T 1值（在0.011-5T的范围内的场强和20-40℃的温度）。

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